Effect of Bit Error Rate in LDPC Based OFDM System over AWGN, Raician And Raileigh Fading Channels

Modern communication systems are adopting new Morden technologies like OFDM (Ortogonal Frequency Division Multiplexing) and LDPC (Low Density Parity Check) for achieving high performance, low Bit Error Rate (BER) and high capacity. The OFDM communication is inspired effectively from the frequencies of channel over the network. In this type of network some kind of distortion occurs over the channel called Inter Carrier Interference (ICI). The OFDM technique can be implemented using Low Density Parity Check (LDPC) Codes because of their ability to reaching near Shannon limit performance. In this paper we are presenting the effect of Bit Error Rate (BER) with Signal to Noise Ratio (SNR) in OFDM system which is based on LDPC over Additive White Gaussian Noise (AWGN), Rician and Rayliegh Fading Channel using MATLAB. The results are then compared with Conventional based OFDM system. DOI: 10.17762/ijritcc2321-8169.15037

Mean platelet volume as an indicator of severity of hypertensive retinopathy in hypertensive subjects

Background: Hypertensive retinopathy (HR) represents the ophthalmic findings of end-organ damage secondary to systemic arterial hypertension. Platelets play a crucial role in the pathogenesis of atherosclerotic complications, contributing to thrombus formation or apposition after plaque rupture. The aim of our study was to investigate whether Mean platelet volume (MPV) is associated with the severity of hypertensive retinopathy in hypertensive patients.Methods: This cross-sectional study was conducted in Department of Medicine of SAMC and PGI, Indore. Total 250 adult hypertensive patients (BP >140/90 mm Hg or taking antihypertensive drugs) recruited for the study.Results: Of the 250 subjects, 158 (63.2%) were male and 92 (36.8%) were female. Elevated MPV >11.5 femtoliter was observed in 84 cases (33.6%). There was statistically significant relationship between the grade of retinopathy and elevated MPV in hypertensive subjects. (r = 0.52, P <0.001).Conclusions: We described a relation between MPV and HR (probably first time in Indian patients). Measurement of MPV is easy to establish and therefore might serve as a valuable predictor of a worse outcome in microvascular complications

Potencial mimético da insulina de Hylocereus undatus extraída de mio-inositol e de proteínas

Diseases are spreading like a trend and victimising every other individual globally. Here, we are referring to one such most common disease that has not even spared young lives i.e., diabetes. Annually, several people lose their lives and loved ones because of this dangerous disease. This has compelled the researchers to think and work on some life saving treatment. People suffering from hyperglycaemic conditions have insulin resistance which can be improved by intake of myo-inositol. Myo-inositol has potential to regulate this insulin hormone which can prevent and control diabetes mellitus. In this research, we have used a natural source (fruit) Hylocereus undatus; it has proved to be a good source of myo-inositol and some proteins that help in insulin regulation naturally. Several techniques and tests were performed such as extraction, purification, crystallisation, proteolytic activity assay, protein estimation, etc. Positive results of myo-inositol were observed through crystallisation together with decent amount of protein concentrations by Folin Lowry test and SDS-PAGE analysis.Las enfermedades se están extendiendo como una tendencia y victimizando a todos los demás individuos a nivel mundial. Aquí, nos referimos a una de esas enfermedades más comunes que ni siquiera perdonó vidas jóvenes, a saber, la diabetes. Cada año, varias personas pierden la vida y sus seres queridos a causa de esta peligrosa enfermedad. Esto obligó a los investigadores a pensar y trabajar en algún tratamiento que salve vidas. Las personas que sufren de hiperglucemia tienen resistencia a la insulina, que puede mejorar tomando myo-inositol. El mioinositol tiene el potencial de regular esta hormona insulina que puede prevenir y controlar la diabetes mellitus. En esta investigación, utilizamos una fuente natural (fruta) de Hylocereus undatus, que demostró ser una buena fuente de mioinositol y algunas proteínas, que ayudan a regular la insulina de forma natural. Se realizaron varias técnicas y pruebas, como extracción, purificación, cristalización, ensayo de actividad proteolítica, estimación de proteínas, etc. Se observaron resultados positivos de mioinositol a lo largo de la cristalización junto con cantidades decentes de concentraciones de proteína mediante la prueba de Folin Lowry y el análisis SDS-PAGE.As doenças estão se espalhando como uma tendência e vitimando todos os outros indivíduos globalmente. Aqui, estamos nos referindo a uma dessas doenças mais comuns que nem mesmo poupou vidas jovens, ou seja, diabetes. Anualmente, várias pessoas perdem suas vidas e entes queridos por causa dessa doença perigosa. Isso obrigou os pesquisadores a pensar e trabalhar em algum tratamento para salvar vidas. As pessoas que sofrem de condições hiperglicêmicas têm resistência à insulina, que pode ser melhorada pela ingestão de mio-inositol. O mio-inositol tem potencial para regular esse hormônio insulina que pode prevenir e controlar o diabetes mellitus. Nesta pesquisa, usamos uma fonte natural (fruto) de Hylocereus undatus, que provou ser uma boa fonte de mio-inositol e algumas proteínas, que ajudam na regulação da insulina naturalmente. Várias técnicas e testes foram realizados, como extração, purificação, cristalização, ensaio de atividade proteolítica, estimativa de proteína etc. Resultados positivos de mio-inositol foram observados através da cristalização juntamente com quantidades decentes de concentrações de proteína pelo teste Folin Lowry e análise SDS-PAGE

Clinical profile of patients with prosthetic heart valve thrombosis undergoing fibrinolytic therapy and NYHA class as a predictor of outcome

Background: Prosthetic heart valve thrombosis (PHVT) is a potentially fatal complication of heart valve replacement with mechanical prostheses mainly due to thrombosis.Aim: The study aimed to evaluate the clinical profile of the patients presenting with PHVT undergoing fibrinolytic therapy and analyzing patients with respect to New York Heart Association (NYHA) functional class on presentation and its association with outcome of fibrinolytic therapy.Settings &amp; design: This was prospective, observational study conducted from June, 2016 to April, 2017. Total 133 patients with prosthetic heart valve thrombosis were included. Materials and methods: Routine blood investigations included complete hemogram, liver and renal function tests. Prothrombin time with INR was done on admission. The diagnosis of PHVT was assessed by fluoroscopy and/or echocardiography (transthoracic/transesophageal). Follow-up at 6 months was scheduled for all patients.Statistical analysis: Parametric values between two groups were performed using the independent sample t-test or chi-square test, as appropriate. Univariate and multivariate logistic regression was used to find out factors associated with outcome.Results: All patients received fibrinolytic therapy in which 108 (81.2%) were treated with streptokinase and 25 (18.8%) were treated with urokinase. On presentation, 48.9% patients were in NYHA class III, 41.4% in NYHA class IV and 9.77% in NYHA class II. Fibrinolytic therapy was successful in 105 patients (78.9%) and it failed in 28 patients (21.1%). Mortality in NYHA class II was 0%, NYHA class III was 4.6% and in NYHA class IV was 23.6%. During 6 months follow up prosthetic heart valve thrombosis recurred in 12 (11.43%) patients.Conclusion: From our single centre experience, fibrinolytic therapy is fairly effective first line therapy for prosthetic heart valve thrombosis and NYHA functional class on presentation can predict the outcome of fibrinolytic therapy

AN ENHANCED SCHEDULING APPROACH WITH CLOUDLET MIGRATIONS FOR RESOURCE INTENSIVE APPLICATIONS

Cloud computing is one of the most advanced technologies to present computerized generation. Scheduling plays a major role in it. The connectivity of Virtual Machines (VM) to schedule the assigned tasks (cloudlet) is a most attractive field to research. This paper introduces a confined Cloudlet Migration based scheduling algorithm using Enhanced-First Come First Serve (CMeFCFS). The objective of this work is to minimize the makespan, cost and to optimize the resource utilization. The proposed work has been simulated in the CloudSim toolkit package. The results have been compared with pre-existing scheduling algorithms with same experimental configuration. Important parameters like execution time, completion time, cost, makespan and utilization of resources are compared to measure the performance of the proposed algorithm. Extensive simulation results prove that introduced work has better results than existing approaches. 99.8% resource utilization has been achieved by CMeFCFS. Plotted graphs and calculated values show that the proposed algorithm is very effective for cloudlet scheduling

Heterologous Expression of Serine Hydroxymethyltransferase-3 From Rice Confers Tolerance to Salinity Stress in E. coli and Arabidopsis

Among abiotic stresses, salt stress adversely affects growth and development in rice. Contrasting salt tolerant (CSR27), and salt sensitive (MI48) rice varieties provided information on an array of genes that may contribute for salt tolerance of rice. Earlier studies on transcriptome and proteome profiling led to the identification of salt stress-induced serine hydroxymethyltransferase-3 (SHMT3) gene. In the present study, the SHMT3 gene was isolated from salt-tolerant (CSR27) rice. OsSHMT3 exhibited salinity-stress induced accentuated and differential expression levels in different tissues of rice. OsSHMT3 was overexpressed in Escherichia coli and assayed for enzymatic activity and modeling protein structure. Further, Arabidopsis transgenic plants overexpressing OsSHMT3 exhibited tolerance toward salt stress. Comparative analyses of OsSHMT3 vis a vis wild type by ionomic, transcriptomic, and metabolic profiling, protein expression and analysis of various traits revealed a pivotal role of OsSHMT3 in conferring tolerance toward salt stress. The gene can further be used in developing gene-based markers for salt stress to be employed in marker assisted breeding programs.HIGHLIGHTS- The study provides information on mechanistic details of serine hydroxymethyl transferase gene for its salt tolerance in rice

Study of Correlation of Pre-Operative Findings with Intra-Operative Ossicular Status in Patients with Chronic Otitis Media

Introduction: Chronic otitis media (COM) has been broadly classified into mucosal and squamous subtypes. COM types are associated with erosion of the ossicular chain. The aim of the present study was to correlate the type of COM, the site of perforation/retraction, and the type of disease pathology with the pattern and degree of ossicular chain necrosis.   Materials and Methods: A prospective cross-sectional study was performed in 76 cases of COM, who were subjected to tympanomastoidectomy. Pre-operative findings were compared with per-operative ossicular chain status and pathology.   Results: Incus was found to be the most vulnerable ossicle for erosion, followed by malleus and suprastructure of stapes. The pattern of multiple ossicle involvement was more common. Ossicular chain erosion was more common in squamous COM than mucosal COM (X2=66.25; P=0.0001) and in the presence of cholesteatoma and granulations. Ossicular necrosis was most common in squamous disease with cholesteatoma, followed by squamous disease with granulations, mucosal disease with granulations, and inactive mucosal disease in that order.   Conclusion: The degree of ossicular necrosis has a positive correlation with the type of disease pathology, being higher in squamous disease than in mucosal disease. The pattern of ossicular necrosis varies with the site of origin of the disease and the pattern of spread of cholesteatoma, being variable for pars tensa and pars flaccida squamous disease

Unraveling Prostaglandin and NLRP3 Inflammasomemediated Pathways of Primary Dysmenorrhea and the Role of Mefenamic Acid and Its Combinations

Painful menstrual cramps during or around the time of the monthly cycle are known as dysmenorrhea. The estimated global prevalence in women of reproductive age ranges from 45% to 95%. It has a significant negative impact on regular activities and productivity at work. However, despite the severe consequences on quality of life, primary dysmenorrhea&nbsp;(PD) is underdiagnosed. Dysmenorrhea has complex pathogenesis. It involves the release of prostaglandins and activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome and also includes the involvement of other mediators such as bradykinin, histamine and acetylcholine. Even though nonsteroidal anti-inflammatory drugs (NSAIDs) remain the most common type of pain medication, the question of which one should be the most preferred is still open to debate. The current review examines the existing evidence for the pathogenesis of PD and makes evidence based and clinical experience based recommendations for the use of mefenamic acid and its combination in the treatment of dysmenorrhea. Mefenamic acid alleviates PD by inhibiting endometrial prostaglandin formation, restoring normal uterine activity, and reducing the inflammatory response by inhibiting the NLRP3 inflammasome and reducing the release of cytokines such as interleukin (IL)-1β. It is also known to have bradykinin antagonist activity. Dicyclomine has a dual action of blocking the muscarinic action of acetylcholine in postganglionic parasympathetic effect or regions and acting directly on uterine smooth muscle by blocking bradykinin and histamine receptors to relieve spasms. According to the experts, mefenamic acid and dicyclomine act synergistically by acting on the different pathways of dysmenorrhea by blocking multifactorial agents attributed to the cause of dysmenorrhea. Hence, the combination of mefenamic acid and dicyclomine should be the preferred treatment option for dysmenorrhea

Scalable noninvasive amplicon-based precision sequencing (SNAPseq) for genetic diagnosis and screening of β-thalassemia and sickle cell disease using a next-generation sequencing platform

β-hemoglobinopathies such as β-thalassemia (BT) and Sickle cell disease (SCD) are inherited monogenic blood disorders with significant global burden. Hence, early and affordable diagnosis can alleviate morbidity and reduce mortality given the lack of effective cure. Currently, Sanger sequencing is considered to be the gold standard genetic test for BT and SCD, but it has a very low throughput requiring multiple amplicons and more sequencing reactions to cover the entire HBB gene. To address this, we have demonstrated an extraction-free single amplicon-based approach for screening the entire β-globin gene with clinical samples using Scalable noninvasive amplicon-based precision sequencing (SNAPseq) assay catalyzing with next-generation sequencing (NGS). We optimized the assay using noninvasive buccal swab samples and simple finger prick blood for direct amplification with crude lysates. SNAPseq demonstrates high sensitivity and specificity, having a 100% agreement with Sanger sequencing. Furthermore, to facilitate seamless reporting, we have created a much simpler automated pipeline with comprehensive resources for pathogenic mutations in BT and SCD through data integration after systematic classification of variants according to ACMG and AMP guidelines. To the best of our knowledge, this is the first report of the NGS-based high throughput SNAPseq approach for the detection of both BT and SCD in a single assay with high sensitivity in an automated pipeline

Determining crystal structures through crowdsourcing and coursework

We show here that computer game players can build high-quality crystal structures. Introduction of a new feature into the computer game Foldit allows players to build and real-space refine structures into electron density maps. To assess the usefulness of this feature, we held a crystallographic model-building competition between trained crystallographers, undergraduate students, Foldit players and automatic model-building algorithms. After removal of disordered residues, a team of Foldit players achieved the most accurate structure. Analysing the target protein of the competition, YPL067C, uncovered a new family of histidine triad proteins apparently involved in the prevention of amyloid toxicity. From this study, we conclude that crystallographers can utilize crowdsourcing to interpret electron density information and to produce structure solutions of the highest quality