Robust and Irreversible Development in Cell Society as a General Consequence of Intra-Inter Dynamics

A dynamical systems scenario for developmental cell biology is proposed, based on numerical studies of a system with interacting units with internal dynamics and reproduction. Diversification, formation of discrete and recursive types, and rules for differentiation are found as a natural consequence of such a system. "Stem cells" that either proliferate or differentiate to different types stochastically are found to appear when intra-cellular dynamics are chaotic. Robustness of the developmental process against microscopic and macroscopic perturbations is shown to be a natural consequence of such intra-inter dynamics, while irreversibility in developmental process is discussed in terms of the gain of stability, loss of diversity and chaotic instability.Comment: 17 pages with 3 ps figures. submitted to Physica A as a proceeding paperfor Paladin Memorial Con

Coupled Maps with Growth and Death: An Approach to Cell Differentiation

An extension of coupled maps is given which allows for the growth of the number of elements, and is inspired by the cell differentiation problem. The growth of elements is made possible first by clustering the phases, and then by differentiating roles. The former leads to the time sharing of resources, while the latter leads to the separation of roles for the growth. The mechanism of the differentiation of elements is studied. An extension to a model with several internal phase variables is given, which shows differentiation of internal states. The relevance of interacting dynamics with internal states (``intra-inter" dynamics) to biological problems is discussed with an emphasis on heterogeneity by clustering, macroscopic robustness by partial synchronization and recursivity with the selection of initial conditions and digitalization.Comment: LatexText,figures are not included. submitted to PhysicaD (1995,revised 1996 May

Relevance of Dynamic Clustering to Biological Networks

Network of nonlinear dynamical elements often show clustering of synchronization by chaotic instability. Relevance of the clustering to ecological, immune, neural, and cellular networks is discussed, with the emphasis of partially ordered states with chaotic itinerancy. First, clustering with bit structures in a hypercubic lattice is studied. Spontaneous formation and destruction of relevant bits are found, which give self-organizing, and chaotic genetic algorithms. When spontaneous changes of effective couplings are introduced, chaotic itinerancy of clusterings is widely seen through a feedback mechanism, which supports dynamic stability allowing for complexity and diversity, known as homeochaos. Second, synaptic dynamics of couplings is studied in relation with neural dynamics. The clustering structure is formed with a balance between external inputs and internal dynamics. Last, an extension allowing for the growth of the number of elements is given, in connection with cell differentiation. Effective time sharing system of resources is formed in partially ordered states.Comment: submitted to Physica D, no figures include

Diversity, Stability, Recursivity, and Rule Generation in Biological System: Intra-inter Dynamics Approach

Basic problems for the construction of a scenario for the Life are discussed. To study the problems in terms of dynamical systems theory, a scheme of intra-inter dynamics is presented. It consists of internal dynamics of a unit, interaction among the units, and the dynamics to change the dynamics itself, for example by replication (and death) of units according to their internal states. Applying the dynamics to cell differentiation, isologous diversification theory is proposed. According to it, orbital instability leads to diversified cell behaviors first. At the next stage, several cell types are formed, first triggered by clustering of oscillations, and then as attracting states of internal dynamics stabilized by the cell-to-cell interaction. At the third stage, the differentiation is determined as a recursive state by cell division. At the last stage, hierarchical differentiation proceeds, with the emergence of stochastic rule for the differentiation to sub-groups, where regulation of the probability for the differentiation provides the diversity and stability of cell society. Relevance of the theory to cell biology is discussed.Comment: 19 pages, Int.J. Mod. Phes. B (in press

Coupled map gas: structure formation and dynamics of interacting motile elements with internal dynamics

A model of interacting motile chaotic elements is proposed. The chaotic elements are distributed in space and interact with each other through interactions depending on their positions and their internal states. As the value of a governing parameter is changed, the model exhibits successive phase changes with novel pattern dynamics, including spatial clustering, fusion and fission of clusters and intermittent diffusion of elements. We explain the manner in which the interplay between internal dynamics and interaction leads to this behavior by employing certain quantities characterizing diffusion, correlation, and the information cascade of synchronization. Keywords: collective motion, coupled map system, interacting motile elementsComment: 27 pages, 12 figures; submitted to Physica

Bifurcations in Globally Coupled Chaotic Maps

We propose a new method to investigate collective behavior in a network of globally coupled chaotic elements generated by a tent map. In the limit of large system size, the dynamics is described with the nonlinear Frobenius-Perron equation. This equation can be transformed into a simple form by making use of the piecewise linear nature of the individual map. Our method is applied successfully to the analyses of stability of collective stationary states and their bifurcations.Comment: 12 pages, revtex, 10 figure

Competition between isoscalar and isovector pairing correlations in N=Z nuclei

We study the isoscalar (T=0) and isovector (T=1) pairing correlations in N=Z nuclei. They are estimated from the double difference of binding energies for odd-odd N=Z nuclei and the odd-even mass difference for the neighboring odd-mass nuclei, respectively. The empirical and BCS calculations based on a T=0 and T=1 pairing model reproduce well the almost degeneracy of the lowest T=0 and T=1 states over a wide range of even-even and odd-odd N=Z nuclei. It is shown that this degeneracy is attributed to competition between the isoscalar and isovector pairing correlations in N=Z nuclei. The calculations give an interesting prediction that the odd-odd N=Z nucleus 82Nb has possibly the ground state with T=0.Comment: 5 pages, 4 figures, to be published in Phys. Rev. C (R

Shell gaps and pn pairing interaction in N = Z nuclei

We analyze the observed shell gaps in N=Z nuclei determined from the binding energy differences. It is found that the shell gaps can be described by the combined contributions from the single-particle level spacing, the like-nucleon pairing, and the proton-neutron pairing interaction. This conclusion is consistent with that of Chasman in Phys. Rev. Lett. 99 (2007) 082501. For the double-closed shell N=Z nuclei, the single-particle level spacings calculated with Woods-Saxon potential are very close to those obtained by subtracting the nn pairing interaction from the observed shell gap. For the sub-closed or non-closed shell N=Z nuclei, the pn pairing interaction is shown to be important for the observed shell gaps.Comment: 9 pages, 5 figure

Macroscopic chaos in globally coupled maps

We study the coherent dynamics of globally coupled maps showing macroscopic chaos. With this term we indicate the hydrodynamical-like irregular behaviour of some global observables, with typical times much longer than the times related to the evolution of the single (or microscopic) elements of the system. The usual Lyapunov exponent is not able to capture the essential features of this macroscopic phenomenon. Using the recently introduced notion of finite size Lyapunov exponent, we characterize, in a consistent way, these macroscopic behaviours. Basically, at small values of the perturbation we recover the usual (microscopic) Lyapunov exponent, while at larger values a sort of macroscopic Lyapunov exponent emerges, which can be much smaller than the former. A quantitative characterization of the chaotic motion at hydrodynamical level is then possible, even in the absence of the explicit equations for the time evolution of the macroscopic observables.Comment: 24 pages revtex, 9 figures included. Improved version also with 1 figure and some references adde

New group of stable icosahedral quasicrystals: structural properties and formation conditions

Structural studies on the icosahedral quasicrystals in Zn-Mg-Sc, Cu-Ga-Mg-Sc, and Zn-Mg-Ti alloys as well as their corresponding 1/1 cubic approximants, have revealed that these quasicrystals belong to a new structural group similar to Cd-based quasicrystals. This group is characterized by a triple-shell icosahedral cluster different from both Mackay- and Bergman-types. The presence of the atomic cluster has been deduced from the structure model of the approximant crystal, Zn17Sc3, in which the clusters are embedded in a periodic network of so-called "glue atoms". Density measurement suggested the presence of at least 2.7 Zn atoms in the first shell of the cluster in this approximant. The substitutional relationship in these three quasicrystals indicates the important role of Hume-Rothery rule for the formation of this type of quasicrystal. The occurrence of a P-type icosahedral quasicrystal in Zn-Mg-Yb alloy is also reported.Comment: 11 pages, 1 table, 6 figure