A Comparison of Procedures to Test for Moderators in Mixed-Effects Meta-Regression Models

Several alternative methods are available when testing for moderators in mixed-effects meta-regression models. A simulation study was carried out to compare different methods in terms of their Type I error and statistical power rates. We included the standard (Wald-type) test, the method proposed by Knapp and Hartung (2003) in 2 different versions, the Huber-White method, the likelihood ratio test, and the permutation test in the simulation study. These methods were combined with 7 estimators for the amount of residual heterogeneity in the effect sizes. Our results show that the standard method, applied in most meta-analyses up to date, does not control the Type I error rate adequately, sometimes leading to overly conservative, but usually to inflated, Type I error rates. Of the different methods evaluated, only the Knapp and Hartung method and the permutation test provide adequate control of the Type I error rate across all conditions. Due to its computational simplicity, the Knapp and Hartung method is recommended as a suitable option for most meta-analyses

Solución para garantizar la privacidad en el internet de las cosas

Los nuevos productos y servicios de “internet de las cosas” nos harán más eficientes, con mayor capacidad de actuación y comprensión del entorno, habrá nuevas ayudas técnicas que permitirán prolongar nuestra vida activa y más. Sin embargo coexistiremos con una gran cantidad de dispositivos que recopilarán información sobre nuestra actividad, costumbres, preferencias,etc., que podrían amenazar nuestra privacidad. La desconfianza podría ser una barrera para el desarrollo pleno de estos nuevos productos y servicios. Se aporta una posible solución para la garantizar la seguridad y privacidad de los datos personales en internet de las cosas, mediante técnicas que resulten de la colaboración entre las áreas empresarial,legislativa y tecnológica para dar confianza a los actores involucrados

Green building rating systems and their application in the Mexican context

Revista indexada en SCOPUSThis article offers a review of the scientific literature aimed at putting forward a proposal on the main variables or categories of sustainable design to take into consideration to manage, plan, design, build and maintain buildings in Mexico. The methodology consisted in reviewing 5 successfully tried international green building models (rating systems), from which a series of requirements by sustainable category were taken in order to propose categories and variables proper to the Mexican context. The result was a checklist that comprises sustainable design requirements broken down by categories: natural, human, technologic and economic to apply in the Mexican context. It is concluded that successfully tried green building international models such as: LEED®, BREAM®, CASBEE®, ESTIDAMA® or Green Star® can be very useful to manage, plan, design and construct sustainable buildings around the world

TRPC Channels in the SOCE Scenario

Transient receptor potential (TRP) proteins form non-selective Ca2+ permeable channels that contribute to the modulation of a number of physiological functions in a variety of cell types. Since the identification of TRP proteins in Drosophila, it is well known that these channels are activated by stimuli that induce PIP2 hydrolysis. The canonical TRP (TRPC) channels have long been suggested to be constituents of the store-operated Ca2+ (SOC) channels; however, none of the TRPC channels generate Ca2+ currents that resemble ICRAC. STIM1 and Orai1 have been identified as the components of the Ca2+ release-activated Ca2+ (CRAC) channels and there is a body of evidence supporting that STIM1 is able to gate Orai1 and TRPC1 in order to mediate non-selective cation currents named ISOC. STIM1 has been found to interact to and activate Orai1 and TRPC1 by different mechanisms and the involvement of TRPC1 in store-operated Ca2+ entry requires both STIM1 and Orai1. In addition to the participation of TRPC1 in the ISOC currents, TRPC1 and other TRPC proteins might play a relevant role modulating Orai1 channel function. This review summarizes the functional role of TRPC channels in the STIM1–Orai1 scenario.Junta de Extremadura Consejería de Economía e Infraestructura-FEDER Grant IB16046 y GR18061Junta de Extremadura TA18011 y TA18054Ministerio de Ciencia, Innovación y Universidade

Firefighter and victims protecting solution based on wireless body area network nodes

Interconnectivity between Web systems and sensor networks is used to provide smart services for the Internet of Things. These services are based on data collection and processing to obtain useful information about the supervised environment. With this information it is possible to provide smart services, but some of them must be considered as protected by the legislation regarding privacy of personal data. In order to face this issue, security and privacy mechanisms must be used. So as to deal with the limited resources in sensor networks, these mechanisms must be as lightweight as possible to preserve the enough Quality of Service. However, these mechanisms must fulfill security and privacy requirements defined by the regulations. This paper describes a Wireless Body Area Network application providing services to protect firefighter work in hazardous environments. The firefighter wears a special shirt with sensors embedded. These sensors are able to monitor not only the firefighter health status, but also they can be connected to external sensors in order to monitor the health status of the victims. These external sensors are part of the equipment carried by the firefighter to face the emergencies and save lives. Thus, they are able to obtain external medical aid

EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction

Background/aims: STIM1 and Orai1 are the key components of store-operated Ca2+ entry (SOCE). Among the proteins involved in the regulation of SOCE, SARAF prevents spontaneous activation of SOCE and modulates STIM1 function. Methods: Cytosolic Ca2+ mobilization was estimated in fura-2-loaded cells using an epifluorescence inverted microscope. STIM1 interaction with Orai1, EFHB (EF-hand domain family member B, also known as CFAP21) and SARAF was detected by immunoprecipitation followed by Western blotting using specific antibodies. The involvement of EFHB in the translocation of NFAT to the nucleus was detected by confocal microscopy. Results: Here, we report the identification of EFHB as a new SOCE regulator. EFHB interacts with STIM1 upon store depletion and dissociates through a Ca2+-dependent mechanism. RNAi-mediated silencing as well as overexpression studies revealed that EFHB plays a relevant role in the interaction of STIM1 and Orai1 upon store depletion, the activation of SOCE and NFAT translocation from the cytosol to the nucleus. Silencing EFHB expression abolished the dissociation of SARAF from STIM1, which indicates that EFHB might play an important role in the dynamic interaction between both proteins, which is relevant for the activation of Orai1 channels upon Ca2+ store depletion and their subsequent modulation via slow Ca2+-dependent inactivation. Conclusion: Our results indicate that EFHB is a new SOCE regulator that modulates STIM1-SARAF interaction.MINECO BFU2013-45564-C2-1-P/2-P, BFU2016-74932-C2-1-P/2-P, BFU2016-74932-C2-1-PJunta de Extremadura-FEDER (Fondo Europeo de Desarrollo Regional Grants) IB16046, GR18061Junta de Extremadura-FEDER European Union (EU) IB16046Ministerio Economía y Competitividad, España IJCI-2015-25665MINECO Grant BFU2016-74932-C2-1-

Estimation of effective diffusion coefficient and its effect on effectiveness factor for hds catalytic process: a multi-scale approach

Effectiveness factors have great relevance in multiphase reactors modeling since they are the conventional way of incorporating the effects of intra-particle resistance reaction rate. This work determines the description level effect of catalytic pellet microstructure on mass and energy effective transport coefficients prediction, isothermal and no isothermal. For such a purpose some results about on evaluation of the effective diffusivity and conductivity with the methodology of volume averaging were applied. The obtained results along with a Langmuir–Hinshelwood/Hougen–Watson kinetic expression were applied to establish the concentration and temperature fields in a catalytic particle. The evaluation of concentration field and effectiveness factors were developed using two different models: pseudohomogeneous mass and energy transport model for a catalytic particle with reaction in all domain, and heterogeneous mass and energy transport model with fluid-catalytic surface interphase reaction for a realistic porous structure model. The results show the differences in concentration and temperature profiles between both models and consequently in effectiveness factors. This could be ascribed to the form of evaluation of effective transport coefficients used in the pseudo-homogeneous model, and presumably to the simple shape of the unit cells used for the solution of the closure problem for the average transport equations with homogeneous reaction