101 research outputs found
Literarisches Er-Zählen. Ein theoretisches Experiment zum mittelalterlichen Erzählen im Spannungsfeld von Quantität und Qualität
‚Zählen‘ und ‚Erzählen‘ stehen in einem engen kulturgeschichtlichen Zusammenhang, der sich auch für das Mittelalter belegen lässt. Hieran ansetzend unternimmt der Beitrag einen neuen historisch-narratologischen Versuch. Im Sinne eines theoretischen Experiments werden für das mittelalterliche literarische Erzählen und dessen Erschließung im Rahmen mediävistischer Erzählforschung verschiedene Spannungsfelder von Quantität und Qualität exploriert, die nicht nur ein anderes Verständnis mittelalterlichen Erzählens erlauben. Sie eröffnen im Blick auf die Konturen historisch-narratologischen Arbeitens auch weitere Differenzierungen, die traditionelle wissenschaftstheoretische Dichotomien nachdrücklich hinterfragbar machen.‘Counting’ and ‘recounting’ are closely connected in terms of cultural history, and this can also be proven for the Middle Ages. This contribution makes a new historical-narratological attempt. For the purpose of theoretical experiment, various fields of tension between quantity and quality are explored for Medieval literary narrative and its examination within the framework of Medieval narrative research, which not only allow for a different understanding of Medieval narrative. With a view to the contours of historical-narratological work, they also expose further differentiations which make traditional epistemological dichotomies emphatically questionable
Untersuchungen zur Erzeugung von organischen Nanopartikeln mittels einer Flüssigkeitsring-Vakuumpumpe
Die vorliegende Arbeit beschäftigt sich mit einer neuer Verfahrensidee zur aerosolbasierten Erzeugung von organischen Nanopartikeln. Durch simultane Kompression und Kühlung eines Gas-Dampf-Gemischs in einer Flüssigkeitsring-Vakuumpumpe tritt Aerosolbildung aufgrund homogener Keimbildung auf. Neben experimentellen Ergebnissen aus Versuchen an einer Pilotanlage liefert die Arbeit einen Modellansatz zur Beschreibung der schnelle Zustandsänderung und des Übersättigungsaufbaus in der Pumpe
A photometric and kinematic study of the stars and interstellar medium in the central two kpc of NGC 3379
HST images of NGC 3379 show that the V and I luminosity profiles in the inner
13 arcsec of this E1 galaxy are represented by two different components: a
stellar bulge following a Sersic Law with exponent n = 2.36, and a central core
(r < 0.7 arcsec) with a characteristic "cuspy" profile. Subtraction of the
underlying stellar component represented by the fitted Sersic profile revealed
the presence of a small (r ~ 105 pc) dust disk of about 150 solar masses,
oriented at PA = 125 degrees and inclined ~ 77 degrees with respect to the line
of sight. The same absorption structure is detected in the color-index (V-I)
image. The stellar rotation in the inner 20 arcsec is well represented by a
parametric planar disk model, inclined ~ 26 degrees relative to the plane of
the sky, and apparent major axis along PA ~ 67 degrees. The gas velocity curves
in the inner 5 arcsec show a steep gradient, indicating that the gas rotates
much faster than the stars, although in the same direction. The velocity field
of the gaseous system, however, is not consistent with the simple model of
Keplerian rotation sustained by the large (7 x 10E9 solar masses within a
radius of ~ 90 pc) central mass implied by the maximum velocity observed, but
the available data precludes a more detailed analysis.Comment: 23 pages, LaTeX(aaspp4.sty), 9 figures included. Figs. 1 and 5 are
colour plates. Accepted for publication in The Astrophysical Journal (part 1
The effect of thermally pulsating asymptotic giant branch stars on the evolution of the rest-frame near-infrared galaxy luminosity function
We address the fundamental question of matching the rest-frame K-band
luminosity function (LF) of galaxies over the Hubble time using semi-analytic
models, after modification of the stellar population modelling. We include the
Maraston evolutionary synthesis models, that feature a higher contribution by
the Thermally Pulsating - Asymptotic Giant Branch (TP-AGB) stellar phase, into
three different semi-analytic models, namely the De Lucia and Blaizot version
of the Munich model, MORGANA and the Menci model. We leave all other input
physics and parameters unchanged. We find that the modification of the stellar
population emission can solve the mismatch between models and the observed
rest-frame K-band luminosity from the brightest galaxies derived from UKIDSS
data at high redshift. For all explored semi-analytic models this holds at the
redshifts - between 2 and 3 - where the discrepancy was recently pointed out.
The reason for the success is that at these cosmic epochs the model galaxies
have the right age (~1 Gyr) to contain a well-developed TP-AGB phase which
makes them redder without the need of changing their mass or age. At the same
time, the known overestimation of the faint end is enhanced in the K-band when
including the TP-AGB contribution. At lower redshifts (z<2) some of the
explored models deviate from the data. This is due to too short merging
timescales and inefficient 'radio-mode' AGN feedback. Our results show that a
strong evolution in mass predicted by hierarchical models is compatible with no
evolution on the bright-end of the K-band LF from z=3 to the local universe.
This means that, at high redshifts and contrary to what is commonly accepted,
K-band emission is not necessarily a good tracer of galaxy mass.Comment: 10 pages, 5 figures, accepted by MNRA
Reflexões sobre o crescente número de cesáreas no Brasil: um chamado à consciência
INTRODUÇÃO: A incidência de cesarianas tem aumentado ao longo das décadas em escala global, e no Brasil, esse índice atingiu uma marca significativa de 56% - colocando-o substancialmente acima da média observada em nações em desenvolvimento. METODOLOGIA: Revisão narrativa da literatura realizada a partir da busca bibliográfica na base de dados PubMed, com os descritores “Cesarean”, “Prenatal care”, “Childbirth”. RESULTADOS: Os estudos pesquisados foram publicados em periódicos internacionais, sendo selecionados artigos de revisão, revisão sistemática e metanálise. DISCUSSÃO: No contexto obstétrico nacional, a tendência de aumento nas taxas de cesáreas começou a se manifestar em 2017 e foi exacerbada pela pandemia. Apesar dos esforços para reorganizar a rede de assistência pré-natal durante o período pandêmico, especialmente para pacientes com risco obstétrico, na prática, esses esforços foram limitados. Consequentemente, observou-se um influxo de gestantes em estágios avançados de complicações obstétricas nas unidades de maternidade, muitas das quais necessitando de cesariana para mitigar desfechos materno-perinatais desfavoráveis. CONCLUSÃO: Em conclusão, o aumento nas taxas de cesáreas no Brasil, que já vinha sendo observado há quase uma década e foi intensificado durante a pandemia, destaca a necessidade urgente de políticas e práticas que promovam uma abordagem mais equilibrada e baseada em evidências na assistência obstétrica
ESPÉCIES INVASORAS DA FAMÍLIA DROSOPHILIDAE (DIPTERA, INSECTA) EM AMBIENTES DA CAATINGA DE PERNAMBUCO
Embora as invasões biológicas sejam fenômenos mundiais, poucos estudos foram desenvolvidos em ambientes tropicais, especialmente no Brasil. A escassez de dados sobre os trópicos atinge todos os processos relacionados à invasão, desde a fase de diagnóstico até a de solução de problemas, passando pela caracterização das espécies invasoras, comunidades e habitats invadidos, bem como a previsão dos impactos sobre a biodiversidade. Apresentamos o registro da presença e da distribuição de três espécies invasoras da família Drosophilidae, Zaprionus indianus, Drosophila simulans e D. malerkotliana. Juntas, as três espécies representaram quase metade da abundância absoluta dos indivíduos coletados nos ambientes da Caatinga de Pernambuco aqui investigados
Совершенствование системы делопроизводства угольной компании
В процессе исследования проводилось изучение содержания понятий "делопроизводство" и "документационное обеспечение управления"; исследование нормативно – правовой базы современного делопроизводства, принципов его организации; изучение цели, задач, функций и назначения службы делопроизводства; анализировалась система делопроизводства ООО "Угольная компания "Заречная"; были выработаны рекомендации по совершенствованию системы документационного обеспечения управления. Результаты исследования и выработанные рекомендации были внедрены в практику работы ООО "Угольная компания "Заречная".In the course of the research, the content of the notions of "office work" and "document management provision" was studied; research of the legal base of modern office work, principles of its organization; the study of the purpose, tasks, functions and appointment of the office work; the system of record keeping of LLC "Coal Company "Zarechnaya" was analyzed; Recommendations were developed to improve the system of document management support. The results of the study and the recommendations developed were introduced into the practice of the LLC "Coal Company "Zarechnaya "
Helden in der Schule. Akten der Tagung Kloster Banz 2014
Ausgehend von der Feststellung, dass die Integration mittelalterlicher Texte im Deutschunterricht in der Schulpraxis weitgehend ein Desiderat darstellt, präsentierten Beitragende aus Schule und Wissenschaft bei der Tagung „Helden in der Schule“ im Oktober 2014 ihre Projekte und Ideen zu und Erfahrungen mit der Implementation germanistisch-mediävistischer Inhalte im Deutschunterricht. Dabei reichen die Beiträge von allgemeinen Überlegungen zum Nutzen mittelalterlicher Literatur in der Schule über konkrete Unterrichtsentwürfe bis hin zur Umsetzung in der Waldorfschule und der Integration schulbezogener Lehrveranstaltungen in der Universität. Bei aller Verschiedenheit in den Herangehensweisen wird in allen Beiträgen eindrucksvoll deutlich gemacht, dass mittelalterliche Literatur auch im 21. Jahrhundert überaus lohnend in die Unterrichtspraxis einbezogen werden kann.Since medieval texts are not treated enough in school, lecturers working in school and university presented their projects, ideas and experiences concerning the implementation of German-mediavistic contents in German school lessons during the conference “Heroes in School” in October 2014. The topics concern general reflection about the profitability of medieval literature in school, concrete lesson plans, the implementation in Rudolf Steiner schools, the integration of seminars in university that deal with the work in school etc. All articles demonstrate that the integration of medieval literature in school worth the effort – also in the 21st century
Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models
Rationale: Human coronaviruses (HCoVs) seriously affect human health by causing respiratory diseases ranging from common colds to severe acute respiratory diseases. Immunophilins, including peptidyl-prolyl isomerases of the FK506-binding protein (FKBP) and the cyclophilin family, are promising targets for pharmaceutical inhibition of coronavirus replication, but cell-type specific effects have not been elucidated. FKBPs and cyclophilins bind the immunosuppressive drugs FK506 and cyclosporine A (CsA), respectively.
Methods: Primary human bronchial epithelial cells (phBECs) were treated with CsA, Alisporivir (ALV), FK506, and FK506-derived non-immunosuppressive analogs and infected with HCoV-229E. RNA and protein were assessed by RT-qPCR and immunoblot analysis. Treatment with the same compounds was performed in hepatoma cells (Huh-7.5) infected with HCoV-229E expressing Renilla luciferase (HCoV-229E-RLuc) and the kidney cell line HEK293 transfected with a SARS-CoV-1 replicon expressing Renilla luciferase (SARS-CoV-1-RLuc), followed by quantification of luminescence as a measure of viral replication.
Results: Both CsA and ALV robustly inhibited viral replication in all models; both compounds decreased HCoV-229E RNA in phBECs and reduced luminescence in HCoV-229E-RLuc-infected Huh7.5 and SARS-CoV-1-RLuc replicon-transfected HEK293. In contrast, FK506 showed inconsistent and less pronounced effects in phBECs while strongly affecting coronavirus replication in Huh-7.5 and HEK293. Two non-immunosuppressive FK506 analogs had no antiviral effect in any infection model.
Conclusion: The immunophilin inhibitors CsA and ALV display robust anti-coronaviral properties in multiple infection models, including phBECs, reflecting a primary site of HCoV infection. In contrast, FK506 displayed cell-type specific effects, strongly affecting CoV replication in Huh7.5 and HEK293, but inconsistently and less pronounced in phBECs
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