209 research outputs found
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Powers of 10: seeking ‘sweet spots’ for rapid climate and sustainability actions between individual and global scales
Achieving the goals of the Paris Agreement and related sustainability initiatives will require halving of global greenhouse gas emissions each decade from now on through to 2050, when net zero emissions should be achieved. To reach such significant reductions requires a rapid and strategic scaling of existing and emerging technologies and practices, coupled with economic and social transformations and novel governance solutions. Here we present a new ‘Powers of 10’ (P10) logarithmic framework and demonstrate its potential as a practical tool for decision makers and change agents at multiple scales to inform and catalyze engagement and actions, complementing and adding nuance to existing frameworks. P10 assists in identifying the suitable cohorts and cohort ranges for rapidly deploying climate and sustainability actions between a single individual and the globally projected ∼ 10 billion persons by 2050. Applying a robust dataset of climate solutions from Project Drawdown’s Plausible scenario that could cumulatively reduce greenhouse gas emissions by 1051 gigatons (Gt) against a reference scenario (2190 Gt) between 2020 and 2050, we seek to identify a ‘sweet spot’ where these climate and sustainability actions are suitably scaled. We suggest that prioritizing the analyzed climate actions between community and urban scales, where global and local converge, can help catalyze and enhance individual, household and local practices, and support national and international policies and finances for rapid sustainability transformations
Rheotaxis facilitates upstream navigation of mammalian sperm cells
A major puzzle in biology is how mammalian sperm determine and maintain the
correct swimming direction during the various phases of the sexual reproduction
process. Whilst chemotaxis is assumed to dominate in the immediate vicinity of
the ovum, it is unclear which biochemical or physical cues guide spermatozoa on
their long journey towards the egg cell. Currently debated mechanisms range
from peristaltic pumping to temperature sensing (thermotaxis) and direct
response to fluid flow variations (rheotaxis), but little is known
quantitatively about their relative importance. Here, we report the first
quantitative experimental study of mammalian sperm rheotaxis. Using
microfluidic devices, we investigate systematically the swimming behavior of
human and bull sperm over the whole range of physiologically relevant shear
rates and viscosities. Our measurements show that the interplay of fluid shear,
steric surface-interactions and chirality of the flagellar beat leads to a
stable upstream spiraling motion of sperm cells, thus providing a generic and
robust rectification mechanism to support mammalian fertilisation. To
rationalise these findings, we identify a minimal mathematical model that is
capable of describing quantitatively the experimental observations. The
combined experimental and theoretical evidence supports the hypothesis that the
shape and beat patterns of mammalian sperm cells have evolved to optimally
exploit rheotaxis for long-distance navigation.Comment: 18 pages, 4 figures, supplementary information available at
eLifesciences.or
Impacts, adaptation and vulnerability to global environmental change: challenges and pathways for an action-oriented research agenda for middle-income and low-income countries
The socio-economic impacts of environmental stresses associated with global environmental change depend to a large extent on how societies organize themselves. Research on climate-related societal impacts, vulnerability and adaptation is currently underdeveloped, prompting international global environmental change research institutions to hold a series of meetings in 2009–2010. One of these aimed at identifying needs in middle-income and low-income countries (MLICs), and found that effective responses to the challenge of reducing vulnerability and enhancing adaptation will drive research and policy into challenging and innovative areas of research. Producing impacts, vulnerability and adaptation knowledge requires greater inclusion of MLIC researchers and a rethinking of the research structures, institutions and paradigms that have dominated global change research to date. Scientific literature discussed in this article suggests that governance issues need to become central objects of empirically based, detailed, multiscalar and action-oriented research, and that this needs to address the politically sensitive and seemingly intractable issue of reducing global inequities in power and resource distribution. The scientific literature suggests that without effective action in those directions, current trends toward greater inequality will continue to both reflect and intensify global environmental threats and their impacts
A Review of the fossil record of turtles of the clade Baenidae
The fossil record of the turtle clade Baenidae ranges from the Early Cretaceous (Aptian—Albian) to the Eocene. The group is present throughout North America during the Early Cretaceous, but is restricted to the western portions of the continents in the Late Cretaceous and Paleogene. No credible remains of the clade have been reported outside of North America to date. Baenids were warmadapted freshwater aquatic turtles that supported high levels of diversity at times through niche partitioning, particularly by adapting to a broad range of dietary preferences ranging from omnivorous to molluscivorous. Current phylogenies place Baenidae near the split of crown-group Testudines. Within Baenidae three more inclusive, named clades are recognized: Baenodda, Palatobaeninae and Eubaeninae. A taxonomic review of the group concludes that of 49 named taxa, 30 are nomina valida, 12 are nomina invalida and 7 are nomina dubia
Maintenance of clinical remission in early axial spondyloarthritis following certolizumab pegol dose reduction
Background: The best strategy for maintaining clinical remission in patients with axial spondyloarthritis (axSpA) has not been defined. C-OPTIMISE compared dose continuation, reduction and withdrawal of the tumour necrosis factor inhibitor certolizumab pegol (CZP) following achievement of sustained remission in patients with early axSpA. Methods: C-OPTIMISE was a two-part, multicentre phase 3b study in adults with early active axSpA (radiographic or non-radiographic). During the 48-week open-label induction period, patients received CZP 200 mg every 2 weeks (Q2W). At Week 48, patients in sustained remission (Ankylosing Spondylitis Disease Activity Score (ASDAS) 3.5 at any time point) during the double-blind period. Results: At Week 48, 43.9% (323/736) patients achieved sustained remission, of whom 313 were randomised to CZP full maintenance dose, CZP reduced maintenance dose or placebo. During Weeks 48 to 96, 83.7% (87/104), 79.0% (83/105) and 20.2% (21/104) of patients receiving the full maintenance dose, reduced maintenance dose or placebo, respectively, were flare-free (p<0.001 vs placebo in both CZP groups). Responses in radiographic and non-radiographic axSpA patients were comparable. Conclusions: Patients with early axSpA who achieve sustained remission at 48 weeks can reduce their CZP maintenance dose; however, treatment should not be completely discontinued due to the high risk of flare following CZP withdrawal. Trial registration number: NCT02505542, ClinicalTrials.gov
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All options, not silver bullets, needed to limit global warming to 1.5 °C: a scenario appraisal
Climate science provides strong evidence of the necessity of limiting global warming to 1.5 °C, in line with the Paris Climate Agreement. The IPCC 1.5 °C special report (SR1.5) presents 414 emissions scenarios modelled for the report, of which around 50 are classified as '1.5 °C scenarios', with no or low temperature overshoot. These emission scenarios differ in their reliance on individual mitigation levers, including reduction of global energy demand, decarbonisation of energy production, development of land-management systems, and the pace and scale of deploying carbon dioxide removal (CDR) technologies. The reliance of 1.5 °C scenarios on these levers needs to be critically assessed in light of the potentials of the relevant technologies and roll-out plans. We use a set of five parameters to bundle and characterise the mitigation levers employed in the SR1.5 1.5 °C scenarios. For each of these levers, we draw on the literature to define 'medium' and 'high' upper bounds that delineate between their 'reasonable', 'challenging' and 'speculative' use by mid century. We do not find any 1.5 °C scenarios that stay within all medium upper bounds on the five mitigation levers. Scenarios most frequently 'over use' CDR with geological storage as a mitigation lever, whilst reductions of energy demand and carbon intensity of energy production are 'over used' less frequently. If we allow mitigation levers to be employed up to our high upper bounds, we are left with 22 of the SR1.5 1.5 °C scenarios with no or low overshoot. The scenarios that fulfil these criteria are characterised by greater coverage of the available mitigation levers than those scenarios that exceed at least one of the high upper bounds. When excluding the two scenarios that exceed the SR1.5 carbon budget for limiting global warming to 1.5 °C, this subset of 1.5 °C scenarios shows a range of 15–22 Gt CO2 (16–22 Gt CO2 interquartile range) for emissions in 2030. For the year of reaching net zero CO2 emissions the range is 2039–2061 (2049–2057 interquartile range)
An integrated framework for sustainable development goals
The United Nations (UN) Rio+20 summit committed nations to develop a set of universal sustainable development goals (SDGs) to build on the millennium development goals (MDGs) set to expire in 2015. Research now indicates that humanity’s impact on Earth’s life support system is so great that further global environmental change risks undermining long-term prosperity and poverty eradication goals. Socioeconomic development and global sustainability are often posed as being in conflict because of trade-offs between a growing world population, as well as higher standards of living, and managing the effects of production and consumption on the global environment. We have established a framework for an evidence-based architecture for new goals and targets. Building on six SDGs, which integrate development and environmental considerations, we developed a comprehensive framework of goals and associated targets, which demonstrate that it is possible, and necessary, to develop integrated targets relating to food, energy, water, and ecosystem services goals; thus providing a neutral evidence-based approach to support SDG target discussions. Global analyses, using an integrated global target equation, are close to providing indicators for these targets. Alongside development-only targets and environment-only targets, these integrated targets would ensure that synergies are maximized and trade-offs are managed in the implementation of SDGs
Defining a sustainable development target space for 2030 and 2050
With the establishment of the sustainable development goals (SDGs), countries worldwide agreed to a prosperous, socially inclusive, and environmentally sustainable future for all. This ambition, however, exposes a critical gap in science-based insights, namely on how to achieve the 17 SDGs simultaneously. Quantitative goal-seeking scenario studies could help explore the needed systems' transformations. This requires a clear definition of the "target space." The 169 targets and 232 indicators used for monitoring SDG implementation cannot be used for this; they are too many, too broad, unstructured, and sometimes not formulated quantitatively. Here, we propose a streamlined set of science-based indicators and associated target values that are quantifiable and actionable to make scenario analysis meaningful, relevant, and simple enough to be transparent and communicable. The 36 targets are based on the SDGs, existing multilateral agreements, literature, and expert assessment. They include 2050 as a longer-term reference point. This target space can guide researchers in developing new sustainable development pathways
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