Maternal protein-energy supplementation does not affect adolescent blood pressure in The Gambia.

BACKGROUND: Birthweight, and by inference maternal nutrition during pregnancy, is thought to be an important determinant of offspring blood pressure but the evidence base for this in humans is lacking data from randomized controlled trials. METHODS: The offspring from a maternal prenatal protein-energy supplementation trial were enrolled into a follow-up study of chronic disease risk factors including blood pressure. Subjects were 11-17 years of age and blood pressure was measured in triplicate using an automated monitor (Omron 705IT). One-thousand two-hundred sixty seven individuals (71% of potential participants) were included in the analysis. RESULTS: There was no difference in blood pressure between those whose mothers had consumed protein-energy biscuits during pregnancy and those whose mothers had consumed the same supplement post-partum. For systolic blood pressure the intention-to-treat regression coefficient was 0.46 (95% CI: -1.12, 2.04). Mean systolic blood pressure for control children was 110.2 (SD +/- 9.3) mmHg and for intervention children was 110.8 (SD +/- 8.8) mmHg. Mean diastolic blood pressure for control children was 64.7 (SD +/- 7.7) mmHg and for intervention children was 64.6 (SD +/- 7.6) mmHg. CONCLUSIONS: We have found no association between maternal prenatal protein-energy supplementation and offspring blood pressure in adolescence amongst rural Gambians. We found some evidence to suggest that offspring body composition may interact with the effect of maternal supplementation on blood pressure

Governance, Coordination and Evaluation: the case for an epistemological focus and a return to C.E. Lindblom

While much political science research focuses on conceptualizing and analyzing various forms of governance, there remains a need to develop frameworks and criteria for governance evaluation (Torfing et al 2012). The post-positivist turn, influential in recent governance theory, emphasizes the complexity, uncertainty and the contested normative dimensions of policy analysis. Yet a central evaluative question still arises concerning the capacity of governance networks to facilitate ‘coordination’. The classic contributions of Charles Lindblom, although pre-dating the contemporary governance literature, can enable further elaboration of and engagement with this question. Lindblom’s conceptualisation of coordination challenges in the face of complexity shares with post-positivism a recognition of the inevitably contested nature of policy goals. Yet Lindblom suggests a closer focus on the complex, dynamically evolving, broadly ‘economic’ choices and trade-offs involved in defining and delivery policy for enabling these goals to be achieved and the significant epistemological challenges that they raise for policy-makers. This focus can complement and enrich both post-positivist scholarship and the process and incentives-orientated approaches which predominate in contemporary political science research on coordination in governance. This is briefly illustrated through a short case study evaluating governance for steering markets towards delivering low and zero carbon homes in England

The problem of gender categorisation: addressing dilemmas past and present in gender and education research

Developments in the field of gender theory as applied to education since the 1970s are briefly reviewed in order to highlight key challenges and debates around gender categorisation and identification in gender and education. We argue that conundrums of categorisation have haunted, and continue to haunt, the field of gender theory, and empirical applications (such as the case of education) in particular. We explain how we have attempted to address some of the conundrums arising in our own theoretical work, and analyse remaining challenges that we feel the field of education needs to address in order to advance theoretically. Identifying two key tensions underpinning this empirical dilemma of gender categorisation – the tension between agency and determinism in gender identification, and that between gender deconstruction and gender analysis – we seek to weave a path through some of these complex debates, and to indicate ways in which they may be addressed in future work. We argue that in order to avoid essentialism and reification of gender distinction, we need to apply a ‘three-fold’ analysis that incorporates three different elements in our categorisation of gender: spectator perspective; respondent perspective and social context

Fore-arc deformation and underplating at the northern Hikurangi margin, New Zealand

Geophysical investigations of the northern Hikurangi subduction zone northeast of New Zealand, image fore‐arc and surrounding upper lithospheric structures. A seismic velocity (Vp) field is determined from seismic wide‐angle data, and our structural interpretation is supported by multichannel seismic reflection stratigraphy and gravity and magnetic modeling. We found that the subducting Hikurangi Plateau carries about 2 km of sediments above a 2 km mixed layer of volcaniclastics, limestone, and chert. The upper plateau crust is characterized by Vp = 4.9–6.7 km/s overlying the lower crust with Vp > 7.1 km/s. Gravity modeling yields a plateau thickness around 10 km. The reactivated Raukumara fore‐arc basin is >10 km deep, deposited on 5–10 km thick Australian crust. The fore‐arc mantle of Vp > 8 km/s appears unaffected by subduction hydration processes. The East Cape Ridge fore‐arc high is underlain by a 3.5 km deep strongly magnetic (3.3 A/m) high‐velocity zone, interpreted as part of the onshore Matakaoa volcanic allochthon and/or uplifted Raukumara Basin basement of probable oceanic crustal origin. Beneath the trench slope, we interpret low‐seismic‐velocity, high‐attenuation, low‐density fore‐arc material as accreted and recycled, suggesting that underplating and uplift destabilizes East Cape Ridge, triggering two‐sided mass wasting. Mass balance calculations indicate that the proposed accreted and recycled material represents 25–100% of all incoming sediment, and any remainder could be accounted for through erosion of older accreted material into surrounding basins. We suggest that continental mass flux into the mantle at subduction zones may be significantly overestimated because crustal underplating beneath fore‐arc highs have not properly been accounted for

Seismic and geochemical evidence for large-scale mantle upwelling beneath the eastern Atlantic and western and central Europe

Seismic tomography and the isotope geochemistry of Cenozoic volcanic rocks suggest the existence of a large, sheet-like region of upwelling in the upper mantle which extends from the eastern Atlantic Ocean to central Europe and the western Mediterranean. A belt of extension and rifting in the latter two areas appears to lie above the intersection of the centre of the upwelling region with the base of the lithosphere. Lead, strontium and neodymium isotope data for all three regions converge on a restricted composition, inferred to be that of the upwelling mantle

A qualitative investigation into the impact of domestic abuse on women’s desistance

While criminological literature, criminal justice practice, and to a lesser extent, state policy have acknowledged a link between women’s criminalisation and gendered violence (MoJ, 2018; Österman, 2018; Prison Reform Trust, 2017; Roberts, 2015), there has been much less acknowledgement of the role of historical and contemporaneous experiences of violence in the desistance scripts of criminalised women. Combining findings from two research projects exploring gender and desistance, this article argues that (i) criminalised women’s experiences of gendered violence are such that any exploration of gender and desistance which does not acknowledge this is incomplete, (ii) coercion and control can inform women’s entry into the criminal justice system, (iii) expressions of agency and resistance in abusive interpersonal relationships can also inform women’s offending, yet (iv) women’s experiences of desistance from crime can mask the harm they face in coercive, controlling, and violent relationships. Thus, the article argues for a reframing of desistance from crime as desistance from harm both theoretically and in practice, and considers what this might entail

The History, Relevance, and Applications of the Periodic System in Geochemistry

Geochemistry is a discipline in the earth sciences concerned with understanding the chemistry of the Earth and what that chemistry tells us about the processes that control the formation and evolution of Earth materials and the planet itself. The periodic table and the periodic system, as developed by Mendeleev and others in the nineteenth century, are as important in geochemistry as in other areas of chemistry. In fact, systemisation of the myriad of observations that geochemists make is perhaps even more important in this branch of chemistry, given the huge variability in the nature of Earth materials – from the Fe-rich core, through the silicate-dominated mantle and crust, to the volatile-rich ocean and atmosphere. This systemisation started in the eighteenth century, when geochemistry did not yet exist as a separate pursuit in itself. Mineralogy, one of the disciplines that eventually became geochemistry, was central to the discovery of the elements, and nineteenth-century mineralogists played a key role in this endeavour. Early “geochemists” continued this systemisation effort into the twentieth century, particularly highlighted in the career of V.M. Goldschmidt. The focus of the modern discipline of geochemistry has moved well beyond classification, in order to invert the information held in the properties of elements across the periodic table and their distribution across Earth and planetary materials, to learn about the physicochemical processes that shaped the Earth and other planets, on all scales. We illustrate this approach with key examples, those rooted in the patterns inherent in the periodic law as well as those that exploit concepts that only became familiar after Mendeleev, such as stable and radiogenic isotopes

Early influences on cardiovascular and renal development

The hypothesis that a developmental component plays a role in subsequent disease initially arose from epidemiological studies relating birth size to both risk factors for cardiovascular disease and actual cardiovascular disease prevalence in later life. The findings that small size at birth is associated with an increased risk of cardiovascular disease have led to concerns about the effect size and the causality of the associations. However, recent studies have overcome most methodological flaws and suggested small effect sizes for these associations for the individual, but an potential important effect size on a population level. Various mechanisms underlying these associations have been hypothesized, including fetal undernutrition, genetic susceptibility and postnatal accelerated growth. The specific adverse exposures in fetal and early postnatal life leading to cardiovascular disease in adult life are not yet fully understood. Current studies suggest that both environmental and genetic factors in various periods of life may underlie the complex associations of fetal growth retardation and low birth weight with cardiovascular disease in later life. To estimate the population effect size and to identify the underlying mechanisms, well-designed epidemiological studies are needed. This review is focused on specific adverse fetal exposures, cardiovascular adaptations and perspectives for new studies. Copyrigh