Ninth Annual Red Clay Conference

How will construction of the Mall of Georgia impact the environment? How can Atlanta\u27s traffic congestion and water system comply with the Clean Air and Clean Water Acts? What will the proposed EPA ozone standard mean for Georgia businesses? These questions and many more were examined

Mnn2 gene affects drug resistance in Candida glabratas biofilms

Eurobiofilms 2017 - 5th European Congress on Microbial BiofilmsInfections caused by Candida species have increased worldwide substantially over the latest decades, and are a significant cause of morbidity and mortality, mostly among critically ill patients. Candida glabrata is the second most common Candida responsible for these infections in the USA and the third in Europe, and is characterized by a high antifungal resistance. The goal of this study was to understand the role of mannans in C. glabrata biofilms and in biofilm cells resistance to antifungal drugs (fluconazole - Flu, amphotericin B - AmB, caspofungin - Csf and micafungin - Mcf)This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norteinfo:eu-repo/semantics/publishedVersio

Nuclear Physics Neutrino PreTown Meeting: Summary and Recommendations

In preparation for the nuclear physics Long Range Plan exercise, a group of 104 neutrino physicists met in Seattle September 21-23 to discuss both the present state of the field and the new opportunities of the next decade. This report summarizes the conclusions of that meeting and presents its recommendations. Further information is available at the workshop's web site. This report will be further reviewed at the upcoming Oakland Town Meeting.Comment: Latex, 31 pages. This version has been updated to include final Comments from the working group

Misperceived pre-pregnancy body weight status predicts excessive gestational weight gain: findings from a US cohort study

<p>Abstract</p> <p>Background</p> <p>Excessive gestational weight gain promotes poor maternal and child health outcomes. Weight misperception is associated with weight gain in non-pregnant women, but no data exist during pregnancy. The purpose of this study was to examine the association of misperceived pre-pregnancy body weight status with excessive gestational weight gain.</p> <p>Methods</p> <p>At study enrollment, participants in Project Viva reported weight, height, and perceived body weight status by questionnaire. Our study sample comprised 1537 women who had either normal or overweight/obese pre-pregnancy BMI. We created 2 categories of pre-pregnancy body weight status misperception: normal weight women who identified themselves as overweight ('overassessors') and overweight/obese women who identified themselves as average or underweight ('underassessors'). Women who correctly perceived their body weight status were classified as either normal weight or overweight/obese accurate assessors. We performed multivariable logistic regression to determine the odds of excessive gestational weight gain according to 1990 Institute of Medicine guidelines.</p> <p>Results</p> <p>Of the 1029 women with normal pre-pregnancy BMI, 898 (87%) accurately perceived and 131 (13%) overassessed their weight status. 508 women were overweight/obese, of whom 438 (86%) accurately perceived and 70 (14%) underassessed their pre-pregnancy weight status. By the end of pregnancy, 823 women (54%) gained excessively. Compared with normal weight accurate assessors, the adjusted odds of excessive gestational weight gain was 2.0 (95% confidence interval [CI]: 1.3, 3.0) in normal weight overassessors, 2.9 (95% CI: 2.2, 3.9) in overweight/obese accurate assessors, and 7.6 (95% CI: 3.4, 17.0) in overweight/obese underassessors.</p> <p>Conclusion</p> <p>Misperceived pre-pregnancy body weight status was associated with excessive gestational weight gain among both normal weight and overweight/obese women, with the greatest likelihood of excessive gain among overweight/obese underassessors. Future interventions should test the potential benefits of correcting misperception to reduce the likelihood of excessive gestational weight gain.</p

UK National Ecosystem Assessment Follow-on. Work package 7: Operationalising scenarios in the UK National Ecosystem Assessment Follow-on

Summary Study aims and approach An aim of the UK NEA Follow-on (UK NEAFO) is to develop and communicate the evidence base of the UK NEA and make it relevant to decision and policy making. It also provides an important opportunity for those working on scenario methods and concepts to scrutinise the role of futures thinking in the management of ecosystem services and so develop their effectiveness as decision support tools. In this study we have therefore asked: how can the UK NEA scenarios help us to understand, manage and communicate the consequences of changes in ecosystem services across all scales? There are many different understandings about what scenarios are, and what they should be used for. To clarify the issues surrounding the role of scenarios, we have approached this work from two angles. We have firstly looked at the way the storylines can support decision making processes. Secondly, we have looked at the content of the scenarios themselves and explored how through the use of models the UK NEA scenarios as products might be refined to enhance their value as analytical tools. Scenarios in Action We used the opportunity of a series of meetings with stakeholders to develop the UK NEA scenarios from a process perspective. These meetings took various forms, but throughout the main aim was to find out whether people found the scenarios sufficiently believable, challenging and relevant. In workshops organised by the scenario team in Leeds, Edinburgh and Belfast, we worked with participants on a series of tasks designed to help them immerse themselves in the scenarios and reflect on them critically. While those we worked with had many comments about the scenarios in detail, the evidence we collected from these meetings suggests that the majority of people found the scenarios to be plausible and the projections consistent. The majority also agreed with the proposition that the suite of scenarios as a whole addressed a relevant ranges of issues. We explored with the workshop participants several ways in which the storylines could be enriched, by: developing the narrative about the way people might live in the different scenario worlds; developing time-lines for the scenarios; thinking more deeply about regional and local differences; and, exploring how the scenarios would frustrate or facilitate the embedding of the ecosystem approach in decision making. We found that while all of these elements had value in terms of stimulating discussion and understanding of the scenarios, they were not needed in order to address deficiencies in the original storylines in terms of plausibility or credibility. The evidence we collected therefore suggests that the existing narratives are probably sufficient as an entry point for discussions about the future of ecosystem services in the UK. What was apparent from the observations that we made in the workshops was that it would probably be a mistake to ‘over-engineer’ or ‘over-specify’ the narratives because there needs to be room for discussion and probing. We were struck how people took the existing scenarios and found new features and ideas in them than had not been identified by in the original work. For example, in one session National Security, with its emphasis on resource efficiency, was found to be ‘greener’ than it initially looks. In another Local Stewardship was discovered to need some degree of central control and regulation to work efficiently. These kinds of discussion are evidence of the reflection, deliberation and social learning that can be promoted by using the UK NEA scenarios. UK NEAFO Work Package 7: Operationalising scenarios 7 In the workshop we organised in Belfast we found that the presentation of the scenarios could be tailored to a specific region (i.e. Northern Ireland) and, through area-specific breakout groups during the workshop, to specific localities within it. However, our experiences here emphasised the need for considerable preparation, consultation with the stakeholder community, and changing of the workshop format to make the scenarios intelligible and engaging to local stakeholders. Work on the use of the scenarios in a more explicit decision support role will be reported via the work on response options (WP8), which considered how they could be used to ‘stress-test’ policy response options. The experience gained from the work undertaken in the early stages of UK NEAFO was that the scenarios appeared to provide a suitable platform for the work, but that the stresstesting methodology needed to be refined. During the follow-on we have also interviewed policy leads in Defra, for example, to gain a better picture of policy needs, and the way scenarios might usefully serve them. Apart from the challenge of ‘relevance’ it is clear that the time needed for people to work with scenarios probably means that they are less useful to policy customers in the context of their everyday work but can be useful at a very broad and strategic level. However, there is clearly an opportunity for scenarios to be used more extensively through commissioned work. The importance of commissioned work has been emphasised during the follow-on phase by invitations to observe the work of the CAMERAS1 work in Scotland, and the Noise Study being undertaken for Defra. Both are actively using the UK NEA scenarios. The outcomes of these on-going studies will be reported elsewhere by others. Nevertheless, even though these projects are at a preliminary stage they help us better understand how scenarios can be used to communicate the consequences of changes in ecosystem services to different groups and individuals. Scenarios as products: developing the model base The UK NEA scenarios were initially used to make both qualitative and quantitative projections. The quantitative work mainly involved modelling how land cover would change under the different scenarios (Haines-Young et al. 2011). Although these data were used to make an analysis of the changes in marginal economic values for some ecosystem services during the initial phase of the UK NEA, they have not been fully exploited. At the time it was recognised that there were many gaps in our understanding of the links between land cover and ecosystem services; UK NEAFO has provided the opportunity to address some of these deficiencies. Thus in the follow-on work we have sought to extend the range of models that can be used to explore the UK NEA scenarios. The modelling work has not sought to change the scenarios fundamentally, but to enrich the insights that can be derived from exploring the differences between them in a systematic, and quantitative way. The goal, has been to extend the analysis that can be built up around the narratives and hence enrich the scenarios as ‘products’. Four topic areas were selected as the focus for this work: flood and drought risk (based on an analysis of changes in river flows), biodiversity (farmland birds), marine and cultural ecosystem services. Catchment modelling We looked at the effects of land-use change on river flows under each of the UK NEA scenarios. We modelled hydrological discharge within 34 UK catchments and calculated four hydrological indicators for each catchment: average annual discharge, flood hazard, and Q5 and Q95 (measures of the magnitude of unusually high (Q5) and unusually low (Q95) flows). For our flood hazard indicator we calculated the interval between floods of a size currently occurring every 30 years. Although we kept climate constant in the models, as we wanted to isolate the effects of land cover change, we ran them for both the high and low climate change land cover variants for each scenario. 1 A Coordinated Agenda for Marine, Environment and Rural Affairs Science, 2011-2016. http://www.scotland.gov.uk/Topics/Research/About/EBAR/CAMERASsite In general, the ‘green’ scenarios, Nature@Work and Green and Pleasant Land, as well as National Security, were associated with lower flows than currently occur (when measured using any of the four indicators). However, for a given scenario there was a great deal of variability between catchments in terms of the size and statistical significance of the differences. The magnitude of change across all scenarios and catchments ranged from -13% to 6% for average annual discharge, -14 to 7% for Q5, -24 to 27 % for Q95 and -16 to 36 years for flood hazard. Differences were particularly evident between Nature@Work and World Markets, with the latter associated with higher flows than occur currently, and the majority of the statistically significant increased flows. Some catchments showed significant changes that were different in sign between these two scenarios. Taken together, our results indicate that that in managing change a balance needs to be struck between alleviating the likelihoods of increased drought and increased flooding, depending on the likely effects of these phenomena in the catchment. Farmland birds We looked at the relationship between land use data produced during the first phase of the UK NEA and models of farmland bird populations, in 1kmx1km squares covered by the Breeding Bird Survey (BBS) and Winter Farmland Bird Survey (WFBS). We used Functional Space Models to estimate the annual population growth rate under each scenario of each of the 19 farmland bird species used to calculate the farmland bird index (Gregory et al. 2004). We used this to look at the relationship between land use under the scenarios and: i) the average population growth rate for all 19 species, and ii) a subset of 11 species showing declining population trends under current land use. Overall we found that land use change across the scenarios had relatively little impact. However, the only statistically significant change was for declining species under Green and Pleasant Land, where population growth rates became significantly more negative. We used Mechanistic Models to estimate the number of over-winter ‘bird-days’ for two types of seed-eating farmland birds, a yellowhammer-type and linnet-type These species were chosen because they differ in their food preferences with respect to cereal, oil and weed seeds, but between them are representative of the diversity of seed-eating farmland birds as a whole. We found a significant decline in the ecological value of lowland agricultural areas for these species across all UK NEA scenarios, but the greatest impact was for scenarios with the highest monetised values for ecosystem services, as measured by the first phase of the UK NEA (Nature@Work, Green and Pleasant Land). This appears to be due to the fact that, compared with the baseline, the area of arable crops declines most sharply under these scenarios, due partly to changes in land use but also because of conversion of arable land to other habitats important for ecosystem services (e.g. woodland). Taken together these results imply a trade-off between overall value for ecosystem services and conservation of farmland birds, and highlight the need to consider the specific impacts of land use change on biodiversity, alongside other ecosystem services. Marine ecosystem services Only a limited attempt was made to model marine ecosystem services during the first phase of the UK NEA. In the follow-on we have conducted preliminary work to produce spatially explicit models for three important marine ecosystem services: fisheries landings, aquaculture production and carbon sequestration. We made comparisons between baseline data and time slices for 2015, 2030 UK NEAFO Work Package 7: Operationalising scenarios 9 and 2060 under four of the UK NEA scenarios that were considered most relevant for the sector, and mapped these across UK territorial waters. There is a high degree of uncertainty associated with the models, mainly due to a lack of suitable data and poor knowledge of the drivers of change. In many cases, in the absence of robust quantitative models, we needed to take the qualitative descriptions of the UK NEA scenarios and combine these with expert knowledge to estimate changes in the three types of ecosystem service. We estimated that in three of the four scenarios: Nature@Work, Local Stewardship and National Security, fisheries landings would be, by 2060 only slightly lower or at higher levels than they are today. Under World Markets, however, projected landings would decline significantly by 2060, due to a lack of regulation combined with high levels of investment from private capital. In the light of this, it was interesting that aquaculture was at higher levels under World Markets than under any of the other scenarios, although all of them showed higher levels than the baseline. This was because under this scenario more investment capital would be available to invest in fish farms. We believe that carbon sequestration would be most likely to be impacted by the World Markets and Natural Security, due to higher CO2 emissions causing an increase in ocean acidification. Our results, although tentative, mark a significant first step in attempts to map and project the impact of possible future change on marine ecosystem services. Cultural Ecosystem Services In the first phase of the UK NEA, the relationship between the drivers of change and cultural ecosystem services (CES) was mainly explored through the impact they had on land cover. For UK NEAFO, we additionally used the Monitor of Engagement for the Natural Environment (MENE) dataset. We examined how the UK NEA scenarios can be used as a framework to explore the relationship between the supply of cultural spaces in the landscape and peoples preferences for different types of natural spaces and practices in them. We have developed a Bayesian Belief Network (BBN) that allows users to explore these relationships interactively and look at the potential impacts of changes socio-demographic structure of the kind described by the UK NEA scenarios. Our spatial analysis of the MENE data showed that people tend to select locations with higher woodland cover than the average for the surroundings, when they travel intermediate distances from their home, but that this tendency declines when they travel longer distances. Woodland cover is projected to double under both Nature@Work and Green and Pleasant Land, and both provide more opportunities to visit woodland close to home than under scenarios such as World Markets. However, our analysis shows that on the basis of the current geography of people and woodlands, the way planting is targeting under Green and Pleasant Land has the potential to deliver greater joint benefits from biodiversity change and cultural ecosystem services than Nature@Work. The BBN we have developed using the HUGIN Expert software allows the relationships within the MENE data to be explored interactively; it is hosted on a prototype website that is open to the wider community. By examining the relationships between socio-demographic characteristics of the MENE respondents, the types of natural spaces they visit and the activities they do in them, this BBN tool allows users to explore the impacts of possible future change on the supply and demand of CES. Conclusion How can plausible future scenarios help understand, manage and communicate the consequences of changes in ecosystem services across all scales? In this work we have shown that they can be used to promote understanding by the deliberative processes that they engender. The UK NEA scenarios appear to be sufficiently rich and comprehensive to support debate across a wide range of topic areas relevant to current policy concerns. The scenarios can also help understanding by providing a framework in which current models can be applied and the outcome used both to test the plausibility of the scenarios themselves and to deepen the insights that can be derived from them. These analytical ‘scenario products’ can be equally important both in terms of deepening our understanding of the assumptions on which the scenarios are built and in stimulating debate about their implications. We have shown that the distinction between the ‘process’ and ‘product’ dimensions of scenario thinking is a useful one, given the many ways scenarios can be used. The distinction clarifies some of the different purposes and problems that scenarios work seeks to address. However, our work also demonstrates that both components have their strengths, and neither can be taken isolation. If we are to use scenarios to understand, manage and communicate the consequences of changes in ecosystem services across different scales and in different contexts, then targeted analytical studies developed within the qualitative framework of the UK NEA scenarios, can enrich our understanding of today’s issues and how we might respond to them

Upper Kellwasser carbon isotope excursion pre-dates the F–F boundary in the Upper Devonian Lennard shelf carbonate system, Canning Basin, Western Australia

Here we report four high-resolution carbon isotope records in addition to trace element data for the Frasnian–Famennian (F–F) boundary interval in the Lennard Shelf carbonate system of the Canning Basin, Western Australia. This region lacks the characteristic black shale horizons associated with the global Late Devonian Kellwasser extinction events, yet still exhibits a trend in carbon isotope character similar to what has been reported from elsewhere in the world (two positive δ13C excursions with ~3–4‰ amplitudes). Enrichments in select trace element ratios suggest that both excursions are related to periods of oxygen deprivation and perhaps increased biological productivity. Given the continuous and stratigraphically expanded nature of Lennard Shelf sections, together with high-density sampling constrained by both conodont biostratigraphy and magnetostratigraphy, we observe that the Upper Kellwasser isotope excursion (maximum δ13C values) and associated trace element enrichments occur distinctly lower than the F–F boundary level. These results have implications for the paleoenvironmental conditions leading up to the Late Devonian Mass Extinction in terms of ocean chemistry and circulation patterns. This data set allows for a rare, detailed look at the temporal relationship between the Kellwasser events and the F–F boundary and constrains the pattern of carbon isotope perturbations at the intra-zonal scale

Integrated stratigraphic correlation of Upper Devonian platform-to-basin carbonate sequences, Lennard Shelf, Canning Basin, Western Australia: advances in carbonate margin-to-slope sequence stratigraphy and stacking patterns

High-resolution, time-significant correlations are integral to meaningful stratigraphic frameworks in depositional systems, but may be difficult to achieve using traditional sequence stratigraphic or biostratigraphic approaches alone, particularly in geologically complex settings. In steep, reefal carbonate margin-to-slope systems, such correlations are essential to unravel shelf-to-basin transitions, characterize strike variability, and develop predictive sequence stratigraphic models – concepts which are currently poorly understood in these heterogeneous settings. The Canning Basin Chronostratigraphy Project (CBCP) integrates multiple independent datasets (including biostratigraphy, magnetostratigraphy, stable isotope chemostratigraphy, and sequence stratigraphy) extracted from Upper Devonian (Frasnian and Famennian) reefal platform exposures along the Lennard Shelf, Canning Basin, Western Australia. These were used to generate a well-constrained stratigraphic framework and shelf-to-basin composite reconstruction of the carbonate system. The resultant integrated framework allows for unprecedented analysis of carbonate margin-to-slope heterogeneity, depositional architecture, and sequence stratigraphy along the Lennard Shelf. Systems tract architecture, facies partitioning, and stacking patterns of margin to lower-slope environments were assessed for six composite-scale sequences that form part of a transgressive-to-regressive supersequence and span the Frasnian-Famennian (F-F) biotic crisis. Variations are apparent in margin styles, foreslope facies proportions, dominant resedimentation processes, downslope contributing sediment factories, and vertical rock successions, related to hierarchical accommodation signals and ecological changes associated with F-F boundary. We present these results in the form of carbonate margin-to-basin sequence stratigraphic models and associations that link seismic-scale architecture to fine-scale facies heterogeneity. These models provide a predictive foundation for characterization of steep-sided flanks of reefal carbonate platform systems that is useful for both industry and academia. This study emphasizes the utility of an integrated stratigraphic approach and the insights gained from better-constrained facies and stratal architecture analysis; insights that were not achievable with traditional sequence stratigraphic or biostratigraphic techniques alone

B844: Checklist of the Vascular Plants of Maine Third Revision

This is the third revision of the Checklist of Vascular Plants of Maine. Like its predecessors, it lists all ferns and related plants, conifers, and flowering plants native and naturalized in Maine and records their county-level distribution in the state. The first Check- list (Ogden et al. 1948) was based on specimens in herbaria at the University of Maine (hereafter referred to as MAINE), Portland Society of Natural History, New England Botanical Club, Gray Herbarium of Harvard University, and the private collection of Glen D. Chamberlain of Presque Isle, Maine (now part of MAINE). Bean et al. (1966) revised the checklist to include additions to the flora and update the nomenclature to follow Fernald (1950). Richards et al. (1983) added many new state and county records in the second revision. The purpose of this revision is twofold. First, we have included many new county and state records. Since Richards et al. (1983) there has been considerable collecting in Maine, much of it directed at searching for new state and county records in relatively neglected regions of the state. Second, there have been numerous changes in the scientific names of Maine plants since Fernald (1950), the nomenclatural basis of Richards et al. (1983). We have largely followed Kartesz\u27s (1994) nomenclature (see Taxonomy and Nomenclature section). Recent work on rare plants and establishment of an official list of endangered and threatened plants in Maine (Dibble et al. 1989; Maine State Planning Office 1990) also motivate updating the known distribution and taxonomy of Maine\u27s flora.https://digitalcommons.library.umaine.edu/aes_bulletin/1121/thumbnail.jp

SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians

To discover susceptibility genes of late-onset Alzheimer’s disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese Genetic Consortium for Alzheimer Disease (JGSCAD), Koreans, and Caucasians from the Alzheimer Disease Genetic Consortium (ADGC). In Stage 1, we evaluated data for 5,877,918 genotyped and imputed SNPs in Japanese cases (n = 1,008) and controls (n = 1,016). Genome-wide significance was observed with 12 SNPs in the APOE region. Seven SNPs from other distinct regions with p-values ,261025 were genotyped in a second Japanese sample (885 cases, 985 controls), and evidence of association was confirmed for one SORL1 SNP (rs3781834, P=7.3361027 in the combined sample). Subsequent analysis combining results for several SORL1 SNPs in the Japanese, Korean (339 cases, 1,129 controls) and Caucasians (11,840 AD cases, 10,931 controls) revealed genome wide significance with rs11218343 (P=1.7761029) and rs3781834 (P=1.0461028). SNPs in previously established AD loci in Caucasians showed strong evidence of association in Japanese including rs3851179 near PICALM (P=1.7161025) and rs744373 near BIN1 (P = 1.3961024). The associated allele for each of these SNPs was the same as in Caucasians. These data demonstrate for the first time genome-wide significance of LOAD with SORL1 and confirm the role of other known loci for LOAD in Japanese. Our study highlights the importance of examining associations in multiple ethnic populations

Counter-intelligence in a command economy

This article provides the first thick description of the counter-intelligence function in a command economy of the Soviet type. Based on documentation from Soviet Lithuania, the article considers the KGB (secret police) as a market regulator, commissioned to prevent the disclosure of secret government business and forestall the disruption of government plans. Where market regulation in open societies is commonly intended to improve market transparency, competition, and fair treatment of consumers and employees, KGB regulation was designed to enforce secrecy, monopoly, and discrimination. One consequence of KGB regulation of the labour market may have been adverse selection for talent. Here it is argued that the Soviet economy was designed to minimize costs