A case report of cornelia de lange syndrome in Northern Iran; a clinical and diagnostic study

As a rare multisystem congenital anomaly disorder, Cornelia de Lange syndrome (CdLS) is featured by delayed growth and development, distinct facial dimorphism, limb malformations and multiple organ defects. CdLS is a genetic syndrome affecting 1/10000-1/60000 neonates with unknown genetic basis. Delayed growth and development, hirsute, structural anomalies of the limbs and distinct facial dimorphism are considered as its main clinical characteristics. Introducing CdLS cases of different ethnic backgrounds could add distinctions to the phenotypic picture of the syndrome and be useful in diagnosis. Early diagnosis and decreased death rates are achievable through enhanced awareness on this syndrome. We present here a 45-day-old girl, as the first case of Cornelia in Golestan (Northern Iran), referred to our hospital with the symptoms as mentioned above. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved

Evaluation of the Bioactive Compounds, and Physicochemical and Sensory Properties of Gluten Free Muffins Enriched with Persimmon 'Rojo Brillante' Flour

[EN] Because of the nutritional need of patients with celiac disease, producing quality gluten-free diet food is important. This study evaluated the use of persimmon flour on the properties of muffins. Persimmon flour obtained from the astringent variety 'Rojo Brillante', which is often discarded due to its characteristic astringency, was added to muffins replacing corn flour (10%, 20%, and 30%). Despite the height differences between the control muffin and the muffins with persimmon flour, similar mechanical parameters were obtained. As the percentage of persimmon flour increased, the muffin color was darker, turning toward a more reddish hue, mainly because of the intensification of nonenzymatic browning reactions. The sensory results showed high scores for taste attributes, the texture attributes were similar to the control, and astringency was hardly detected when persimmon flour was used. The content of tannins and carotenoids and their antioxidant activity increased significantly with an increasing amount of persimmon flour. After in vitro digestion, high recovery index values of soluble tannins and carotenoids were obtained in muffins with added persimmon flour. This study shows that the use of persimmon flour as a functional ingredient offers an opportunity to develop quality gluten-free muffins that reduce agricultural losses. Astringent varieties can be used, without applying a de-astringency treatment, as the astringency is removed during muffin baking due to tannins' insolubilization.This research was funded by MCIN/AEI/10.13039/501100011033, and by "ERDF A way of making Europe" grant number RTA2017-00045-C02-02.Hosseininejad, S.; Larrea Santos, V.; Moraga Ballesteros, G.; Hernando Hernando, MI. (2022). Evaluation of the Bioactive Compounds, and Physicochemical and Sensory Properties of Gluten Free Muffins Enriched with Persimmon 'Rojo Brillante' Flour. Foods. 11(21):1-13. https://doi.org/10.3390/foods11213357113112

MAC-Oriented Programmable Terahertz PHY via Graphene-based Yagi-Uda Antennas

Graphene is enabling a plethora of applications in a wide range of fields due to its unique electrical, mechanical, and optical properties. In the realm of wireless communications, graphene shows great promise for the implementation of miniaturized and tunable antennas in the terahertz band. These unique advantages open the door to new reconfigurable antenna structures which, in turn, enable novel communication protocols at different levels of the stack. This paper explores both aspects by, first, presenting a terahertz Yagi-Uda-like antenna concept that achieves reconfiguration both in frequency and beam direction simultaneously. Then, a programmable antenna controller design is proposed to expose the reconfigurability to the PHY and MAC layers, and several examples of its applicability are given. The performance and cost of the proposed scheme is evaluated through full-wave simulations and comparative analysis, demonstrating reconfigurability at nanosecond granularity with overheads below 0.02 mm$^{2}$ and 0.2 mW.Comment: Accepted for presentation in IEEE WCNC '1

The effect of intravenous metoclopramide on pain, nausea, discomfort, and ease of insertion of nasogastric tube in emergency department: a double-blind randomized clinical trial

Background: Placement of nasogastric tube (NGT) is a routine procedure in the emergencydepartments, which can be uncomfortable, painful, and cause nausea. The aim of this study was to investigate the effect of intravenous metoclopramide on the ease of NGT insertion, as well as reduction of patients’ pain, nausea, and discomfort during NGT insertion in the emergency department.Methods: In this randomized, double-blind, placebo-controlled trial, 80 patients referred to Imam Khomeini Hospital, Mazandaran Province, Iran were enrolled. Data were collected from December 2015 to March 2016. Participants were selected via convenience sampling and randomly divided into two equal groups (placebo and intervention groups). In metoclopramide and placebo groups, 10 mg of metoclopramide and 10 mg of normal saline solution were administered, respectively. All of the NGT was inserted 15–20 mins after the intravenous infusion. Patient-reported pain, discomfort, and nausea were evaluated using visual analogue scale (VAS), at four time points including before (T0), immediately (T1), 30 min after (T2), and 1hr after the NGT placement (T3). The ease of NGT insertion was evaluated as easy, moderate, and difficult to pass.Results: None of the patients had pain, nausea, and discomfort in T0. Additionally, for those who received intravenous metoclopramide, pain intensity significantly decreased compared with the placebo group in T1 (37.7 vs 55.0), T2 (26.2 vs 41.7), and T3 (20.5 vs 33.7), respectively (P < 0.001). Nausea intensity decreased significantly over time among patients in the interventiongroup compared with the placebo group in T1 (32.7 vs 43.2), T2 (19.5 vs 31.2), and T3 (9.0 vs 21.7), respectively (P < 0.001). The intensity of patients’ discomfort decreased significantlyamong patients in the intervention group compared with the placebo group in T1 (39.5 vs 54.0), T2 (28.7 vs 40.2), and T3 (26.2 vs 39.6), respectively (P < 0.001). Patients in the intervention group had easier placement of NGT compared with the placebo group (Easy: 40.0% vs 0.0%, Moderate: 45.0% vs 62.5%, and Difficult: 15.0% vs 37.5%; P < 0.001).Conclusion: Based on the results of the present study, it seems that intravenous metoclopramide can be used as a promising modality for improving the ease of NGT placement and reducing patients’ pain, nausea, and discomfort during NGT insertion in the emergency department

Assessment of postural response after sudden perturbation in subjects with genu valgum

زمینه و هدف: بد شکلی های وضعیتی اندام تحتانی به عنوان عاملی که در ترتیب قرار گیری بخش های مختلف بدن نسبت به یکدیگر تغییراتی ایجاد می کند، مورد توجه می باشد. حفظ تعادل بدن، می تواند از این تغییرات که راستای طبیعی وضعیت بدنی را بر هم می زند، متاثر گردد. هدف این تحقیق ارزیابی پاسخ وضعیتی و فعالیت الکترومایوگرافی سطحی منتخبی از عضلات اندام تحتانی افراد دارای زانوی والگوس یا ضربدری برای بازیابی تعادل بدن، هنگام مواجهه با اغتشاش ناگهانی بیرونی می‌باشد. روش بررسی: در این مطالعه مورد-شاهدی، شانزده فرد مبتلا به زانوی ضربدری به روش در دسترس و شانزده فرد با ساختار قامتی نرمال در اندام تحتانی و زانو با توجه به همتا سازی دو گروه، انتخاب شدند. جابجایی مرکز فشار پاها (COP) و فعالیت الکترومایوگرافی منتخبی از عضلات اندام تحتانی پس از اعمال اغتشاش ناگهانی اندازه گیری و ثبت شد. برای تجزیه و تحلیل داده ها از t مستقل استفاده شد. یافته ها: جابجایی مرکز فشار پاها به طور معنی داری در گروه آزمون با زانوی ضربدری نسبت به گروه کنترل بیشتر بود (05/0

A 33-day-old Infant with the Transposition of the Great Arteries; A Rare Case Report

Dextro-transposition of the great arteries (d-TGA) is the one most common cyanotic congenital heart disease in neonates. The discordant ventriculoarterial arrangement results in parallel circulation, it so is vital to understand the management. We report a rare interesting but critical case of 33-day-old boy who developed cyanosis and had transposition of great arteries combined with interrupted aortic arch (IAA), diagnosed as d-TGA, and describe the entire interventional management. The patient underwent surgical correction of the transfection and defects

The Effect of Intravenous Metoclopramide on Pain, Nausea, Discomfort, and Ease of Insertion of Nasogastric Tube in Emergency Department: A Double-blind Randomized Clinical Trial

Background: Placement of nasogastric tube (NGT) is a routine procedure in the emergency departments, which can be uncomfortable, painful, and cause nausea. The aim of this study was to investigate the effect of intravenous metoclopramide on the ease of NGT insertion, as well as reduction of patients’ pain, nausea, and discomfort during NGT insertion in the emergency department. Methods: In this randomized, double-blind, placebo-controlled trial, 80 patients referred to Imam Khomeini Hospital, Mazandaran Province, Iran were enrolled. Data were collected from December 2015 to March 2016. Participants were selected via convenience sampling and randomly divided into two equal groups (placebo and intervention groups). In metoclopramide and placebo groups, 10 mg of metoclopramide and 10 mg of normal saline solution were administered, respectively. All of the NGT was inserted 15–20 mins after the intravenous infusion. Patient-reported pain, discomfort, and nausea were evaluated using visual analogue scale (VAS), at four time points including before (T0), immediately (T1), 30 min after (T2), and 1 hr after the NGT placement (T3). The ease of NGT insertion was evaluated as easy, moderate, and difficult to pass. Results: None of the patients had pain, nausea, and discomfort in T0. Additionally, for those who received intravenous metoclopramide, pain intensity significantly decreased compared with the placebo group in T1 (37.7 vs 55.0), T2 (26.2 vs 41.7), and T3 (20.5 vs 33.7), respectively (P < 0.001). Nausea intensity decreased significantly over time among patients in the intervention group compared with the placebo group in T1 (32.7 vs 43.2), T2 (19.5 vs 31.2), and T3 (9.0 vs 21.7), respectively (P < 0.001). The intensity of patients’ discomfort decreased significantly among patients in the intervention group compared with the placebo group in T1 (39.5 vs 54.0), T2 (28.7 vs 40.2), and T3 (26.2 vs 39.6), respectively (P < 0.001). Patients in the intervention group had easier placement of NGT compared with the placebo group (Easy: 40.0% vs 0.0%, Moderate: 45.0% vs 62.5%, and Difficult: 15.0% vs 37.5%; P < 0.001). Conclusion: Based on the results of the present study, it seems that intravenous metoclopramide can be used as a promising modality for improving the ease of NGT placement and reducing patients’ pain, nausea, and discomfort during NGT insertion in the emergency department

DETERMINATION OF FUNCTIONAL GROUPS IN DIFFERENT LEVELS IN RUNNING GAIT; LOWER LIMB MECHANICAL ENERGY ANALYSIS

The purpose of this study was to determine the functional groups in different levels during stance phase of running. 118 students (58 males and 60 females) ran in two footwear conditions (Nike free5 and Vibram FiveFingers shoes) and barefoot. Mechanical energy of pelvic, thigh, leg and right foot were calculated. Functional groups were determined using principal component analysis, self-organizing maps, k-means clustering and support vector machine methods based on lower limb mechanical energy. Five first level functional groups were defined in barefoot, Nike and FiveFinger running conditions with accuracy of 95.80%, 91.60% and 91.60%, respectively. 41 subjects were identified as the third level functional groups. According to our results, the functional groups were well recognized with the use of dimension reduction and unsupervised clustering methods

Diagnostic Accuracy of Ascites Fluid Gross Appearance in Detection of Spontaneous Bacterial Peritonitis

Introduction: Spontaneous bacterial peritonitis (SBP) as a monomicrobial infection of ascites fluid is one of the most important causes of morbidity and mortality in cirrhotic patients. This study was aimed to determine the diagnostic accuracy of ascites fluid color in detection of SBP in cirrhotic cases referred to the emergency department. Methods: Cirrhotic patients referred to the ED for the paracentesis of ascites fluid were enrolled. For all studied patients, the results of laboratory analysis and gross appearance of ascites fluid registered and reviewed by two emergency medicine specialists. The sensitivity, specificity, positive and negative predictive value, and positive and negative likelihood ration of the ascites fluid gross appearance in detection of SBP were measured with 95% confidence interval. Results: The present project was performed in 80 cirrhotic patients with ascites (52.5 female). The mean of the subjects’ age was 56.25±12.21 years (35-81). Laboratory findings revealed SBP in 23 (29%) cases. Fifty nine (73%) cases had transparent ascites fluid appearance of whom 17 (29%) ones suffered from SBP. From 21 (26%) cases with opaque ascites appearance, 15 (71%) had SBP. The sensitivity and specificity of the ascites fluid appearance in detection of SBP were 46.88% (Cl: 30.87-63.55) and 87.50% (95% Cl: 75.3-94.14), respectively. Conclusion: It seems that the gross appearance of ascites fluid had poor diagnostic accuracy in detection of SBP and considering its low sensitivity, it could not be used as a good screening tool for this propose

Study of hybrid and pure plasmonic terahertz antennas based on graphene guided-wave structures

Graphene is a unique material for the implementation of terahertz antennas due to extraordinary properties of the resulting devices, such as tunability and compactness. Existing graphene antennas are based on pure plasmonic structures, which are compact but show moderate to high losses. To achieve higher efficiency with low cost, one can apply the theory behind dielectric resonator antennas widely used in millimeter-wave systems. This paper presents the concept of hybridization of surface plasmon and dielectric wave modes. Then, via an analysis of one-dimensional structures, a comparison of the potential capabilities of pure and hybrid plasmonic antennas is performed from the perspectives of radiation efficiency, tunability, and miniaturization. Additionally, the impact of the quality of graphene upon the performance of the compared structures is evaluated. On the one hand, results show that hybrid structures deliver high gain with moderate miniaturization and tunability, rendering them suitable for applications requiring a delicate balance between the three aspects. On the other hand, pure plasmonic structures can provide higher miniaturization and tunability, yet with low efficiency, suggesting their use for application domains with high flexibility requirements or stringent physical constraints.Author's final draf