The continuous star formation history of a giant HII region in M101

We present results about the star formation process in the giant HII region NGC 5471 in the outskirts of M101. From resolved HST/WPFC2 photometry we find that star formation has been going for the last 70 Myr. We further compare previous results from integrated infrared-optical photometry with the stellar resolved CMD and we discuss the star formation properties of this region and its individual knots, as well as characterizing the different stellar content. This result has very important consequences in our understanding of the burst versus continuous star formation activity in spiral galaxies.Comment: 2 pages, 2 figures. Proceeding of the conference From Stars to Galaxies: Building the pieces to build up the Universe (Venice, Italy

Analysis of water-soluble vitamins in biopharma raw materials by electrophoresis micro-chips with contactless conductivity detection

Detailed information concerning the composition of the raw materials employed in the production of biologics is important for the efficient control and optimization of bioprocesses. The analytical methods used in these applications must be simple and fast as well as be easily transferable from one site to another. In that context, microchip‐based electrophoresis represents a promising tool for application in the analysis of raw materials in biologics. Using electrophoresis micro‐chips, analysis times can be reduced to seconds and high separation efficiencies can be achieved using extremely low volume samples, minimal reagent consumption and waste generation, low cost/disposability, portability and ease of mass‐production [1]. Additionally the use of Capacitively Coupled Contactless Conductivity Detection (C4D) offers a rather simple and yet sensitive method for detection of ionic species. Recently, C4D has gained much popularity as on‐chip detection in electrophoresis micro‐chips [2]. The main reason for this is that there is no physical contact of the detection electrodes with the electrolyte solution. Therefore, the integration of this detection mode within the analytical system is rather simple. Furthermore, the background noise is significantly reduced leading to lower detection limits than the conventional contact conductivity detection. Vitamins are present at very low concentrations in biopharma raw materials and are usually determined using HPLC and CE methods [3]. Electrophoresis micro‐chips are a very good alternative to these techniques due to the shorter analysis time and yet very good resolution, among others. In this paper, we present the application of electrophoresis micro‐chips with C4D detection to the analysis of water‐soluble vitamins in raw materials used for the production of biologics in bioreactors. For that purpose, hybrid PDMS/glass chips were fabricated by using standard photolithographic techniques (Figure 1). The chip structure contains an extremely long channel of 101 mm (50 x 50 μm width x depth). Figure 2 shows the setup used for vitamins detection

Spectroscopic Observations of Planetary Nebulae in the Northern Spur of M31

We present spectroscopy of three planetary nebulae (PNe) in the Northern Spur of the Andromeda Galaxy (M31) obtained with the Double Spectrograph on the 5.1 m Hale Telescope at the Palomar Observatory. The samples are selected from the observations of Merrett et al. Our purpose is to investigate formation of the substructures of M31 using PNe as a tracer of chemical abundances. The [O III] 4363 auroral line is detected in the spectra of two objects, enabling temperature determinations. Ionic abundances are derived from the observed collisionally excited lines, and elemental abundances of nitrogen, oxygen, and neon as well as sulphur and argon are estimated. Correlations between oxygen and the alpha-element abundance ratios are studied, using our sample and the M31 disk and bulge PNe from the literature. In one of the three PNe, we observed relatively higher oxygen abundance compared to the disk sample in M31 at similar galactocentric distances. The results of at least one of the three Northern Spur PNe might be in line with the proposed possible origin of the Northern Spur substructure of M31, i.e. the Northern Spur is connected to the Southern Stream and both substructures comprise the tidal debris of the satellite galaxies of M31.Comment: 5 tables, 17 figures; accepted for publication in Ap

Analysis of biopharma raw materials by electrophoresis microchips with contactless conductivity detection

Detailed information concerning the composition of the raw materials employed in the production of biologics is important for the efficient control and optimization of bioprocesses. We demonstrate the application of electrophoresis microchips with capacitively-coupled contactless conductivity detection (C4D) to the analysis of wa-ter-soluble vitamins and metal cations in raw material solutions that are subse-quently fed into bioreactors for the production of biologics

El petit amfiox: el miratge de l'origen dels vertebrats

L'origen dels vertebrats és un dels centres d'interès de molts científics i de la societat, i el nostre animal favorit, el petit i amigable amfiox, fa més d'un segle que ocupa aquesta posició privilegiada, i reflecteix en un miratge, com a fòssil vivent, el que va ocórrer en aquell transcendental moment de l'evolució. No és només morfològicament el representant viu de l'ancestre de tots els cordats, sinó que a més posseeix un genoma preduplicatiu, un model en versió simple del genoma de tots els vertebrats, incloent-hi l'humà. L'anàlisi del genoma de l'amfiox ha permès clarificar l'origen del nostre genoma propi, alhora que l'ha situat en una posició clau per entendre l'origen i funcionament de famílies i xarxes gèniques importants per al desenvolupament embrionari i la fisiologia. A més, els avenços tècnics en la reproducció i experimentació permeten raonadament somiar a resoldre els secrets dels nostres orígens i del funcionament del genoma.The little amphious: a mirage to the origen of vertebrates. The origin of vertebrates is one of the top interests for many scientists and the society, and our favorite animal has occupied this privileged position for more than a century, reflecting in a mirage, as a living fossil, what occurred in this critical landmark of evolution. It is not only morphologically the closest living relative of Chordates, but also possesses a preduplicative genome, a simple model for the genome of all vertebrates, including humans. The analysis of the amphioxus genome has served to clarify the origin of our own genome, and as showed it is in a key position to understand the origin and functioning of gene families and gene networks critical for embryonic development and physiology. Besides, technical advances in its reproduction and experimentation make plausible to dream in illuminating the secrets of our origins and the functioning of the genome

Acoustic Rock Art Landscapes: A comparison between the Acoustics of three Levantine Rock Art areas in Mediterranean Spain

This article focuses on the relationship between acoustics and rock art in Levantine art in Mediterranean Spain. It takes as a case study three rock art areas where Levantine-style rock art was produced: the Valltorta Gorge, the Mortero Gorge and the Godall mountains. The study centres on the analysis of reverberation and echoes. In each area a comparison was made between the acoustic properties of sections of the area with rock art and of others with none. Different sounds were also tested in order to identify which possible instruments had the best chance of producing a sensory reaction. Although we cannot hypothesise on the specific practices that may have taken place in these areas, we conclude with the proposition that the acoustic properties of a site indicate a sacred use of the landscape, in which sound was a key element of ritual performance

Situación actual de la ganadería de bovinos en el municipio de Tejupilco

La ganadería constituye una actividad importante en zonas rurales a pesar del acelerado crecimiento de actividades alternativas. El objetivo de este trabajo fue caracterizar unidades de producción (UP) de ganado bovino en el municipio de Tejupilco, Estado de México, desde un enfoque sistémico. Se recopiló información primaria mediante encuestas estructuradas y entrevista directa a 55 ganaderos. Las UP se agruparon en cuatro estratos en función del tamaño del hato (E1 = UP entre 1 y 10 unidades ganaderas totales; E2 = UP entre 11 y 21 UGT; E3 = UP entre 22 y 31 UGT; y E4 = UP con más de 32 UGT). La estructura de las UP, el manejo del ganado y la orientación de la producción depende del tamaño del hato y de la disponibilidad de tierra. UP de menor tamaño tienen mayor orientación a la producción de leche, mientras que UP grandes se orientan a la producción de becerros para abasto en un sistema extensivo, aunque también se observa la engorda de animales. Se destacó la diversidad de UP y se evidenció que hatos de menor tamaño aprovechan eficientemente la tierra, y UP de mayor tamaño hacen eficiente el uso de la mano de obraUNIVERSIDAD AUTÓNOMA DEL ESTADO DE MÉXICO CONSEJO NACIONAL DE CIENCIA Y TECNOLOGÍ

Dinámicas y tendencias de la ganadería doble propósito en el sur del Estado de México

El sur del Estado de México, es zona ganadera y tiene el mayor inventario de bovinos en unidades de producción (UP) orientadas al doble propósito (DP). La información para este estudio se obtuvo de 78 UP seleccionadas mediante muestreo probalístico y se analizó de acuerdo a tres grupos: extensivo ( UPDPE ), tradicionalista ( UPDPT ) y semi-intensivo, ( UPDPSI ). El objetivo fue evaluar la dinámica, entendida como los cambios o innovaciones a través del tiempo (eva - luación ex-ante y ex-post), los objetivos y las opiniones de los ganaderos sobre el medio socioeconómico en el cual se desarrollan y la toma de decisiones en las UP, mediante Escala de Likert. Hubo cambios importantes en el aprovechamiento de la tierra y mayor tendencia al pastoreo, aumento del tamaño del hato, cuidado del ambiente e importancia de la toma de decisiones del ganadero. Resalta el manejo diferenciado de la ganadería, producto de las decisiones de los ganaderos sobre puntos estratégicos que determinan la capacidad de adaptación de las UP al medio socioeconómico en el cual se desarrollan

Chemical Abundances of Planetary Nebulae in the Substructures of M31

We present deep spectroscopy of planetary nebulae (PNe) that are associated with the substructures of the Andromeda Galaxy (M31). The spectra were obtained with the OSIRIS spectrograph on the 10.4 m GTC. Seven targets were selected for the observations, three in the Northern Spur and four associated with the Giant Stream. The most distant target in our sample, with a rectified galactocentric distance >100 kpc, was the first PN discovered in the outer streams of M31. The [O III] 4363 auroral line was well detected in the spectra of all targets, enabling electron temperature determination. Ionic abundances are derived based on the [O III] temperatures, and elemental abundances of helium, nitrogen, oxygen, neon, sulfur, and argon are estimated. The relatively low N/O and He/H ratios as well as abundance ratios of alpha-elements indicate that our target PNe might belong to populations as old as ~2 Gyr. Our PN sample, including the current seven and the previous three observed by Fang et al., have rather homogeneous oxygen abundances. The study of abundances and the spatial and kinematical properties of our sample leads to the tempting conclusion that their progenitors might belong to the same stellar population, which hints at a possibility that the Northern Spur and the Giant Stream have the same origin. This may be explained by the stellar orbit proposed by Merrett et al. Judging from the position and kinematics, we emphasize that M32 might be responsible for the two substructures. Deep spectroscopy of PNe in M32 will help to assess this hypothesis.Comment: Accepted for publication in the ApJ. 23 pages, including 13 figures and 7 table

Implications for acetylsalicylic acid-sensitive pregnant women

Low-dose acetylsalicylic acid (ASA) is widely used during pregnancy to prevent obstetric complications of placental dysfunction, such as preeclampsia, stillbirth and fetal growth restriction, and obstetric complications in pregnant women with antiphospholipid syndrome. ASA-sensitive pregnant women cannot benefit from the effects of ASA due to the possibility of severe or potentially life-threatening hypersensitivity reactions to ASA. ASA desensitization is a valuable and safe therapeutic option for these women, allowing them to start daily prophylaxis with ASA and prevent pregnancy complications. The authors discuss the recent advances in obstetric conditions preventable by ASA and the management of ASA hypersensitivity in pregnancy, including ASA desensitization. To encourage the implementation of ASA desensitization protocols in ASA-sensitive pregnant women, they also propose a practical approach for use in daily clinical practice.publishersversionpublishe