The torment of exile and the aesthetics of nostalgia : transnational Chinese neo-romanticism in Xu Xu’s post-war fiction

Physical exile certainly was a painful reality for Xu Xu. Restorative nostalgia might to some extent have informed his literary activity in those years. However, nostalgia in Xu Xu’s postwar fiction, I will argue in this paper, constitutes above all the expression of a quest for a purely aesthetic utopia that had already begun to take shape in his pre-war oeuvre and that came to full fruition in his post-war fiction. By analyzing a number of Xu Xu’s novellas from Hong Kong, such as Bird Talk, The Other Shore 彼岸 (1951), and The All-Souls Tree 百靈樹 (1954), I will show that nostalgia in Xu’s fiction is ultimately time and place unspecific, and that Xu himself was aware of the limits and fallacy of restorative nostalgia. Nostalgia, I will illustrate, was a way for Xu Xu to give expression both to a real sense of loss as well as a sense of metaphysical homelessness that did not directly result from his exile in Hong Kong, but that is bound up with the experience of modernity and the reality of China’s cultural post-war politics. Nostalgia thus becomes the expression of a literary aesthetic that connects Xu Xu to a number of other writers who are typically associated with a twentieth-century revival of romanticism, foremost Hermann Hesse (1877−1962). Like for Xu Xu, the expression of nostalgia was as much an aesthetic gesture for Hesse as it was a political gesture. My reading of Xu Xu’s use of nostalgia thus challenges conventional interpretations of the use of nostalgia in postwar Chinese literature and enhances our understanding of the interplay of aesthetics and politics in the work of Chinese writers in exile. In my analysis of Xu’s work in the context of neo-romanticism, I will draw on the work of Michael Löwy who understands the romantic critique of modernity as bound up with an experience of loss. “The Romantic vision,” Löwy writes, “is characterized by the painful and melancholic conviction that in the modern reality something precious has been lost, at the level of both individuals and humanity at large; certain essential human values have been alienated. This alienation, keenly sensed, is often experienced as exile […]” (Löwy 2001, 21). Löwy quotes Friedrich Schlegel as speaking of the soul, the seat of humanness, as living “under the willows of exile (unter den Trauerweiden der Verbannung),” far removed from the true hearth of homeland (Löwy 2001, 21). It is precisely this sense of metaphysical homelessness, I will argue, that lies at the root of the nostalgic longing expressed by Xu Xu’s fictional protagonists. Yet Löwy’s study on romanticism informs this paper in another way. Löwy understands romanticism as a highly diverse movement the numerous strands of which can be found in genres and literatures not usually thought to be part of the romantic canon. By drawing on Xu’s own critical writing on the role of the artist in society and by illustrating his intellectual proximity to writers and thinkers of the romantic movement, I will argue that Xu Xu’s postwar fiction contributes to a transnational romantic canon and constitutes a creative engagement with romantic aesthetics that links modern Chinese literature to global literary modernity

China on the move : travel, exile, and migration in Chinese literature and film of the 20th century

During no previous century in China’s long history has society experienced more profound and far-reaching changes than during that nation’s long twentieth century. The contact with Western modernity and institutional change during the late Qing dynasty, the end of dynastic rule and the birth of the Republic, the Pacific War and the Civil War, the founding of the People’s Republic of China (PRC), Taiwan’s gradual democratization and finally the era of opening and reform in China under Deng Xiaoping 鄧小平 (1904−97) and the ensuing economic rise are only some of the key historical events that have profoundly transformed Chinese society and culture. What these events have in common is that they all gave rise to various forms of displacement, both voluntary and involuntary, and both internally within China proper as well as from China to the outside world. This special issue intends to explore the degree to which displacement in the form of travel, migration, and exile has given rise to modern literary and cinematic works and how intellectuals, writers, and filmmakers have responded to the various forms of displacement in their works. The theme of this special issue is deliberately broad in scope. The editors believe that only if studied over the entire span of the twentieth century and in all its various facets can the impact of displacement on the creative imagination of Chinese writers and filmmakers be adequately explored

Development of PCL polyHIPE substrates for 3D breast cancer cell culture

Cancer is a becoming a huge social and economic burden on society, becoming one of the most significant barriers to life expectancy in the 21st century. In particular, breast cancer is one of the leading causes of death for women. One of the most significant difficulties to finding efficient therapies for specific cancers, such as breast cancer, is the efficiency and ease of drug development and testing. Tissue-engineered (TE) in vitro models are rapidly developing as an alternative to animal testing for pharmaceuticals. Additionally, porosity included within these structures overcomes the diffusional mass transfer limit whilst enabling cell infiltration and integration with surrounding tissue. Within this study, we investigated the use of high-molecular-weight polycaprolactone methacrylate (PCL-M) polymerised high-internal-phase emulsions (polyHIPEs) as a scaffold to support 3D breast cancer (MDA-MB-231) cell culture. We assessed the porosity, interconnectivity, and morphology of the polyHIPEs when varying mixing speed during formation of the emulsion, successfully demonstrating the tunability of these polyHIPEs. An ex ovo chick chorioallantoic membrane assay identified the scaffolds as bioinert, with biocompatible properties within a vascularised tissue. Furthermore, in vitro assessment of cell attachment and proliferation showed promising potential for the use of PCL polyHIPEs to support cell growth. Our results demonstrate that PCL polyHIPEs are a promising material to support cancer cell growth with tuneable porosity and interconnectivity for the fabrication of perfusable 3D cancer models

Surfactant-free gelatin-stabilised biodegradable polymerised high internal phase emulsions with macroporous structures

High internal phase emulsion (HIPE) templating is a well-established method for the generation of polymeric materials with high porosity (>74%) and degree of interconnectivity. The porosity and pore size can be altered by adjusting parameters during emulsification, which affects the properties of the resulting porous structure. However, there remain challenges for the fabrication of polyHIPEs, including typically small pore sizes (∼20–50 μm) and the use of surfactants, which can limit their use in biological applications. Here, we present the use of gelatin, a natural polymer, during the formation of polyHIPE structures, through the use of two biodegradable polymers, polycaprolactone-methacrylate (PCL-M) and polyglycerol sebacate-methacrylate (PGS-M). When gelatin is used as the internal phase, it is capable of stabilising emulsions without the need for an additional surfactant. Furthermore, by changing the concentration of gelatin within the internal phase, the pore size of the resulting polyHIPE can be tuned. 5% gelatin solution resulted in the largest mean pore size, increasing from 53 μm to 80 μm and 28 μm to 94 µm for PCL-M and PGS-M respectively. In addition, the inclusion of gelatin further increased the mechanical properties of the polyHIPEs and increased the period an emulsion could be stored before polymerisation. Our results demonstrate the potential to use gelatin for the fabrication of surfactant-free polyHIPEs with macroporous structures, with potential applications in tissue engineering, environmental and agricultural industries

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

Multiple sclerosis (MS), a chronic disorder of the central nervous system and common cause of neurological disability in young adults, is characterized by moderate but complex risk heritability. Here we report the results of a genome-wide association study performed in a 1000 prospective case series of well-characterized individuals with MS and group-matched controls using the Sentrix® HumanHap550 BeadChip platform from Illumina. After stringent quality control data filtering, we compared allele frequencies for 551 642 SNPs in 978 cases and 883 controls and assessed genotypic influences on susceptibility, age of onset, disease severity, as well as brain lesion load and normalized brain volume from magnetic resonance imaging exams. A multi-analytical strategy identified 242 susceptibility SNPs exceeding established thresholds of significance, including 65 within the MHC locus in chromosome 6p21.3. Independent replication confirms a role for GPC5, a heparan sulfate proteoglycan, in disease risk. Gene ontology-based analysis shows a functional dichotomy between genes involved in the susceptibility pathway and those affecting the clinical phenotyp

Emulsion Templated Scaffolds with Tunable Mechanical Properties for Bone Tissue Engineering

Polymerised High Internal Phase Emulsions (PolyHIPEs) are manufactured via emulsion templating and exhibit a highly interconnected microporosity. These materials are commonly used as thin membranes for 3D cell culture. This study uses emulsion templating in combination with microstereolithography to fabricate PolyHIPE scaffolds with a tightly controlled and reproducible architecture. This combination of methods produces hierarchical structures, where the microstructural properties can be independently controlled from the scaffold macrostructure. PolyHIPEs were fabricated with varying ratios of two acrylate monomers (2-ethylhexyl acrylate (EHA) and isobornyl acrylate (IBOA)) and varying nominal porosity to tune mechanical properties. Young's modulus, ultimate tensile stress (UTS) and elongation at failure were determined for twenty EHA/IBOA compositions. Moduli ranged from 63.01±9.13 to 0.36±0.04MPa, UTS from 2.03±0.33 to 0.11±0.01MPa and failure strain from 21.86±2.87% to 2.60±0.61%. Selected compositions were fabricated into macro-porous woodpile structures, plasma treated with air or acrylic acid and seeded with human embryonic stem-cell derived mesenchymal progenitor cells (hES-MPs). Confocal and two-photon microscopy confirmed cell proliferation and penetration into the micro- and macro-porous architecture. The scaffolds supported osteogenic differentiation of mesenchymal cells and interestingly, the stiffest IBOA-based scaffolds that were plasma treated with acrylic acid promoted osteogenesis more strongly than the other scaffolds

Lack of Phylogeographic Structure in the Freshwater Cyanobacterium Microcystis aeruginosa Suggests Global Dispersal

Background : Free-living microorganisms have long been assumed to have ubiquitous distributions with little biogeographic signature because they typically exhibit high dispersal potential and large population sizes. However, molecular data provide contrasting results and it is far from clear to what extent dispersal limitation determines geographic structuring of microbial populations. We aimed to determine biogeographical patterns of the bloom-forming freshwater cyanobacterium Microcystis aeruginosa. Being widely distributed on a global scale but patchily on a regional scale, this prokaryote is an ideal model organism to study microbial dispersal and biogeography. Methodology/Principal Findings : The phylogeography of M. aeruginosa was studied based on a dataset of 311 rDNA internal transcribed spacer (ITS) sequences sampled from six continents. Richness of ITS sequences was high (239 ITS types were detected). Genetic divergence among ITS types averaged 4% (maximum pairwise divergence was 13%). Preliminary analyses revealed nearly completely unresolved phylogenetic relationships and a lack of genetic structure among all sequences due to extensive homoplasy at multiple hypervariable sites. After correcting for this, still no clear phylogeographic structure was detected, and no pattern of isolation by distance was found on a global scale. Concomitantly, genetic differentiation among continents was marginal, whereas variation within continents was high and was mostly shared with all other continents. Similarly, no genetic structure across climate zones was detected. Conclusions/Significance : The high overall diversity and wide global distribution of common ITS types in combination with the lack of phylogeographic structure suggest that intercontinental dispersal of M. aeruginosa ITS types is not rare, and that this species might have a truly cosmopolitan distribution

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Impacts of the Tropical Pacific/Indian Oceans on the Seasonal Cycle of the West African Monsoon

The current consensus is that drought has developed in the Sahel during the second half of the twentieth century as a result of remote effects of oceanic anomalies amplified by local land–atmosphere interactions. This paper focuses on the impacts of oceanic anomalies upon West African climate and specifically aims to identify those from SST anomalies in the Pacific/Indian Oceans during spring and summer seasons, when they were significant. Idealized sensitivity experiments are performed with four atmospheric general circulation models (AGCMs). The prescribed SST patterns used in the AGCMs are based on the leading mode of covariability between SST anomalies over the Pacific/Indian Oceans and summer rainfall over West Africa. The results show that such oceanic anomalies in the Pacific/Indian Ocean lead to a northward shift of an anomalous dry belt from the Gulf of Guinea to the Sahel as the season advances. In the Sahel, the magnitude of rainfall anomalies is comparable to that obtained by other authors using SST anomalies confined to the proximity of the Atlantic Ocean. The mechanism connecting the Pacific/Indian SST anomalies with West African rainfall has a strong seasonal cycle. In spring (May and June), anomalous subsidence develops over both the Maritime Continent and the equatorial Atlantic in response to the enhanced equatorial heating. Precipitation increases over continental West Africa in association with stronger zonal convergence of moisture. In addition, precipitation decreases over the Gulf of Guinea. During the monsoon peak (July and August), the SST anomalies move westward over the equatorial Pacific and the two regions where subsidence occurred earlier in the seasons merge over West Africa. The monsoon weakens and rainfall decreases over the Sahel, especially in August.Peer reviewe