4,693 research outputs found

    Evidence for dynamic and multiple roles for huntingtin in Ciona intestinalis

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    Pendidikan Sebagai Agen Perubahan Menuju Masyarakat Indonesia Seutuhnya

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    : This paper discusses about social change in Indonesia, the process of education in Indonesia, the complete Indonesian people and the role of education as an agent of social change. Nowadays, our education is still far to be called as an agent of change. That is because of the varied challenges such as problems of education quality, relevance of education, access to education, national education system management, financing sources, differences in management priorities inter regency/city as a consequence of regional autonomy. Challenges must be overcome to realize the Indonesian people; which are religious and moral, master of science and skills, have physically and mentally healthy, have good personality and have responsiblity. To realize the complete Indonesian society, education should be relevant to the four pillars of learning, namely: learning to know, learning to do, learning to live together, and learning to be

    Effects of Controller and Nonuniform Temperature Profile on the Onset of Rayleigh-Bénard-Marangoni Electroconvection in a Micropolar Fluid

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    Linear stability analysis is performed to study the effects of nonuniform basic temperature gradients on the onset of Rayleigh-Bénard-Marangoni electroconvection in a dielectric Eringen’s micropolar fluid by using the Galerkin technique. In the case of Rayleigh-Bénard-Marangoni convection, the eigenvalues are obtained for an upper free/adiabatic and lower rigid/isothermal boundaries. The influence of various parameters has been analysed. Three nonuniform basic temperature profiles are considered and their comparative influence on onset of convection is discussed. Different values of feedback control and electric number are added up to examine whether their presence will enhance or delay the onset of electroconvection

    Observation and Analysis of Departure Operations at Boston Logan International Airport

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    The Departure Planner (DP) is a concept for a decision-aiding tool that is aimed at improving the departure operations performance at major congested airports. In order to support the development of the DP tool, the flow constraints and their causalities in the departure process - primarily responsible for generating inefficiencies and delays- need to be identified. This thesis is an effort to identify such flow constraints and gain a deep understanding of the underlying dynamics of the departure process based on field observations and data analysis at Boston Logan International Airport. It was observed that the departure process is a complex interactive queuing system, where aircraft queues form as a manifestation of the flow constraints. While departure delays were observed in all airport components (runways, taxiways, ramps and gates), it was concluded that the flow constraints manifest mainly at the runway system, which exhibits the largest delays and queues. Major delays and inefficiencies were also observed due to downstream flow constraints, which propagate back and block the departure flow from the airport. It was also observed that the airport system is a highly controlled system as the air traffic controllers manage the flow constraints. The air traffic controllers were, therefore, identified as another flow constraint due to their workload and their main strategies in managing the flow constraints were observed. Based on the observations, a core departure process was identified consisting of two main elements: a queuing element generated by the flow constraints and a control element representing the air traffic controller actions. This core process was abstracted using a controlled queuing framework, where the air traffic controller actions are represented by blocking the flow of aircraft in order to maintain safe operation of the airport resources according to the ATC rules and procedures and regulate the outbound flow to constrained downstream resources. The controlled queuing framework was used to analyze the departure process highlighting the queuing dynamics and the control behavior for different flow constraint examples. In conclusion, a number of implications for the Departure Planner and other improved methods for departure operations are inferred from the observations and analysis.This work was supported by the National Aeronautics and Space Administration Ames Research Center under grant NAG 2-1128

    Single-, Dual- and Triple-band Frequency Reconfigurable Antenna

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    The paper presents a frequency reconfigurable slot dipole antenna. The antenna is capable of being switched between single-band, dual-band or triple-band operation. The antenna incorporates three pairs of pin-diodes which are located within the dipole arms. The antenna was designed to operate at 2.4 GHz, 3.5 GHz and 5.2 GHz using the aid of CST Microwave Studio. The average measured gains are 1.54, 2.92 and 1.89 dBi for low, mid and high band respectively. A prototype was then constructed in order to verify the performance of the device. A good level of agreement was observed between simulation and measurement

    Pengaruh Implementasi Manajemen Kelas Terhadap Perilaku Belajar Mahasiswa Pada Jurusan Manajemen Pendidikan Islam Fakultas Tarbiyah Dan Keguruan UIN Alauddin Makassar

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    This paper contains the results of the research which aimed to determine the ef-fect of the implementation of classroom management on students learning beha-vior at the Department of Islamic Education Management at Tarbiyah and Tea-ching Faculty of UIN Alauddin Makassar. The research approach was quantita-tive with the type of Ex Post Facto and the model of research was descriptive cor-relational study. The population of the research was all of the students of the De-partment of Islamic Education Management of Tarbiyah and Teaching Faculty. The sample consisted of 31 students. The methods that were used in the data col-lection was a questionnaire on the implementation of classroom management and a scale of learning behavior. Data analysis techniques used was simple linear reg-ression formula. The results of the research pointed-out that there was a positive correlation between the implementation of classroom management and students learning behavior. This means that the better the implementation of class mana-gement, the better the student learning behavior

    Pengaruh Asap Rokok Kretek Terhadap Imunitas Seluler Tikus Betina Strain Lmr

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    Experimental research was done to understand the effect of cigarette smoke to cellular immunity. In this research, 3 groups of rats were exposed by cigarette smoke for 7, 14, and 21 estrous cycles. Each group had a control group that was not exposed by cigarette smoke. Percentage of T lymphocytes blastransformation that cultured in 72 hours was used as the parameter. T Lymphocytes blastransformation was measured with the blood culture preparation. The result showed the groups exposed in 7 and 14 cycles had no significant influence in cellular immunity. But the groups exposed in 21 cycles showed a decline of the cellular immunity function. This research has provided that the cellular immunity of the rats declines by the cigarette smoke in 21 cycle's exposure. Based on this research, people who are exposed by cigarette smoke for long time can decrease of their immunity, especially cellular immunity

    Albuminuria regression and all-cause mortality among insulin-treated patients with Type 2 diabetes: analysis of a large UK Primary Care cohort

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    Background: Overt albuminuria (urinary albumin-creatinine ratio (ACR) >300mg/g) is an established risk factor for progression of nephropathy and total mortality. However, whether, a reduction in ACR translates into a reduction in mortality and/or cardiovascular events among insulintreated patients with Type 2 diabetes (T2D) in routine practice is currently not known.Methods We obtained data on a large cohort of insulin users with T2D and nephropathy (baseline ACR ≥ 300mg/g) from UK general practices between 2007 and 2014. Their corresponding ACR values after one year of follow up were thereafter categorised into: (1) less than 300mg/g (i.e. albuminuria regression) or (2) >300mg/g (i.e. non-regression of albuminuria), and the cohort was followed up for 5 years for all-cause mortality and cardiovascular events. Cox proportional hazard models were fitted to estimate the risk of all-cause death.Results A total of 11,074 patients with insulin-treated T2D met the inclusion criteria. Their mean age was 62.3(13.6) years; mean HbA1c: 8.7(1.8) %; and 53% were male. 682 deaths occurred after a follow-up period of 43,393 person-years with a mortality rate of 16 per 1000 person-years. 5-year survival was markedly reduced in the group whose proteinuria persisted or progressed (91 vs 95%; log-rank p-value less than 0.001). Compared to patients whose ACR levels remained above 300mg/g, all-cause mortality and cardiovascular events were 31% and 27% lower in those whose albuminuria regressed to less than 300mg/g (aHR: 0.69; 95%CI: 0.52 to 0.91; p=0.008 and aHR: 0. 73; 95%CI: 0.54 to 0.98; p=0.041) respectively.Conclusion: In patients with insulin-treated T2D and nephropathy in routine practice, a regression in albuminuria (e.g. via better BP or glycaemic control) is associated with a significant reduction in all-cause mortality. Thus, albuminuria is not simply a risk marker of renal and cardiovascular disease, but also an independent target for therapy. Albuminuria reduction should be viewed as a goal for renal and cardiovascular protection

    Obesity independently predicts responders to biphasic insulin 50/50 (Humalog Mix50 and Insuman Comb 50) following conversion from other insulin regimens: a retrospective cohort study

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    Aims This study aims to examine the metabolic effects of intensification or initiation of insulin treatment with biphasic insulin 50/50, and determine the predictors of responders or non-responders to biphasic insulin 50/50.Methods A cohort of 2183 patients ≥18 years with diabetes, newly treated with biphasic insulin 50/50 between January 2000 and May 2012, were sourced from UK General Practices via The Health Improvement Network (THIN) database. Baseline clinical parameters of 1267 patients with suboptimal glycated hemoglobin (HbA1c) >7.5% (>58 mmol/mol) who had received background insulin regimens for at least 6 months preceding biphasic insulin 50/50 were compared against 12-month outcome data. Responders were defined as those with HbA1c 30 kg/m2), treatment duration for ≥9 months, and baseline HbA1c are independent determinants of responders. In addition, stratified for baseline HbA1c levels, HM50 was associated with better HbA1c outcome compared with IC50.Conclusions biphasic insulin 50/50 is effective for achieving glycemic control in suboptimal HbA1c levels, especially among obese patients with insulin-treated diabetes. Stratified for baseline HbA1c, HM50 was associated with improved HbA1c outcome compared with IC50
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