Simultaneous Determination of Signal and Background Asymmetries

This article discusses the determination of asymmetries. We consider a sample of events consisting of a peak of signal events on top of some background events. Both signal and background have an unknown asymmetry, e.g. a spin or forward-backward asymmetry. A method is proposed which determines signal and background asymmetries simultaneously using event weighting. For vanishing asymmetries the statistical error of the asymmetries reaches the minimal variance bound (MVB) given by the Cram\'er-Rao inequality and it is very close to it for large asymmetries. The method thus provides a significant gain in statistics compared to the classical method of side band subtraction of background asymmetries. It has the advantage with respect to the unbinned maximum likelihood approach, reaching the MVB as well, that it does not require loops over the event sample in the minimization procedure

Lutte contre les vecteurs de l'onchocercose aux alentours d'un camp de réfugiés situé en zone de savane du Cameroun

International audienceIn view of the risks of onchocerciasis facing Chadian refugees who have settled in a camp in a savanna hyperendemic area of northern Cameroon, the authors concluded that a vector control directed against the black fly larvae located on small seasonal tributaries of the main water course of this area should be carried out during the four to five months of the rainy season, i.e., during the whole period of transmission of this disease. The operations were undertaken during two consecutive rainy seasons. The first year consisted in developing ground-based control techniques and evaluating the larvicidal efficacy at the larval level. The second year was, particularly, devoted to the study of the impact of the vector control on the biting rate and on the transmission of onchocerciasis. Every week, three of the tributaries close to the camp were treated with an Emulsifiable Concentrate of temephos. Throughout the rainy season, the larvicide eliminated almost all the pre-adult black fly stages on these water courses. At the point in a high onchocercal endemicity area, it also reduced the biting rate by 60% and the Annual Transmission Potential by 72%, i.e., to values corresponding to the lower meso-endemicity threshold. Since these results were obtained at a very unfavourable point from the standpoint of black fly density and onchocerciasis transmission, the authors consider that vector control carried out under these conditions protects the local populations and the Chadian refugees effectively from black fly bites and a risk of severe onchocerciasis

New approach for precise computation of Lyman-alpha forest power spectrum with hydrodynamical simulations

Current experiments are providing measurements of the flux power spectrum from the Lyman-α forests observed in quasar spectra with unprecedented accuracy. Their interpretation in terms of cosmological constraints requires specific simulations of at least equivalent precision. In this paper, we present a suite of cosmological N-body simulations with cold dark matter and baryons, specifically aiming at modeling the low-density regions of the inter-galactic medium as probed by the Lyman-α forests at high redshift. The simulations were run using the GADGET-3 code and were designed to match the requirements imposed by the quality of the current SDSS-III/BOSS or forthcoming SDSS-IV/eBOSS data. They are made using either 2 × 7683 1 billion or 2 × 1923 14 million particles, spanning volumes ranging from (25 Mpc h−1)3 for high-resolution simulations to (100 Mpc h−1)3 for large-volume ones. Using a splicing technique, the resolution is further enhanced to reach the equivalent of simulations with 2 × 30723 58 billion particles in a (100 Mpc h−1)3 box size, i.e. a mean mass per gas particle of 1.2 × 105M⊙ h−1. We show that the resulting power spectrum is accurate at the 2% level over the full range from a few Mpc to several tens of Mpc. We explore the effect on the one-dimensional transmitted-flux power spectrum of four cosmological parameters (ns, σ8, Ωm and H0) and two astrophysical parameters (T0 and γ) that are related to the heating rate of the intergalactic medium. By varying the input parameters around a central model chosen to be in agreement with the latest Planck results, we built a grid of simulations that allows the study of the impact on the flux power spectrum of these six relevant parameters. We improve upon previous studies by not only measuring the effect of each parameter individually, but also probing the impact of the simultaneous variation of each pair of parameters. We thus provide a full second-order expansion, including cross-terms, around our central model. We check the validity of the second-order expansion with independent simulations obtained either with different cosmological parameters or different seeds. Finally, a comparison to the one-dimensional Lyman-α forest power spectrum obtained with BOSS by [1] shows an excellent agreement

Detection of Ly\beta auto-correlations and Ly\alpha-Ly\beta cross-correlations in BOSS Data Release 9

The Lyman-$\beta$ forest refers to a region in the spectra of distant quasars that lies between the rest-frame Lyman-$\beta$ and Lyman-$\gamma$ emissions. The forest in this region is dominated by a combination of absorption due to resonant Ly$\alpha$ and Ly$\beta$ scattering. When considering the 1D Ly$\beta$ forest in addition to the 1D Ly$\alpha$ forest, the full statistical description of the data requires four 1D power spectra: Ly$\alpha$ and Ly$\beta$ auto-power spectra and the Ly$\alpha$-Ly$\beta$ real and imaginary cross-power spectra. We describe how these can be measured using an optimal quadratic estimator that naturally disentangles Ly$\alpha$ and Ly$\beta$ contributions. Using a sample of approximately 60,000 quasar sight-lines from the BOSS Data Release 9, we make the measurement of the one-dimensional power spectrum of fluctuations due to the Ly$\beta$ resonant scattering. While we have not corrected our measurements for resolution damping of the power and other systematic effects carefully enough to use them for cosmological constraints, we can robustly conclude the following: i) Ly$\beta$ power spectrum and Ly$\alpha$-Ly$\beta$ cross spectra are detected with high statistical significance; ii) the cross-correlation coefficient is $\approx 1$ on large scales; iii) the Ly$\beta$ measurements are contaminated by the associated OVI absorption, which is analogous to the SiIII contamination of the Ly$\alpha$ forest. Measurements of the Ly$\beta$ forest will allow extension of the usable path-length for the Ly$\alpha$ measurements while allowing a better understanding of the physics of intergalactic medium and thus more robust cosmological constraints.Comment: 26 pages, 10 figures; matches version accepted by JCA

Evaluation of voriconazole anti-Acanthamoeba polyphaga in vitro activity, rat cornea penetration and efficacy against experimental rat Acanthamoeba keratitis

International audienceBackground: Acanthamoeba keratitis (AK) is a sight-threatening infectious disease. Its effective and safe medical therapy remains highly debated. Recently, voriconazole, a monotriazole with noted in vitro activity against a large variety of fungi, has been successfully used both topically and systemically to treat human AK cases.Objectives: To measure anti-Acanthamoeba polyphaga in vitro activity, anti-rat AK efficiency and rat cornea penetration of eye-drop and oral voriconazole.Methods: A. polyphaga was maintained in axenic cultures. In vitro, amoebicidal and cysticidal activities of voriconazole were measured using an XTT assay. AK lesions of Sprague Dawley rats were scored from grade 0 to grade 3. For 21 days, from day 7 post-infection, voriconazole (1% solution) eye drops were instilled or voriconazole was administered by gavage (60 mg/kg/day). After killing, superficial corneal epithelium scrapings were cultured and analysed by PCR, and eye-globe histology was performed. Cornea and plasma concentrations were determined using 2D HPLC separation and tandem MS.Results: In vitro, voriconazole inhibited trophozoite proliferation with an IC50 value of 0.02 mg/L and an IC90 value of 2.86 mg/L; no cysticidal effect was found. In AK rats, eye drops reduced clinical worsening from day 7 to day 14 post-infection and oral voriconazole was not effective. Voriconazole cornea concentrations were directly dependent on the frequency of eye-drop instillations, which resulted in lower plasma concentrations, whilst oral voriconazole resulted in lower cornea concentrations.Conclusions: Present data underline the need for high-frequency eye-drop instillation regimens for efficient AK therapy

Exploring cosmic homogeneity with the BOSS DR12 galaxy sample

In this study, we probe the transition to cosmic homogeneity in the Large Scale Structure (LSS) of the Universe using the CMASS galaxy sample of BOSS spectroscopic survey which covers the largest effective volume to date, 3 h-3 Gpc3 at 0.43 ≤ z ≤ 0.7. We study the scaled counts-in-spheres, N(2.97 for r>RH, we find RH = (63.3±0.7) h-1 Mpc, in agreement at the percentage level with the predictions of the ΛCDM model RH=62.0 h-1 Mpc. Thanks to the large cosmic depth of the survey, we investigate the redshift evolution of the transition to homogeneity scale and find agreement with the ΛCDM prediction. Finally, we find that 2 is compatible with 3 at scales larger than 300 h-1 Mpc in all redshift bins. These results consolidate the Cosmological Principle and represent a precise consistency test of the ΛCDM model.PostprintPeer reviewe

Mock Quasar-Lyman-{\alpha} Forest Data-sets for the SDSS-III Baryon Oscillation Spectroscopic Survey

We describe mock data-sets generated to simulate the high-redshift quasar sample in Data Release 11 (DR11) of the SDSS-III Baryon Oscillation Spectroscopic Survey (BOSS). The mock spectra contain Ly{\alpha} forest correlations useful for studying the 3D correlation function including Baryon Acoustic Oscillations (BAO). They also include astrophysical effects such as quasar continuum diversity and high-density absorbers, instrumental effects such as noise and spectral resolution, as well as imperfections introduced by the SDSS pipeline treatment of the raw data. The Ly{\alpha} forest BAO analysis of the BOSS collaboration, described in Delubac et al. 2014, has used these mock data-sets to develop and cross-check analysis procedures prior to performing the BAO analysis on real data, and for continued systematic cross checks. Tests presented here show that the simulations reproduce sufficiently well important characteristics of real spectra. These mock data-sets will be made available together with the data at the time of the Data Release 11.Comment: 35 pages, 19 figures, Accepted by JCA