Experiences in teaching Hydrogen Technologies in the framework of the International Campus of Excellence Andalucia TECH

The increasing importance of hydrogen technologies is demanding prepared professionals in the numerous topics related to this energy vector. Apart from some basic and advanced courses given by actual experts in these topics, universities must play an important role in the general formation of future professionals. In this way, the International Campus of Excellence (ICE) Andalucía TECH has created several degrees taught jointly by its participating universities of Seville (US) and Málaga (UMA). Among those degrees, Energy Engineering is the best suited to the field of this conference because this degree provide future engineers with specialized training in energy generation, transformation and management. In relation to hydrogen technologies this degree includes a cross sectional optional unit named Hydrogen Based Systems (4.5 ECTS/112.5 h), which is placed in the last term of the fourth year and sharing space with work placement and mobility courses. This paper will present some author’s experiences as teachers of that unit during its short history of only three years. In spite of being a joint degree, which is coordinated between both universities (US and UMA) trying to give similar contents, it is interesting to highlight the differential experiences coming from the teachers of both universities in relation to the teaching methodologies and academic results.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Cephalopods caught in the outer Patagonian shelf and its upper and medium slope in relation to the main oceanographic features

Ninety cephalopod specimens were collected during the bottom trawl survey ATLANTIS 2009 undertaken between 24 February and 1 April 2009 The surveyed area was the zone between parallels 44◦and 48◦S, east of the Argentinean EEZ down to the 1500m depth on the HS of the SW Atlantic The collection was composed of 16 species of squids and 5 of octopods. The best represented groups were Histioteuthida (5 species) and Octopodidae(5). The most abundant species were Gonatusantarcticus(25.5%), Histioteuthisatlantica (11.1%), and Muusoctopuseureka (8.9%) The geographic and/or bathymetric distribution ranges of 9 species are extended, and this is the first record of Galiteuthis glacialis outside circumpolar Antarctic water

New insights into the morphology, reproduction and distribution of the large-tuberculate octopus Graneledone macrotyla from the Patagonian slope

The new information reported in this paper is based on 11 specimens of the large-tuberculate octopus Graneledone macrotyla. These specimens were caught in bottom trawl surveys ATLANTIS 2009 and 2010 carried out on the Patagonian slope off the Argentinean Economic Exclusive Zone between 24 February and 1 April 2009 and from 9 March to 5 April 2010 respectively. A new diagnosis and a complete description of the species are provided. This is the first time that stylets, beaks and spermatophores are described. This is also the first time in which mature females have been studied and the female genitalia described. Like other eledonid octopods, G. macrotyla does not have spermathecae in the oviducal glands. The presence of fertilized eggs inside the ovary suggests that fertilization takes place within the ovary. The simultaneous occurrence of oocyte cohorts at different oogenic stages suggests that the species is a multiple spawner. G. macrotyla inhabits shallower waters on the Patagonian slope (475-921 m) than in the subantartic area (1647-2044 m). From a biogeographical point of view, our data show that G. macrotyla inhabits the plume of cold subantarctic waters, which is pushed far north into the southwestern Atlantic by the Falkland (Malvinas) Current.Nueva información sobre la morfología, reproducción y distribución del pulpo megatuberculado Graneledone macrotyla del talud continental Patagónico. – La novedosa información que se proporciona en este trabajo se basa en 11 ejemplares del pulpo megatuberculado Graneledone macrotyla. Esos ejemplares se capturaron en las campañas de prospección ATLANTIS 2009 y 2010, realizadas con arte de arrastre bentónico en el talud patagónico por fuera de la Zona Económica Exclusiva de Argentina, entre el 24 de febrero y el 1 de abril de 2009 y desde el 9 de marzo hasta el 5 de abril de 2010, respectivamente. Se ofrece una nueva diagnosis y una descripción completa de la especie. Esta es la primera vez en que se describen los estiletes, picos y espermatóforos. También es totalmente novedoso el estudio de hembras maduras, lo que ha permitido la descripción de su órgano genital. Como ocurre en otros pulpos de la subfamilia Eledoninae, G. macrotyla carece de espermatecas en las glándulas oviductales. La presencia de huevos fecundados en el ovario sugiere que la fecundación acontece dentro de este órgano. La presencia simultánea de varias cohortes de ovocitos de diferente tamaño sugiere que se trata de una especie cuya freza es múltiple. G. macrotyla vive en aguas más someras del talud patagónico (475-921 m) que en la región subantártica (1647-2044 m). Estos datos muestran que G. macrotyla vive en la pluma de aguas subantárticas, que transportan agua fría hacia el norte del Atlántico sudoccidental a través de la corriente de Malvinas (Falkland)

Olaparib in combination with pegylated liposomal doxorubicin for platinum-resistant ovarian cancer regardless of BRCA status: a GEICO phase II trial (ROLANDO study)

Inhibidor de PARP; Olaparib; Càncer d'ovari recurrent resistent al platíInhibidor de PARP; Olaparib; Cáncer de ovario recurrente resistente al platinoPARP inhibitor; Olaparib; Platinum-resistant recurrent ovarian cancerBackground There is limited evidence for the benefit of olaparib in platinum-resistant ovarian cancer (PROC) patients with BRCA wild-type tumors. This study investigated whether this combination of a DNA-damaging chemotherapy plus olaparib is effective in PROC regardless BRCA status. Patients and methods Patients with high-grade serous or endometrioid ovarian carcinoma and one previous PROC recurrence were enrolled regardless of BRCA status. Patients with ≤4 previous lines (up to 5 in BRCA-mut) with at least one previous platinum-sensitive relapse were included; primary PROC was allowed only in case of BRCA-mut. Patients initially received six cycles of olaparib 300 mg b.i.d. (biduum) + intravenous pegylated liposomal doxorubicin (PLD) 40 mg/m2 (PLD40) every 28 days, followed by maintenance with olaparib 300 mg b.i.d. until progression or toxicity. The PLD dose was reduced to 30 mg/m2 (PLD30) due to toxicity. The primary endpoint was progression-free survival (PFS) at 6 months (6m-PFS) by RECIST version 1.1. A proportion of 40% 6m-PFS or more was considered of clinical interest. Results From 2017 to 2020, 31 PROC patients were included. BRCA mutations were present in 16%. The median of previous lines was 2 (range 1-5). The overall disease control rate was 77% (partial response rate of 29% and stable disease rate of 48%). After a median follow-up of 10 months, the 6m-PFS and median PFS were 47% and 5.8 months, respectively. Grade ≥3 treatment-related adverse events occurred in 74% of patients, with neutropenia/anemia being the most frequent. With PLD30 serious AEs were less frequent than with PLD40 (21% versus 47%, respectively); moreover, PLD30 was associated with less PLD delays (32% versus 38%) and reductions (16% versus 22%). Conclusions The PLD–olaparib combination has shown significant activity in PROC regardless of BRCA status. PLD at 30 mg/m2 is better tolerated in the combination.This work was supported by Grupo Español de Investigación en Cáncer de Ovario (GEICO) (no grant number). AstraZeneca provided olaparib and awarded a grant to GEICO (no grant number) to pay the costs of the study but did not take part in the conduct of the current clinical trial or in the analysis and interpretation of the results. Pegylated ribosomal doxorubicin was provided by the sites according to local standard procedures

LA PERSONA EN EL PROCESO DE MUERTE

One of the greatest aspects that nursing usually deal with in their daily practice is the death of the person they are looking alter, and in many cases is considered as a failure of the therapeutic and care action, and so rejected due to its traumatic aspect for professionals and clients of sanitary attention. The poor study of our responsibilities when taking care of a person, defined by V. Henderson as “the help to a dignified death” makes us think about the cycle health-illness-death, to comprehend a process where nursing professionals can and have to be a fundamental help for the patient and his family. In this work we have tried to reflect on death process from philosophy and anthropology, with the aim of defusing, assume and relate our practice to this reality social and professionally rejected to help a person to die decently.Uno de los grandes aspectos con los que, a menudo, se enfrenta la enfermería en su práctica diaria es la muerte de la persona cuidada, en muchos casos, considerada como un fracaso de la acción terapéutica y cuidadora, y por lo tanto rechazada, por su aspecto traumático, tanto para los profesionales como para los clientes de la atención sanitaria. El escaso abordaje de una de nuestras responsabilidades en el cuidado de la persona, expresamente definido por V. Henderson como “la ayuda a una muerte digna” nos obliga a reflexionar sobre esta realidad ineludible del ciclo Salud-enfermedad-muerte, a fin de comprender un proceso en el que los profesionales de enfermería podemos y debemos ser una ayuda fundamental, tanto para el paciente como para su entorno familiar. En este trabajo hemos intentado reflexionar sobre el proceso de muerte desde la filosofía y antropología, con el fin de desdramatizar, asumir y entroncar en nuestra práctica esta realidad, social y profesionalmente rechazada, para poder ayudar a la persona a morir dignamente

El estrés oxidativo en la fertilidad y desempeño reproductivo de mamíferos hembras y machos

Free radicals are highly reactive oxidation agents, which act as short-lived chemical  intermediates on lipids, amino acids, carbohydrates and nucleic acids. When there is an imbalance and the amount of free radicals exceeds the balance between oxidant production and antioxidant capacity in the cell, a phenomenon known as oxidative stress is generated, which has negative consequences on multiple cellular processes, both in females as in males and therefore negative effect on fertility and reproductive performance. In this work, the oxidative stress in the spermatozoa, plasma membrane, mitochondria, acrosome and DNA is briefly described, as well as the effect of oxidative stress on female and male fertility.Los radicales libres son agentes de oxidación altamente reactivos, que actúan como intermediarios químicos de vida corta sobre lípidos, aminoácidos, carbohidratos y ácidos nucleicos. Cuando ocurren desequilibrios y la cantidad de radicales libres sobrepasa el balance entre la producción oxidante y la capacidad antioxidante en la célula, se genera un fenómeno conocido como estrés oxidativo. Tal anomalía genera consecuencias negativas sobre múltiples procesos celulares de los mamíferos, tanto en las hembras como en los machos, y -por lo tanto- daños en la fertilidad y desempeño reproductivo. En esta revisión se describe brevemente el estrés oxidativo en la membrana plasmática, las mitocondrias, el acrosoma y el ADN de los espermatozoides, así como el efecto del estrés oxidativo sobre la fertilidad de machos y hembras

Automatic Classification of Field Winding Faults in Synchronous Motors based on Bicoherence Image Segmentation and Higher Order Statistics of Stray Flux Signals

[EN] In this work, the application of the bicoherence (a squared normalized version of the bispectrum) of the stray flux signal is proposed as a way of detecting faults in the field winding of synchronous motors. These signals are analyzed both under the starting and at steady state regime. Likewise, two quantitative indicators are proposed, the first one based on the maximum values of the asymmetry and the kurtosis of the bicoherence matrix obtained from the flux signals and the second one relying on an algorithm based on the bicoherence image segmentation of the obtained pattern for each analyzed state. The results are analyzed through a comparative study for the two considered motor regimes, obtaining satisfactory results that sustain the potential application of the proposed methodology for the automatic field winding fault detection in real applications.Miguel E. Iglesias Martínez s work was supported by the postdoctoral research scholarship "Ayudas para la recualificación del sistema universitario español 2021-2023. Modalidad: Margarita Salas", UPV, Ministerio de Universidades, Plan de Recuperación, Transformación y Resiliencia, Spain. Funded by the European Union-Next Generation EU. This work is also supported by Generalitat Valenciana (reference CIAICO/2021/020)Iglesias-Martínez, ME.; Guerra Carmenate, J.; Antonino-Daviu, J.; Dunai, L.; Platero, CA.; Conejero, JA.; Fernández De Córdoba, P. (2023). Automatic Classification of Field Winding Faults in Synchronous Motors based on Bicoherence Image Segmentation and Higher Order Statistics of Stray Flux Signals. IEEE Transactions on Industry Applications. 59(4):3945-3954. https://doi.org/10.1109/TIA.2023.32622203945395459

Feasibility study of culture of the Pacific oyster Crassostrea gigas (Thunberg, 1793) in different Galician rias (northwest Spain): First biological results

Batches of the Pacific oyster Crassostrea gigas (Thunberg, 1793) have been experimentally cultivated in three rías from Galicia (northwest Spain) using two different techniques: raft and intertidal culture. Performance of these batches was assessed by analysing the growth, mortality and quality of the oysters produced. First results suggested a good growth in the majority of the raft-cultured batches and in the intertidal zone with commercial oysters after 14 months. Mortality was low ( 15 %), especially in intertidal culture. Oysters were affected by blisters and mud worms, but without impairment to their market acceptability.Los problemas que la producción ostrícola tradicional gallega tiene planteados han puesto en peligro la continuidad del sector. En el marco de exploración de una alternativa parcial que contribuya a superarlos, se ha llevado a cabo el cultivo experimental de varios lotes de ostra rizada Crassostrea gigas (Thunberg, 1793) en tres rías gallegas empleando dos técnicas diferentes: cultivo en batea y en zona intermareal. Se evaluó el rendimiento de los mismos mediante el análisis del crecimiento, la mortalidad y la calidad de las ostras producidas. Los primeros resultados mostraron un crecimiento adecuado en la mayor parte de los lotes cultivados, produciéndose ostras comerciales en 14 meses de cultivo, tanto en batea como en intermareal. La mortalidad fue baja en general (inferior al 15 %), especialmente en el cultivo intermareal. Las ostras se vieron afectadas por poliquetos perforadores y por anomalías de calcificación, pero sin llegar a condicionar su aceptabilidad comercial.Instituto Español de Oceanografí

Consecuencias del estrés calórico sobre la reproducción del ganado vacuno

Heat stress represents one of the major environmental factors that adversely affect the reproductive performance of cattle. In this paper the behavioral adjustments, physical mechanisms and physiological responses to heat loss are described; bos indicus adaptive advantages with respect to bos Taurus, pathophysiology of heat stress and heat stress effects in animal reproduction, both the male and the female.El estrés calórico representa unos de los principales factores del medio ambiente que repercuten negativamente en el desempeño reproductivo del ganado vacuno. En este trabajo se describen los ajustes conductuales, mecanismos físicos y respuestas fisiológicas para la pérdida calórica; ventajas adaptativas del bos indicus con respecto al bos Taurus, fisiopatología del estrés calórico y repercusiones del estrés calórico en la reproducción animal, tanto en el macho como en la hembra