What in Hell Conflicts with God? The Divine Promulgation View of Hell Confirms the Reality of Hell Does Not Make God a Moral Monster

The aim of this thesis is to demonstrate that God is not morally at fault for humans consigned to eternal punishment in hell. In this work, I contribute to the ongoing conversation of hell in the following ways: (1) I provide an exposition on the words translated as hell in the Bible; (2) I uncover the progressive nature of the doctrine of hell as sin increases and God advances His plan of salvation to rescue humans from such an eternal fate; (3) I argue that Christianity and the biblical doctrine of hell are bound principally as Christ’s work on the cross ultimately saves humans from being consigned to hell; (4) I demonstrate that God assists humanity to avoid hell by promulgating necessary information on hellish doctrine in various ways such as the creation, Scriptures, general and special revelation, Jesus, Holy Spirit and ministers of the gospel. The Divine Promulgation View of Hell will be introduced and elucidated in this thesis as a fresh perspective in defense of God’s attributes in the face of hellish doctrine

MECHANISMS OF TRINUCLEOTIDE REPEAT INSTABILITY DURING DNA SYNTHESIS

Genomic instability, in the form of gene mutations, insertions/deletions, and gene amplifications, is one of the hallmarks in many types of cancers and other inheritable genetic disorders. Trinucleotide repeat (TNR) disorders, such as Huntington’s disease (HD) and Myotonic dystrophy (DM) can be inherited and repeats may be extended through subsequent generations. However, it is not clear how the CAG repeats expand through generations in HD. Two possible repeat expansion mechanisms include: 1) polymerase mediated repeat extension; 2) persistent TNR hairpin structure formation persisting in the genome resulting in expansion after subsequent cell division. Recent in vitro studies suggested that a family A translesion polymerase, polymerase θ (Polθ), was able to synthesize DNA larger than the template DNA. Clinical and in vivo studies showed either overexpression or knock down of Polθ caused poor survival in breast cancer patients and genomic instability. However, the role of Polθ in TNR expansion remains unelucidated. Therefore, we hypothesize that Polθ can directly cause TNR expansion during DNA synthesis. The investigation of the functional properties of Polθ during DNA replication and TNR synthesis will provide insight for the mechanism of TNR expansion through generations

A new model for the hazardous waste location-routing problem

Cataloged from PDF version of article.Hazardous waste management involves the collection, transportation, treatment and disposal of hazardous wastes. In this paper a new multiobjective location-routing model is proposed. Our model also includes some constraints, which were observed in the literature but were not incorporated into previous models. The aim of the proposed model is to answer the following questions: where to open treatment centers and with which technologies, where to open disposal centers, how to route different types of hazardous waste to which of the compatible treatment technologies, and how to route waste residues to disposal centers. The model has the objective of minimizing the total cost and the transportation risk. A large-scale implementation of the model in the Central Anatolian region of Turkey is presented. © 2005

On the single assignment p-Hub center problem

Cataloged from PDF version of article.We study the computational aspects of the single-assignment p-hub center problem on the basis of a basic model and a new model. The new model's performance is substantially better in CPU time than different linearizations of the basic model. We also prove the NP-Hardness of the problem. (C) 2000 Elsevier Science B.V. All rights reserved

Securitization, bank behaviour and financial stability: A systematic review of the recent empirical literature

We systematically review the recent empirical literature to investigate whether and how securitization influences bank behaviour and its implication on financial stability. We find that, in the years preceding the 2007–2009 financial crisis, banks with higher credit and market risk were more likely to securitize assets. Banks became riskier and increased systemic risk as they took advantage of securitization in order to obtain capital relief. There is robust evidence indicating that mortgage securitization led to a deterioration in bank lending standards via weaker screening, lower denial rates, and misreporting of credit quality. For corporate loan securitization, the empirical findings on lax bank lending are inconclusive. However, it is evident that securitization resulted in poorer ex-post bank monitoring of corporate borrowers. Even though Europe is the second largest securitization market, there is a dearth of evidence on the impact of securitization on European banks' lending behaviour. Research is also very limited on the post-crisis regulatory incentive aligning mechanisms such as the risk retention requirements and the credit ratings reform. Finally, evidence on securitization activity in emerging markets, such as Latin America and China, where securitization volumes have been increasing recently, is relatively non-existent

A 56-year-old with diarrhea and weakness

A 56-YEAR-OLD MAN presents to the emergency department with nausea, weakness, and exertional dyspnea, which have been going on for 1 week. He is sent by his primary care physician after being noted to be hypotensive with a weak, thready pulse. He has had diarrhea with intermittent abdominal pain over the past year, with 10 stools daily, including 3 or 4 at night. The stools are described as large, nonbloody, sticky, greasy, and occasionally watery. Stools are fewer when he curtails his food intake. The diarrhea is associated with occasional diffuse abdominal pain he describes as a burning sensation. He has no incontinence or tenesmus. He reports that he has unintentionally lost 137 lb (62 kg) over the past year. He has not taken over-the-counter antidiarrheal agents

The P-Hub maximal covering problem and extensions for gradual decay functions

Cataloged from PDF version of article.The p-hub maximal covering problem aims to find the best locations for hubs so as to maximize demands within a coverage distance with a predetermined number of hubs. Classically, the problem is defined in the framework of binary coverage only; an origin-destination pair is covered if the cost (time, etc.) is lower than the critical value, and not covered at all if the cost is greater than the critical value. In this paper, we extend the definition of coverage, introducing "partial coverage", which changes with distance. We present new and efficient mixed-integer programming models that are also valid for partial coverage for single and multiple allocations. We present and discuss the computational results with different data sets. (C) 2015 Elsevier Ltd. All rights reserved

Designing emergency response networks for hazardous materials transportation

Cataloged from PDF version of article.Undesirable consequences of dangerous goods incidents can be mitigated by quick arrival of specialized response teams at the accident site. We present a novel methodology to determine the optimal design of a specialized team network so as to maximize its ability to respond to such incidents in a region. We show that this problem can be represented via a maximal arc-covering model.We discuss two formulations for the maximal arc-covering problem, a known one and a new one. Through computational experiments, we establish that the known formulation has excessive computational requirements for large-scale problems, whereas the alternative model constitutes a basis for an efficient heuristic. The methodology is applied to assess the emergency response capability to transport incidents, that involve gasoline, in Quebec and Ontario. We point out the possibility of a significant improvement via relocation of the existing specialized teams, which are currently stationed at the shipment origins. 2005 Elsevier Ltd. All rights reserved

Evaluating performance of missing data imputation methods in IRT analyses

Missing data is a common problem in datasets that are obtained by administration of educational and psychological tests. It is widely known that existence of missing observations in data can lead to serious problems such as biased parameter estimates and inflation of standard errors. Most of the missing data imputation methods are focused on datasets containing continuous variables. However, it is very common to work with datasets that are made of dichotomous responses of individuals to a set of test items to which IRT models are fitted. This study compared the performances of missing data imputation methods that are IRT model-based imputation (MBI), Expectation-Maximization (EM), Multiple Imputation (MI), and Regression Imputation (RI). Parameter recoveries were evaluated by repetitive analyses that were conducted on samples that were drawn from an empirical large-scale dataset. Results showed that MBI outperformed other imputation methods in recovering item difficulty and mean of the ability parameters, especially with higher sample sizes. However, MI produced the best results in recovery of item discrimination parameters