A new class of smart gadolinium contrast agent for tissue pH probing using magnetic resonance imaging

Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment decisions. To this end, many investigations have been carried out to develop an accurate and efficient method of in vivo pH measurement. Most of the techniques developed so far suffer from inadequate accuracy, due to poor sensitivity at low concentration of the target or nonspecific interactions within the tissue matrix. To overcome these issues, we describe herein the development of a simple, yet reliable, way to estimate pH with high precision using a Gd(III)-DOTA-silyl-based acid-labile group as a pH-sensitive contrast agent with Magnetic Resonance Imaging (MRI). With this method, a change in T1 weighted image intensity of the newly developed pH-sensitive contrast is directly linked to the proton concentration in the media. As a result, we were able estimate the pH of the target with 95% reliability

Background independent quantization and the uncertainty principle

It is shown that polymer quantization leads to a modified uncertainty principle similar to that obtained from string theory and non-commutative geometry. When applied to quantum field theory on general background spacetimes, corrections to the uncertainty principle acquire a metric dependence. For Friedmann-Robertson-Walker cosmology this translates to a scale factor dependence which gives a large effect in the early universe.Comment: 6 page

Foreign body aspiration in adults.

Foreign body aspiration is not an uncommon problem, particularly in children, the elderly, and those with predisposing factors like neurological impairment. In adults, regional differences exist in the type of foreign body aspirated. We report four cases of foreign body aspiration in South Asian adults, three of which were related to the widespread habit of chewing stimulant seeds such as betel nuts (two) and tamarind seed (one). It is important for clinicians to maintain a high index of suspicion for the diagnosis of foreign body inhalation in the appropriate clinical setting. Bronchoscopy is necessary not only for the diagnosis but also for the removal of foreign body from the bronchial tree. Once the foreign body is removed, the improvement in symptoms is usually dramatic, making it rewarding for any physician to manage. Keywords: betel nut, bronchoscopy, foreign body aspiration, stimulant seeds, tamarind see

Morphological Variation between Life and Death Gastropod Populations in the Nile Delta: A Pollution-Induced Evolution

Wetland ecosystems of the Nile Delta face severe threats due to natural climatic changes and anthropogenic activities. Life and death assemblage comparisons can be implemented as a historical record to detect anthropogenic-induced environmental changes in the past few decades. A geometric morphometric approach was applied to quantify the pollution-induced morphological variation between life and death populations of the gastropod Melanoides tuberculata. The results indicated that life populations differ significantly from the death ones, where the first tend to be much smaller, more globular, and with a depressed aperture and whorl section. In addition, the phenetic diversity of the life populations was also decreased, and the allometric growth was shifted. These morphological changes in the life populations are well-known adaptations for reducing the cost of shell maintenance in polluted water. No distinct morphospace was found between life populations from different habitats, suggesting that habitats have no significant role in the current pollution-induced evolution.This work is funded by the Researchers Supporting Project number (RSP2023R455), King Saud University, Riyadh, Saudi Arabia

The Impact of Media Globalization of English Football: The Kuwaiti Experience

The new technologies of broadcasting, sports coverage, sports casters, and sports analysis, especially in Europe, have attracted many local sports players and fans to enjoy and imitate famed European players. The globalization of football (soccer) has affected sports culture in Kuwait. In-depth interviews with 17 interviewees including sports academics, experts, practitioners, coaches, sports players, fans, and sports reporters revealed that the English Premier League not only entertained the fans in Kuwait but also affected their popular culture behavior and local football league performance and attendance. The English Premier League also affected fandom lifestyle and expenditure through expensive sports subscriptions or even traveling to Europe to attend football matches.Output Status: Forthcoming/Available Onlin

Measurement of the dynamic charge response of materials using low-energy, momentum-resolved electron energy-loss spectroscopy (M-EELS)

One of the most fundamental properties of an interacting electron system is its frequency- and wave-vector-dependent density response function, $\chi({\bf q},\omega)$. The imaginary part, $\chi''({\bf q},\omega)$, defines the fundamental bosonic charge excitations of the system, exhibiting peaks wherever collective modes are present. $\chi$ quantifies the electronic compressibility of a material, its response to external fields, its ability to screen charge, and its tendency to form charge density waves. Unfortunately, there has never been a fully momentum-resolved means to measure $\chi({\bf q},\omega)$ at the meV energy scale relevant to modern elecronic materials. Here, we demonstrate a way to measure $\chi$ with quantitative momentum resolution by applying alignment techniques from x-ray and neutron scattering to surface high-resolution electron energy-loss spectroscopy (HR-EELS). This approach, which we refer to here as "M-EELS," allows direct measurement of $\chi''({\bf q},\omega)$ with meV resolution while controlling the momentum with an accuracy better than a percent of a typical Brillouin zone. We apply this technique to finite-q excitations in the optimally-doped high temperature superconductor, Bi$_2$Sr$_2$CaCu$_2$O$_{8+x}$ (Bi2212), which exhibits several phonons potentially relevant to dispersion anomalies observed in ARPES and STM experiments. Our study defines a path to studying the long-sought collective charge modes in quantum materials at the meV scale and with full momentum control.Comment: 26 pages, 10 sections, 7 figures, and an appendi

Deposition of stainless steel thin films: an electron beam physical vapour deposition approach

This study demonstrates an electron beam physical vapour deposition approach as an alternative stainless steel thin films fabrication method with controlled layer thickness and uniform particles distribution capability. The films were fabricated at a range of starting electron beam power percentages of 3–10%, and thickness of 50–150 nm. Surface topography and wettability analysis of the samples were investigated to observe the changes in surface microstructure and the contact angle behaviour of 20 °C to 60 °C deionised waters, of pH 4, pH 7, and pH 9, with the as-prepared surfaces. The results indicated that films fabricated at low controlled deposition rates provided uniform particles distribution and had the closest elemental percentages to stainless steel 316L and that increasing the deposition thickness caused the surface roughness to reduce by 38%. Surface wettability behaviour, in general, showed that the surface hydrophobic nature tends to weaken with the increase in temperature of the three examined fluids

Multi-environmental evaluation of wheat tetraploid genotypes for agronomic traits under rainfed conditions in Syria

This study was conducted at Homs, Al-Swaida and Tartous, General Commission for Scientific Agricultural Research, Syria during 2016/2017 season. Seven wheat genotypes were planted under rainfed conditions in randomized complete block design with three replications. Studied traits were days to maturity, plant height, number of grain per spike, grain weight per spike, 1000 kernal weight and grain yield per plant to evaluate variance between genotypes and locations. Results showed existence of high variance between studied genotypes in all traits especially plant height. It resulted that genotype W45193 was significantly superior in grain yield per plant with an increasing rate of 69.62% comparing to control Sham 5. Also, it was significantly superior in spike numbers with an increasing rate of 53.53%, 57.24% compared to both controls Sham 3 and Sham 5, respectively. Genotype W45064 was significantly superior in grain weight per spike and 1000 kernal weight compare to both controls Sham 3 and Sham 5. W 45194 was significantly superior in 1000 kernal weight comparing to control Sham 5 (36.34, 31.16 g), respectively. Furthermore, all studied traits (except spike number per plant) were more significant in Tartous compare to both Homs and Al-Swaida

Prevalence and Correlates of Common Mental Disorders among Mothers of Young Children in Kilimanjaro Region of Tanzania.

Although poor maternal mental health is a major public health problem, with detrimental effects on the individual, her children and society, information on its correlates in low-income countries is sparse. This study investigates the prevalence of common mental disorders (CMD) among at-risk mothers, and explores its associations with sociodemographic factors. This population-based survey of mothers of children aged 0-36 months used the 14-item Shona Symptom Questionnaire (SSQ). Mothers whose response was "yes" to 8 or more items on the scale were defined as "at risk of CMD." Of the 1,922 mothers (15-48 years), 28.8% were at risk of CMD. Risk of CMD was associated with verbal abuse, physical abuse, a partner who did not help with the care of the child, being in a polygamous relationship, a partner with low levels of education, and a partner who smoked cigarettes. Cohabiting appeared to be protective. Taken together, our results indicate the significance of the quality of relations with one's partner in shaping maternal mental health. The high proportion of mothers who are at risk of CMD emphasizes the importance of developing evidence-based mental health programmes as part of the care package aimed at improving maternal well-being in Tanzania and other similar settings