5 research outputs found
Chart a Course for Holistic Admissions Transformation Using an Interprofessional Model
Implementing comprehensive holistic admissions requires schools to evaluate, and perhaps think differently, about recruitment and marketing, admission and retention practices, as well as the extent to which these practices align with the institutional mission and goals. Developing and implementing holistic admissions is time, and resource intensive and requires tremendous leadership and faculty support. This course is designed to give physical therapy educators background rationale and a formal structure to operationalize comprehensive holistic admissions, from recruitment to workforce placement, including strategies for gaining higher administration support. The Dean, former Associate Dean for Academic Affairs, and Admissions Committee Chair of the College of Allied Health Professions (CAHP) at the University of Nebraska Medical Center will share their experience with developing, implementing and evaluating comprehensive holistic admissions for the entire college, consisting of 14 programs. The interactive course format will invite participants to engage the presenters as it pertains to the participantsâ unique journeys with implementing holistic admission practices at their own institutions, allowing for a rich exchange of information and experiences.https://digitalcommons.unmc.edu/cahp_pres/1000/thumbnail.jp
LSST: from Science Drivers to Reference Design and Anticipated Data Products
(Abridged) We describe here the most ambitious survey currently planned in
the optical, the Large Synoptic Survey Telescope (LSST). A vast array of
science will be enabled by a single wide-deep-fast sky survey, and LSST will
have unique survey capability in the faint time domain. The LSST design is
driven by four main science themes: probing dark energy and dark matter, taking
an inventory of the Solar System, exploring the transient optical sky, and
mapping the Milky Way. LSST will be a wide-field ground-based system sited at
Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m
effective) primary mirror, a 9.6 deg field of view, and a 3.2 Gigapixel
camera. The standard observing sequence will consist of pairs of 15-second
exposures in a given field, with two such visits in each pointing in a given
night. With these repeats, the LSST system is capable of imaging about 10,000
square degrees of sky in a single filter in three nights. The typical 5
point-source depth in a single visit in will be (AB). The
project is in the construction phase and will begin regular survey operations
by 2022. The survey area will be contained within 30,000 deg with
, and will be imaged multiple times in six bands, ,
covering the wavelength range 320--1050 nm. About 90\% of the observing time
will be devoted to a deep-wide-fast survey mode which will uniformly observe a
18,000 deg region about 800 times (summed over all six bands) during the
anticipated 10 years of operations, and yield a coadded map to . The
remaining 10\% of the observing time will be allocated to projects such as a
Very Deep and Fast time domain survey. The goal is to make LSST data products,
including a relational database of about 32 trillion observations of 40 billion
objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures
available from https://www.lsst.org/overvie
Standardized multi-omics of Earthâs microbiomes reveals microbial and metabolite diversity
Despite advances in sequencing, lack of standardization makes comparisons across studies challenging and hampers insights into the structure and function of microbial communities across multiple habitats on a planetary scale. Here we present a multi-omics analysis of a diverse set of 880 microbial community samples collected for the Earth Microbiome Project. We include amplicon (16S, 18S, ITS) and shotgun metagenomic sequence data, and untargeted metabolomics data (liquid chromatography-tandem mass spectrometry and gas chromatography mass spectrometry). We used standardized protocols and analytical methods to characterize microbial communities, focusing on relationships and co-occurrences of microbially related metabolites and microbial taxa across environments, thus allowing us to explore diversity at extraordinary scale. In addition to a reference database for metagenomic and metabolomic data, we provide a framework for incorporating additional studies, enabling the expansion of existing knowledge in the form of an evolving community resource. We demonstrate the utility of this database by testing the hypothesis that every microbe and metabolite is everywhere but the environment selects. Our results show that metabolite diversity exhibits turnover and nestedness related to both microbial communities and the environment, whereas the relative abundances of microbially related metabolites vary and co-occur with specific microbial consortia in a habitat-specific manner. We additionally show the power of certain chemistry, in particular terpenoids, in distinguishing Earthâs environments (for example, terrestrial plant surfaces and soils, freshwater and marine animal stool), as well as that of certain microbes including Conexibacter woesei (terrestrial soils), Haloquadratum walsbyi (marine deposits) and Pantoea dispersa (terrestrial plant detritus). This Resource provides insight into the taxa and metabolites within microbial communities from diverse habitats across Earth, informing both microbial and chemical ecology, and provides a foundation and methods for multi-omics microbiome studies of hosts and the environment
Standardized multi-omics of Earth's microbiomes reveals microbial and metabolite diversity
Despite advances in sequencing, lack of standardization makes comparisons across studies challenging and hampers insights into the structure and function of microbial communities across multiple habitats on a planetary scale. Here we present a multi-omics analysis of a diverse set of 880 microbial community samples collected for the Earth Microbiome Project. We include amplicon (16S, 18S, ITS) and shotgun metagenomic sequence data, and untargeted metabolomics data (liquid chromatography-tandem mass spectrometry and gas chromatography mass spectrometry). We used standardized protocols and analytical methods to characterize microbial communities, focusing on relationships and co-occurrences of microbially related metabolites and microbial taxa across environments, thus allowing us to explore diversity at extraordinary scale. In addition to a reference database for metagenomic and metabolomic data, we provide a framework for incorporating additional studies, enabling the expansion of existing knowledge in the form of an evolving community resource. We demonstrate the utility of this database by testing the hypothesis that every microbe and metabolite is everywhere but the environment selects. Our results show that metabolite diversity exhibits turnover and nestedness related to both microbial communities and the environment, whereas the relative abundances of microbially related metabolites vary and co-occur with specific microbial consortia in a habitat-specific manner. We additionally show the power of certain chemistry, in particular terpenoids, in distinguishing Earthâs environments (for example, terrestrial plant surfaces and soils, freshwater and marine animal stool), as well as that of certain microbes including Conexibacter woesei (terrestrial soils), Haloquadratum walsbyi (marine deposits) and Pantoea dispersa (terrestrial plant detritus). This Resource provides insight into the taxa and metabolites within microbial communities from diverse habitats across Earth, informing both microbial and chemical ecology, and provides a foundation and methods for multi-omics microbiome studies of hosts and the environment
Standardized multi-omics of Earthâs microbiomes reveals microbial and metabolite diversity
Extended data is available for this paper at https://doi.org/10.1038/s41564-022-01266-x.Despite advances in sequencing, lack of standardization makes
comparisons across studies challenging and hampers insights into
the structure and function of microbial communities across multiple
habitats on a planetary scale. Here we present a multi-omics analysis of a
diverse set of 880 microbial community samples collected for the Earth
Microbiome Project. We include amplicon (16S, 18S, ITS) and shotgun
metagenomic sequence data, and untargeted metabolomics data (liquid
chromatography-tandem mass spectrometry and gas chromatography
mass spectrometry). We used standardized protocols and analytical
methods to characterize microbial communities, focusing on relationships
and co-occurrences of microbially related metabolites and microbial taxa
across environments, thus allowing us to explore diversity at extraordinary
scale. In addition to a reference database for metagenomic and
metabolomic data, we provide a framework for incorporating additional
studies, enabling the expansion of existing knowledge in the form of an
evolving community resource. We demonstrate the utility of this database
by testing the hypothesis that every microbe and metabolite is everywhere
but the environment selects. Our results show that metabolite diversity
exhibits turnover and nestedness related to both microbial communities
and the environment, whereas the relative abundances of microbially
related metabolites vary and co-occur with specific microbial consortia in a habitat-specific manner. We additionally show the power of certain
chemistry, in particular terpenoids, in distinguishing Earthâs environments
(for example, terrestrial plant surfaces and soils, freshwater and marine
animal stool), as well as that of certain microbes including Conexibacter
woesei (terrestrial soils), Haloquadratum walsbyi (marine deposits) and
Pantoea dispersa (terrestrial plant detritus). This Resource provides insight
into the taxa and metabolites within microbial communities from diverse
habitats across Earth, informing both microbial and chemical ecology, and
provides a foundation and methods for multi-omics microbiome studies of
hosts and the environment.The Samuel Freeman Charitable Trust, US National Institute of Health (NIH), US Department of Agriculture â National Institute of Food and Agriculture, the US National Science Foundation (NSF) - Center for Aerosol Impacts on Chemistry of the Environment, Crohnâs & Colitis Foundation Award (CCFA), US Department of Energy - Office of Science - Office of Biological and Environmental Research - Environmental System Science Program, Semiconductor Research Corporation and Defence Advanced Research Projects Agency (SRC/DARPA), Department of Defense, the Office of Naval Research (ONR, the Emerald Foundation, IBM Research AI through the AI Horizons Network, and the Center for Microbiome Innovation, the NIH, the Danish Council for Independent Research (DFF) , the Research Foundation â Flanders, Deutsche Forschungsgemeinschaft, the Gordon and Betty Moore Foundation. Metabolomics analyses at Pacific Northwest National Laboratory (PNNL) were supported by the Laboratory Directed Research and Development program via the Microbiomes in Transition Initiative and performed in the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the US Office of Biological and Environmental Research and located at PNNL.http://www.nature.com/nmicrobiolam2023GeneticsNon