EuReCa ONE—27 Nations, ONE Europe, ONE Registry A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

AbstractIntroductionThe aim of the EuReCa ONE study was to determine the incidence, process, and outcome for out of hospital cardiac arrest (OHCA) throughout Europe.MethodsThis was an international, prospective, multi-centre one-month study. Patients who suffered an OHCA during October 2014 who were attended and/or treated by an Emergency Medical Service (EMS) were eligible for inclusion in the study. Data were extracted from national, regional or local registries.ResultsData on 10,682 confirmed OHCAs from 248 regions in 27 countries, covering an estimated population of 174 million. In 7146 (66%) cases, CPR was started by a bystander or by the EMS. The incidence of CPR attempts ranged from 19.0 to 104.0 per 100,000 population per year. 1735 had ROSC on arrival at hospital (25.2%), Overall, 662/6414 (10.3%) in all cases with CPR attempted survived for at least 30 days or to hospital discharge.ConclusionThe results of EuReCa ONE highlight that OHCA is still a major public health problem accounting for a substantial number of deaths in Europe.EuReCa ONE very clearly demonstrates marked differences in the processes for data collection and reported outcomes following OHCA all over Europe. Using these data and analyses, different countries, regions, systems, and concepts can benchmark themselves and may learn from each other to further improve survival following one of our major health care events

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Evaluation de la prise en charge des agressions cérébrales secondaires d'origine systémique à la phase pré hospitalière chez les patients atteints de traumatisme crânien grave

Etude rétrospective de 125 dossiers de patients atteint de T.C.G.Comparaison des pressions artérielles systoliques, capnie, saturation en oxygène, hémoglobinémie durant le transport et à l'arrivée au déchoquage. Résultats : incidence hypocapnie 33,6% ;hypercapnie 30,4% ; anémie 19,2% ; hypotension 13% ; hypoxémie 7,2% ; hypertension 4,8%. 83,2% des patients ont été exposés à au moins une ACSOS.Discussion :étude rétrospective et beaucoup de dossiers non renseignés, malgré tout il y a amélioration par rapport à des séries antérieures. Conclusions : 4/5 des patients sont soumis à des ACSOS, nécessité d'amélioration de la prise en charge des patients traumatisés crâniens graves.GRENOBLE1-BU Médecine pharm. (385162101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Mesure de l'hémoglobinémie par un appareil de biologie délocalisée (intérêts et limites en SMUR étudiés par une analyse de concordance)

Le dosage de l'hémoglobine est recommandé dans certaines situations d'urgences préhospitalières. La précision des mesures d'hémoglobinémie faites en SMUR par HemoCue® (HC) n est pas connue. L objectif de cette étude était d évaluer cette précision. Méthodes: les mesures de l'hémoglobinémie veineuse et capillaire par HC ont été comparées aux mesures de laboratoire (méthode de Bland et Altman et commutabilité au seuil de tolérance acceptable de +- 10g/l). Résultats: 153 patients inclus. Biais moyen des mesures veineuses: 1g/l +- 17 (IC95%: -33; 34). 55% des mesures étaient acceptables au seuil de +- 10g/l. Biais moyen des mesures capillaires 7g/l +-17 (IC95%: -21; 41). 54% des mesures étaient acceptables au seuil de +- 10g/l (70% en utilisant des lancettes longues, 39% en utilisant des lancettes courtes). Conclusion: le dosage de l'hémoglobine en préhospitalier par HC est peu précis. L'usage de lancettes longues pour piqûre cutanée est préférable. Devant la dispersion des mesures obtenues en préhospitalier, l examen clinique du patient reste primordial pour guider les décisions thérapeutiques.GRENOBLE1-BU Médecine pharm. (385162101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Mesure et évaluation de la température centrale des traumatisés graves à la phase pre hospitalière

GRENOBLE1-BU Médecine pharm. (385162101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Hypothermia in trauma victims at first arrival of ambulance personnel: an observational study with assessment of risk factors

Abstract Background Hypothermia is common in trauma victims and is associated with increased mortality, however its causes are little known. The objective of this study was to identify the risk factors associated with hypothermia in prehospital management of trauma victims. Methods This was an ancillary analysis of data recorded in the HypoTraum study, a prospective multicenter study conducted by the emergency medical services (EMS) of 8 hospitals in France. Inclusion criteria were: trauma victim, age over 18 years, and victim receiving prehospital care from an EMS team and transported to hospital by the EMS team in a medically equipped mobile intensive care unit. The following data were recorded: victim demographics, circumstances of the trauma, environmental factors, patient presentation, clinical data and time from accident to EMS arrival. Independent risk factors for hypothermia were analyzed in a multivariate logistic regression model. Results A total of 461 trauma patients were included in the study. Road traffic accidents (N = 261; 57%) and falls (N = 65; 14%) were the main causes of trauma. Hypothermia (<35 °C) was present in 136/461 cases (29%). Independent factors significantly associated with the presence of hypothermia were: a low GCS (Odds Ratio (OR) = 0,87 ([0,81-0,92]; p < 0.0001), a low air temperature (OR = 0,93 [0,91-0,96]; p < 0.0001) and a wet patient (OR = 2,08 [1,08-4,00]; p = 0.03). Conclusion The incidence of hypothermia was high on EMS arrival at the scene. Body temperature measurement and immediate thermal protection should be routine, and special attention should be given to patients who are wet. Level of evidence Prospective, multicenter, open, observational study; Level IV

Synthesis and biological evaluation of (3,4,5-trimethoxyphenyl)indol-3-ylmethane derivatives as potential antivascular agents.

International audienceCombretastatin A-4 (CSA-4), a stilbene derivative, is a potent vascular disrupting agent (VDA) with the structural requirement of a cis-configuration to maintain a molecular geometry and a correct orientation of both phenyl groups. A series of indolic analogues of CSA-4 was synthesized by means of an efficient strategy. Six compounds (20b, 25b-27b, 32b, and 35b) were identified as potent inhibitors of tubulin polymerization and also displayed cytotoxic activities on B16 melanoma cells at a nanomolar level. Both activities were well correlated with the ability to induce morphological changes of EA.hy 926 endothelial cells. In conclusion, the cis-stilbene skeleton of CSA-4 could conveniently be replaced by the 3-aroylindolic moiety, thus avoiding any isomerization leading to inactive trans compounds

Team Emergency Assessment Measure (TEAM) for the assessment of non-technical skills during resuscitation: Validation of the French version

International audienc

Impact of laryngeal tube use on chest compression fraction during out-of-hospital cardiac arrest. A prospective alternate month study

International audienc