Pengaruh Asap Rokok Kretek Terhadap Imunitas Seluler Tikus Betina Strain Lmr

Abstract

Experimental research was done to understand the effect of cigarette smoke to cellular immunity. In this research, 3 groups of rats were exposed by cigarette smoke for 7, 14, and 21 estrous cycles. Each group had a control group that was not exposed by cigarette smoke. Percentage of T lymphocytes blastransformation that cultured in 72 hours was used as the parameter. T Lymphocytes blastransformation was measured with the blood culture preparation. The result showed the groups exposed in 7 and 14 cycles had no significant influence in cellular immunity. But the groups exposed in 21 cycles showed a decline of the cellular immunity function. This research has provided that the cellular immunity of the rats declines by the cigarette smoke in 21 cycle's exposure. Based on this research, people who are exposed by cigarette smoke for long time can decrease of their immunity, especially cellular immunity