Matrix Optimization of ZnO for Mass Spectrometry Imaging of Small Neurochemicals in Rat and Mouse Brain Tissue

Testing experimental parameters in order to optimize ZnO nanoparticles as a matrix for low molecular weight neurochemicals in rat and mouse brain tissue

Propuesta de una metodología de reemplazo de activos y desarrollo de un SIA para el mantenimiento de ingeniería y construcciones Santa Fe S.A

166 p.En primera instancia se plantea la problemática de resolución y los objetivos asociados al desarrollo del trabajo, así también se caracteriza el lugar de ejecución. Con el fin de desarrollar en forma sólida el proyecto, es que se realiza una recopilación de información relacionada a herramientas y metodologías que permitan resolver de la mejor manera posible la problemática identificada. El primer paso del desarrollo corresponde a la metodología de reemplazo de activos, en ella se establecen los pasos para llevarla a cabo y un claro ejemplo de su uso. El ejemplo apunta a la determinación de la vida útil económica de las motoniveladoras, en el caso de ser adquiridas nuevas y de segunda mano. Con el fin de realizar un sistema de información que sea fidedigno a las necesidades de la empresa, es que se realiza un levantamiento de los requerimientos funcionales y no funcionales. Estos son identificados desde la etapa de diagnóstico y pos medio de entrevistas a los distintos usuarios.En esta etapa se realizan el diseño lógico global del sistema, en donde se identifican las entradas y salidas del sistema. Posteriormente se realiza el diseño lógico detallado, en este se detallan los procedimientos para el uso del sistema. Al terminar los diseños anteriores se procede a confeccionar los formularios que facilitarán el manejo de los datos.Finalmente se elaboran ciertas propuestas de mejora para el correcto funcionamiento del proyecto una vez finalizado el proyecto, dichas propuestas apuntan al rediseño de los procesos para incluir el uso del sistema dentro del diario vivir de la empresa

Immersive Platform for Neuroscience Experimental Studies

In this work, we present a computational toolkit to perform neuroscience experiments with people inside virtual immersive environment like a CAVE (Computer Assisted Virtual Environment). Several experiments can be designed, performed and measured for customized virtual scenes. Each participant is exposed to experiences in which they search and collect objects within a three-dimensional space, where they have to use spatial strategies to solve the task. The purpose is to study cognitive functions such as perception, attention, cognition and short term memory. These tools can reduce the time of experiments formulations and helps to discover mechanisms of attention and spatial and episodic memory. All information about each participant trajectory, the virtual scene configuration, the location of objects in these scenes, and answers to particular questions regarding the experience is collected and presented in.XV Workshop de Computación Gráfica, Imágenes y Visualización (WCGIV).Red de Universidades con Carreras en Informática (RedUNCI

Immersive Platform for Neuroscience Experimental Studies

In this work, we present a computational toolkit to perform neuroscience experiments with people inside virtual immersive environment like a CAVE (Computer Assisted Virtual Environment). Several experiments can be designed, performed and measured for customized virtual scenes. Each participant is exposed to experiences in which they search and collect objects within a three-dimensional space, where they have to use spatial strategies to solve the task. The purpose is to study cognitive functions such as perception, attention, cognition and short term memory. These tools can reduce the time of experiments formulations and helps to discover mechanisms of attention and spatial and episodic memory. All information about each participant trajectory, the virtual scene configuration, the location of objects in these scenes, and answers to particular questions regarding the experience is collected and presented in.XV Workshop de Computación Gráfica, Imágenes y Visualización (WCGIV)

An endemic and endangered new species of the lizard liolaemus montanus group from southwestern peru (Iguania: Liolaemidae), with a key for the species of the l. reichei clade

The southwestern Andes of Peru harbor a hidden taxonomic diversity of reptiles. We describe a new species of Liolaemus Wiegmann (Iguania: Liolaemidae) from xerophytic environments of the southwestern slopes of the Andes of Peru, 2,400– 2,900 m asl. The new species, previously considered to be a population of L. insolitus Cei, exhibits unique diagnostic characters of morphology, scalation and color pattern, and molecular evidence that suggest that it belongs in the Liolaemus montanus species group and the L. reichei clade. Moreover, the species is endemic to the eastern slopes of La Caldera batholith in the Department of Arequipa, southern Peru. We also provide information on the conservation status of the species and suggest it be included in the IUCN red list of the threatened species as endangered (EN). A key for the species of the L. reichei clade is provided.Fil: Quiroz, Aarón J.. Universidad Nacional de San Agustin de Arequipa; PerúFil: Huamaní Valderrama, Ling. Universidad Nacional de San Agustin de Arequipa; PerúFil: Gutiérrez, Roberto C.. Universidad Nacional de San Agustin de Arequipa, Museo de Historia Natural; PerúFil: Aguilar Kirigin, Alvaro Juan. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: López Tejeda, Evaristo Luciano. Universidad Nacional de San Agustin de Arequipa; PerúFil: Lazo Rivera, Ana. Universidad Nacional de San Agustin de Arequipa; PerúFil: Huanca Mamani, Wilson. Universidad de Tarapacá; ChileFil: Valladares Faúndez, Pablo. Universidad de Tarapacá; ChileFil: Morrone, Juan José. Universidad Nacional Autónoma de México; MéxicoFil: Cerdeña, José. No especifíca;Fil: Chaparro, Juan C.. No especifíca;Fil: Abdala, Cristian Simón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - Tucumán. Unidad Ejecutora Lillo; Argentin

Plan estratégico 2020-2022 - Guayakí - bebidas orgánicas

Guayakí es una empresa ubicada en el estado de California, Estados Unidos que se dedica, principalmente, a la producción y comercialización de bebidas orgánicas y naturales a base de yerba mate. El presente trabajo de investigación se remonta a todo lo conseguido por la empresa Guayakí hasta el año 2016 e inicios del 2017 y donde la alta dirección se plantea y cuestiona sobre las estrategias que debe seguir en búsqueda del crecimiento económico, pero sin poner en riesgo su cultura organizacional e imagen obtenida. Ante ello, se realizó un análisis de toda la información histórica, misión, visión, cultura, valores, análisis interno, externo y aspectos financieros de la compañía, y con ello proponemos desarrollar el plan estratégico para Guayakí a tres años desde el 2020 al 2022

Immersive Platform for Neuroscience Experimental Studies

In this work, we present a computational toolkit to perform neuroscience experiments with people inside virtual immersive environment like a CAVE (Computer Assisted Virtual Environment). Several experiments can be designed, performed and measured for customized virtual scenes. Each participant is exposed to experiences in which they search and collect objects within a three-dimensional space, where they have to use spatial strategies to solve the task. The purpose is to study cognitive functions such as perception, attention, cognition and short term memory. These tools can reduce the time of experiments formulations and helps to discover mechanisms of attention and spatial and episodic memory. All information about each participant trajectory, the virtual scene configuration, the location of objects in these scenes, and answers to particular questions regarding the experience is collected and presented in.XV Workshop de Computación Gráfica, Imágenes y Visualización (WCGIV).Red de Universidades con Carreras en Informática (RedUNCI

Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk

Background: About 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months of infection but may remain at risk of inflammaging, aging, and liver and non-liver disease complications. This study evaluated the differences in the plasma levels of immune checkpoints (ICs) and senescence-associated secretory phenotype (SASP) biomarkers between patients who had spontaneously eliminated HCV infection (SC group) and individuals without evidence of HCV infection (C group). Methods: We performed a multicenter retrospective study of 56 individuals: 32 in the SC and 24 in the C groups. ICs and SASP proteins were analyzed using a Luminex 200TM analyzer. The statistical analysis used Generalized Linear Models with gamma distribution (log-link) adjusted by significant variables and sex. Results: 13 ICs (BTLA, CD137(4-1BB), CD27, CD28, CD80, GITR, HVEM, IDO, LAG-3, PD-1, PD-L1, PD-L2, and TIM-3) and 13 SASP proteins (EGF, Eotaxin, IL-1alpha, IL-1RA, IL-8, IL-13, IL-18, IP-10, SDF-1alpha, HGF, beta-NGF, PLGF-1, and SCF) were significantly higher in SC group after approximately more than two years of HCV clearance. After stratifying by sex, differences remained significant for males, which showed higher levels for 13 ICs and 4 SASP proteins in SC. While only PD-L2 was significantly higher in SC women, and no differences in SASP were found. Conclusions: Higher plasma levels of different IC and SASP proteins were found in individuals after more than two years of HCV clearance, mainly in men. Alterations in these molecules might be associated with an increased risk of developing liver and non-hepatic diseases.This study was supported by grants from Instituto de Salud Carlos III (ISCIII; grant number CP14/0010) to AFR), Fundación Universidad Alfonso X el Sabio (FUAX) – Santander (grant number 1.010.932 to AFR) and by PID2021–126781OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. The study was also funded by the CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB 2021), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación and Unión Europea–Next‑GenerationEU (CB21/13/00044, CB21/13/00118, and GVC16/EHD/4). M.A.J.-S. is Miguel Servet researcher supported and funded by ISCIII (grant numbers CP17CIII/00007). RME is Juan de la Cierva researcher supported and fnanced by MICINN of Spain (FJC2020-042865-I).S

World Health Organization (WHO) antibiotic regimen against other regimens for the treatment of leprosy : a systematic review and meta-analysis

Altres ajuts: Maria Lazo-Porras is funded by the Swiss Goverment Excellence Scholarship (2018.0698).To evaluate the effectiveness and safety of the World Health Organization antibiotic regimen for the treatment of paucibacillary (PB) and multibacillary (MB) leprosy compared to other available regimens. We performed a search from 1982 to July 2018 without language restriction. We included randomized controlled trials, quasi-randomized trials, and comparative observational studies (cohorts and case-control studies) that enrolled patients of any age with PB or MB leprosy that were treated with any of the leprosy antibiotic regimens established by the WHO in 1982 and used any other antimicrobial regimen as a controller. Primary efficacy outcomes included: complete clinical cure, clinical improvement of the lesions, relapse rate, treatment failure. Data were pooled using a random effects model to estimate the treatment effects reported as relative risk (RR) with 95% confidence intervals (CI). We found 25 eligible studies, 11 evaluated patients with paucibacillary leprosy, while 13 evaluated patients with MB leprosy and 1 evaluated patients of both groups. Diverse regimen treatments and outcomes were studied. Complete cure at 6 months of multidrug therapy (MDT) in comparison to rifampin-ofloxacin-minocycline (ROM) found RR of 1.06 (95% CI 0.88-1.27) in five studies. Whereas six studies compare the same outcome at different follow up periods between 6 months and 5 years, according to the analysis ROM was not better than MDT (RR of 1.01 (95% CI 0.78-1.31)) in PB leprosy. Not better treatment than the implemented by the WHO was found. Diverse outcome and treatment regimens were studied, more statements to standardized the measurements of outcomes are needed

Importance of the clinical diagnosis of temporomandibular dysfunctions in relation to posture alterations

La postura es el resultado de un proceso dinámico de entrada y salida de información que modulan el tono postural y el equilibrio, por medio de procesos complejos que están fuertemente condicionados por la información que proviene de receptores específicos de la postura. En equilibrio dinámico la postura se encuentra regulada por la información recibida desde distintos receptores, el cuerpo oscila sin cesar alrededor de un punto, que es la proyección del centro de gravedad del organismo en el interior de una superficie delimitada por los pies del individuo. El sistema nervioso central tiene una acción de integración y control, de forma tal, que la información nerviosa de los receptores sensoriales se dirige hacia estructuras subcorticales y corticales permitiendo el control del sistema tónico postural mediante un cierto número de reflejos que son involuntarios. La estabilidad ortostática postural del cráneo sobre la columna cervical es un factor importante en el diagnóstico de trastornos disfuncionales craneomandibulares, tanto en el niño como en el adulto. El objetivo de este trabajo es lograr dimensionar la implicancia que tiene una alteración postural en el origen de la hiperactividad muscular, pudiendo variar la relación anatómica normal entre la cabeza, el cuello, y la cintura escapular, generando con frecuencia una importante causa de dolor y disfunción craneomandibular. A través de un estudio de tipo observacional, descriptivo y transversal de las diferentes vistas de la postura normal, se va a determinar mediante una evaluación clínica si los pacientes presentan algún tipo de patología o trastorno postural.Posture is the result of a dynamic process of input and output of information that modulates postural tone and balance, through complex processes that are strongly conditioned by the information that comes from specific posture receptors. In dynamic balance, posture is regulated by the information received from different receptors, the body oscillates continuously around a point, which is the projection of the body's center of gravity inside a surface delimited by the individual's feet. The central nervous system has an integration and control action, in such a way that the nervous information from the sensory receptors is directed towards subcortical and cortical structures, allowing the control of the postural tonic system through a certain number of reflexes that are involuntary. Postural orthostatic stability of the skull on the cervical spine is an important factor in the diagnosis of dysfunctional craniomandibular disorders, both in children and adults. The objective of this work is to measure the implication that a postural alteration has in the origin of muscular hyperactivity, being able to vary the normal anatomical relationship between the head, the neck, and the shoulder girdle, frequently generating an important cause of pain and craniomandibular dysfunction. Through an observational, descriptive and cross-sectional study of the different views of normal posture, it will be determined through a clinical evaluation if the patients present some type of pathology or postural disorder.Facultad de Odontologí