The association of statin use after cancer diagnosis with survival in pancreatic cancer patients: a SEER-medicare analysis.

BackgroundPancreatic cancer has poor prognosis and existing interventions provide a modest benefit. Statin has anti-cancer properties that might enhance survival in pancreatic cancer patients. We sought to determine whether statin treatment after cancer diagnosis is associated with longer survival in those with pancreatic ductal adenocarcinoma (PDAC).MethodsWe analyzed data on 7813 elderly patients with PDAC using the linked Surveillance, Epidemiology, and End Results (SEER) - Medicare claims files. Information on the type, intensity and duration of statin use after cancer diagnosis was extracted from Medicare Part D. We treated statin as a time-dependent variable in a Cox regression model to determine the association with overall survival adjusting for follow-up, age, sex, race, neighborhood income, stage, grade, tumor size, pancreatectomy, chemotherapy, radiation, obesity, dyslipidemia, diabetes, chronic pancreatitis and chronic obstructive pulmonary disease (COPD).ResultsOverall, statin use after cancer diagnosis was not significantly associated with survival when all PDAC patients were considered (HR = 0.94, 95%CI 0.89, 1.01). However, statin use after cancer diagnosis was associated with a 21% reduced hazard of death (Hazard ratio = 0.79, 95% confidence interval (CI) 0.67, 0.93) in those with grade I or II PDAC and to a similar extent in those who had undergone a pancreatectomy, in those with chronic pancreatitis and in those who had not been treated with statin prior to cancer diagnosis.ConclusionsWe found that statin treatment after cancer diagnosis is associated with enhanced survival in patients with low-grade, resectable PDAC

Semi-classical buckling of stiff polymers

A quantitative theory of the buckling of a worm like chain based on a semi-classical approximation of the partition function is presented. The contribution of thermal fluctuations to the force-extension relation that allows to go beyond the classical Euler buckling is derived in the linear and non-linear regime as well. It is shown that the thermal fluctuations in the nonlinear buckling regime increase the end-to-end distance of the semiflexible rod if it is confined to 2 dimensions as opposed to the 3 dimensional case. Our approach allows a complete physical understanding of buckling in D=2 and in D=3 below and above the Euler transition.Comment: Revtex, 17 pages, 4 figure

Rational optimization of tolC as a powerful dual selectable marker for genome engineering

Selection has been invaluable for genetic manipulation, although counter-selection has historically exhibited limited robustness and convenience. TolC, an outer membrane pore involved in transmembrane transport in E. coli, has been implemented as a selectable/counter-selectable marker, but counter-selection escape frequency using colicin E1 precludes using tolC for inefficient genetic manipulations and/or with large libraries. Here, we leveraged unbiased deep sequencing of 96 independent lineages exhibiting counter-selection escape to identify loss-of-function mutations, which offered mechanistic insight and guided strain engineering to reduce counter-selection escape frequency by ∼40-fold. We fundamentally improved the tolC counter-selection by supplementing a second agent, vancomycin, which reduces counter-selection escape by 425-fold, compared colicin E1 alone. Combining these improvements in a mismatch repair proficient strain reduced counter-selection escape frequency by 1.3E6-fold in total, making tolC counter-selection as effective as most selectable markers, and adding a valuable tool to the genome editing toolbox. These improvements permitted us to perform stable and continuous rounds of selection/counter-selection using tolC, enabling replacement of 10 alleles without requiring genotypic screening for the first time. Finally, we combined these advances to create an optimized E. coli strain for genome engineering that is ∼10-fold more efficient at achieving allelic diversity than previous best practices

Perancangan Tabung Vaksin Hewan Berbahan Dasar Polivinil Klorida (PVC) Dengan Mengunakan Elemen Peltier

The vaccine is one of the ways to prevent disease in livestock as an antibody. These vaccines are very vulnerable because it should not be exposed to direct sunlight and should not be frozen. For some types of vaccines should be stored at a temperature 2oC - 8oC. The toughest obstacle when should bring the vaccine to remote areas that are difficult to reach and have no major infrastructure such as adequate road. The cooling tubes planning has the dimensions of the tubes used are 3 inches and 4 inches. High tube 3 inches is 14.6 cm in size and high 4 inches is 19.8 cm made polyvinyl chloride. The planning results retrieved the tensile that occurs in the cooling tube sheath 38,144 kg/〖cm〗^2. Tensile on sheath insulating space 68,766 kg/〖cm〗^2. The shear stress of cooling space cover 0,00093 kg/〖cm〗^2. Shear stress on the cover tube 9,479 kg/〖cm〗^2. Press the voltage going to the metal welding 8,656 kg/〖cm〗^2. Voltage drop bolt permits 74 N/mm2. The shear stress permits 44,4 N/mm2. The diameter bolt required 0,278 m

Indirect Detection of a Light Higgsino Motivated by Collider Data

Kane and Wells recently argued that collider data point to a Higgsino-like lightest supersymmetric partner which would explain the dark matter in our Galactic halo. They discuss direct detection of such dark-matter particles in laboratory detectors. Here, we argue that such a particle, if it is indeed the dark matter, might alternatively be accessible in experiments which search for energetic neutrinos from dark-matter annihilation in the Sun. We provide accurate analytic estimates for the rates which take into account all relevant physical effects. Currently, the predicted signal falls roughly one to three orders of magnitude below experimental bounds, depending on the mass and coupling of the particle; however, detectors such as MACRO, super-Kamiokande, and AMANDA will continue to take data and should be able to rule out or confirm an interesting portion of the possible mass range for such a dark-matter particle within the next five years.Comment: 10 pages, RevTe

Tracing the colonization history of the Indian Ocean scops-owls (Strigiformes: Otus) with further insight into the spatio-temporal origin of the Malagasy avifauna

BACKGROUND:The island of Madagascar and surrounding volcanic and coralline islands are considered to form a biodiversity hotspot with large numbers of unique taxa. The origin of this endemic fauna can be explained by two different factors: vicariance or over-water-dispersal. Deciphering which factor explains the current distributional pattern of a given taxonomic group requires robust phylogenies as well as estimates of divergence times. The lineage of Indian Ocean scops-owls (Otus: Strigidae) includes six or seven species that are endemic to Madagascar and portions of the Comoros and Seychelles archipelagos; little is known about the species limits, biogeographic affinities and relationships to each other. In the present study, using DNA sequence data gathered from six loci, we examine the biogeographic history of the Indian Ocean scops-owls. We also compare the pattern and timing of colonization of the Indian Ocean islands by scops-owls with divergence times already proposed for other bird taxa. RESULTS: Our analyses revealed that Indian Ocean islands scops-owls do not form a monophyletic assemblage: the Seychelles Otus insularis is genetically closer to the South-East Asian endemic O. sunia than to species from the Comoros and Madagascar. The Pemba Scops-owls O. pembaensis, often considered closely related to, if not conspecific with O. rutilus of Madagascar, is instead closely related to the African mainland O. senegalensis. Relationships among the Indian Ocean taxa from the Comoros and Madagascar are unresolved, despite the analysis of over 4000 bp, suggesting a diversification burst after the initial colonization event. We also highlight one case of putative back-colonization to the Asian mainland from an island ancestor (O. sunia). Our divergence date estimates, using a Bayesian relaxed clock method, suggest that all these events occurred during the last 3.6 myr; albeit colonization of the Indian Ocean islands were not synchronous, O. pembaensis diverged from O. senegalensis about 1.7 mya while species from Madagascar and the Comoro diverged from their continental sister-group about 3.6 mya. We highlight that our estimates coincide with estimates of diversification from other bird lineages. CONCLUSION: Our analyses revealed the occurrence of multiple synchronous colonization events of the Indian Ocean islands by scops-owls, at a time when faunistic exchanges involving Madagascar was common as a result of lowered sea-level that would have allowed the formation of stepping-stone islands. Patterns of diversification that emerged from the scops-owls data are: 1) a star-like pattern concerning the order of colonization of the Indian Ocean islands and 2) the high genetic distinctiveness among all Indian Ocean taxa, reinforcing their recognition as distinct species

What Can the Accretion Induced Collapse of White Dwarfs Really Explain?

The accretion induced collapse (AIC) of a white dwarf into a neutron star has been invoked to explain gamma-ray bursts, Type Ia supernovae, and a number of problematic neutron star populations and specific binary systems. The ejecta from this collapse has also been claimed as a source of r-process nucleosynthesis. So far, most AIC studies have focussed on determining the event rates from binary evolution models and less attention has been directed toward understanding the collapse itself. However, the collapse of a white dwarf into a neutron star is followed by the ejection of rare neutron-rich isotopes. The observed abundance of these chemical elements may set a more reliable limit on the rate at which AICs have taken place over the history of the galaxy. In this paper, we present a thorough study of the collapse of a massive white dwarf in 1- and 2-dimensions and determine the amount and composition of the ejected material. We discuss the importance of the input physics (equation of state, neutrino transport, rotation) in determining these quantities. These simulations affirm that AICs are too baryon rich to produce gamm-ray bursts and do not eject enough nickel to explain Type Ia supernovae (with the possible exception of a small subclass of extremely low-luminosity Type Ias). Although nucleosynthesis constraints limit the number of neutron stars formed via AICs to <0.1% of the total galactic neutron star population, AICs remain a viable scenario for forming systems of neutron stars which are difficult to explain with Type II core-collapse supernovae.Comment: Latex File, aaspp4 style, 18 pages total (5 figures), accepted by Ap

Model-Independent Comparison of Direct vs. Indirect Detection of Supersymmetric Dark Matter

We compare the rate for elastic scattering of neutralinos from various nuclei with the flux of upward muons induced by energetic neutrinos from neutralino annihilation in the Sun and Earth. We consider both scalar and axial-vector interactions of neutralinos with nuclei. We find that the event rate in a kg of germanium is roughly equivalent to that in a $10^5$- to $10^7$-m$^2$ muon detector for a neutralino with primarily scalar coupling to nuclei. For an axially coupled neutralino, the event rate in a 50-gram hydrogen detector is roughly the same as that in a 10- to 500-m$^2$ muon detector. Expected experimental backgrounds favor forthcoming elastic-scattering detectors for scalar couplings while the neutrino detectors have the advantage for axial-vector couplings.Comment: 10 pages, self-unpacking uuencoded PostScript fil

Co-evolution of density and topology in a simple model of city formation

We study the influence that population density and the road network have on each others' growth and evolution. We use a simple model of formation and evolution of city roads which reproduces the most important empirical features of street networks in cities. Within this framework, we explicitely introduce the topology of the road network and analyze how it evolves and interact with the evolution of population density. We show that accessibility issues -pushing individuals to get closer to high centrality nodes- lead to high density regions and the appearance of densely populated centers. In particular, this model reproduces the empirical fact that the density profile decreases exponentially from a core district. In this simplified model, the size of the core district depends on the relative importance of transportation and rent costs.Comment: 13 pages, 13 figure