Estimating Moving Regions out of Point Data – from Excavation Sites in the Amazon region to Areas of Influence of Prehistoric Cultures

Ponencias, comunicaciones y pósters presentados en el 17th AGILE Conference on Geographic Information Science "Connecting a Digital Europe through Location and Place", celebrado en la Universitat Jaume I del 3 al 6 de junio de 2014.How can we derive the changing area of influence of specific cultures from only a few excavation sites in the Amazon region? The approach used for calculating areas of influence for several time intervals strongly depends on the kind of available input data and the examined issues. Our approach divides the input point data into different time intervals and calculates an area (or areas) of influence for each, factoring in spatial and temporal uncertainties inherent in the data. The computation is based on a cost surface, which is derived from the needs and capabilities of the analyzed prehistoric culture or tradition. To take into ac-count that archaeological data is inherently vague, the database is able to handle spatial uncertainties by applying varying maximum distances. Based on the cost raster and the maximum distance a maximum cost value is calculated which is used to derive the said area(s) of influence, which can then be analyzed for changes

Trastuzumab (Herceptin (R)): Monoclonal antibody in the treatment of HER2/neu-overexpressing breast cancer in the metastatic and (neo)adjuvant situation

Trastuzumab (Herceptin (R)) is a humanized monoclonal antibody that specifically targets HER2/neu (human epidermal growth factor receptor-2) breast cancer cells, which are overexpressed in about 25-30% of breast carcinomas. After phase I and II trials, several phase III studies of trastuzumab alone or in combination with various chemotherapies were conducted. Patients with HER2/neu overexpression levels of 3+ determined by immunohistochemical assay or gene amplification (fluorescence in situ hybridization) derive most clinical benefit from trastuzumab. Taking into consideration efficacy and side effect profile, the combination of trastuzumab and paclitaxel showed an improvement of all clinical parameters, including overall survival, for the first time in the history of palliative breast cancer therapy. The application of trastuzumab has meanwhile become an established part of systemic therapy of metastastic breast cancer, and excellent data of its application in the adjuvant setting now exist (NSABP-B31, NCCTG-N9831, HERA), with significantly better relapse-free survival in the treatment arms with trastuzumab. Ongoing trials investigate the role of trastuzumab in the neoadjuvant setting. Trastuzumab is generally well tolerated. Cardiotoxicity is the main concern, thus monitoring of cardiac function is recommended

Making the sustainability hotspot analysis more participatory—experiences from field research in Zambia

Food value chains constitute a core element of food systems. Along any value chain, several bottlenecks, and obstacles negatively affect the sustainability of the entire chain. Therefore, the identification and assessment of such sustainability hotspots is a vital step in the process towards higher levels of sustainability. Over the past few decades food value chains have been supported as part of development cooperation to help alleviate poverty and ensure food and nutrition security. However, so far, a suitable methodology to assess aspects of sustainability along such food value chains was not available. Therefore, we have adapted the sustainability hotspot analysis, originally developed by the Wuppertal Institute, and enhanced it with a participatory approach, thereby making it suitable for application in the context of development cooperation. In this paper, we present a step-by-step overview of the entire assessment process by using examples from its application in Zambia’s dairy and groundnut value chains. The developed methodology allows, through participatory means, the identification and assessment of sustainability aspects by stakeholders themselves, with the validation and amplification of assessment results by locally-based value chain experts. We demonstrate that results from this participatory hotspot analysis are aligned with the principles of agroecology promoted by the FAO, and are geared towards supporting transformative food system change processes. Our key findings from the application of the participatory hotspot analysis showed that sustainability hotspots occur in the social, economic, and ecological dimensions of sustainability along both value chains. It also became clear that hotspots are frequently interconnected, requiring a holistic approach based on a solid understanding of strong sustainability when designing solutions. We conclude that our participatory hotspot analysis provides a user-friendly methodology that generates action-oriented recommendations, and provides an ideal starting point in the development process for co-learning and co-creation of knowledge aimed at generating sustainability-enhancing innovations. The application of the participatory hotspot analysis reveals information on aspects that threaten the sustainability of value chains from a stakeholder perspective. Knowledge of these perspectives is essential, especially for development practitioners tasked with designing implementation strategies to improve the sustainability of value chains

Analyses of murine GBP homology clusters based on in silico, in vitro and in vivo studies

The interactions between pathogens and hosts lead to a massive upregulation of antimicrobial host effector molecules. Among these, the 65 kDa guanylate binding proteins (GBPs) are interesting candidates as intricate components of the host effector molecule repertoire. Members of the GBP family are highly conserved in vertebrates. Previous reports indicate an antiviral activity of human GBP1 (hGBP1) and murine GBP2 (mGBP2). We recently demonstrated that distinct murine GBP (mGBP) family members are highly upregulated upon Toxoplasma gondii infection and localize around the intracellular protozoa T. gondii. Moreover, we characterised five new mGBP family members within the murine 65 kDa GBP family. Here, we identified a new mGBP locus named mGbp11. Based on bacterial artificial chromosome (BAC), expressed sequence tag (EST), and RT-PCR analyses this study provides a detailed insight into the genomic localization and organization of the mGBPs. These analyses revealed a 166-kb spanning region on chromosome 3 harboring five transcribed mGBPs (mGbp1, mGbp2, mGbp3, mGbp5, and mGbp7) and one pseudogene (pseudomGbp1), as well as a 332-kb spanning region on chromosome 5 consisting of six transcribed mGBPs (mGbp4, mGbp6, mGbp8, mGbp9, mGbp10, and mGbp11), and one pseudogene (pseudomgbp2). Besides the strikingly high homology of 65% to 98% within the coding sequences, the mGBPs on chromosome 5 cluster also exhibit a highly homologous exon-intron structure whereas the mGBP on chromosome 3 reveals a more divergent exon-intron structure. This study details the comprehensive genomic organization of mGBPs and suggests that a continuously changing microbial environment has exerted evolutionary pressure on this gene family leading to multiple gene amplifications. A list of links for this article can be found in the Availability and requirements section

Benthic phosphorus cycling in the Peruvian oxygen minimum zone

Oxygen minimum zones (OMZs) that impinge on continental margins favor the release of phosphorus (P) from the sediments to the water column, enhancing primary productivity and the maintenance or expansion of low-oxygen waters. A comprehensive field program in the Peruvian OMZ was undertaken to identify the sources of benthic P at six stations, including the analysis of particles from the water column, surface sediments, and pore fluids, as well as in situ benthic flux measurements. A major fraction of solid-phase P was bound as particulate inorganic P (PIP) both in the water column and in sediments. Sedimentary PIP increased with depth in the sediment at the expense of particulate organic P (POP). The ratio of particulate organic carbon (POC) to POP exceeded the Redfield ratio both in the water column (202 ± 29) and in surface sediments (303 ± 77). However, the POC to total particulate P (TPP = POP + PIP) ratio was close to Redfield in the water column (103 ± 9) and in sediment samples (102 ± 15). This suggests that the relative burial efficiencies of POC and TPP are similar under low-oxygen conditions and that the sediments underlying the anoxic waters on the Peru margin are not depleted in P compared to Redfield. Benthic fluxes of dissolved P were extremely high (up to 1.04 ± 0.31 mmol m−2 d−1), however, showing that a lack of oxygen promotes the intensified release of dissolved P from sediments, whilst preserving the POC / TPP burial ratio. Benthic dissolved P fluxes were always higher than the TPP rain rate to the seabed, which is proposed to be caused by transient P release by bacterial mats that had stored P during previous periods when bottom waters were less reducing. At one station located at the lower rim of the OMZ, dissolved P was taken up by the sediments, indicating ongoing phosphorite formation. This is further supported by decreasing porewater phosphate concentrations with sediment depth, whereas solid-phase P concentrations were comparatively high

Superballistic electron flow through a point contact in a Ga[Al]As heterostructure

We measure electronic transport through point contacts in the high-mobility electron gas in a Ga[Al]As heterostructure at different temperatures and bulk electron densities. The conductance through all point contacts increases with increasing temperature in a temperature window around $T \sim 10 K$ for all investigated electron densities and point contact widths. For high electron densities this conductance exceeds the fundamental ballistic limit (Sharvin limit). These observations are in agreement with a viscous electron transport model and previous experiments in graphene.Comment: 5 pages, 2 figure

Исследования функциональности и состояния защитных сооружений ГО г. Юрги

Immunogenetics and cellular immunology of bacterial infectious disease