Activation of RyR2 by class I kinase inhibitors

Kinase inhibitors are a common treatment for cancer. Class I kinase inhibitors that target the ATP-binding pocket are particularly prevalent. Many of these compounds are cardiotoxic and can cause arrhythmias. Spontaneous release of Ca2+ via cardiac ryanodine receptors (RyR2), through a process termed store overload-induced Ca2+ release (SOICR), is a common mechanism underlying arrhythmia. We explored whether class I kinase inhibitors could modify the activity of RyR2 and trigger SOICR to determine if this contributes to the cardiotoxic nature of these compounds.Centro de Investigaciones Cardiovasculare

The LOFAR Two-Metre Sky Survey (LoTSS): VI. Optical identifications for the second data release

The second data release of the LOFAR Two-Metre Sky Survey (LoTSS) covers 27% of the northern sky, with a total area of $\sim 5,700$ deg$^2$. The high angular resolution of LOFAR with Dutch baselines (6 arcsec) allows us to carry out optical identifications of a large fraction of the detected radio sources without further radio followup; however, the process is made more challenging by the many extended radio sources found in LOFAR images as a result of its excellent sensitivity to extended structure. In this paper we present source associations and identifications for sources in the second data release based on optical and near-infrared data, using a combination of a likelihood-ratio cross-match method developed for our first data release, our citizen science project Radio Galaxy Zoo: LOFAR, and new approaches to algorithmic optical identification, together with extensive visual inspection by astronomers. We also present spectroscopic or photometric redshifts for a large fraction of the optical identifications. In total 4,116,934 radio sources lie in the area with good optical data, of which 85% have an optical or infrared identification and 58% have a good redshift estimate. We demonstrate the quality of the dataset by comparing it with earlier optically identified radio surveys. This is by far the largest ever optically identified radio catalogue, and will permit robust statistical studies of star-forming and radio-loud active galaxies.Comment: 29 pages. Accepted by A&A; data products available at https://lofar-surveys.org/dr2_release.htm

The LOFAR Two-Metre Sky Survey (LoTSS):VI. Optical identifications for the second data release

The second data release of the LOFAR Two-Metre Sky Survey (LoTSS) covers 27% of the northern sky, with a total area of $\sim 5,700$ deg$^2$. The high angular resolution of LOFAR with Dutch baselines (6 arcsec) allows us to carry out optical identifications of a large fraction of the detected radio sources without further radio followup; however, the process is made more challenging by the many extended radio sources found in LOFAR images as a result of its excellent sensitivity to extended structure. In this paper we present source associations and identifications for sources in the second data release based on optical and near-infrared data, using a combination of a likelihood-ratio cross-match method developed for our first data release, our citizen science project Radio Galaxy Zoo: LOFAR, and new approaches to algorithmic optical identification, together with extensive visual inspection by astronomers. We also present spectroscopic or photometric redshifts for a large fraction of the optical identifications. In total 4,116,934 radio sources lie in the area with good optical data, of which 85% have an optical or infrared identification and 58% have a good redshift estimate. We demonstrate the quality of the dataset by comparing it with earlier optically identified radio surveys. This is by far the largest ever optically identified radio catalogue, and will permit robust statistical studies of star-forming and radio-loud active galaxies

La vacanza in Sardegna. Esperienze turistiche a confronto

Il volume affronta la questione della dimensione \u2018reale\u2019 del fenomeno turistico in Sardegna e offre un quadro completo del turismo esterno (incoming) che gravita su questo territorio. Viene inoltre approfondito il tema della domanda turistica nazionale ed internazionale sulla base di un sondaggio diretto effettuato sui turisti in partenza dai principali porti/aeroporti della regione: si indagano vari aspetti, come la diversit\ue0 delle motivazioni, la durata della vacanza, la geografia del fenomeno e la mobilit\ue0, la soddisfazione complessiva e i livelli di spesa, i profili e le tipologie di turista

The Official Data and the Underestimated Tourist Flow: The Sardinia Case

The touristic phenomenon represents a more and more relevant factor for the social and economic development in Sardinia. For this reason, researchers and policy makers need correct data about touristic flows. In this paper, we propose a method to estimate correctly tourist flows and to provide exact measures of the tourist arrivals. In Italy, the National Institute of Statistics measures tourist flows by organizing direct, total and periodic surveys based on registrations of customers in touristic structures like hotels, camping, etc. However the official data are significant underestimated. As a matter of fact, the official source considers only the official tourist flow, since the real flow includes also a non-observed component. This hidden segment mainly comprises tourists in second homes or summer houses that official agencies generally do not take into account. The aim of this study is to measure this hidden component of the Sardinian tourism and to identify the most relevant features of these tourists. The data of the analysis was collected in 2009 and 2010 by using a survey technique based on the Time Location Sampling methodology. This survey has been carried out in the ports and the airports of the Sardinia Island, interviewing tourist before leave. A specific question registered the kind of accommodation in which tourists spent their holidays. By using specific sampling techniques, we will estimate the proportion of tourists that are not included in the official data. These proportions will be provided according to different typologies of tourists (e.g. Italian and foreign tourists) in order to identify which kind of tourists are more underestimated. Basing on some preliminary results, we can say that the hidden component of tourism in Sardinia represents almost half of the official estimations. Moreover, this phenomenon seems to be mainly related to the second houses and the houses for vacations

Zeri e LODE. Extracting the Zeri photo archive to Linked Open Data: formalizing the conceptual model

This paper presents the first steps of a project to convert the notable Italian \u201cZeri photo archive\u201d to a linked and open dataset. The full project entails the analysis of the records\u2019 description model (Scheda F) in order to define a suitable ontology by exploring existing data models, the creation of the RDF triple store, the creation of links to the cloud, and the definition of the user interface for browsing the linked open dataset. This paper presents and discusses the conceptual modeling of the data stored in the Zeri archival database

Increase of Serum α1-Acid Glycoprotein Despite the Decline of Liver Synthetic Function in Cirrhotics with Hepatocellular Carcinoma

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