Circadian rhythm of metabolism indicators in healthy people according to saliva study findings

In recent years, the concept of functional-metabolic continuum (FMС) has been formulated, which indicates the relatively constant nature of metabolism and its parameters in the intercellular environment. Thus, in its turn, is closely and adequately connected to the functional activity of organs and cells, thus forming a single system – the continuum. In addition, the functional activity of key low molecular weight antioxidants in the tissues and biological fluids of the body may, to a large extent, indicate the adaptive abilities and reactions at the level of the entire organism. One of the possible approaches to FMC study, depending on the physiological activity of the body, is to determine the parameters of metabolism and regulatory molecules relative to the daily rhythm, i.e., their comparison in the morning and in the evening, when the changes in the body over the day are observed, in other words, when there is an overall load. The aim of this research was to examine the circadian rhythm of FMC in healthy people according to saliva study findings. Thus, the obtained results, firstly, represent the existence of daily changes in FMC, and secondly, constitute a possible information channel that can be used to study these changes, to determine and compare indicators in the morning and evening about the functional activity of the body involving the regulatory systems

The study of functional and metabolic continuum by metabolism parameters in blood plasma of healthy people as compared with patients with type 2 diabetes and hypertension against the background of type 2 diabetes

It is known that existing systems of regulation of energy homeostasis provide adequate needs of the body, depending on both the receipt and use of energy. Moreover, the organization of energy supply has its own characteristics in insulin-dependent and insulin-independent tissues. The main thing in the organization of energy supply is the achievement of the principle of compliance with the functional needs of the body, that is, the maintenance of the functional and metabolic continuum (FMC) We studied the metabolic parameters of FMC in healthy people and patients with type 2 DM and patients with hypertension against the background of type 2 DM according to the study of some indicators of blood plasma. The identified features, in our opinion, are one of the first manifestations of FMC disorder due to insulin resistance With the advent of insulin deficiency, there are increasing disturbances of energy metabolism, which are mainly caused by endothelial dysfunction and neuro-hormonal regulatory shifts of a stressful nature. The consequences or manifestations of these processes can probably be found in all environments of the body: blood, saliva, condensed air, that is, they have a systemic character

Changes in the circadian rhythm of metabolic rates in the saliva of patients with compensated type 2 diabetes mellitus

In our previous studies, we have shown that salivary parameters differ during the day when one compares the morning and evening samples. That is, the analysis of biochemical components in saliva can be used to monitor the general state of the body's health, which is especially important in metabolic disorders that occur in type 2 diabetes mellitus (DM2). It is possible to assume that the study of daily metabolic changes in patients with type 2 diabetes will help to determine the mechanisms of functional and metabolic continuum (FMC) in this pathology. Patients with diabetes mellitus present with certain changes in saliva as compared to apparently healthy people. That is, although the daily rhythm of metabolism in saliva remains the same, the metabolic changes occur against this background. They are not significant, but their presence allows us to conclude that even in compensated type 2 DM, changes in metabolism are observed, and this can be explained by the disrupted carbohydrate metabolism with the mobilization of both lipid and protein metabolism. These changes can be observed in the parameters of metabolism in saliva and, especially in the form of a disrupted daily rhythm. Thus, even in compensated type 2 DM, there are changes in the energy metabolism, induced by hormonal regulation. These changes can be controlled using the daily saliva monitoring

Results and perspectives on policing as part of the national security sector

The police are one of the actors involved in ensuring national security. Therefore, the relevance of this article stems from the need to ensure effective performance. The issue of studying the experience of countries in this field is relevant to find the best models to assess the activities of these structures, which will contribute to a better performance of tasks assigned to them by law - this is one of the tools to assess the performance of the police. The aim of the article was to investigate the peculiarities of police performance assessment, thereby identifying practices that can improve the assessment of police performance. The objective was achieved by using dogmatic, statistical, comparative legal methods and a system-structural approach. The authors revealed the peculiarities of police assessment in Ukraine, the USA, Canada, France and the UK. The focus is on the assessment of police performance based on the level of citizens' trust and statistical data. The conclusion is made that citizens' trust in the police is necessary for the effective performance of its tasks. It is noted that the use of statistics to draw an objective conclusion about police performance is questionable because of the ability of police management to manipulate the data. It is concluded that each of these areas needs significant improvement. The findings are complementary to previous studies and have implications for improving the assessment of Ukrainian police performance and police performance in foreign countries

The study of functional and metabolic continuum by metabolism parameters in blood plasma of healthy people as compared with patients with type 2 diabetes and hypertension against the background of type 2 diabetes

It is known that existing systems of regulation of energy homeostasis provide adequate needs of the body, depending on both the receipt and use of energy. Moreover, the organization of energy supply has its own characteristics in insulin-dependent and insulin-independent tissues. The main thing in the organization of energy supply is the achievement of the principle of compliance with the functional needs of the body, that is, the maintenance of the functional and metabolic continuum (FMC). We studied the metabolic parameters of FMC in healthy people and patients with type 2 DM and patients with hypertension against the background of type 2 DM according to the study of some indicators of blood plasma. The identified features, in our opinion, are one of the first manifestations of FMC disorder due to insulin resistance

Results and perspectives on policing as part of the national security sector

The police are one of the actors involved in ensuring national security. Therefore, the relevance of this article stems from the need to ensure effective performance. The issue of studying the experience of countries in this field is relevant to find the best models to assess the activities of these structures, which will contribute to a better performance of tasks assigned to them by law - this is one of the tools to assess the performance of the police. The aim of the article was to investigate the peculiarities of police performance assessment, thereby identifying practices that can improve the assessment of police performance. The objective was achieved by using dogmatic, statistical, comparative legal methods and a system-structural approach. The authors revealed the peculiarities of police assessment in Ukraine, the USA, Canada, France and the UK. The focus is on the assessment of police performance based on the level of citizens' trust and statistical data. The conclusion is made that citizens' trust in the police is necessary for the effective performance of its tasks

A multiscale hybrid model for pro-angiogenic calcium signals in a vascular endothelial cell

Cytosolic calcium machinery is one of the principal signaling mechanisms by which endothelial cells (ECs) respond to external stimuli during several biological processes, including vascular progression in both physiological and pathological conditions. Low concentrations of angiogenic factors (such as VEGF) activate in fact complex pathways involving, among others, second messengers arachidonic acid (AA) and nitric oxide (NO), which in turn control the activity of plasma membrane calcium channels. The subsequent increase in the intracellular level of the ion regulates fundamental biophysical properties of ECs (such as elasticity, intrinsic motility, and chemical strength), enhancing their migratory capacity. Previously, a number of continuous models have represented cytosolic calcium dynamics, while EC migration in angiogenesis has been separately approached with discrete, lattice-based techniques. These two components are here integrated and interfaced to provide a multiscale and hybrid Cellular Potts Model (CPM), where the phenomenology of a motile EC is realistically mediated by its calcium-dependent subcellular events. The model, based on a realistic 3-D cell morphology with a nuclear and a cytosolic region, is set with known biochemical and electrophysiological data. In particular, the resulting simulations are able to reproduce and describe the polarization process, typical of stimulated vascular cells, in various experimental conditions.Moreover, by analyzing the mutual interactions between multilevel biochemical and biomechanical aspects, our study investigates ways to inhibit cell migration: such strategies have in fact the potential to result in pharmacological interventions useful to disrupt malignant vascular progressio