Glacial Aerodynamic Roughness Estimates:Uncertainty, Sensitivity, and Precision in Field Measurements

Calculation of the sensible and latent heat (turbulent) fluxes is required in order to close the surface energy budget of glaciers and model glacial melt. The aerodynamic roughness length, z0, is a key parameter in the bulk approach to calculating sensible heat flux; yet, z0 is commonly considered simply as a tuning parameter or generalized between surfaces and over time. Spatially and temporally distributed observations of z0 over ice are rare. Both direct (from wind towers and sonic anemometers) and indirect (from microtopographic surveys) measurements of z0 are subject to sensitivities and uncertainties that are often unstated or overlooked. In this study, we present a quantitative evaluation of aerodynamic profile-based and microtopographic methods and their effect on z0 using data collected from Storglaciären and Sydöstra Kaskasatjäkkaglaciären, Tarfala Valley, Arctic Sweden. Aggressive data filters discard most of the wind tower data but still produce realistic z0 values of 1.9 mm and 2 mm. Despite uncertainty introduced by scale and resolution dependence, microtopographic methods produced estimates of z0 comparable to wind tower values and those found on similar surfaces. We conclude that (1) in the absence of direct turbulent flux measurements from sonic anemometers, the profile and microtopographic methods provide realistic z0 values, (2) both 2D and 3D microtopographic methods are dependent on scale, resolution, and the chosen detrending method, and (3) careful calibration of these parameters could enable glacier-wide investigations of z0 from remotely sensed data, including those increasingly available from satellite platforms

Characterization of the Differentiation and Leptin Secretion Profile of Adult Stem Cells on Patterned Polylactide Films

Several issues need to be better understood before breast tissue engineering becomes a clinically viable option. One of the most important aspects is the interaction between cells and the microtopography of the implant surface. The aim of this study was to evaluate the efficacy of D1 cells, multipotent mouse bone marrow stromal precursors, in differentiating to adipocytes and to characterize their metabolic activity (lactic acid released and glucose consumed), leptin secretion and lipid production when cultured on patterned poly(L-lactide) (PLLA) films. It was determined that, by appropriate stimulation, the D1 cells displayed morphological characteristics of adipocytes and produced lipid. The results showed that a patterned surface did affect the rate of lipid production. Polynomial models were proposed to predict the amount of leptin secreted by the cells over a period of time

Initiator Types and the Causal Question of the Prevalent New-User Design: A Simulation Study

New-user designs restricting to treatment initiators have become the preferred design for studying drug comparative safety and effectiveness using nonexperimental data. This design reduces confounding by indication and healthy-adherer bias at the cost of smaller study sizes and reduced external validity, particularly when assessing a newly approved treatment compared with standard treatment. The prevalent new-user design includes adopters of a new treatment who switched from or previously used standard treatment (i.e., the comparator), expanding study sample size and potentially broadening the study population for inference. Previous work has suggested the use of time-conditional propensity-score matching to mitigate prevalent user bias. In this study, we describe 3 "types"of initiators of a treatment: new users, direct switchers, and delayed switchers. Using these initiator types, we articulate the causal questions answered by the prevalent new-user design and compare them with those answered by the new-user design. We then show, using simulation, how conditioning on time since initiating the comparator (rather than full treatment history) can still result in a biased estimate of the treatment effect. When implemented properly, the prevalent new-user design estimates new and important causal effects distinct from the new-user design

R-parity violation effect on the top-quark pair production at linear colliders

We investigate in detail the effects of the R-parity lepton number violation in the minimal supersymmetric standard model (MSSM) on the top-quark pair production via both $e^--e^+$ and $\gamma-\gamma$ collision modes at the linear colliders. We find that with the present experimental constrained $\rlap/{R}$ parameters, the effect from $\rlap/{R}$ interactions on the processes $e^+e^-\to t\bar{t}$ and $e^+e^- \to \gamma\gamma \to t\bar{t}$ could be significant and may reach -30% and several percent, respectively. Our results show that the $\rlap/{R}$ effects are sensitive to the c.m.s. energy and the relevant $\rlap/{R}$ parameters. However, they are not sensitive to squark and slepton masses when $m_{\tilde{q}} \geq 400 GeV$ (or $m_{\tilde{l}} \geq 300 GeV$) and are almost independent on the $\tan\beta$Comment: Accepted by Phys.Rev.

Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies

Chromosomal translocations that target HMGA2 at chromosome band 12q14 are seen in a variety of malignancies, notably lipoma, pleomorphic salivary adenoma and uterine leiomyoma. Although some HMGA2 fusion genes have been reported, several lines of evidence suggest that the critical pathogenic event is the expression of truncated HMGA2 isoforms. We report here the involvement of HMGA2 in six patients with myeloid neoplasia, dysplastic features and translocations or an inversion involving chromosome bands 12q13-15 and either 7p12, 8q22, 11q23, 12p11, 14q31 or 20q11. Breaks within or very close to HMGA2 were found in all six cases by molecular cytogenetic analysis, leading to overexpression of this gene as assessed by RT-PCR. Truncated transcripts consisting of HMGA2 exons 1-2 or exons 1-3 spliced to intron-derived sequences were identified in two patients, but were not seen in controls. These findings suggest that abnormalities of HMGA2 play an important and previously unsuspected role in myelodysplasia

High-precision calculations of van der Waals coefficients for heteronuclear alkali-metal dimers

Van der Waals coefficients for the heteronuclear alkali-metal dimers of Li, Na, K, Rb, Cs, and Fr are calculated using relativistic ab initio methods augmented by high-precision experimental data. We argue that the uncertainties in the coefficients are unlikely to exceed about 1%.Comment: 11 pages, 2 figs, graphicx.st

Consistent Anisotropic Repulsions for Simple Molecules

We extract atom-atom potentials from the effective spherical potentials that suc cessfully model Hugoniot experiments on molecular fluids, e.g., $O_2$ and $N_2$. In the case of $O_2$ the resulting potentials compare very well with the atom-atom potentials used in studies of solid-state propertie s, while for $N_2$ they are considerably softer at short distances. Ground state (T=0K) and room temperatu re calculations performed with the new $N-N$ potential resolve the previous discrepancy between experimental and theoretical results.Comment: RevTeX, 5 figure

KRAS mutation testing of tumours in adults with metastatic colorectal cancer: a systematic review and cost-effectiveness analysis

__Abstract__ Background: Bowel cancer is the third most common cancer in the UK. Most bowel cancers are initially treated with surgery, but around 17% spread to the liver. When this happens, sometimes the liver tumour can be treated surgically, or chemotherapy may be used to shrink the tumour to make surgery possible. Kirsten rat sarcoma viral oncogene (KRAS) mutations make some tumours less responsive to treatment with biological therapies such as cetuximab. There are a variety of tests available to detect these mutations. These vary in the specific mutations that they detect, the amount of mutation they detect, the amount of tumour cells needed, the time to give a result, the error rate and cost. Objectives: To compare the performance and cost-effectiveness of KRAS mutation tests in differentiating adults with metastatic colorectal cancer whose metastases are confined to the liver and are unresectable and who may benefit from first-line treatment with cetuximab in combination with standard chemotherapy from those who should receive standard chemotherapy alone

Effort and work-of-breathing parameters strongly correlate with increased resistance in an animal model

Background: Effort of Breathing (EOB) calculations may be a reliable alternative to Work of Breathing (WOB) calculations in which Respiratory Inductance Plethysmography (RIP) replaces spirometry. We sought to compare EOB and WOB measurements in a nonhuman primate model of increasing extrathoracic inspiratory resistance simulating upper airway obstruction (UAO).Methods: RIP, spirometry, and esophageal manometry were measured in spontaneously breathing, intubated Rhesus monkeys utilizing 11 calibrated resistors randomly applied for 2-min. EOB was calculated breath-by-breath as Pressure Rate Product (PRP) and Pressure Time Product (PTP). WOB was calculated from the Pressure-Volume curve based on spirometry (WOBSPIR) or RIP flow (WOBRIP).Results: WOB, PRP and PTP showed similar linear increases when exposed to higher levels of resistive loads. When comparing WOBSPIR to WOBRIP, a similar strong correlation was seen for both signals as resistance increased and there were no statistically significant differences.Conclusion: EOB and WOB parameters utilizing esophageal manometry and RIP, independent of spirometry, showed a strong correlation as a function of increasing inspiratory resistance in nonhuman primates. This allows several potential monitoring possibilities for non-invasively ventilated patients or situations where spirometry is not available. Impact: EOB and WOB parameters showed a strong correlation as a function of increasing inspiratory resistance in nonhuman primates.There was a strong correlation between spirometry-based WOB versus RIP-based WOB.To date, it has remained untested as to whether EOB is a reliable alternative for WOB and if RIP can replace spirometry in these measurements.Our results enable additional potential monitoring possibilities for non-invasively ventilated patients or situations where spirometry is not available.Where spirometry is not available, there is no need to apply a facemask post extubation to a spontaneously breathing, non-intubated infant to make objective EOB measurements.</p