Presencia de la literatura hispanoamericana en las revistas españolas de vanguardia: 1918-1939.

Sin resume

Formas cuspidales de playas y procesos de la zona de rompientes interna: ¿crecimiento o destrucción? Aplicación a la playa de Trafalgar (Cádiz, España)

Large beach cusps (LBC, wavelength of ~ 30 m) are intertidal features that can alternately exist in the swash and in the inner surf zone due to tidal sea level changes. They have a larger cross-shore extent (up to 50 m) than traditional cusps. This extent has been explained by a shift of the swash zone during falling tide. The cusps immerse at rising tide and previous studies indicate that surf zone processes are exclusively destructive. Here, the behaviour of large beach cusps in the inner surf zone is investigated by using a 2DH morphological numerical model applied to Trafalgar Beach (Cádiz, Spain). The model results indicate that the inner surf zone processes do not always destroy the cusps but can in fact reinforce them by considering neither the swash processes nor the tidal changes. More generally, in conditions favouring the presence of the LBC the surf zone of a beach can be unstable, leading to the formation of transverse/oblique sand bars that can have characteristics similar to the LBC. Thus, in principle, the LBC could emerge not only due to swash zone morphodynamics but also due to surf zone morphodynamics or a combination of both.Las formas cuspidales de grandes dimensiones (LBC, longitudes de onda ~30 m) constituyen un sistema morfológico rítmico a lo largo de la playa que tiene una parte que se encuentra alternativamente en la zona de swash (flujo/reflujo) y en la zona de rompientes interna debido a los cambios del nivel del mar. Tienen una distancia de penetración de hasta 50 m, superior por tanto a la de las cúspides ordinarias. Esta elongación parece debido a la traslación de la zona de swash durante la marea descendente. En marea ascendente estas estructuras están sumergidas y los estudios previos consideran que los procesos de la zona de rompientes las destruyen. En este trabajo se analiza el comportamiento de estas formas en la zona de rompientes de la playa de Trafalgar (Cádiz) usando un modelo numérico morfológico 2DH. Los resultados muestran que, sin considerar ni los procesos de swash ni el cambio de marea, los procesos de la zona de rompientes no necesariamente destruyen LBC, sino que pueden reforzarlas. De forma más general, en condiciones favorables a la presencia de LBC, se pueden formar barras de arena con características similares a LBC debido a procesos de auto-organización en la zona de rompientes.The work of R. Garnier was supported by the University of Nottingham and is part of the Spanish Government project under contract CTM2006-08875. The Spanish Ministry of Science and Education (Project BORRASCAS CTM2005-06583) and the Junta de Andalucía (Projects P05-RNM-968 and P06-RNM-1573) funded part of this research

Mapping giant mass transport deposits (MTDs) for delineating the extended Continental Shelf of Spain to the West of Canary Islands according UNCLOS Art. 76

European Geosciences Union General Assembly (2017. Viena)On 19 December 2014, Spain presented a third partial submission for the delineation of the Extended Continental in the area west of the Canary Islands to the Commission on the Limits of the Continental Shelf (CLCS) according to the United Nations Convention on the Law of Sea (UNCLOS). The Canary Islands are located within a NE-SW 1,350 km long ridge of hotspot-inferred volcanic islands and seamounts (composed by more of 100, from Lars to Tropic seamounts). This submission has been documented with an extensive dataset specifically obtained for the project during ten oceanographic cruises between 2010 and 2014 aboard the Spanish research vessels Hespérides, Sarmiento de Gamboa and Miguel Oliver. This new dataset allows to investigate an area of 440,000 km2 with acoustic backscatter images and multibeam echosounder bathymetric (MBES) data (Simrad EM-12, EM-120 and EM-302, and Atlas HYDROSWEEP DS), a dense network of 65,800 km of very-high resolution (VHR) seismic lines (including chirp parametric source TOPAS PS-18 and Atlas PARASOUND P-35) and 4,471 km of multichannel seismic reflection lines (MCS) acquired with an array of air-guns yielding a total volume of 4,600 inch3 (75.38 L) and a 3,500 m long streamer composed of 280 channels.Instituto Geológico y Minero de España, EspañaInstituto Español de Oceanografía, EspañaInstituto Hidrográfico de la Marina, Españ

LipoDDx: a mobile application for identification of rare lipodystrophy syndromes

BACKGROUND: Lipodystrophy syndromes are a group of disorders characterized by a loss of adipose tissue once other situations of nutritional deprivation or exacerbated catabolism have been ruled out. With the exception of the HIV-associated lipodystrophy, they have a very low prevalence, which together with their large phenotypic heterogeneity makes their identification difficult, even for endocrinologists and pediatricians. This leads to significant delays in diagnosis or even to misdiagnosis. Our group has developed an algorithm that identifies the more than 40 rare lipodystrophy subtypes described to date. This algorithm has been implemented in a free mobile application, LipoDDx(R). Our aim was to establish the effectiveness of LipoDDx(R). Forty clinical records of patients with a diagnosis of certainty of most lipodystrophy subtypes were analyzed, including subjects without lipodystrophy. The medical records, blinded for diagnosis, were evaluated by 13 physicians, 1 biochemist and 1 dentist. Each evaluator first gave his/her results based on his/her own criteria. Then, a second diagnosis was given using LipoDDx(R). The results were analysed based on a score table according to the complexity of each case and the prevalence of the disease. RESULTS: LipoDDx(R) provides a user-friendly environment, based on usually dichotomous questions or choice of clinical signs from drop-down menus. The final result provided by this app for a particular case can be a low/high probability of suffering a particular lipodystrophy subtype. Without using LipoDDx(R) the success rate was 17 +/- 20%, while with LipoDDx(R) the success rate was 79 +/- 20% (p < 0.01). CONCLUSIONS: LipoDDx(R) is a free app that enables the identification of subtypes of rare lipodystrophies, which in this small cohort has around 80% effectiveness, which will be of help to doctors who are not experts in this field. However, it will be necessary to analyze more cases in order to obtain a more accurate efficiency value

Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand.

OBJECTIVE: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. DESIGN: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. METHODS: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. RESULTS: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20-0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least -1 maintained a similar height to the WHO reference mean. CONCLUSION: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age

Phylodynamics of HIV-1 from a Phase III AIDS Vaccine Trial in Bangkok, Thailand

In 2003, a phase III placebo-controlled trial (VAX003) was completed in Bangkok, Thailand. Of the 2,546 individuals enrolled in the trial based on high risk for infection through injection drug use (IDU), we obtained clinical samples and HIV-1 sequence data (envelope glycoprotein gene gp120) from 215 individuals who became infected during the trial. Here, we used these data in combination with other publicly available gp120 sequences to perform a molecular surveillance and phylodynamic analysis of HIV-1 in Thailand.Phylogenetic and population genetic estimators were used to assess HIV-1 gp120 diversity as a function of vaccination treatment, viral load (VL) and CD4(+) counts, to identify transmission clusters and to investigate the timescale and demographics of HIV-1 in Thailand. Three HIV-1 subtypes were identified: CRF01_AE (85% of the infections), subtype B (13%) and CRF15_AE (2%). The Bangkok IDU cohort showed more gp120 diversity than other Asian IDU cohorts and similar diversity to that observed in sexually infected individuals. Moreover, significant differences (P<0.02) in genetic diversity were observed in CRF01_AE IDU with different VL and CD4(+) counts. No phylogenetic structure was detected regarding any of the epidemiological and clinical factors tested, although high proportions (35% to 50%) of early infections fell into clusters, which suggests that transmission chains associated with acute infection play a key role on HIV-1 spread among IDU. CRF01_AE was estimated to have emerged in Thailand in 1984.5 (1983-1986), 3-6 years before the first recognition of symptomatic patients (1989). The relative genetic diversity of the HIV-1 population has remained high despite decreasing prevalence rates since the mid 1990s.Our study and recent epidemiological reports indicate that HIV-1 is still a major threat in Thailand and suggest that HIV awareness and prevention needs to be strengthened to avoid AIDS resurgence

Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.

The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens

Overview of recent TJ-II stellarator results

The main results obtained in the TJ-II stellarator in the last two years are reported. The most important topics investigated have been modelling and validation of impurity transport, validation of gyrokinetic simulations, turbulence characterisation, effect of magnetic configuration on transport, fuelling with pellet injection, fast particles and liquid metal plasma facing components. As regards impurity transport research, a number of working lines exploring several recently discovered effects have been developed: the effect of tangential drifts on stellarator neoclassical transport, the impurity flux driven by electric fields tangent to magnetic surfaces and attempts of experimental validation with Doppler reflectometry of the variation of the radial electric field on the flux surface. Concerning gyrokinetic simulations, two validation activities have been performed, the comparison with measurements of zonal flow relaxation in pellet-induced fast transients and the comparison with experimental poloidal variation of fluctuations amplitude. The impact of radial electric fields on turbulence spreading in the edge and scrape-off layer has been also experimentally characterized using a 2D Langmuir probe array. Another remarkable piece of work has been the investigation of the radial propagation of small temperature perturbations using transfer entropy. Research on the physics and modelling of plasma core fuelling with pellet and tracer-encapsulated solid-pellet injection has produced also relevant results. Neutral beam injection driven Alfvénic activity and its possible control by electron cyclotron current drive has been examined as well in TJ-II. Finally, recent results on alternative plasma facing components based on liquid metals are also presentedThis work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 under Grant Agreement No. 633053. It has been partially funded by the Ministerio de Ciencia, Inovación y Universidades of Spain under projects ENE2013-48109-P, ENE2015-70142-P and FIS2017-88892-P. It has also received funds from the Spanish Government via mobility grant PRX17/00425. The authors thankfully acknowledge the computer resources at MareNostrum and the technical support provided by the Barcelona S.C. It has been supported as well by The Science and Technology Center in Ukraine (STCU), Project P-507F