The Spectrum of Crab Nebula X-Rays to 120 Kev

Counting rate and pulse height distribution spectral data of Crab Nebula telemetered from balloon detector

Spoken Corpora Good Practice Guide 2006

International audienceThere is currently a vast amount of fundamental or applied research, which is based on the exploitation of oral corpora (organized recorded collections of oral and multimodal language productions). Created as a result of linguists becoming aware of the importance to ensure the durability of sources and a diversified access to the oral documents they produce, this Guide to good practice mainly deals with “oral corpora”, created for and used by linguists. But the questions raised by the creation and documentary exploitation of these corpora can be found in numerous disciplines: ethnology, anthropology, sociology, psychology, demography, oral history notably use oral surveys, testimonies, interviews, life stories. Based on a linguistic approach, this Guide also touches on the preoccupations of other researchers who use oral corpora (for example in the field of speech synthesis and recognition), even if their specific needs aren’t consistently dealt with in the present document

Corpus oraux, Guide des bonnes pratiques 2006. Version allemande

International audienceViele Grundlagen- oder angewandte Forschungen beruhen zur Zeit auf der Auswertung von „Korpora der gesprochenen Sprache“ (geordneten Sammelwerken der Aufnahmen von mündlichen und multimodalen sprachlichen Produktionen). Dieses Handbuch der guten Praktiken entsteht aus der Erkenntnis von Sprachwissenschaftlern, die darauf bedacht sind, den Fortbestand der Quellen und einen verschiedenartigen Zugang zu den mündlichen von ihnen produzierten Produktionen zu sichern ; es schneidet zuerst die „Korpora der gesprochenen Sprache“ an, die von Sprachwissenschaftlern und für sie geschaffen und verwendet wurden. Die durch die Erschaffung und die dokumentarische Auswertung dieser Korpora hervorgerufenen Fragen trifft man aber in vielen Fächern : die Völkerkunde, die Anthropologie, die Soziologie, die Psychologie, die Demographie, die mündlich überlieferte Geschichte gebrauchen vor allem die verbale Befragung, die Aussage, das Interview, die Lebensgeschichte. Dieses Handbuch beruft sich auf das Verfahren der Sprachwissenschaftler, es stimmt aber mit den Beschäftigungen anderer Forscher überein, die Korpora der gesprochenen Sprache (z. B. in Sprachsynthese und -entzifferung) gebrauchen, auch wenn ihre spezifischen Bedürfnisse im vorliegenden Dokument nicht systematisch angeschnitten werden

Non-suicidal self-injury in adolescence: a longitudinal study of the relationship between NSSI, psychological distress and perceived parenting

Objective: The present study investigates whether either adolescents' psychological distress and/or perceived parenting predicted the occurrence of NSSI. Furthermore, the consequences of NSSI are examined in a three-wave longitudinal study. Design: The sample at time 1 (age 12) consisted of 1396 adolescent reports and 1438 parent reports. At time 2 (age 13), 827 adolescent reports and 936 parent reports were obtained. Time 3 (age 14) included 754 adolescent reports and 790 parent reports. Psychological distress of adolescents was measured using the Strengths and Difficulties Questionnaire. Perceived parenting behaviors were examined by the Parental Behavior Scale and the Psychological Control Scale. Results: A total of 10% of the adolescents engaged in NSSI at least once before age 15. Higher psychological distress of adolescents at time 1 was associated with the presence of NSSI at time 2 or 3. The association between psychological distress at time 1 and perception of decreased parental rule setting at time 3 was mediated by the presence of NSSI at time 2. Conclusions: The present study showed that psychological distress at age 12 predicts NSSI over time and that parental awareness of NSSI changes the perception of parenting behaviors. (C) 2014 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved

Of temporality and plurality: an epistemic and governance agenda for accelerating just transitions for energy access and sustainable development

The complementarity of sustainable energy transitions and energy access provision are one of the key characteristics of both the Sustainable Development Goals and the Paris Agreement on climate change. In this perspective piece, we offer an epistemic and governance agenda to advance the imperative of speed in meeting both ambitions and to acknowledge the plurality of disciplines, actors, and institutions involved. Recognizing that the processes required to achieve these global goals entail navigating tensions, we suggest that shifts in ways knowledge is produced and transitions are governed could be based on a justice framework

Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance

Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance may lead to improved therapeutic options for type 2 diabetes and other obesity-related diseases. Here, we find that adipose expression of the small neutral amino acid transporter SLC7A10, also known as alanine-serine-cysteine transporter-1 (ASC-1), shows strong inverse correlates with visceral adiposity, insulin resistance, and adipocyte hypertrophy across multiple cohorts. Concordantly, loss of Slc7a10 function in zebrafish in vivo accelerates diet-induced body weight gain and adipocyte enlargement. Mechanistically, SLC7A10 inhibition in human and murine adipocytes decreases adipocyte serine uptake and total glutathione levels and promotes reactive oxygen species (ROS) generation. Conversely, SLC7A10 overexpression decreases ROS generation and increases mitochondrial respiratory capacity. RNA sequencing revealed consistent changes in gene expression between human adipocytes and zebrafish visceral adipose tissue following loss of SLC7A10, e.g., upregulation of SCD (lipid storage) and downregulation of CPT1A (lipid oxidation). Interestingly, ROS scavenger reduced lipid accumulation and attenuated the lipid-storing effect of SLC7A10 inhibition. These data uncover adipocyte SLC7A10 as a novel important regulator of adipocyte resilience to nutrient and oxidative stress, in part by enhancing glutathione levels and mitochondrial respiration, conducive to decreased ROS generation, lipid accumulation, adipocyte hypertrophy, insulin resistance, and type 2 diabetes.acceptedVersio