Intestinal microbiota and colorectal cancer

Colorectal cancer may be influenced by changes in the intestinal microbiota that affect the mucosa and cause an immune response capable of producing inflammatory effects. Although there are still few studies in this regard, it is necessary to emphasize the need to expand the studies on this topic and to state the usefulness of the new technologies based on metagenomics.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Case study of the intestinal microbiota using the XGN-MBI metagenomic assay

The microbiota of the colon and rectum is the most abundant and diverse of the human body, with a density of up to 1-2 kg of weight and a diversity that exceeds a thousand species. Metagenomics can be defined as the application of modern genomic techniques for the direct study of communities of microorganisms in their natural environment The aim of this study is to prove the usefulness of new technologies based on metagenomics, such as the XGN-MBI assay to realize gut microbiota studies.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Dependence From The Perspective Of Primary Caregivers Of People With Disabilities

The paper is focused on informal caregivers of people with disabilities, particularly in mentally handicapped persons. Informal caregiver refers to those relatives, friends or any person who make this task without any formal economic remuneration. Only in few cases, caregivers are able to receive some economic aid by the administration. We develop a questionnaire to analyze personal, familiar, economic and social situation of primary caregivers. The empirical results are based on a sample of 128 caregivers of a spanish association created for people with disabilities

Epidemiological Profile of Patients of Aged 65 Years and Over in a University Private Hospital

Objectives: An increase in life expectancy is predicted for the general population and, by 2050, about one billion people will be older than 65 years. The Global Cancer Incidence, Mortality and Prevalence database estimates that 1.2 million people of this age will have cancer; this number represents 58% of new cases in the American population. This represents a challenge for diagnosis and treatment, given that some older people have multiple comorbidities and disabilities. Materials and Methods: This was a retrospective descriptive study of 204 patients aged 65 years and over. All had a solid tumor that was diagnosed in a private hospital from January 2015 to December 2017. Results: The median age was 72.2 years; the most frequent age group (48.5% of patients) was 65–75 years, and only a small percentage (4.4%) were aged > 85 years. The most common type of cancer was lung cancer (22.5%), followed by colorectal and urinary cancer. Most patients received cancer treatment after the disease diagnosis. Conclusion: There are no epidemiological studies of the older oncology population in Mexico. We believe it is necessary to perform larger studies to understand this population and to undertake actions to facilitate greater attention to patient diagnosis, treatment, and alleviation

Searching for the Culprit: Metastases from a Cancer of Unknown Primary

We report a case of metastases from a cancer of unknown primary whose primary site could not be identified during the appropriate pretreatment evaluation. The patient was a 58-year-old woman with a history of passive smoking and with no history of cancer in the family. Her current condition started with asthenia, adynamia, and pallor, followed by palpitations. An abdominopelvic computed tomography (CT) scan was performed, showing multiple osteolytic lesions distributed in all bone structures and axillary adenopathy on the left side. As part of the approach and given the high suspicion of multiple myeloma, tests were performed. The results were negative for multiple myeloma. A PET-CT scan was performed and showed left axillary adenopathy. The breasts and other organs were not affected. Left axillary lymph node resection revealed breast primary metastatic pleomorphic lobular carcinoma. Due to the metastatic disease (caused by the primary breast cancer), it was decided to start chemotherapy

El proyecto GLOSARIO-SEA. Traducción y adapatación del glosario de la Clay Minerals Society (CMS)

El proyecto de realización de un glosario relacionado con las arcillas se planteó como objetivo de la Sociedad Española de Arcillas (SEA) durante su reunión en Madrid en 2016. Para el proyecto se propuso como coordinador al profesor Manuel Pozo, miembro del “Nomenclature Committee” de la CMS en 2014-2017. Por la magnitud del glosario, fue necesaria la creación de un grupo de trabajo constituido, en 2019, por miembros de la SEA, para llevar a cabo la tarea de traducción y adaptación al español del documento original en inglés. El equipo de trabajo estaba formado por los firmantes de este trabajo. La traducción y adaptación se ha realizado de la versión en inglés del glosario de la Clay Minerals Society (2018) dentro del denominado “The Clay Minerals Society Glossary for Clay Science Project”, cuyos objetivos y restricciones son las siguientes: (1) La inclusión de términos sobre la arcilla. Las definiciones se refieren a términos que se utilizan en la ciencia de la arcilla no apartándose de las definiciones de la ciencia básica, como se haría en química y física. 2) Evitar las definiciones provisionales o tentativas, incluyéndose solo los términos bien definidos. (3) No son objetos de debate las definiciones establecidas por los Comités de Nomenclatura de la Asociación Internacional de Mineralogía (IMA), la CMS y la Asociación Internacional para el Estudio de las Arcillas (AIPEA), o cualquier otro organismo internacional. (4) En general, los nombres de programas informáticos y otros nombres similares no forman parte del glosario. Tras seis envíos para la traducción de términos y tres revisiones del manuscrito se ha conseguido finalizar la versión en español del glosario, que se ha enriquecido con la adición de una selección de imágenes de campo y de microscopía óptica y electrónica. El resultado actual es un documento con 491 entradas referidas a términos relacionados con las arcillas y minerales de la arcilla.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Cov-caldas: A new COVID-19 chest X-Ray dataset from state of Caldas-Colombia

The emergence of COVID-19 as a global pandemic forced researchers worldwide in various disciplines to investigate and propose efficient strategies and/or technologies to prevent COVID-19 from further spreading. One of the main challenges to be overcome is the fast and efficient detection of COVID-19 using deep learning approaches and medical images such as Chest Computed Tomography (CT) and Chest X-ray images. In order to contribute to this challenge, a new dataset was collected in collaboration with “S.E.S Hospital Universitario de Caldas” (https://hospitaldecaldas.com/) from Colombia and organized following the Medical Imaging Data Structure (MIDS) format. The dataset contains 7,307 chest X-ray images divided into 3,077 and 4,230 COVID-19 positive and negative images. Images were subjected to a selection and anonymization process to allow the scientific community to use them freely. Finally, different convolutional neural networks were used to perform technical validation. This dataset contributes to the scientific community by tackling significant limitations regarding data quality and availability for the detection of COVID-19. © 2022, The Author(s)

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

publishersversionPeer reviewe

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio