Social and Environmental Justice for Communities of the Mekong River

During the mid-twentieth century the construction of hydroelectric dams in developing countries became a contentious issue in economic and political arenas. Governments and pro-damming parties, particularly those with a direct commercial interest, often consider the dams to be necessary for economic growth, as well as being in the national interest. Others directly impacted by the altered hydrology and ecology, as well as experts concerned with environmental and demographic impacts, are less sure about the benefits of hydro-electric dams. Concerns about the environmental and human impacts of dams are heightened on a waterway such as the Mekong River, which flows through six sovereign states. When the impacts are to be felt across entire regions, ensuring just outcomes for all the stakeholders is crucial to long-term regional political stability and economic wellbeing. Engineers are pivotal in the design and construction of dams, and engineering teams also play an increasingly important role in assisting communities impacted by the altered hydrology. This article focuses on the community and environmental implications of engineering decisions on the Mekong River, and suggests ways in which engineers involved in dam design and construction can play a role in ensuring that socially and environmentally just outcomes are achieve

Cloud fragmentation and proplyd-like features in HII regions imaged by HST

We have analyzed HST ACS and WFPC2 new and archival images of eight HII regions to look for new proto-planetary disks (proplyds) similar to those found in the Orion Nebula. We find a wealth of features similar in size (though many are larger) to the bright cusps around the Orion Nebula proplyds. None of them, however, contains a definitive central star. From this, we deduce that the new cusps may not be proplyds, but instead are fragments of molecular cloud material. Out of all the features found in the eight HII regions examined, only one, an apparent edge-on silhouette in M17, may have a central star. This feature might join the small number of bona fide proplyds found outside the Orion Nebula, in M8, M20 and possibly in M16. In line with the results found recently by Smith et al. (2005), the paucity of proplyds outside the Orion Nebula, may be explained by their transient nature as well as by the specific environmental conditions under whichthey can be observed.Comment: 51 pages; 19 figures; 5 tables. Accepted by A

Spectroscopic and physical parameters of Galactic O-type stars. I. Effects of rotation and spectral resolving power in the spectral classification of dwarfs and giants

The modern-era spectral classification of O-stars relies on either the Walborn or the Conti-Mathys scheme. Since both of these approaches have been developed using low-quality photographic data, their application to high-quality digital data might not be straightforward and be hampered by problems and complications that have not yet been appreciated. Using high-resolution spectra obtained with the ESO/MPG 2.2\,m telescope in La Silla and following the premises of the Walborn and Conti classification schemes, we determined the spectral types and luminosity classes of 19 Galactic O-type stars and compared them to those attributed by Walborn and Mathys based on low-quality data. Our analysis reveals that the morphological spectral types assigned using high-resolution data are systematically later (by up to 1.5 subtypes) then those attributed by Walborn. By means of line-profile simulations, we show that part of this discrepancy is more likely caused by the combined effect of stellar rotation and high spectral resolution on the depth of helium lines used as spectral type indicators. In addition, we demonstrate that at least for narrow-lined stars the "rotational effect" does not disappear when the high-resolution spectra are degraded to the resolution of the Walborn standards. We also find evidence of a systematic difference between our high-resolution quantitative spectral types and those assigned by Mathys. Rotation and spectral resolution are important third parameters in the spectral classification of O-type stars. To obtain reliable spectral classes within the Walborn approach, the unknown and the standard spectra must be compared at the same resolution and \vsini. Owing to resolution effects, the Conti approach might also need to be updated.Comment: paper accepted for publication in A&

Abnormal expression of p27kip1 protein in levator ani muscle of aging women with pelvic floor disorders – a relationship to the cellular differentiation and degeneration

BACKGROUND: Pelvic floor disorders affect almost 50% of aging women. An important role in the pelvic floor support belongs to the levator ani muscle. The p27/kip1 (p27) protein, multifunctional cyclin-dependent kinase inhibitor, shows changing expression in differentiating skeletal muscle cells during development, and relatively high levels of p27 RNA were detected in the normal human skeletal muscles. METHODS: Biopsy samples of levator ani muscle were obtained from 22 symptomatic patients with stress urinary incontinence, pelvic organ prolapse, and overlaps (age range 38–74), and nine asymptomatic women (age 31–49). Cryostat sections were investigated for p27 protein expression and type I (slow twitch) and type II (fast twitch) fibers. RESULTS: All fibers exhibited strong plasma membrane (and nuclear) p27 protein expression. cytoplasmic p27 expression was virtually absent in asymptomatic women. In perimenopausal symptomatic patients (ages 38–55), muscle fibers showed hypertrophy and moderate cytoplasmic p27 staining accompanied by diminution of type II fibers. Older symptomatic patients (ages 57–74) showed cytoplasmic p27 overexpression accompanied by shrinking, cytoplasmic vacuolization and fragmentation of muscle cells. The plasma membrane and cytoplasmic p27 expression was not unique to the muscle cells. Under certain circumstances, it was also detected in other cell types (epithelium of ectocervix and luteal cells). CONCLUSIONS: This is the first report on the unusual (plasma membrane and cytoplasmic) expression of p27 protein in normal and abnormal human striated muscle cells in vivo. Our data indicate that pelvic floor disorders are in perimenopausal patients associated with an appearance of moderate cytoplasmic p27 expression, accompanying hypertrophy and transition of type II into type I fibers. The patients in advanced postmenopause show shrinking and fragmentation of muscle fibers associated with strong cytoplasmic p27 expression

Peptide ion channel toxins from the bootlace worm, the longest animal on Earth

Polypeptides from animal venoms have found important uses as drugs, pharmacological tools, and within biotechnological and agricultural applications. We here report a novel family of cystine knot peptides from nemertean worms, with potent activity on voltage-gated sodium channels. These toxins, named the α-nemertides, were discovered in the epidermal mucus of Lineus longissimus, the ‘bootlace worm’ known as the longest animal on earth. The most abundant peptide, the 31-residue long α-1, was isolated, synthesized, and its 3D NMR structure determined. Transcriptome analysis including 17 species revealed eight α-nemertides, mainly distributed in the genus Lineus. α-1 caused paralysis and death in green crabs (Carcinus maenas) at 1 µg/kg (~300 pmol/kg). It showed profound effect on invertebrate voltage-gated sodium channels (e.g. Blattella germanica Nav1) at low nanomolar concentrations. Strong selectivity for insect over human sodium channels indicates that α-nemertides can be promising candidates for development of bioinsecticidal agents

Milestones in the Observations of Cosmic Magnetic Fields

Magnetic fields are observed everywhere in the universe. In this review, we concentrate on the observational aspects of the magnetic fields of Galactic and extragalactic objects. Readers can follow the milestones in the observations of cosmic magnetic fields obtained from the most important tracers of magnetic fields, namely, the star-light polarization, the Zeeman effect, the rotation measures (RMs, hereafter) of extragalactic radio sources, the pulsar RMs, radio polarization observations, as well as the newly implemented sub-mm and mm polarization capabilities. (Another long paragraph is omitted due to the limited space here)Comment: Invited Review (ChJA&A); 32 pages. Sorry if your significant contributions in this area were not mentioned. Published pdf & ps files (with high quality figures) now availble at http://www.chjaa.org/2002_2_4.ht

The Palomar Testbed Interferometer Calibrator Catalog

The Palomar Testbed Interferometer (PTI) archive of observations between 1998 and 2005 is examined for objects appropriate for calibration of optical long-baseline interferometer observations - stars that are predictably point-like and single. Approximately 1,400 nights of data on 1,800 objects were examined for this investigation. We compare those observations to an intensively studied object that is a suitable calibrator, HD217014, and statistically compare each candidate calibrator to that object by computing both a Mahalanobis distance and a Principal Component Analysis. Our hypothesis is that the frequency distribution of visibility data associated with calibrator stars differs from non-calibrator stars such as binary stars. Spectroscopic binaries resolved by PTI, objects known to be unsuitable for calibrator use, are similarly tested to establish detection limits of this approach. From this investigation, we find more than 350 observed stars suitable for use as calibrators (with an additional $\approx 140$ being rejected), corresponding to $\gtrsim 95$ sky coverage for PTI. This approach is noteworthy in that it rigorously establishes calibration sources through a traceable, empirical methodology, leveraging the predictions of spectral energy distribution modeling but also verifying it with the rich body of PTI's on-sky observations.Comment: 100 pages, 7 figures, 7 tables; to appear in the May 2008ApJS, v176n

A search for white dwarfs in the Galactic plane: : the field and the open cluster population

This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society. The Version of Record [R. Raddi, et al, ‘A search for white dwarfs in the Galactic plane: the field and the open cluster population’, Monthly Notices of the Royal Astronomical Society, Vol. 457 (2): 1988-2004, first published online 5 February 2016] is available online at doi: https://doi.org/10.1093/mnras/stw042. © 2016 The Author(s). Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved.We investigated the prospects for systematic searches of white dwarfs at low Galactic latitudes, using the VLT Survey Telescope (VST) H$\alpha$ Photometric Survey of the Galactic plane and Bulge (VPHAS+). We targeted 17 white dwarf candidates along sightlines of known open clusters, aiming to identify potential cluster members. We confirmed all the 17 white dwarf candidates from blue/optical spectroscopy, and we suggest five of them to be likely cluster members. We estimated progenitor ages and masses for the candidate cluster members, and compared our findings to those for other cluster white dwarfs. A white dwarf in NGC 3532 is the most massive known cluster member (1.13 M$_{\odot}$), likely with an oxygen-neon core, for which we estimate an $8.8_{-4.3}^{+1.2}$ M$_{\odot}$ progenitor, close to the mass-divide between white dwarf and neutron star progenitors. A cluster member in Ruprecht 131 is a magnetic white dwarf, whose progenitor mass exceeded 2-3 M$_{\odot}$. We stress that wider searches, and improved cluster distances and ages derived from data of the ESA Gaia mission, will advance the understanding of the mass-loss processes for low- to intermediate-mass stars.Peer reviewedFinal Published versio

The management and survival outcomes of nasopharyngeal cancer in the Nordic countries

Peer reviewe