7 research outputs found
Erstellung einer radargestĂŒtzten Niederschlagsklimatologie
Es ist Konsens in der Klimaforschungsgemeinschaft, dass der globale
Klimawandel mit groĂer Wahrscheinlichkeit mit einer erhöhten HĂ€ufigkeit von
witterungsbedingten Naturkatastrophen einhergeht [IPCC, 2011]. Grundlage fĂŒr
diese Schlussfolgerung sind im Wesentlichen die Ergebnisse globaler und
regionaler Klimasimulationen. Neben WindstĂŒrmen sind insbesondere Auftreten
und HĂ€ufigkeit von hydrometeorologischen Extremereignissen wie z. B.
Starkregen oder DĂŒrre ursĂ€chlich fĂŒr korrespondierende Naturkatastrophen, die
fĂŒr den Katastrophenschutz relevant sind. So sind die Anzahl von
UmwelteinsÀtzen der Feuerwehr im Nachgang von Extremereignissen wie Starkregen
oder Hagel [Geier, 2009] sowie die Zahl der wetterbedingten EinsÀtze des
Technischen Hilfswerks in den vergangenen Jahren gestiegen [Strotmann, 2011].
Dieser Trend wird von einer Befragung der im Katastrophenschutz eingebundenen
Organisationen bestÀtigt, nach deren Ergebnissen neben Sturmereignissen vor
allem Hochwasser vermehrt EinsÀtze nach sich ziehen
New Research Opportunities by Open Data: Open Source GIS meets the DWD Open Data Portal
A conference poster (EaPEC 2018) highlighting the new opportunities for (citizen) science enabled by open source software tools and open data provided by DWD
Characteristic spatial extent of hourly and daily precipitation events in Germany derived from 16Â years of radar data
Neue radarbasierte Produkte des DWD zum prÀventiven Starkregenrisikomanagement in Deutschland
Cadmium and decabrominated diphenyl ether mixture: In vitro evaluation of cytotoxic, prooxidative and genotoxic effects
Galectin-1 and Its Involvement in Hepatocellular Carcinoma Aggressiveness
Hepatocellular carcinoma is one of the most common cancers worldwide. Despite several efforts to elucidate hepatocellular carcinoma molecular pathogenesis, it is still not fully understood. To acquire further insights into the molecular mechanisms of hepatocellular carcinoma, we performed a systematic functional genomic approach on human HuH-7 and JHH-6 cells. The subsequent analysis of the differentially expressed genes in human specimens revealed a molecular signature of 11 genes from which we selected the LGALS1 gene, which was overexpressed in hepatocellular carcinoma. The expression analysis in humans of Galectin-1 (Gal-1), the protein encoded by LGALS1, showed a Gal-1 preferential accumulation in the stromal tissue around hepatocellular carcinoma tumors. Moreover, a significant association between increased expression of Gal-1 in hepatocellular carcinoma and the presence of metastasis was observed. Interestingly, Gal-1 overexpression resulted in an increase of cell migration and invasion. In conclusion, this study provides a portfolio of targets useful for future investigations into molecular markerâdiscovery studies on a large number of patients and functional assays. In addition, our data provide evidence that Gal-1 plays a role in hepatocellular carcinoma cell migration and invasion, and we suggest that further studies should be conducted to fully establish the role of Gal-1 in hepatocellular carcinoma pathogenesis and evaluate Gal-1 as a potential molecular therapeutic target