Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity.

This study was financed by Turkish Republic Prime Ministry State Planning Organization (DPT), (Project no: 2010K120440) for (MS). Work from Supuran lab was financed by an FP 7 EU grant (Metoxia project)

Multi-Period Production Capacity Planning for Integrated Product and Production System Design

This paper presents a simulation-based method to aid multi-period production capacity planning by quantifying the trade-off between product quality and production cost. The product quality is estimated as the statistical variation from the target performances obtained from the output tolerances of the production machines that manufacture the components. The production cost is estimated as the total cost of owning and operating a production facility during the planning horizon. Given demand forecasts in future production periods, a multi-objective genetic algorithm searches for the optimal types and quantity of the production machines to be purchased during each period, which simultaneously maximize the product quality and minimize the production cost during the entire planning horizon. Case studies on automotive valvetrain production are presented as a demonstrationPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87270/4/Saitou68.pd

How could multimedia information about dental implant surgery effects patients? anxiety level?

To evaluate the effects of different patient education techniques on patients? anxiety levels before and after dental implant surgery. Sixty patients were randomized into three groups; each contained 20 patients; [group 1, basic information given verbally, with details of operation and recovery; group 2 (study group), basic information given verbally with details of operative procedures and recovery, and by watching a movie on single implant surgery]; and a control group [basic information given verbally ?but it was devoid of the details of the operative procedures and recovery?]. Anxiety levels were assessed using the Spielberger?s State-Trait Anxiety Inventory (STAI) and Modified Dental Anxiety Scale (MDAS). Pain was assessed with a visual analog scale (VAS). The most significant changes were observed in the movie group (P < 0.05). Patients who were more anxious also used more analgesic medication. Linear regression analysis showed that female patients had higher levels of anxiety (P < 0.05). Preoperative multimedia information increases anxiety level

Faktör VIII’e Karşı İnhibitör Gelişen Hemofili Hastalarında Dental Tedavi Yaklaşımı

Hemofili A erkek bebeklerin 1/5000’ini etkileyen en yaygın kalıtımsal koagülasyon bozukluğudur. Hemofili A hastalarının %25-30’unda, Hemofili B hastalarının ise %1-3’ünde yaşamları boyunca inhibitör gelişebilir. İnhibitör gelişen hemofili hastalarını tedavilerini yapmanın en etkili yol ise bu hastalara rekombinant faktör VIIa uygulanmasıdır. FVIIa plazmada pıhtının erime zamanını uzatır ve trombin ile aktive olabilen fibrinolizis inhibitörü yolu ile fibrinolizisi azaltır. Bu makalede faktör VIII’e karşı aşırı inhibitör gelişen bir hemofili hastasının yapılan başarılı dental tedavisini anlattık. rFVIIa’nın geleneksel tedavilere(örneğin faktör konsantresi) göre avantajları antijenitesinin olmaması ve viral güvenliğidir. Ancak geleneksel yöntemlere göre daha pahalı bir tedavi yöntemidir

Demographic Analysis of Renal Failure Patients Presenting to the Emergency Unit

BackgroundThe incidence and mortality of renal failure remain high. Dialysis continues to be a major supportive intervention in renal failure, but late referral is associated with the risk of higher morbidity and mortality.MethodsWe investigated the demographic data of renal failure patients requiring dialysis who presented to our emergency unit between August 2003 and June 2005. Demographic characteristics, presentation complaints, current treatment, initial laboratory values and vascular access type were determined.ResultsNinety patients (52 male, 38 female; mean age, 56.63 ± 17.33 years) were included in the study. The most common presenting complaints were dyspnea, weakness and edema. Twenty (22.2%) patients had acute renal failure and the other 70 patients had chronic renal failure. Only seven (7.7%) patients had the necessary documents for dialysis treatment, and only six patients had available radial arteriovenous fistula. During follow-up, eight (8.8%) patients died. We found inadequate hemodialysis readiness in our end-stage renal disease patients.ConclusionImproving the quality of pre-dialysis care might improve long-term survival, so appropriate timing for nephrology referral is important in patients with end-stage renal disease. [Hong Kong J Nephrol 2007;9(2): 82–5

Oral Findings and Health Status among Turkish Geriatric Patients with or without Dementia (Oral Lesions and Dementia Patients)

SummaryBackgroundIn this study, we aimed to investigate the frequency of oral mucosal lesions and systemic disease in patients with or without dementia.MethodsThe patient group comprised patients from the Istanbul Metropolitan Municipality Darulaceze Retirement Home and the control group consisted of patients who attended university clinics. The examination took place in a quiet room within the nursing home in the company of a member of the care staff well-known to the patient, and the control group was collected from participants who wanted to be included in the study. The study group consisted of 250 patients with dementia (110 male, 140 female) with a mean age of 74.1 ± 10.9 years and 200 control patients (90 male, 110 female) with mean age of 70.5 ± 10.2 years. We examined patients using a mouth mirror. Medical information was collected from patients and nurses.ResultsIn this study, 164 patients with dementia (64.8%) and 109 control patients (54.5 %) had one or more oral mucosal lesions (p = 0.016). Eighty-eight patients with dementia (35.2%) and sixty control patients (30%) were edentulous (p > 0.05), and 28 in the patient group (31.8 %) and 43 in the control group (71.6 %) were able to use prostheses (p < 0.05).ConclusionOral mucosal lesions are more common in patients with dementia and dental care should be performed regularly for this group. In addition, because removable prostheses can be lost by patients with dementia, implant-supported fixed prostheses should be preferred for this group

Point-of-care testing for disasters: needs assessment, strategic planning, and future design.

Objective evidence-based national surveys serve as a first step in identifying suitable point-of-care device designs, effective test clusters, and environmental operating conditions. Preliminary survey results show the need for point-of-care testing (POCT) devices using test clusters that specifically detect pathogens found in disaster scenarios. Hurricane Katrina, the tsunami in southeast Asia, and the current influenza pandemic (H1N1, "swine flu") vividly illustrate lack of national and global preparedness. Gap analysis of current POCT devices versus survey results reveals how POCT needs can be fulfilled. Future thinking will help avoid the worst consequences of disasters on the horizon, such as extensively drug-resistant tuberculosis and pandemic influenzas. A global effort must be made to improve POC technologies to rapidly diagnose and treat patients to improve triaging, on-site decision making, and, ultimately, economic and medical outcomes

Effect of Educational Level on Oral Health in Peritoneal and Hemodialysis Patients

Background. In previous studies, the oral and dental health statuses were compared in hemodialysis (HD) and peritoneal dialysis (PD) patients without taking into account the effect of educational levels on oral health. Hence we aimed to make a comparison of these parameters based upon the subjects educational levels. Patients and Methods. 76 PD (33 males, 43 females-mean age: 44 ± 12 years) and 100 HD (56 males, 44 females-mean age: 46 ± 14 years) patients were included. The number of decayed, missing and filled teeth were detected, DMFT index was calculated and plaque index (PI) values were assessed. Results. Significantly higher numbers of filled teeth (P < .001) and lower PI values (P < .01) in the PD group were detected with higher educational levels, whereas no significance was detected in the HD group. Higher DMFT index values were assessed in the lower educated and high school levels in PD than HD patients (P < .05). Higher numbers of filled teeth (P < .05) were detected in the secondary school level in PD patients. This difference was even more significant in the high school level (P < .001). Conclusion. We assume that PD patients, who were found to be in a higher educational level, are more caring for their oral health as compared to HD patients

The optimization of peritoneal dialysis training in long-term

Peritoneal dialysis is a home based therapy for patients with advanced chronic kidney disease. This method provides adequate clearance of uremic toxins and removal of excess fluid when a proper dialysis prescription is combined with patient adherence. Peritonitis is the most frequent infectious complication among these patients and may render the continuity of the treatment. Training patients and their caregivers have prime importance to provide proper treatment and prevent complications including infectious ones. The training methods before the onset of treatment are relatively well established. However, patients may break the rules in the long term and tend to take shortcuts. So, retraining may be necessary during follow-up. There are no established guidelines to guide the retraining of PD patients yet. This review tends to summarize data in the literature about retraining programs and also proposes a structured program for this purpose