EBSD texture analysis of an AlCuMg alloy for different solidification rates

The 3xx series aluminium alloys are widely used for automotive applications. However, increments in engine power density result in higher alloy mechanical properties requirements for components such as cylinder heads. These alloys should perform better at high temperatures (>200 °C). A good alternative to the traditional Al-Si alloys are the Al- Cu based alloys. However, hot tear tendency is a big obstacle for the widespread use of this family of alloys [1]. The present work focus on determine the relationship between crack occurrence and grain orientation, as a result of the solidification rate. Grain refinement elements such as Ti and Zn are added to the alloy to reduce hot tearing tendency. Two different variants of AlCuMg alloy are evaluated at different solidification rates.Postprint (published version

Purificación del agua por medio de membranas en la ciudad de Pampas Tayacaja-Huancavelica

At present, environmental requirements and the growth of environmental management systems, have generated a change of consciousness at an industrial level, leading this to satisfy the expectations of customers both in the quality of products or services, as well as in the ways environmentally friendly production facilities, the above added to environmental regulations, have generated a change in the production culture in which the enormous losses of raw materials that are discarded into the sewers must be recovered and reincorporated into the production process, resulting in in economic and environmental benefits. In the city of Pampas Tayacaja there is a very latent problem which is the lack of water treatment, which is why most of the population often uses contaminated water in their food thus causing some diseases. For this reason, in this present work an investigation will be proposed on the use of membranes that is certainly suitable today for water treatment. In general, the efficiency of a membrane depends of the composition of the liquid fluid to be treated, other related factors with its maintenance are hydraulic pressure and fouling what is as a result of research, the cleaning of the membranes is key for the issue of treatment costs and efficiency. In conclusion, the technology of the membranes improves water quality and its efficiency influences the maintenance costs.En la actualidad, los requerimientos ambientales y el crecimiento de los sistemas de gestión ambiental, han generado un cambio de conciencia a nivel industrial, llevando a satisfacer las expectativas de los clientes tanto en la calidad de los productos o servicios, como en las formas de producción amigables con el medio ambiente, lo anterior sumado a las regulaciones ambientales, han generado un cambio en la cultura de producción en la cual las pérdidas enormes de materias primas que se desechan a los alcantarillados deben ser recuperadas y reincorporadas al proceso productivo, redundando en beneficios económicos y ambientales. En la ciudad de Pampas Tayacaja existe un problema muy latente, el cual es la falta de tratamiento del agua, por lo que la mayoría de la población muchas veces utiliza el agua contaminada en sus alimentos, así produciendo algunas enfermedades. Por tal motivo, en este presente trabajo se planteará una investigación sobre el uso de membranas que ciertamente resulta adecuado en la actualidad para el tratamiento del agua.  En general, la eficiencia de una membrana depende de la composición del fluido líquido a tratar, otros factores relacionados con su mantenimiento son la presión hidráulica y ensuciamiento lo que es motivo de investigaciones, la limpieza de las membranas resulta clave por el tema de costos y eficiencia del tratamiento. En conclusión, la tecnología de las membranas mejora la calidad del agua y su eficiencia influye en los costos de mantenimiento

Enabling planetary science across light-years. Ariel Definition Study Report

Ariel, the Atmospheric Remote-sensing Infrared Exoplanet Large-survey, was adopted as the fourth medium-class mission in ESA's Cosmic Vision programme to be launched in 2029. During its 4-year mission, Ariel will study what exoplanets are made of, how they formed and how they evolve, by surveying a diverse sample of about 1000 extrasolar planets, simultaneously in visible and infrared wavelengths. It is the first mission dedicated to measuring the chemical composition and thermal structures of hundreds of transiting exoplanets, enabling planetary science far beyond the boundaries of the Solar System. The payload consists of an off-axis Cassegrain telescope (primary mirror 1100 mm x 730 mm ellipse) and two separate instruments (FGS and AIRS) covering simultaneously 0.5-7.8 micron spectral range. The satellite is best placed into an L2 orbit to maximise the thermal stability and the field of regard. The payload module is passively cooled via a series of V-Groove radiators; the detectors for the AIRS are the only items that require active cooling via an active Ne JT cooler. The Ariel payload is developed by a consortium of more than 50 institutes from 16 ESA countries, which include the UK, France, Italy, Belgium, Poland, Spain, Austria, Denmark, Ireland, Portugal, Czech Republic, Hungary, the Netherlands, Sweden, Norway, Estonia, and a NASA contribution

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

XXV Curso Monográfico de Psiquiatría Infantil y la Adolescencia: Tópicos de Psicofarmacología Infantil - 2023

El XXV Curso Monográfico de Psiquiatría Infantil y de la Adolescencia, titulado "Tópicos de Psicofarmacología Infantil," fue un evento destacado en el campo de la salud mental infantil y adolescente. Durante tres días en septiembre de 2023, expertos líderes en la materia se reunieron para explorar a fondo la psicofarmacología en este grupo de edad. El evento, dedicado a la memoria del Dr. Francisco Javier Valencia Granados, comenzó con una ceremonia de inauguración en la que participaron autoridades institucionales. Luego, se sucedieron conferencias magistrales que abordaron una amplia variedad de temas cruciales. Estos incluyeron aspectos fundamentales como la neurobioquímica farmacológica y una introducción a la psicofarmacología. El programa se adentró en cuestiones específicas, como el uso de antipsicóticos en paidopsiquiatría, el abordaje de trastornos del aprendizaje, el tratamiento del suicidio desde una perspectiva psicofarmacológica, y la gestión farmacológica del insomnio en niños. Se exploraron temas especializados, como el tratamiento de la esquizofrenia en pacientes infantiles. El segundo día se centró en trastornos emocionales en niños y adolescentes, destacando el tratamiento del trastorno depresivo, los trastornos ansiosos y el espectro autista. Se presentaron enfoques vanguardistas, como el uso de psicodélicos en adolescentes y las novedades en psicofarmacología, como el dextrometorfano y el bupropión. También se discutió el manejo de la epilepsia y la adicción a los videojuegos. El tercer día se enfocó en el tratamiento farmacológico de trastornos pediátricos específicos, como el trastorno bipolar, el déficit de atención e hiperactividad, la enuresis y encopresis, parasomnias, y el abordaje neuropsiquiátrico en pacientes pediátricos con VIH. Se exploraron también trastornos de la conducta alimentaria y la disforia de género. El evento culminó con una reflexión sobre la salud mental en niños y un emotivo tributo al Dr. Francisco Javier

EBSD texture analysis of an AlCuMg alloy for different solidification rates

The 3xx series aluminium alloys are widely used for automotive applications. However, increments in engine power density result in higher alloy mechanical properties requirements for components such as cylinder heads. These alloys should perform better at high temperatures (>200 °C). A good alternative to the traditional Al-Si alloys are the Al- Cu based alloys. However, hot tear tendency is a big obstacle for the widespread use of this family of alloys [1]. The present work focus on determine the relationship between crack occurrence and grain orientation, as a result of the solidification rate. Grain refinement elements such as Ti and Zn are added to the alloy to reduce hot tearing tendency. Two different variants of AlCuMg alloy are evaluated at different solidification rates

EBSD texture analysis of an AlCuMg alloy for different solidification rates

The 3xx series aluminium alloys are widely used for automotive applications. However, increments in engine power density result in higher alloy mechanical properties requirements for components such as cylinder heads. These alloys should perform better at high temperatures (>200 °C). A good alternative to the traditional Al-Si alloys are the Al- Cu based alloys. However, hot tear tendency is a big obstacle for the widespread use of this family of alloys [1]. The present work focus on determine the relationship between crack occurrence and grain orientation, as a result of the solidification rate. Grain refinement elements such as Ti and Zn are added to the alloy to reduce hot tearing tendency. Two different variants of AlCuMg alloy are evaluated at different solidification rates