27 research outputs found
Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma
- Author
- Publication venue
- Springer Nature
- Publication date
- 01/01/2017
- Field of study
Kras activation and p16 inactivation are required to develop pancreatic ductal adenocarcinoma (PDAC). However, the biochemical mechanisms underlying these double alterations remain unclear. Here we discover that NAD(P)H oxidase 4 (NOX4), an enzyme known to catalyse the oxidation of NAD(P)H, is upregulated when p16 is inactivated by looking at gene expression profiling studies. Activation of NOX4 requires catalytic subunit p22phox, which is upregulated following Kras activation. Both alterations are also detectable in PDAC cell lines and patient specimens. Furthermore, we show that elevated NOX4 activity accelerates oxidation of NADH and supports increased glycolysis by generating NAD+, a substrate for GAPDH-mediated glycolytic reaction, promoting PDAC cell growth. Mechanistically, NOX4 was induced through p16-Rb-regulated E2F and p22phox was induced by KrasG12V-activated NF-κB. In conclusion, we provide a biochemical explanation for the cooperation between p16 inactivation and Kras activation in PDAC development and suggest that NOX4 is a potential therapeutic target for PDAC
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
- Binda Filipo
- Birgisdottir Hrönn
- Birgisdóttir Hrönn
- Bispo Bruno Miguel
- Biston Patrick
- Bjorgen Hege
- Blackwood Bronagh
- Blanc Agnès
- Blanco Daniel
- Blanco Maria Pilar Sogues
- Blasco Maria Luisa
- Bliksted Inger Abildgaard
- Blondal Asbjorn
- Bloos Frank
- Blot Stijn I.
- Bo Qi
- Bocui Nie
- Boedjawan Naraindath N.
- Bogarin Javier
- Bogoevska-Miteva Zaneta
- Bonaccorso Luciano
- Bongiorno Benjamin
- Bonsignore Pablo Julio Maldonaldo
- Borgognoni Cinzia
- Borin Christophe
- Borkowska Marta
- Bormans Laura
- Boroli Filippo
- Borys Michal
- Boschetto Margherita
- Bossolasco Matteo
- Bota Marc
- Boulanger Carole
- Boulton Karen
- Bowes Bonnie
- Boyer Laetitia
- Bozbay Suha
- Bozena Armanda
- Bratsberg Bjorn
- Bravo Silvina
- Brett Carole
- Brett Stephen
- Brett Stephen J.
- Briva Arturo
- Brizio Elisabetta
- Brizuela Patricia
- Broadhurst Phil
- Brown Wendy
- Browne Troy
- Bruel Cédric
- Bruhn Louise
- Brumwell Sarah
- Bruni Andrea
- Bruno Anna Vita
- Buckley Sarah
- Bull Rhian
- Bumbasirevic Vesna
- Buregeya Egide
- Burns Karen
- Butcher Rand
- Byers Heather
- Bösl Kathrin
- Cabral Dolly Mabel Bordon
- Cabral João
- Cabrita Paula
- Caddell Paul
- Caicedo Nestor
- Calamai Italo
- Calili Duygu Kayar
- Caliskan Gulbahar
- Calleja Pablo Lopez-Arcas
- Calpe Neus
- Calvino-Gunther Silvia
- Campanili Ticiane
- Campbell Elizabeth
- Campos Pierina Arias
- Campos-Perez Margarita
- Camputaro Luis
- Camsooksai Julie
- Canales Julieta
- Canete Fidelina
- Cani Alma
- Cano Anastasio Espejo
- Cao Deyan
- Cao Wenzhen
- Cao Ying
- Cao Zu Qing
- Capuzzi Fabio
- Cardenas Yenny
- Carey Annette
- Carney Dominic
- Carter Charlotte
- Casaioli Simona
- Castelain Vincent
- Castiglione Giacomo
- Cata Juan
- Cavaco Raquel
- Cengiz Melike
- Cerezo Franklin Dean
- Cesar Helena
- Cespedes Laura
- Chaboyer Wendy
- Chadwick Llesley
- Chang Shu Chuan
- Chang Youjin
- Chantziara Vasiliki
- Chao Yu
- Chaparro Javiera
- Chaparro Silvia
- Chapeta Edwin
- Chapman Carmel
- Charalabous Iwy
- Chatzis Marinos
- Chee Hyun Keun
- Chen Feifei
- Chen Haiyan
- Chen Hongjuan
- Chen Jingfang
- Chen Lei
- Chen Meili
- Chen Tianfei
- Chen Wenmin
- Chen Xiaoyan
- Chen Zhihong
- Cheng
- Cheng Jiyin
- Chime Christiana
- Chimunda Tim
- Chinardet Benoît
- Chovas Achilleas
- Christ Martin
- Christofis Christos
- Chueca Ramon Molina
- Chunhua Gao
- Cinel İsmail
- Ciorba Paolo
- Clark Michele
- Clement Ana Isabel
- Clesi Tara
- Cody Caitriona
- Collet Marie
- Collins Amy
- Coman Mary
- Conde Belen Burgos
- Conejo Isabel
- Constantinou Constantina
- Corcoran Ailesh
- Coremans Stefano
- Correia Malcolm C.
- Corso Amalia
- Cortegiani Andrea
- Cortellazi Paolo
- Cosano Rosario
- Cossu Maria
- Costa Humberto
- Cotoia Antonella
- Coyer Fiona
- Craig Geraldine
- Craig Jayne
- Cranmer Karen
- Cranshaw Julius
- Creber Peter
- Crone Petra
- Cui Xia
- Cummings Donna
- Cupitt Jason
- Curilen Veronica
- Czuczwar Miroslaw
- Dagooc Rica
- Dai Zhaoxing
- Dal Hayriye Cankar
- Dallaire Julie
- Das Sasidharan Nair Vishnu
- Daubin Cédric
- Davidow Jon
- Davidson Cheryl
- Dawn Frances
- Dayan Meneses
- de Almeida Angelica Olivetto
- de Anda Gilberto Felipe Vazquez
- De Bels David
- de Ceballos José Peral Gutierrez
- De Decker Koen
- De Haan Marina
- de Jesús Ortiz Alberto
- de la Ventana Ana Belén Sánchez
- De lange Dylan
- De Lange Dylan
- de Molina Serrano José Ivan Rodriguez
- De Montmollin Etienne
- De Pablo Ana María
- De Rosa Silvia
- De Sanctis Francesca
- De Schryver Nicolas
- De Wit Irene
- Dean Emiliano
- Debue Anne-Sophie
- Del Bosque Diez Rosa
- del Cotillo Mercedes
- del Mar Diaz Salcedo Maria
- Del Moral Armengol Mario
- Del Rio Cabajo Lorena
- del Rosario Villar Redondo M.
- del Valle Gimenez Graciela
- Delgado Carlos Castro
- Delgado Patricia
- Dellafiore Federica
- Delossantos Shella
- Delve Peter
- Demarré Liesbet
- Demirkiran Oktay
- Dendane Tarek
- Deng Xiaoqiong
- Depuydt Tanja
- Derbyshire Claire
- Derrick Helen
- Deschepper Mieke
- Deva Shanti Rudra
- Dhaliwal Jasdeep
- Di Gravio Valentina
- Di Risio Alessandro
- Di Yanhong
- Diakaki Chrisi
- Dias Sofia
- Diaz Ana
- Diaz Anna
- Diaz Monica Garcia
- Dieperink Willem
- Diers Anja
- Dikmen Yalım
- Dikmen Yalim
- Dilek Ozcengiz
- Dimoula Aikaterini
- Dimski Thomas
- Ding Min
- Ding Xinran
- Ding Yajun
- Ding Yanming
- Dlamini-Sserumaga Lomangisi
- Dobric Milena
- Dolenc Simon
- Dolgusevs Mihails
- Domenech Laura Claramunt
- Dong Jingwen
- Dong Yunchun
- Donvito Maria
- Dormans Tom
- Douschan Philipp
- Doyle Deirdre
- Dragoumanis Christos
- Du Guifang
- Duan Huan
- Dugernier Thierry
- Duggal Abhijit
- Dullenkopf Alexander
- Dungca Adonis
- Dunne Lisa
- Duran Karely
- Déserts Marc Danguy des
- D’Ambrosio Francesco
- D’Ambrosio Paolo
- Ebaid Maie
- Ebaid Maie Salem
- Efe Serdar
- Efthimiou Aikaterini
- Efthymiou Anna
- Egi Moritoki
- Egorova Natalya
- Ei Poe Poe
- Elatrous Souheil
- Elay Gülseren
- Elgammudi Mala
- Elhadi Ahmed
- Elhadi Muhammed
- Elhechmi Youssef Zied
- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
- Enamorado Judy Enamorado
- Eneas Antony
- Eng Timothy
- Erdivanli Başar
- Erdogan Elif
- Eroglu Ahmet
- Ershova Olga
- Escalante Rosana Gabriela
- Espinosa Cristina Paños
- Esposito Romina
- Essardy Fatiha
- Etourneau Fabienne
- Evers Mirjam
- Fadeeva Liudmila
- Fan Limei
- Fang Xiuhua
- Farkas Jean-christophe
- Farmakis Epaminontas
- Farnell-Ward Sarah
- Farre Olga
- Fartoukh Muriel
- Favre René
- Feghaly Michel El
- Fei Qin
- Feng ZhangXia
- Feng Zhaoxia
- Feranandes Ana Margarida
- Fernadez Inmaculada Lorenzo
- Fernandes Fatima
- Fernandez Alejandra Azahara Marguello
- Fernandez Maria Alejandra
- Fernandez Maria Cristina Iglesias
- Fernandez Oscar
- Fernandez Ruben
- Fernandez Silvia
- Fernández Ana Wensell
- Ferreira Amelia
- Ferreira Fatima
- Ferreira Hilaryano
- Ferreira Susana
- Ferretti Christian
- Ffarcsi Madiha Hashmi
- Fiedler Christine
- Fielding Clare
- Fielding Mark
- Figaro-Barclay Dianne
- Figueiredo Margarida Ferreira
- Fijen Jan-Willem
- Filipescu Daniela Carmen
- Filipović-Grčić Ina
- Finn Damien O’Connell Rosemary
- Finnstrom Inger Johanne
- Fioretti Audrey
- Firment Peter
- Fischer Susanne
- Fishman Anne
- Fister Misa
- Fitzpatrick Gerry
- Fivecoat Pauline
- Flessel Nadine
- Fletcher Kelly
- Fleury Yvan
- Flevari Aikaterini
- Flores Leah
- Foka Maria
- Fonseca Imelda Perdomo
- Foong Kit Weng
- Fores Meritxell Tapia
- Fox Natalie
- Fox Nathalie
- Fraipont Vincent
- Franco Natalia
- Frandsen Tine Melgaard
- François Guy
- Frey Christian
- From Mette
- Fu Jing
- Fujimoto Koji
- Galaaen Britt
- Galazzi Alessandro
- Galiana Maria
- Galishevskiy Dmitriy
- Gallart Elisabet
- Gallegos-Perez Humberto
- Gallion Marc
- Gama Luz Marina Silva
- Ganeshalingam Vaarisan
- Gao Guangyuan
- Gao Jie
- Gao Li
- Gao Yan
- Garcia Amilcar
- Garcia Barbara
- Garcia Paulo Carlos
- Garcia Rosa
- García Maria Fernanda
- Garofalo Eugenio
- Garzón-Tovar Carolina
- Gatti Chiara
- Gautam Prabha
- Gautheret Nathalie
- Gavrilovic Srđan
- Gawda Ryszard
- Ge Liuyan
- Geijer Sebastian
- Georgakas Ioannis
- George Shaly
- Georgiev Carmel
- Georgiou Marios
- Gerretsen Benjamin
- Gerritsen Rik T.
- Gharios Elie
- Ghioldi Davide Massimo
- Ghosh Rishi
- Ghula Mohamed Abdurazzag Ali
- Giacardi Christophe
- Giampaoletti Andrea
- Gievski Vanja
- Gilder Eileen
- Gill Sirley
- Gils Fränk
- Girianni Salvatore
- Girona Mercè
- Giusti Gian Domenico
- Gkiokas Georgios
- Glinka Lidia
- Goksu Senay
- Goller Stefan
- Gomes Vitor
- Gomez Monica
- Gomez Saira
- Gong Yue Ying
- Gonzalez Ana Laura
- Gonzalez Daira
- Gonzalez Jeniffer
- Gonzalez Juan Ignacio Torres
- Gonzalez Rafael
- Gonzalez Roberto
- Gonzalez Victor
- González Iván Areán
- Goodson Jennifer
- Goranovic Tanja
- Gordo Federico
- Gordon Patricia
- Gorgolas Maria Carmen
- Gorokhovatsky Uri
- Gorordo-Delsol Luis
- Graeser Stephan
- Greca Alban
- Gregorio Ricardo
- Grigoras Ioana
- Grishina Liudmila
- Groba Casiano Barrera
- Grotheer Sarah
- Groznik Matjaž
- Gu Yanmei
- Guadi-Gosh Belinda
- Guarracino Fabio
- Guenther Ulf
- Guereschi Matias
- Guerrero Alvaro Ortega
- Guerrero Fausto
- Guillén Carmen Velasco
- Guixiang Jia
- Gunter Una
- Guo Hailing
- Guo Jiye
- Guo Yinhua
- Gupta Amit
- Gupta Manish
- Guran Catalin Traian
- Gurevich Vladimir
- Gurjar Mohan
- Gusarev Vitaly
- Gusarov V.
- Gusarov Vitaly
- Gutierrez Pedro
- Gutysz-Wojnicka Aleksandra
- Gül Fethi
- Gümüş Ayça
- Günther Silvia Calvino
- Haas Lenneke
- Habgood Karen
- Hachimi Abdelhamid
- Hacking Danielle
- Hadri Burhan
- Hadzibegovic Adi
- Hagan Samantha
- Hagau Natalia
- Hajjej Zied
- Han Ting
- Han Yu
- Hannes Francis
- Hansen Anja
- Hansen Siri
- Hansen Tina Charlotte Bitsch
- Hao Junping
- Hao Yanhua
- Harding-Goldson Hyacinth
- Hargott Rita Foss
- Haringman Jasper
- Harris Stephanie
- Hashemian Seyed Mohammadreza
- Hashimoto Satoru
- Hashmi Madiha
- Hassan W. Nazaruddin W.
- Hastings Jennifer
- Hatton Kevin
- Haugom Hanne
- Hawchar Fatime
- Hayashi Yoshiro
- Hayden Paul
- He Guoxue
- He Yin
- Heidari Farshad
- Heinicke Tobias
- Heitzler Nathalie
- Hellkvist Viveca Hamback
- Henning Grit
- Hentchoya Romuald
- Herceg Ivana
- Hernandez Aaron Mark
- Hernandez Juan Sebastian
- Hernandez-Ponce Lucia
- Hernandez-Romero Marcos
- Hernandez-Sanchez Nancy
- Herrera Jorge Guerra
- Herrera María Ocotlan Gonzalez
- Higgins David
- Hilario Badiola
- Hirao Akemi
- Ho Sung Wai
- Hoegenhaven Anisette
- Hojden Susanna
- Holmquist Dagmar
- Hong Li
- Hong Liu
- Hong Ma
- Honore Patrick M.
- Honoré Patrick M.
- Horner Daniel
- Horrigan Nicola
- Hoste Pieter
- Houghton Victoria
- Howcroft Clare
- Hsu Mei Yu
- Hu Li Ping
- Hu Lili
- Hu Rongjun Ling
- Hu XiaoChun
- Hua Ngu Pei
- Huang LiPing
- Huang Qingping
- Huang Rong Fen
- Huang Xia
- Hughes Jennifer
- Hughes Mandy
- Huh Jin Won
- Hui Caihong
- Huo Yuxia
- Hurtado Cintia Valencia
- Hurtado Clara
- Husted Birthe
- Hylen Mia
- Hyska Genci
- Høgvall Lisa
- Ibao Jowena
- Ibarra Alejandro
- Iburrigarro Sergio Reyes
- Idowu Olakunle
- Iglesias Federico
- Ignatenko Olga
- Ilesanmi Rose
- Ilesanmi Rose Ekama
- Inal Volkan
- InSu Lin
- Ioannides Panagiotis
- Iovenko Ihor
- Iozzo Pasquale
- Isanan Michael
- Isasi Maria Aranzazu
- Ismail Nahla
- Ismail Wan Nasrudin Wan
- İzdes Seval
- Jackson Matthew
- Jacob Reni
- Jacquet Luc-Marie
- Jafaraghaee Fateme
- Jali Phumele
- Jankovic Radmilo
- Jans Anita
- Jansson Erika Backlund
- Jarman Rachel
- Jaschinski Ulrich
- Jasiewicz Przemyslaw
- Jaundoo Helen
- Jensen Hanne Irene
- Jensen Karianne Dale
- Jeon Kyeongman
- Jepsen Britta
- Jha Simant
- Ji Hua
- Jia Na
- Jian Yanman
- Jiang Jing Hua
- Jiang Mei
- Jiang Qun Xia
- Jiang Shumin
- Jiang Youru
- Jiang Zhixia
- Jiang ZhiXia
- Jianhong Mu
- Jiao Qing Feng
- Jiao Xueping
- Jibrin Deborah
- Jimenez Raquel
- Jin Wangyan
- Jochmans Sébastien
- Joelsson-Alm Eva
- Joffe Aaron
- Johansen Birgitte Fosser
- Johansen Edda
- Johansson Lotta
- John Sini
- Jonasdottir Rannveig J.
- Jones Jo
- Jones Sarah
- Jong Margaret Lynn
- Jorge Silvia Angelica
- Jovaisa Tomas
- Jovanovic Bojan
- Ju Wenjie
- Judd Harriet
- Kaasby Karin
- Kakaras Nikolaos
- Kamal Manoj
- Kamenshchikov Nikolaj
- Kamoun Salma
- Kampayana Betty Star
- Kanakaki Sofia
- Kanda Fumiya
- Kang Byung Ju
- Kannan Santhana
- Kapoor Ritoo
- Kara Iskender
- Karabacak Pınar
- Karakurt Sait
- Karamchandani Kunal
- Karaoren Gulsah
- Karathanou Antigoni
- Karjula Elina
- Kartalov Andrijan
- Kataoka Jun
- Katerina Kounougeri
- Katsenos Chrysostomos
- Kauppi Outi
- Kaushik Shuchi
- Kazakos Nikolaos
- Kağnıcı Ali
- Kehoe Jennifer
- Kerslake Ian
- Kesti Ulla
- Khaled Ala
- Khaled Taha
- Khanna Ashish
- Khanna Ashish K.
- Khoo Tien Meng
- Khoronenko Victoria
- Khwannimit Bodin
- Kilapong Bram
- Kim Je Hyeong
- Kim Junghyun
- Kim Kyung Chan
- Kim Seok Chan
- Kindgen-Milles Detlef
- Kiselev Alexander
- Kjærgård Inger Ebbesen
- Kleanthous Pavlina
- Knafelj Rihard
- Kodal Anne Marie
- Kolbe Nina
- Kolussi Uta
- Kondili Eumorfia
- Koopmans Matty
- Kotanidi Veronika
- Kotze Michelle
- Koulouras Vasilios
- Kourelea Styliani
- Koutsodimitropoulos Ioannis
- Kovaleva Julia
- Krastins Ivasr
- Kristoffersen Elin
- Kubisz-Pudelko Agnieszka
- Kuijpers Paul
- Kulakov Vladimir
- Kuscu Ozlem Ozkan
- Kushare Vilas
- Kusi-Appiah Anita-Chrysolyte
- Kuzmanovska Biljana
- Kyriakoudi Anna
- Kütimets Martin
- Labeau Sonia O.
- Lacaden Grace
- Lafuente Estevão
- Lagerhäll Caroline
- Laizner Andréa Maria
- Lajara Miguel Angel Gimenez
- Lajeunesse Jennifer
- Lakshmanan Ramanathan
- Lalor Jennifer
- Landaverde Antonio
- Lang Martin
- Langvad Anne
- Lančaričová Danca
- Larina Eugeniya
- Larsson Ing-Marie
- Lausch Martina
- Lavrentieva Athena
- Lavy Alinoy
- Le Guen Yann
- Lebon Richard
- Ledochowski Stanislas
- Lee Heung Bum
- Lee Jarone
- Lee Jongmin
- Lee Sang-Miin
- Lee Sang-Min
- Lee Seok Jeong
- Lee Won-Yeon
- Legorburo Maria Schofield
- Lei DeHong
- Lei Lei
- Lei Yang
- Leong Thomas
- Leonova Anna
- Lepida Dimitra
- Leslie Gavin D.
- Lestari Mayang Indah
- Levy Dassy
- Lewis Abby
- Li Biyan
- Li Chunxia
- Li Ji
- Li Jing
- Li Jinhua
- Li Li Chuntang
- Li Ling
- Li Miao
- Li Ning
- Li Qi
- Li Qing
- Li Tingting
- Li Weiwei
- Li Xiaohan
- Li Xingguo
- Li Xinjian
- Li Xinxia
- Li Xue Qin
- Li Yan
- Li Ying
- Li ZhangShuangzi
- Li Zhuqing
- Liang Jinxian
- Liang Qiong
- Liang Xuejuan
- Liarmakopoulou Antonia
- Lijuan Sun
- Lima Ângela
- Lin Dongliang
- Lin Frances
- Lin Qiang
- Lin Xue
- Lind Ranveig
- Lipovestky Fernando
- Lipovesty Fernando
- Liu Congcong
- Liu Guangyan
- Liu Hongmei
- Liu Jin
- Liu Jingyu
- Liu Kewei
- Liu Lihong
- Liu Ling
- Liu Lu
- Liu Man
- Liu Miao
- Liu Sophie
- Liu Xiaodi
- Liu XiaoZhe
- Liu XiuMei
- Liu XueLian
- Liu Yan
- Liu Yang
- Liu Ying
- Liu Yu
- Liu Yupeng
- Llaurado-Serra M.
- Llaurado-Serra Mireia
- Llewellym Thomas
- Llinas Ana Alabart
- Loef Bert
- Lois Manuel
- Long Yan
- Long Yanfei
- Lord Jenny
- Lorenzo Javier
- Losilla Monica Recio
- Lospitao Sara
- Loudet Cecilia
- Loudet Cecilia Inés
- Luan Linlin
- Luchian Mihail
- Luis Eulália
- Lukic Milica
- Lund Mette
- Lunde Gro Anne
- Luo Feifei
- Luo Xianping
- Luo Xiaofang
- Luque Carmen Partera
- Lusenius Virpi
- Lv Mengmeng
- Lv Shanshan
- Lye India
- Lynch Ceri
- Löf Gun
- Löfqvist Carita
- Ma Chaoqun
- Ma Fuying
- Maddison Liivi
- Maggiore Salvatore Maurizio
- Magomedov Marat
- Maguire Teena
- Mahanes Dea
- Mahmood Saeed
- Mahmoodpoor Ata
- Maidana Elizabeth
- Maiyalagan Sundaresan
- Malmin Siv Karin
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- Wahab Sherliza
- Wahlbom Ewa
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- Wan Jianhong
- Wan Yan
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- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
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- Whitticase Richard
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- Wilby Liz
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- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
- Bakas Apostolos
- Baker Helen
- Baker Nerilee
- Balasubramanian Madhu
- Balbay Abidin Oner
- Balon Sandrine
- Bantar Ana
- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
- Barefield Cindy
- Barkas Diane
- Barnes Christopher
- Barone Antonio
- Baronia Arvind
- Barr Louise
- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
- Baskoro Windu
- Bastani Styliani
- Baumber Rachel
- Baxter Karen
- Bayraktar Yesim Serife
- Bealer Cheryl
- Bean Sarah
- Becker Cathy
- Becker Delmiro
- Behan Helena
- Beker Tatjana
- Bekos Vasileios
- Belii Adrian
- Belkhair Wesal Ali
- Belskiy Vladislav
- Ben-Hamouda Nawfel
- Ben-Jacob Talia
- Benbenishty Julie
- Bench Suzanne
- Bendelari Valentina
- Benlamin Mohamed
- Berry Gillian
- Bertoletti Fernando Pablo
- Besbes Lamia
- Besbes Lamia Ouanes
- Besch Guillaume
- Bestle Morten
- Beuret Pascal
- Bhakhtiani Lakshay
- Bhargava Vaibhav
- Bi AiPing
- Bianchini Suzana
- Bielskute Egidija
- Bilawicz Jan
- Binda Filipo
- Birgisdottir Hrönn
- Birgisdóttir Hrönn
- Bispo Bruno Miguel
- Biston Patrick
- Bjorgen Hege
- Blackwood Bronagh
- Blanc Agnès
- Blanco Daniel
- Blanco Maria Pilar Sogues
- Blasco Maria Luisa
- Bliksted Inger Abildgaard
- Blondal Asbjorn
- Bloos Frank
- Blot Stijn I.
- Bo Qi
- Bocui Nie
- Boedjawan Naraindath N.
- Bogarin Javier
- Bogoevska-Miteva Zaneta
- Bonaccorso Luciano
- Bongiorno Benjamin
- Bonsignore Pablo Julio Maldonaldo
- Borgognoni Cinzia
- Borin Christophe
- Borkowska Marta
- Bormans Laura
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- Petrushin Maxim
- Pečenković Suzana
- Philippart François
- Piergentili Federica
- Pili-Floury Sébastien
- Pillard Cindy
- Pineda Ana Alícia Velarde
- Pinheiro Cristiana Mota
- Pinto Susana
- Pinto Vitor Manuel Vaz
- Piradov Michael
- Pires Filpe
- Pivkina Alexandra
- Piza Petr
- Piñan Isabel Santín
- Plantefève Gaëtan
- Pleitinckx Vincianne
- Polgarova Petra
- Polo Ana Belén Curto
- Popescu Mihai
- Popescu Monica
- Potestio Christopher
- Powell Madeleine
- Preda Gabriel
- Prol-Silva Estefanía
- Prowle John
- Psarulis Konstantinos
- Pulak Paul
- Pulletz Mark
- Putruele Sofia
- Qawasmeh Khaled Al
- Qiao Hongmei
- Quagliotto Catia
- Quaini Attilio
- Quintard Hervé
- Quiroga Cristian
- Rabarova Daria
- Radavidson Anthony
- Radivojevic Renata Curic
- Rahim Azmin Huda Abdul
- Raimondo Arena
- Raitsiou Bogdan
- Raizman Rose
- Raj Ashok Sundai
- Rajendran Ajitha
- Rajković Marija
- Ramaker Bart
- Ramalho Aline
- Ramirez Mario
- Ramiro Charalice
- Ran Qiong
- Ranalli Flavia
- Randell Claire
- Rapley Jackie
- Rastegar Touraj
- Ratnam Shanthi
- Ratnam Shanti
- Ravani Ifigenia
- Reece-Anthony Rosie
- Reidinga Auke
- Reijntjens Jennifer
- Remor Natalie
- Ren Aiua
- Reyes Amylkar Garay
- Reyes Amylkar José Garay
- Reyes Laura Martinez
- Reyes Paul Eric
- Reynolds Claire
- Ribas Antoni Margarit
- Ribas Antonio Margarit
- Riera Alba
- Riessen Reimer
- Ringdal Mona
- Rinket Martin
- Ripolles-Melchor Javier
- Rita Clara Santa
- Rivas Juan Carlos
- Rivas Noelia
- Riveiro Marilyn
- Rizzo Antonino
- Rocco Monica
- Rocha Pamela
- Rodriguez Gabriel Enrique
- Rojas-Suarez José
- Rokosh Ella
- Roller Martin
- Roman-Pognuz Erik
- Romero-Gonzalez Juan P.
- Ronchini Ana Lucia Vitti
- Rooney Glenda
- Rosado Ines
- Rosalia Rodney
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- Rose Bernd Oliver
- Rose Louise
- Rostello Oscar Fernández
- Rothenfusser Monika
- Rubulotta Francesca
- Rubulotta Giorgia
- Rygvadottir Brynja
- Saager Leif
- Sabbag Ignacio
- Saha Rajnish
- Sakki Jenni-Katarina
- Sakuramoto Hideaki
- Salazar Janel
- Salberg Armorel
- Salman Fatema
- Salo Swagotika
- Salvà-Costa Vicent
- Samat Noryani Mohd
- Sanchez Losune Cano
- Sanchez Maria Angeles Hurtado
- Sanchez-Hurtado Luis Alejandro
- Sandberg Ulla
- Sandesc Dorel
- Sankar-Maharaj Sasha
- Sankey Babangida John
- Santiago Eleanor
- Santos Jacinta
- Santos Rayanne
- Sanz Luz Coronado
- Sanz Miquel
- Sarkar Nikki
- Saul Pablo
- Sawawiboon Chaiwut
- Schaller Stefan
- Schallom Marilyn
- Schefold Joerg C.
- Schmidt Raysa Cristina
- Schmollgruber Shelley
- Schmukler Armando
- Schmutz René
- Schulze Tobias
- Schüppel Sebastian
- Scire Giovanni
- Scutariu Monica Adriana
- Sellami Walid
- Sepulveda Maria Idalia
- Sergeev Dmitry
- Serin Sibel Ocak
- Seromenho Vanda
- Serpa Leticia
- Sertznig Claude
- Setten Mariano
- Shah Bhagyesh
- Shao Hongyan
- Shaw David
- Shawish Sabah Abu
- Shayamano Rosina
- Sheehan Christine
- Shen Yanling
- Sherwin James
- Shi Guanxiu
- Shi Zeya
- Shime Nobuaki
- Shimizu Masako
- Short Jack
- Shosholcheva Mirjana
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- Sierra Rafael
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- Silva Pedro
- Sim Yun Su
- Simi Marcelo
- Simon Philipp
- Singh Keevan
- Singh Mukta
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- Skorstad Elin Mari
- Slobodianiuk Gari
- Slobodianiuk Garri
- Smajic Jasmina
- Smiley Kathleen Ann
- Smith Catherine
- Smith Chris
- Smith Julie
- Smith Neil
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- Soledad Javiera
- Somerville Justine
- Sona Carrie
- Song Bing
- Song Caiju
- Song JinHui
- Song Min
- Song Rima
- Sosa Miguel Ángel
- Sosnowski Kellie
- Sostaric Maja
- Soula Enas
- Soulisse Léa
- Soundoulounaki Stella
- Souppart Virginie
- Sourla Evdokia
- Sousa Bruno
- Spadaro Savino
- Spina Rosario
- Spyropoulou Anastasia
- Spångfors Martin
- Stafylaraki Maria
- Staikos Ioannis
- Stalika Kristina Mariana Matei
- Stanojević Maja
- Starchenko Irina
- Stefanovic Branislava
- Steffenak Elin
- Stehr Sebastian
- Stenset Ane
- Stiban Sonia
- Stivanello Lucia
- Stojanovic Milena
- Stones Elizabeth
- Straede Esben
- Stübner Andeas
- Subedi Nisha Bhandari
- Suen Gabriel
- Sulaiman Siti Rohayah
- Sun Chengxia
- Sun Wei
- Sun Yue
- Susanti Ade
- Sustic Alan
- Swinnen Walter
- Syed Muhommed Ridwaan
- Sykehus Drammen
- Szakmany Tamas
- Sánchez-Hurtado Luis
- Tababa Osama Wanees Emhemid
- Tabah Alexis
- Tabib Majd
- Taghavi Noushin
- Taibi Maria Rosa
- Taito Shunsuke
- Tak Poon Shing
- Takahashi Kenji
- Talik Imen
- Tallot Mandy
- Tamayo Luis Mario
- Tamme Kadri
- Tan Lei
- Tao Jing
- Tapia Fernando
- Tavares Ana
- Taşdemir Banu
- Teig Magnus
- Tejeda-Huezo Brigitte
- Telleria Vanesa Mercado
- Templeton Mae
- Terry Dorothy
- Tervo-Heikkinen Tarja
- Thankamma Bindu
- Theisen Christian
- Thix Cyril
- Tholioti Thomai
- Thoma Giannoula
- Thomas Beverley
- Thompson Amy
- Thompson Lorraine
- Thomsen Tina Damgaar
- Thorpe Elaine
- Tian Eryun
- Tian Xiao Fang
- Tian Yani
- Tian Zhixia
- Timsit Jean-Francois
- Tingsvik Catarina
- Tirado Celia
- Toellefsen Annette
- Tokareva Ekaterina
- Tokur Murat Emre
- Tole Eunice
- Tomescu Dana
- Tong Jenny May Geok
- Tonkovic Dinko
- Toppin Patrick
- Torlinski Tomasz
- Traina Lidia
- Tranello Francesca Paola
- Tribulev Maksim
- Tridente Ascanio
- Triki Ahmed Ramadan
- Tripathy Swagata
- Trongtrakul Konlawij
- Trongtratul Konlawij
- Trposak Angela
- Trudvang Siw
- Trueman-Dawkins Treiza
- Tsarev Alexander
- Tsikriki Syragoula
- Tsikritsaki Kyriaki
- Tsujimoto Mayumi
- Tubacka Marta
- Tuinstra Binny
- Tuo Lili
- Turan Can
- Turan Sema
- Turc Jean
- Turner Sarah Jane
- Turčan Anton
- Tutillo Diego Rolando Morocho
- Twagirumugabe Theogene
- Twiggs Hilary
- Uba Stella
- Uccelli Francesco
- Udiljak Nikolina
- Ugwu Innocent
- Umek Nejc
- Undar Hasan Nabi
- Vakalos Aristeidis
- Valerio Idália
- Valgolio Emanuel
- Valta Maija
- Valta Maija Anniina
- van Axel Alisha
- Van Cotthem Ilse
- Van de Velde Stijn
- Van Den Berg Lettie
- Van Den Brink Mark
- Van Den Elst Arlette
- van der Kuil Mark
- Van Gulik Laura
- Van Regenmortel Niels
- Van Vliet Peter
- Vanroest Margijske
- Varela Maria
- Vaschetto Rosanna
- Vasquez Alexandra
- Vaughan-Jones Nicola
- Velickovic Jelena
- Veličković Dejan
- Ventour Dale
- Vermeijden Jan Wytze
- Vieira João
- Villa Robert
- Villafuerte Missael Vladimir Espinoza
- Villanueva Ximena
- Villegas Paula
- Viveiros Abel
- Vizcaychipi Marcela
- Vlaovic Janko
- Vochin Ana
- Volta Carlo Alberto
- von der Osten Ingrid
- Von Der Osten Ingrid
- von Lewinski Dirk
- Vosylius Saulius
- Vuković Anita
- Vullum Sylvi
- Vymazal Tamas
- Vymazal Tomas
- Wahab Sherliza
- Wahlbom Ewa
- Waibel Hansjoerg
- Wallin Ewa
- Walsh Amy
- Wan Jianhong
- Wan Yan
- Wang Damei
- Wang Fanglan
- Wang GuoXian
- Wang Hai Yun
- Wang Haiyan
- Wang Jing
- Wang Kefang
- Wang LingLing
- Wang RuiXia
- Wang Shuhui
- Wang Shuo
- Wang Wei
- Wang Wenmei
- Wang Xiaomin
- Wang Yan
- Wang Ying
- Wang Yingli
- Wang Yuping
- Wang Yuxia
- Watts Stacey
- Waweru-Siika Wangari
- Wei Dongfang
- Wei Wei
- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
- White Nigel
- Whiteley Simon
- Whitticase Richard
- Wiborg Elisabeth
- Wijnands Patricia
- Wilby Liz
- Williams Anne
- Williams Ged
- Williams Helen
- Williams Karen
- Williams Lynne
- Wilting Rob
- Wise Robert
- Woods Justin
- Wright Kerry
- Wu Juan
- Wu ShiFen
- Wu Xiaojun
- Wu Xiaoying
- Wu Yang
- Wu Yun
- Wu Zijing
- Xhindi Nordian
- Xia Chun Jie
- Xia Xinhua
- Xiao Lina
- Xiao Min
- Xiao Yan
- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Aaron Joffe
- Aaron Mark Hernandez
- Aaron Mark Hernandez
- Abby Lewis
- Abdelhamid Hachimi
- Abdualhamid I Alshrif
- Abel Viveiros
- Abhijit Duggal
- Abidin Oner Balbay
- Achilleas Chovas
- Ade Susanti
- Adi Hadzibegovic
- Adonis Dungca
- Adrian Belii
- Adrian Belii
- Adriana Onelli
- Afolabi Owojuyigbe
- Agnieszka Kubisz-Pudelko
- Agnès Blanc
- Ahmed Ali Aboufray
- Ahmed Elhadi
- Ahmed Ramadan Triki
- Ahmed Subhy Alsheikhly
- Ahmed Zaki
- Ahmet Eroglu
- Aidan O'Shea
- Aikaterini Dimoula
- Aikaterini Efthimiou
- Aikaterini Flevari
- Ailesh Corcoran
- AiPing Bi
- Aiua Ren
- Aizhi Zhang
- Ajitha Rajendran
- Akemi Hirao
- Akira Ohuchi
- Aktham Yaghi
- Ala Khaled
- Alan Sustic
- Alan Sustic
- Alba Riera
- Alban Greca
- Alberto de Jesús Ortiz
- Alberto Peratoner
- Alejandra Aucapina
- Alejandra Azahara Marguello Fernandez
- Alejandro Ibarra
- Aleksandar Šuput
- Aleksandra Gutysz-Wojnicka
- Alessandra Negro
- Alessandro Di Risio
- Alessandro Galazzi
- Alexander Dullenkopf
- Alexander Kiselev
- Alexander Tsarev
- Alexandra Pivkina
- Alexandra Vasquez
- Alexis Tabah
- Ali Kağnıcı
- Alida Moise
- Aline Ramalho
- Alinoy Lavy
- Alisha van Axel
- Alma Cani
- Alvaro Ortega Guerrero
- Amalia Corso
- Amber Markham
- Amelia Ferreira
- Amer Assiri
- Amilcar Garcia
- Amilcar Garcia
- Amit Gupta
- Amit Gupta
- Amy Collins
- Amy Thompson
- Amy Walsh
- Amylkar Garay Reyes
- Amylkar José Garay Reyes
- Ana Alabart Llinas
- Ana Alícia Velarde Pineda
- Ana Bantar
- Ana Belén Curto Polo
- Ana Belén Sánchez de la Ventana
- Ana Diaz
- Ana Diaz
- Ana Isabel Clement
- Ana Laura Gonzalez
- Ana Lucia Vitti Ronchini
- Ana Margarida Feranandes
- Ana María De Pablo
- Ana Pascual-Bielsa
- Ana Tavares
- Ana Vochin
- Ana Wensell Fernández
- Anastasia Spyropoulou
- Anastasio Espejo Cano
- Andeas Stübner
- Andrea Bruni
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Giampaoletti
- Andrea Martonova
- Andrea Martonova
- Andrea McDonnell
- Andrea McLucas
- Andrej Markota
- Andrijan Kartalov
- Andréa Maria Laizner
- Andréa Maria Laizner
- Andréa Maria Laizner
- Ane Stenset
- Angela Trposak
- Angelica Olivetto de Almeida
- Anisette Hoegenhaven
- Anita Alias
- Anita Jans
- Anita Vuković
- Anita-Chrysolyte Kusi-Appiah
- Anja Diers
- Anja Hansen
- Ann-Sofie Malvemyr
- Anna Alexandrou
- Anna Diaz
- Anna Efthymiou
- Anna Kyriakoudi
- Anna Leonova
- Anna Vita Bruno
- Anne Fishman
- Anne Langvad
- Anne Marie Kodal
- Anne Sofie Bomholt Pedersen
- Anne Williams
- Anne-Sophie Debue
- Annette Carey
- Annette Toellefsen
- Anthony Adenekan
- Anthony Radavidson
- Antigoni Karathanou
- Anton Turčan
- Antonella Cotoia
- Antonella Mo
- Antoni Margarit Ribas
- Antonia Liarmakopoulou
- Antonija Petosic
- Antonino Rizzo
- Antonio Abdala
- Antonio Barone
- Antonio Landaverde
- Antonio Manzo
- Antonio Margarit Ribas
- Antony Eneas
- Apostolos Bakas
- Arena Raimondo
- Arif Moghal
- Aristeidis Vakalos
- Arlette Van Den Elst
- Armanda Bozena
- Armando Schmukler
- Armorel Salberg
- Artemis Patsalos
- Arturo Briva
- Arvind Baronia
- Asbjorn Blondal
- Ascanio Tridente
- Ashish K Khanna
- Ashish K Khanna
- Ashish Khanna
- Ashley Szabo Eltorai
- Ashok Sundai Raj
- Ashwaq Ali
- Asmah Zainudin
- Asu Ozgultekin
- Ata Mahmoodpoor
- Athena Lavrentieva
- Attilio Quaini
- Audrey Fioretti
- Audrey Massard
- Auke Reidinga
- Auli Palmu
- Avşar Zerman
- Aya Alabuzidi
- Ayako Noguchi
- Ayça Gümüş
- Azmin Huda Abdul Rahim
- Babangida John Sankey
- Badiola Hilario
- Banu Taşdemir
- Baoke Zhang
- Barbara Garcia
- Barbro Meland
- Bart Ramaker
- Basri Mat Nor
- Battsetseg Baasanjav
- Başar Erdivanli
- Başar Erdivanli
- Beatrice Pastore
- Begoña Zalba-Etayo
- Belen Burgos Conde
- Belinda Guadi-Gosh
- Ben Attwood
- Benjamin Bongiorno
- Benjamin Gerretsen
- Benoît Chinardet
- Berenice Navarro
- Bernardo Panka
- Bernardo Panka
- Bernd Oliver Rose
- Bert Loef
- Betty Star Kampayana
- Beverley Thomas
- Beysim Özcan
- Beysim Özcan
- Bhagyesh Shah
- Biljana Kuzmanovska
- Bindu Thankamma
- Bing Song
- Binny Tuinstra
- Birgitte Fosser Johansen
- Birthe Husted
- Biyan Li
- Bjoern Monsen
- Bjorn Bratsberg
- Bodin Khwannimit
- Bogdan Raitsiou
- Bojan Jovanovic
- Bonnie Bowes
- Boğaç Özserezli
- Bram Kilapong
- Bram Kilapong
- Branislava Stefanovic
- Brian Marsh
- Brigitte Tejeda-Huezo
- Brita Fosser Olsen
- Britt Galaaen
- Britt Sjobo
- Britta Jepsen
- Bronagh Blackwood
- Bruno Miguel Bispo
- Bruno Sousa
- Bruno Sousa
- Brynja Rygvadottir
- Burhan Hadri
- Burhan Hadri
- Byung Ju Kang
- Caihong Hui
- Caiju Song
- Caitriona Cody
- Can Turan
- Carita Löfqvist
- Carlo Alberto Volta
- Carlos Alejandro Bascary
- Carlos Castro Delgado
- Carmel Chapman
- Carmel Georgiev
- Carmen Partera Luque
- Carmen Velasco Guillén
- Carole Boulanger
- Carole Boulanger
- Carole Brett
- Carolina Garzón-Tovar
- Carolina Palaez
- Caroline Lagerhäll
- Caroline O'Donnell
- Caroline Paillet
- Carrie Sona
- Casiano Barrera Groba
- Catalin Traian Guran
- Catarina Nunes
- Catarina Tingsvik
- Catherine Motherway
- Catherine O'Brien
- Catherine Smith
- Cathy Becker
- Catia Quagliotto
- Cecilia Inés Loudet
- Cecilia Loudet
- Celia Tirado
- Ceri Lynch
- Cesar Aponte
- Cesar Rodriguez Nuñez
- Chaiwut Sawawiboon
- Chaoqun Ma
- Charalampos Martinos
- Charalice Ramiro
- Charikleia Nikolaou
- Charlotte Carter
- Charlotte Young
- Charlotte Young
- Chen Yumei
- Cheng
- Chenghau Mu
- Chengxia Sun
- Cheryl Bealer
- Cheryl Davidson
- Chiara Gatti
- Chiara Megna
- Chiara Megna
- Cho Young-Jae
- Chris Gerome Ellazar
- Chris Smith
- Chrisi Diakaki
- Christian Ferretti
- Christian Frey
- Christian Theisen
- Christiana Chime
- Christine Fiedler
- Christine Sheehan
- Christophe Borin
- Christophe Giacardi
- Christopher Barnes
- Christopher Barnes
- Christopher Palfreeman
- Christopher Potestio
- Christos Christofis
- Christos Dragoumanis
- Chrysanthos Markoulias
- Chrysostomos Katsenos
- Chun Jie Xia
- Chunxia Li
- Cindy Barefield
- Cindy Pillard
- Cintia Valencia Hurtado
- Cinzia Borgognoni
- Claire Derbyshire
- Claire Randell
- Claire Reynolds
- Clara Hurtado
- Clara Santa Rita
- Clare Fielding
- Clare Howcroft
- Claude Sertznig
- Claudia Lizbeth Lopez Nava
- Claudia Martins
- Congcong Liu
- Constantina Constantinou
- Cristal April Jane Aperocho
- Cristian Quiroga
- Cristiana Mota Pinheiro
- Cristina Paños Espinosa
- Cristina Petrisor
- Cui Yuan
- Cynthia Xing
- Cyril Thix
- Cyril Thix
- Cédric Bruel
- Cédric Daubin
- Dagmar Holmquist
- Daira Gonzalez
- Daisy Mehay
- Dale Ventour
- Damei Wang
- Damien O'Connell Rosemary Finn
- Dana Tomescu
- Dana Tomescu
- Danca Lančaričová
- Daniel Blanco
- Daniel Horner
- Daniel Owens
- Daniel Sancho Muriel
- Daniela Alampi
- Daniela Carmen Filipescu
- Danielle Hacking
- Danil Baskakov
- Daria Rabarova
- Dassy Levy
- David De Bels
- David Higgins
- David Perez-Torres
- David Shaw
- Davide Massimo Ghioldi
- Dea Mahanes
- Debbie Noblezada-Uy
- Deborah Jibrin
- DeHong Lei
- Deirdre Doyle
- Dejan Veličković
- Delmiro Becker
- Delphine Ngo
- Demet Tok Aydin
- Detlef Kindgen-Milles
- Devrim Akdağ
- Deyan Cao
- Diana Alvarez
- Diane Barkas
- Dianne Figaro-Barclay
- Dick Nahar
- Diego Rolando Morocho Tutillo
- Dimitra Lepida
- Dimitrios Papadopoulos
- Dinko Tonkovic
- Dirk von Lewinski
- Dmitriy Galishevskiy
- Dmitry Sergeev
- Dolly Mabel Bordon Cabral
- Dominic Carney
- Donaldo S Arteta Arteta
- Dongfang Wei
- Dongliang Lin
- Dongmei Bai
- Dongshu Ni
- Donna Cummings
- Dorel Sandesc
- Dorothee Mueller
- Dorothy Terry
- Drammen Sykehus
- Dritan Muzha
- Dritan Muzha
- Duygu Kayar Calili
- Dylan De Lange
- Dylan De Lange
- Edda Johansen
- Edwin Chapeta
- Egide Buregeya
- Egidija Bielskute
- Eileen Gilder
- Eirini Pantiora
- Eirini Papageorgiou
- Eirini-Chysovalanto Patsiou
- Ekaterina Tokareva
- Elaine Barros
- Elaine Thorpe
- Eleanor Santiago
- Elena Molinos
- Eleni Achilleos
- Eliane Mazocoli
- Elie Gharios
- Elif Erdogan
- Elif Erdogan
- Elin Kristoffersen
- Elin Mari Skorstad
- Elin Steffenak
- Elina Karjula
- Elisabet Gallart
- Elisabeth Wiborg
- Elisabetta Brizio
- Elizabeth Campbell
- Elizabeth Maidana
- Elizabeth Stones
- Ella Rokosh
- Elsa Afonso
- Elsa Afonso
- Emanuel Valgolio
- Emiliano Dean
- Emilio Maseda
- Emma Aves
- Emma Moreno Barreiro
- Emma Parkin
- Enas Soula
- Eneli Anvelt
- Enora Atchade
- Epaminontas Farmakis
- Erik Roman-Pognuz
- Erika Backlund Jansson
- Eryun Tian
- Esben Straede
- Esteban Milioto
- Estefania Orozco
- Estefanía Prol-Silva
- Estevão Lafuente
- Etienne De Montmollin
- Eugenio Garofalo
- Eugenio Martinez-Hurtado
- Eugeniya Larina
- Eulália Luis
- Eumorfia Kondili
- Eunice Tole
- Eva Joelsson-Alm
- Eva Joelsson-Alm
- Eva Åkerman
- Eva Åkerman
- Evangelia Michailidou
- Evdokia Sourla
- Evellyn Oliveira
- Evgeniy Zuev
- Evren Şentürk
- Ewa Wahlbom
- Ewa Wallin
- Fabienne Etourneau
- Fabio Capuzzi
- Fabio Guarracino
- Fan Yang
- Fanglan Wang
- Farid Zand
- Farshad Heidari
- Fatema Salman
- Fateme Jafaraghaee
- Fatemeh Zarei
- Fatiha Essardy
- Fatima Fernandes
- Fatima Ferreira
- Fatima Kasem El Ahmad
- Fatime Hawchar
- Faustina Excel Adipa
- Fausto Guerrero
- Faye Morren
- Fayez François Abillama
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- Sini John
- Siobhan O'Nuallain
- Siri Hansen
- Sirley Gill
- Siti Rohayah Sulaiman
- Siv Karin Malmin
- Siw Trudvang
- Slobodan Mihaljevic
- So Young Park
- Soad Imhmed R Alkhumsi
- Sofia Dias
- Sofia Kanakaki
- Sofia Putruele
- Sofia Zepoy
- Solenne Ory
- Sonia O Labeau
- Sonia Stiban
- Sonika Agarwal
- Sophie Liu
- Souheil Elatrous
- Souzana Anisoglou
- Srđan Gavrilovic
- Stacey Watts
- Stanislas Ledochowski
- Stefan Goller
- Stefan Schaller
- Stefano Coremans
- Stella Soundoulounaki
- Stella Uba
- Stephan Graeser
- Stephanie Harris
- Stephen Brett
- Stephen J Brett
- Stephen M Pastores
- Stijn I Blot
- Stijn Van de Velde
- Styliani Bastani
- Styliani Kourelea
- Suha Bozbay
- Sun Lijuan
- Sun Zhiping
- Sundaresan Maiyalagan
- Sundaresan Maiyalagan
- Sundaresan Maiyalagan
- Sung Wai Ho
- Sunghoon Park
- Sunthiti Morakul
- Susana Ferreira
- Susana Pinto
- Susanna Hojden
- Susanne Fischer
- Suzana Bianchini
- Suzana Pečenković
- Suzanne Barrowcliffe
- Suzanne Bench
- Swagata Tripathy
- Swagotika Salo
- Sylvi Vullum
- Syragoula Tsikriki
- Sébastien Jochmans
- Sébastien Pili-Floury
- Taha Khaled
- Tai Sun Park
- Takoua Merhabene
- Talia Ben-Jacob
- Tamas Szakmany
- Tamas Vymazal
- Tanja Depuydt
- Tanja Goranovic
- Tao Zan
- Tara Clesi
- Tarek Dendane
- Tarja Tervo-Heikkinen
- Tatiana Patrichi
- Tatjana Beker
- Taís Pantaleao
- Teena Maguire
- Theogene Twagirumugabe
- Theogene Twagirumugabe
- Theonymfi Papavasilopoulou
- Thierry Dugernier
- Thomai Tholioti
- Thomas Dimski
- Thomas Leong
- Thomas Llewellym
- Tianfei Chen
- Ticiane Campanili
- Tien Meng Khoo
- Tim Chimunda
- Timothy Eng
- Tina Charlotte Bitsch Hansen
- Tina Damgaar Thomsen
- Tine Melgaard Frandsen
- Ting Han
- Tingting Li
- Tingting Yu
- Tobias Heinicke
- Tobias Odenthal
- Tobias Schulze
- Tom Dormans
- Tomas Jovaisa
- Tomas Jovaisa
- Tomas Vymazal
- Tomasz Torlinski
- Tomislav Mirkovic
- Tonia Onyeka
- Touraj Rastegar
- Treiza Trueman-Dawkins
- Trina Zhivotneva
- Troy Browne
- Turkay Akbas
- Ulf Guenther
- Ulla Kesti
- Ulla Sandberg
- Ulrica Mickelsson
- Ulrich Jaschinski
- Umeda Aya
- Una Gunter
- Uri Gorokhovatsky
- Uta Kolussi
- V Gusarov
- Vaarisan Ganeshalingam
- Vaibhav Bhargava
- Valentina Bendelari
- Valentina Di Gravio
- Vanda Seromenho
- Vanesa Mercado Telleria
- Vanesa Mercado Telleria
- Vanja Gievski
- Vanja Misic
- Vasileios Bekos
- Vasiliki Chantziara
- Vasilios Koulouras
- Vasilios Koulouras
- Veronica Curilen
- Veronika Kotanidi
- Vesna Bumbasirevic
- Vicent Salvà-Costa
- Victor Gonzalez
- Victoria Houghton
- Victoria Khoronenko
- Victoria Marriott
- Vilas Kushare
- Vincent Castelain
- Vincent Fraipont
- Vincianne Pleitinckx
- Virginie Souppart
- Virpi Lusenius
- Vishnu Das Sasidharan Nair
- Vitaly Gusarev
- Vitaly Gusarov
- Vitor Gomes
- Vitor Manuel Vaz Pinto
- Viveca Hamback Hellkvist
- Višnja Nesek Adam
- Vladimir Gurevich
- Vladimir Kulakov
- Vladislav Belskiy
- Volkan Inal
- Volodymyr Babych
- Vongayi Ogbeide
- W Nazaruddin W Hassan
- Walid Naija
- Walid Sellami
- Walter Swinnen
- Wan Nasrudin Wan Ismail
- Wang Zhijuan
- Wangari Waweru-Siika
- Wangari Waweru-Siika
- Wangyan Jin
- Wei Sun
- Wei Wang
- Wei Wei
- Wei Zhang
- Wei Zhang
- Weilian Yuan
- Weiwei Li
- Wenche Arntsen
- Wendy Brown
- Wendy Chaboyer
- Wendy Chaboyer
- Wendy Milner
- Wenjie Ju
- Wenmei Wang
- Wenmin Chen
- Wenwen Zhao
- Wenzhen Cao
- Wesal Ali Belkhair
- Willem Dieperink
- Windu Baskoro
- Won-Yeon Lee
- Wu Yuchen
- Xia Cui
- Xia Huang
- Xianhong Zheng
- Xianping Luo
- Xiao Fang Tian
- Xiao Xu
- XiaoChun Hu
- Xiaodi Liu
- Xiaofang Luo
- Xiaohan Li
- Xiaohan Li
- Xiaojun Wu
- Xiaoli Yan
- Xiaomin Wang
- Xiaoqiong Deng
- Xiaowu Bai
- Xiaoyan Chen
- Xiaoyan Chen
- Xiaoying Wu
- XiaoZhe Liu
- Ximena Villanueva
- Xingguo Li
- Xinhua Xia
- Xinhua Xia
- Xinjian Li
- Xinran Ding
- Xinxia Li
- Xinxia Li
- Xiuhua Fang
- Xiuhua Fang
- Xiujuan Xue
- XiuMei Liu
- Xiuying Yao
- Xiyan Wei
- Xu Peipei
- Xue Lin
- Xue Qin Li
- Xuejuan Liang
- XueLian Liu
- Xuelian Pang
- Xuelian Xu
- Xueping Jiao
- Yajun Ding
- Yakubu H Yakubu
- Yali Zhang
- Yalım Dikmen
- Yalım Dikmen
- Yalim Dikmen
- Yan Gao
- Yan Li
- Yan Liu
- Yan Liu
- Yan Long
- Yan Wan
- Yan Wang
- Yan Xiao
- Yan Xie
- Yan Xu
- Yan Yan
- Yanfei Long
- Yang Lei
- Yang Liu
- Yang Wu
- Yang Xiaoyan
- Yanhong Di
- Yanhua Hao
- Yani Tian
- Yanlan Yao
- Yanling Shen
- Yanman Jian
- Yanmei Gu
- Yanming Ding
- Yann Le Guen
- Yanping Yang
- Yasser Mandourah
- Yenny Cardenas
- Yenny Cardenas
- Yesim Serife Bayraktar
- Yin He
- Ying Cao
- Ying Li
- Ying Liu
- Ying Wang
- Ying Wei
- Ying Zhang
- Yingjuan Zhao
- Yingli Wang
- Yinhua Guo
- Yolanda Mendiara
- YongXia Yang
- Yoshimasa Nishime
- Yoshiro Hayashi
- Youjin Chang
- Youru Jiang
- Youssef Zied Elhechmi
- Ysica Acosta
- Yu Chao
- Yu Han
- Yu Liu
- Yu Liu
- Yue Sun
- Yue Ying Gong
- Yuming Zhou
- Yun Su Sim
- Yun Wu
- Yunchun Dong
- Yunfeng Xiong
- Yupeng Liu
- Yuping Wang
- Yuxia Huo
- Yuxia Wang
- Yuxia Yuan
- Yvan Fleury
- Yvonne Andersen
- Zainab Ateya
- Zaneta Bogoevska-Miteva
- Zeya Shi
- Zhang Zhigang
- ZhangShuangzi Li
- ZhangXia Feng
- Zhaoxia Feng
- Zhaoxing Dai
- Zhenxia Zhang
- Zhihong Chen
- Zhiru Yao
- Zhixia Jiang
- ZhiXia Jiang
- Zhixia Tian
- Zhu Jun Yu
- Zhuqing Li
- Zied Hajjej
- Zijing Wu
- Zsuzsann Ágoston
- Zu Qing Cao
- Zulkifli Zulkifli
- Ângela Lima
- Publication venue
- Intensive Care Medicine
- Publication date
- 29/08/2020
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Nicotinamide nucleotide transhydrogenase-mediated redox homeostasis promotes tumor growth and metastasis in gastric cancer
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/09/2018
- Field of study
Overcoming oxidative stress is a critical step for tumor growth and metastasis, however the underlying mechanisms in gastric cancer remain unclear. In this study, we found that overexpression of nicotinamide nucleotide transhydrogenase (NNT) was associated with shorter overall and disease free survival in gastric cancer. The NNT is considered a key antioxidative enzyme based on its ability to regenerate NADPH from NADH. Knockdown of NNT caused significantly NADPH reduction, induced high levels of ROS and significant cell apoptosis under oxidative stress conditions such as glucose deprival and anoikis. In vivo experiments showed that NNT promoted tumor growth, lung metastasis and peritoneal dissemination of gastric cancer. Moreover, intratumoral injection of NNT siRNA significantly suppressed gastric tumor growth in patient-derived xenograft (PDX) models. Overall, our study highlights the crucial functional roles of NNT in redox regulation and tumor progression and thus raises an important therapeutic hypothesis in gastric cancer. Keywords: NNT, Gastric cancer, NADPH, Anoikis resistance, Metastasi
ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis
- Author
- Publication venue
- 'American Association for Cancer Research (AACR)'
- Publication date
- Field of study
Retraction Note: Suppression of fumarate hydratase activity increases the efficacy of cisplatin-mediated chemotherapy in gastric cancer
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2023
- Field of study
IL1 Receptor Antagonist Inhibits Pancreatic Cancer Growth by Abrogating NF-\u3baB Activation
- Author
- Publication venue
- 'American Association for Cancer Research (AACR)'
- Publication date
- 01/01/2016
- Field of study
Constitutive NF-\u3baB activation is identified in about 70% of pancreatic ductal adenocarcinoma (PDAC) cases and is required for oncogenic KRAS-induced PDAC development in mouse models. We sought to determine whether targeting IL-1\u3b1 pathway would inhibit NF-\u3baB activity and thus suppress PDAC cell growth
A New Orchid Genus, <i>Danxiaorchis</i>, and Phylogenetic Analysis of the Tribe Calypsoeae
- Author
- Publication venue
- Publication date
- 04/04/2013
- Field of study
<div><p>Background</p><p>Orchids have numerous species, and their speciation rates are presumed to be exceptionally high, suggesting that orchids are continuously and actively evolving. The wide diversity of orchids has attracted the interest of evolutionary biologists. In this study, a new orchid was discovered on Danxia Mountain in Guangdong, China. However, the phylogenetic clarification of this new orchid requires further molecular, morphological, and phytogeographic analyses.</p> <p>Methodology/Principal Findings</p><p>A new orchid possesses a labellum with a large Y-shaped callus and two sacs at the base, and cylindrical, fleshy seeds, which make it distinct from all known orchid genera. Phylogenetic methods were applied to a matrix of morphological and molecular characters based on the fragments of the nuclear internal transcribed spacer, chloroplast <i>mat</i>K, and rbcL genes of Orchidaceae (74 genera) and Calypsoeae (13 genera). The strict consensus Bayesian inference phylogram strongly supports the division of the Calypsoeae alliance (not including <i>Dactylostalix</i> and <i>Ephippianthus</i>) into seven clades with 11 genera. The sequence data of each species and the morphological characters of each genus were combined into a single dataset. The inferred Bayesian phylogram supports the division of the 13 genera of Calypsoeae into four clades with 13 subclades (genera). Based on the results of our phylogenetic analyses, Calypsoeae, under which the new orchid is classified, represents an independent lineage in the Epidendroideae subfamily.</p> <p>Conclusions</p><p>Analyses of the combined datasets using Bayesian methods revealed strong evidence that Calypsoeae is a monophyletic tribe consisting of eight well-supported clades with 13 subclades (genera), which are all in agreement with the phytogeography of Calypsoeae. The Danxia orchid represents an independent lineage under the tribe Calypsoeae of the subfamily Epidendroideae. This lineage should be treated as a new genus, which we have named <i>Danxiaorchis</i>, that is parallel to <i>Yoania</i>. Both genera are placed under the subtribe Yoaniinae.</p> </div
Eukaryotic initiation factor 4A2 promotes experimental metastasis and oxaliplatin resistance in colorectal cancer
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/05/2019
- Field of study
Abstract Background Deregulation of protein translation control is a hallmark of cancers. Eukaryotic initiation factor 4A2 (EIF4A2) is required for mRNA binding to ribosome and plays an important role in translation initiation. However, little is known about its functions in colorectal cancer (CRC). Methods Analysis of CRC transcriptome data from TCGA identified that EIF4A2 was associated with poor prognosis. Immunohistochemistry study of EIF4A2 was carried out in 297 paired colorectal tumor and adjacent normal tissue samples. In vitro and in vivo cell-biological assays were performed to study the biological functions of EIF4A2 on experimental metastasis and sensitivity to oxaliplatin treatment. Bioinformatic prediction, chromatin immunoprecipitation (ChIP) and dual-luciferase reporter assay were carried out to unveil the transcription factor of EIF4A2 regulation. Results EIF4A2 Expression is significantly higher in colorectal tumors. Multivariate analysis suggests EIF4A2 as an independent predictor of overall, disease-free and progression-free survival. Dysfunction of EIF4A2 by genetic knock-down or small-molecule inhibitor silvestrol dramatically inhibited CRC invasion and migration, sphere formation and enhanced sensitivity to oxaliplatin treatment in vitro and in vivo. Notably, EIF4A2 knock-down also suppressed lung metastasis in vivo. qRT-PCR and immunoblotting analyses identified c-Myc as a downstream target and effector of EIF4A2. ChIP and dual-luciferase reporter assays validated the bioinformatical prediction of ZNF143 as a specific transcription factor of EIF4A2. Conclusions EIF4A2 promotes experimental metastasis and oxaliplatin resistance in CRC. Silvestrol inhibits tumor growth and has synergistic effects with oxaliplatin to induce apoptosis in cell-derived xenograft (CDX) and patient-derived xenograft (PDX) models