Variations of OCT measurements corrected for the magnification effect according to axial length and refractive error in children

The aim of this paper was to examine the distribution of macular, retinal nerve fiber layer (RNFL) thickness and optic disc parameters of myopic and hyperopic eyes in comparison with emmetropic control eyes and to investigate their variation according to axial length (AL) and spherical equivalent (SE) in healthy children. Methods: This study included 293 pairs of eyes of 293 children (145 boys and 148 girls), ranging in age from 6 to 17 years. Subjects were divided according to SE in control (emmetropia, 99 children), myopia (100 children) and hyperopia (94 children) groups and according to axial AL in 68 short ((Formula presented.)22.00(Formula presented.)mm, 68), medium (from (Formula presented.)22.00(Formula presented.)mm to 25.00(Formula presented.)mm, 189) and long eyes ((Formula presented.)25.00(Formula presented.)mm, 36). Macular parameters, RNFL thickness and optic disc morphology were assessed by the CirrusTM HD-OCT. AL was measured using the IOL-Master system. Littmann’s formula was used for calculating the corrected AL-related ocular magnification. Results: Mean age ((Formula presented.)(Formula presented.)SD) was 10.84(Formula presented.)(Formula presented.)(Formula presented.)3.05 years; mean ((Formula presented.)(Formula presented.)SD) SE was (Formula presented.)0.14(Formula presented.)(Formula presented.)(Formula presented.)0.51 D (range from (Formula presented.)8.75 to (Formula presented.)8.25 D) and mean AL ((Formula presented.)(Formula presented.)SD) was 23.12(Formula presented.)(Formula presented.)(Formula presented.)1.49. Average RNFL thickness, average macular thickness and macular volume decreased as AL and myopia increased. No correlations between AL/SE and optic disc parameters were found after correcting for magnification effect. Conclusions: AL and refractive error affect measurements of macular and RNFL thickness in healthy children. To make a correct interpretation of OCT measurements, ocular magnification effect should be taken into account by clinicians or OCT manufacturers.Postprint (published version

Conocimiento e importancia, que los profesionales de enfermería tienen sobre el consentimiento informado aplicado a los actos de cuidado de enfermería

Introduction: Nursing acts are based on the nurse-patient relationship, respect for the dignity and autonomy of people. This implies understanding the importance and meaning from the human sphere, which is an aspect that gives an ethical sense of care practices. This reflective process deserves adequate knowledge of the actions that are necessary to obtain the informed consent. Objective: Identify the knowledge and importance that nursing professionals have about the informed consent applied in the acts of care, based on the theory of knowledge patterns. Materials and methods: A descriptive, quantitative, cross-sectional study was conducted with a sample of 221 nursing professionals, who undertook a questionnaire type Likert scale. Descriptive statistics, factorial and inferential analysis were applied for the analysis. Results: It could be seen that there was little knowledge about the use of informed consent in the participants. The variable called importance is focused on the legal, administrative and instrumental aspect of the informed consent. Conclusion: The use of informed consent should be encouraged in acts of care of the profession. The ways to explain the risks, benefits and alternatives to the patient must be reinforced as well as the ethical aspects

A new sports garment with elastomeric technology optimizes physiological, mechanical, and psychological acute responses to pushing upper-limb resistance exercises

This study aimed to compare the mechanical (lifting velocity and maximum number of repetitions), physiological (muscular activation, lactate, heart rate, and blood pressure), and psychological (rating of perceived exertion) responses to upper-body pushing exercises performed wearing a sports elastomeric garment or a placebo garment. Nineteen physically active young adults randomly completed two training sessions that differed only in the sports garment used (elastomeric technology or placebo). In each session, subjects performed one set of seated shoulder presses and another set of push-ups until muscular failure. The dependent variables were measured immediately after finishing the set of each exercise. Compared to the placebo garment, the elastomeric garment allowed participants to obtain greater muscular activation in the pectoralis major (push-ups: p = 0.04, d = 0.49; seated shoulder press: p < 0.01, d = 0.64), triceps brachialis (push-ups, p < 0.01, d = 0.77; seated shoulder press: p < 0.01, d = 0.65), and anterior deltoid (push-ups: p < 0.01, d = 0.72; seated shoulder press: p < 0.01, d = 0.83) muscles. Similarly, participants performed more repetitions (push-ups: p < 0.01; d = 0.94; seated shoulder press: p = 0.03, d = 0.23), with higher movement velocity (all p ≤ 0.04, all d ≥ 0.47), and lower perceived exertion in the first repetition (push-ups: p < 0.01, d = 0.61; seated shoulder press: p = 0.05; d = 0.76) wearing the elastomeric garment compared to placebo. There were no between-garment differences in most cardiovascular variables (all p ≥ 0.10). Higher diastolic blood pressure was only found after the seated shoulder press wearing the elastomeric garment compared to the placebo (p = 0.04; d = 0.49). Finally, significantly lower blood lactate levels were achieved in the push-ups performed wearing the elastomeric garment (p < 0.01; d = 0.91), but no significant differences were observed in the seated shoulder press (p = 0.08). Overall, the findings of this study suggest that elastomeric technology integrated into a sports garment provides an ergogenic effect on mechanical, physiological, and psychological variables during the execution of pushing upper-limb resistance exercises

Revista de libros

Se reseñan los siguientes libros: - Saúl Taborda: La psicología y la pedagogía. Instituto de Pedagogía de la Facultad de Filosofía y Humanidades de la Universidad Nacional de Córdoba. Córdoba, 1959. 1 vol. de 173 págs. - Edmon Michaud: Acción y pensamiento infantiles. Editorial Nova; Biblioteca Nova de Educación, Buenos Aires, 1959. Vol. rústica, 131 págs. Prólogo de Maurice Debesse. Traducción de Susana de Aldecoa. - John I. H. Baur: Revolución y tradición en el arte moderno norteamericano. Editorial Poseidon, Buenos Aires, 1957. Vol. rústica, ilustrado, 188 págs. - Viktor Lowenfeld: El niño y su arte (Traducción de Alfredo M. Ghioldi). Editorial Kapelusz. Biblioteca de Cultura Pedagógica, Buenos Aires, 1958. Vol. rústica, 202 págs. - Ilse T. M. de Brugger: Teatro alemán expresionista. Ed. La Mandragora, Buenos Aires, 1959. Vol. rústica, 172 págs. - José Ortega y Gasset: La idea de principio en Leibniz y la evolución de la teoría deductiva; Emecé Editores, Biblioteca de la Revista de Occidente, Buenos Aires, 1958. Vol. rústica, 444 págs. - Andre Lothe: Los grandes pintores hablan de su arte. Traducción de Horacio A. Maniglia. Edit. Librería Hachette; Buenos Aires, 1958. Vol. de 381 págs.Universidad Nacional de La Plat

Revista de libros

Se reseñan los siguientes libros: - Saúl Taborda: La psicología y la pedagogía. Instituto de Pedagogía de la Facultad de Filosofía y Humanidades de la Universidad Nacional de Córdoba. Córdoba, 1959. 1 vol. de 173 págs. - Edmon Michaud: Acción y pensamiento infantiles. Editorial Nova; Biblioteca Nova de Educación, Buenos Aires, 1959. Vol. rústica, 131 págs. Prólogo de Maurice Debesse. Traducción de Susana de Aldecoa. - John I. H. Baur: Revolución y tradición en el arte moderno norteamericano. Editorial Poseidon, Buenos Aires, 1957. Vol. rústica, ilustrado, 188 págs. - Viktor Lowenfeld: El niño y su arte (Traducción de Alfredo M. Ghioldi). Editorial Kapelusz. Biblioteca de Cultura Pedagógica, Buenos Aires, 1958. Vol. rústica, 202 págs. - Ilse T. M. de Brugger: Teatro alemán expresionista. Ed. La Mandragora, Buenos Aires, 1959. Vol. rústica, 172 págs. - José Ortega y Gasset: La idea de principio en Leibniz y la evolución de la teoría deductiva; Emecé Editores, Biblioteca de la Revista de Occidente, Buenos Aires, 1958. Vol. rústica, 444 págs. - Andre Lothe: Los grandes pintores hablan de su arte. Traducción de Horacio A. Maniglia. Edit. Librería Hachette; Buenos Aires, 1958. Vol. de 381 págs.Universidad Nacional de La Plat

Revista de libros

Se reseñan los siguientes libros: - Saúl Taborda: La psicología y la pedagogía. Instituto de Pedagogía de la Facultad de Filosofía y Humanidades de la Universidad Nacional de Córdoba. Córdoba, 1959. 1 vol. de 173 págs. - Edmon Michaud: Acción y pensamiento infantiles. Editorial Nova; Biblioteca Nova de Educación, Buenos Aires, 1959. Vol. rústica, 131 págs. Prólogo de Maurice Debesse. Traducción de Susana de Aldecoa. - John I. H. Baur: Revolución y tradición en el arte moderno norteamericano. Editorial Poseidon, Buenos Aires, 1957. Vol. rústica, ilustrado, 188 págs. - Viktor Lowenfeld: El niño y su arte (Traducción de Alfredo M. Ghioldi). Editorial Kapelusz. Biblioteca de Cultura Pedagógica, Buenos Aires, 1958. Vol. rústica, 202 págs. - Ilse T. M. de Brugger: Teatro alemán expresionista. Ed. La Mandragora, Buenos Aires, 1959. Vol. rústica, 172 págs. - José Ortega y Gasset: La idea de principio en Leibniz y la evolución de la teoría deductiva; Emecé Editores, Biblioteca de la Revista de Occidente, Buenos Aires, 1958. Vol. rústica, 444 págs. - Andre Lothe: Los grandes pintores hablan de su arte. Traducción de Horacio A. Maniglia. Edit. Librería Hachette; Buenos Aires, 1958. Vol. de 381 págs.Universidad Nacional de La Plat

Assessing the cost effectiveness of using prognostic biomarkers with decision models: case study in prioritising patients waiting for coronary artery surgery

Objective To determine the effectiveness and cost effectiveness of using information from circulating biomarkers to inform the prioritisation process of patients with stable angina awaiting coronary artery bypass graft surgery

iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types.

Large-scale collections of induced pluripotent stem cells (iPSCs) could serve as powerful model systems for examining how genetic variation affects biology and disease. Here we describe the iPSCORE resource: a collection of systematically derived and characterized iPSC lines from 222 ethnically diverse individuals that allows for both familial and association-based genetic studies. iPSCORE lines are pluripotent with high genomic integrity (no or low numbers of somatic copy-number variants) as determined using high-throughput RNA-sequencing and genotyping arrays, respectively. Using iPSCs from a family of individuals, we show that iPSC-derived cardiomyocytes demonstrate gene expression patterns that cluster by genetic background, and can be used to examine variants associated with physiological and disease phenotypes. The iPSCORE collection contains representative individuals for risk and non-risk alleles for&nbsp;95% of SNPs associated with human phenotypes through genome-wide association studies. Our study demonstrates the utility of iPSCORE for examining how genetic variants influence molecular and physiological traits in iPSCs and derived cell lines

Earth BioGenome Project: Sequencing life for the future of life.

Increasing our understanding of Earth's biodiversity and responsibly stewarding its resources are among the most crucial scientific and social challenges of the new millennium. These challenges require fundamental new knowledge of the organization, evolution, functions, and interactions among millions of the planet's organisms. Herein, we present a perspective on the Earth BioGenome Project (EBP), a moonshot for biology that aims to sequence, catalog, and characterize the genomes of all of Earth's eukaryotic biodiversity over a period of 10 years. The outcomes of the EBP will inform a broad range of major issues facing humanity, such as the impact of climate change on biodiversity, the conservation of endangered species and ecosystems, and the preservation and enhancement of ecosystem services. We describe hurdles that the project faces, including data-sharing policies that ensure a permanent, freely available resource for future scientific discovery while respecting access and benefit sharing guidelines of the Nagoya Protocol. We also describe scientific and organizational challenges in executing such an ambitious project, and the structure proposed to achieve the project's goals. The far-reaching potential benefits of creating an open digital repository of genomic information for life on Earth can be realized only by a coordinated international effort