Characterization of Pporous materials as radon source and its radiological implications

In this work, a magnitude is proposed in order to compare the potential radiological risk due to radon exposition generated by different materials, and a method based in the ^^^Rn accumulation technique is presented for its determination.. The obtained results indicate that the proposed magnitude and their corresponding measurement methodology are useful in order to take decisions about the management of different kinds of porous materials

Estudio de la resistencia a compresión de morteros fabricados con conglomerante compuesto de polvo de vidrio

This research evaluates the resistance of mortars made with mixtures of different compositions, where a part of the traditional binder is replaced by glass power in a simple way to analyze the mechanical properties of the reactive samples obtained in this way. The tests were carried out with mortars. To facilitate the reactions are added to the mixtures being analyzed different reagents, mixing the glass powder with basic reagents, allowing the collection of conditions of pH greater than 12, ins which the soda-lime glass is very reactive. Analyzed the different specimens of mortar, shows, that the glass powder and its fineness, play an important role in the increasing the compressive strength of the mixtures.Esta investigación evalúa la resistencia de morteros realizados con mezclas de diferentes composiciones, donde una parte del conglomerante tradicional es sustituido por el polvo de vidrio para analizar de una forma sencilla las características mecánicas de las muestras reactivas obtenidas de esta forma. Los ensayos se han realizado con morteros. Para facilitar las reacciones se añaden a las mezclas objeto del análisis diferentes reactivos: se mezcla el polvo de vidrio con reactivos básicos, lo que permite la obtención de condiciones de pH superiores a 12, en las que el vidrio sodo-cálcico es muy reactivo. Analizadas las diferentes probetas de morteros, se observa que el polvo de vidrio, así como su granulometría, juegan un importante papel en el aumento de las resistencias mecánicas a compresión de las mezclas

Germline MC1R status influences somatic mutation burden in melanoma

The major genetic determinants of cutaneous melanoma risk in the general population are disruptive variants (R alleles) in the melanocortin 1 receptor (MC1R) gene. These alleles are also linked to red hair, freckling, and sun sensitivity, all of which are known melanoma phenotypic risk factors. Here we report that in melanomas and for somatic C>T mutations, a signature linked to sun exposure, the expected single-nucleotide variant count associated with the presence of an R allele is estimated to be 42% (95% CI, 15-76%) higher than that among persons without an R allele. This figure is comparable to the expected mutational burden associated with an additional 21 years of age. We also find significant and similar enrichment of non-C>T mutation classes supporting a role for additional mutagenic processes in melanoma development in individuals carrying R alleles

Registration system of professional performances defendants in Community Pharmacy.

INTRODUCCION El diseño de una herramienta o sistema de registro de todas las actuaciones profesionales (AP) que demanda el usuario en la farmacia comunitaria, en el mostrador, donde el farmacéutico realiza la mayor parte de su labor, es imprescindible para entender la barrera de falta de “tiempo” para implantar o desarrollar servicios cognitivos en la farmacia comunitaria. MATERIAL Y METODO El equipo investigador del estudio diseñó la herramienta de registro utilizando como soporte informático el sistema de gestión disponible en las farmacias participantes en el estudio (FARMATCR). Después de un pilotaje de 15 días y de los ajustes necesarios se creó la herramienta definitiva. Los requisitos básicos que se persiguieron para el diseño de la herramienta, fueron: Registrar todas las AP demandadas en el mostrador de la farmacia comunitaria. Recopilar la máxima información para cada una de las AP. Mantener la agilidad en la resolución de las mismas. Se decide hacer un control de calidad de la herramienta para saber si satisface las necesidades para lo que se ha diseñado. RESULTADO: herramienta FINAL La herramienta consiste en la introducción en el sistema informático (FARMATCR,) de una serie de códigos de trabajo nuevos (artículos, aportaciones y desplegables). DISCUSION Es difícil encontrar un equilibrio entre agilidad y rigor del registro. La herramienta es capaz de cuantificar las AP que se realizan en el mostrador, pero con limitaciones.INTRODUCTION Designing a tool or registration system for all professional activities requested by all user over the counter in the community pharmacy, where the pharmacist conducts most of its work, is essential to enable the understanding of the barrier of “lack of time” in order to establish or develop cognitive services in the community pharmacy . METHOD The research team working on this survey, designed the registered tool using the management system available in all pharmacies participants in the survey, as a computerized record (FARMATICR) The ultimate tool was created after 15 days of pile work and needed adjustments. The basic requirements pursued for the design of the tool were: The recording of all professional activities requested at the counter in pharmacies. The compiling of all information for each of the professional activities To maintain the flexibility in the resolutions of these. It was decided to have constant feedback of the quality of the tool to see if it met the requirements for its designed purpose. RESULTS The tool is the introduction into the computer system (FARMATICR,) of a series of new labor codes (articles, transfers and leaflets). DISCUSSION. It is difficult to find a balance between the speed and the inflexibility of the record. The tool is able to quantify the professional activities carried out in the pharmacy counter, but with its limitations

Actuaciones profesionales realizadas en la farmacia comunitaria

Objetivo: Describir todas las actuaciones profesionales (AP) que se llevan a cabo como respuesta a las demandas realizadas por los usuarios en la farmacia comunitaria (FC). Material y métodos: Estudio observacional, descriptivo y transversal, realizado durante 6 meses en dos farmacias comunitarias de Denia (Alicante). La población de estudio fueron todas las demandas de servicio que realizaron los usuarios de ambas farmacias. La variable de estudio fue la AP, es decir, cada uno de los servicios demandados por el usuario en la FC: dispensación, indicación, automedicación, consultas y ventas, clasificándose cada uno en sus resoluciones e incidencias. Resultados: En el estudio se realizaron 30.617 AP, correspondiendo un 42% a la dispensación con receta, y se registró casi un 23% de incidencias. Las indicaciones farmacéuticas supusieron un 9% del total, resolviéndose en la mayoría de casos con la recomendación de un medicamento. Un 33% fueron demandas de automedicación, cursando con casi un 20% de incidencias. Un 7% fueron consultas y un 10% ventas de productos sanitarios. Conclusiones: Del total de AP realizadas, el 90% se consideran farmacéuticas. El 83% fueron dispensaciones de medicamentos, más de la mitad de éstas sin prescripción médica, lo que revela la importancia del asesoramiento farmacéutico en las dispensaciones sin receta. El hecho de que 9 de cada 10 incidencias que se producen en la dispensación con receta y en la automedicación sean por la falta de información del paciente nos pone en alerta sobre la necesidad de implementar medidas que mejoren esta carencia

Actuaciones profesionales realizadas en la farmacia comunitaria

Objetivo: Describir todas las actuaciones profesionales (AP) que se llevan a cabo como respuesta a las demandas realizadas por los usuarios en la farmacia comunitaria (FC). Material y métodos: Estudio observacional, descriptivo y transversal, realizado durante 6 meses en dos farmacias comunitarias de Denia (Alicante). La población de estudio fueron todas las demandas de servicio que realizaron los usuarios de ambas farmacias. La variable de estudio fue la AP, es decir, cada uno de los servicios demandados por el usuario en la FC: dispensación, indicación, automedicación, consultas y ventas, clasificándose cada uno en sus resoluciones e incidencias. Resultados: En el estudio se realizaron 30.617 AP, correspondiendo un 42% a la dispensación con receta, y se registró casi un 23% de incidencias. Las indicaciones farmacéuticas supusieron un 9% del total, resolviéndose en la mayoría de casos con la recomendación de un medicamento. Un 33% fueron demandas de automedicación, cursando con casi un 20% de incidencias. Un 7% fueron consultas y un 10% ventas de productos sanitarios. Conclusiones: Del total de AP realizadas, el 90% se consideran farmacéuticas. El 83% fueron dispensaciones de medicamentos, más de la mitad de éstas sin prescripción médica, lo que revela la importancia del asesoramiento farmacéutico en las dispensaciones sin receta. El hecho de que 9 de cada 10 incidencias que se producen en la dispensación con receta y en la automedicación sean por la falta de información del paciente nos pone en alerta sobre la necesidad de implementar medidas que mejoren esta carencia

CX3CR1/CX3CL1 AXIS mediates platelet-leukocyte adhesion to arterial endothelium in younger patients with a history of idiopathic deep vein thrombosis.

Mechanisms linking deep vein thrombosis (DVT) and subclinical atherosclerosis and risk of cardiovascular events are poorly understood. The aim of this study was to investigate the potential impact of CX3CR1/CX3CL1 axis in DVT-associated endothelial dysfunction. The study included 22 patients (age: 37.5 ± 8.2 years) with a history of idiopathic DVT and without known cardiovascular risk factors and 23 aged-matched control subjects (age: 34 ± 7.8 years). Flow cytometry was used to evaluate peripheral markers of platelet activation, leukocyte immunophenotypes and CX3CR1/CX3CL1 expression in both groups. A flow chamber assay was employed to measure leukocyte arrest under dynamic conditions. Platelet activation and the percentage of circulating CX3CR1-expressing platelets, CX3CR1-expressing platelet-bound monocytes and CD8+ lymphocytes were higher in patients with DVT than in controls. Additionally, patients with DVT had increased plasma levels of CX3CL1, soluble P-selectin and platelet factor 4/CXCL4. Interestingly, this correlated with enhanced platelet-leukocyte interaction and leukocyte adhesion to TNFα-stimulated arterial endothelial cells, which was partly dependent on endothelial CX3CL1 upregulation and increased CX3CR1 expression on platelets, monocytes and lymphocytes. In conclusion, increased CX3CR1 expression on circulating platelets may constitute a prognostic marker for long-term adverse cardiovascular events in patients with DVT. Blockade of CX3CL1/CX3CR1 axis may represent a new therapeutic strategy for the prevention of cardiovascular comorbidities associated with DVT

Assessment of a laboratory critical risk result notification protocol in a tertiary care hospital and their use in clinical decision making

Introduction: Communication of laboratory critical risk results is essential for patient safety, as it allows early decision making. Our aims were: 1) to retrospectively evaluate the current protocol for telephone notification of critical risk results in terms of rates, efficiency and recipient satisfaction, 2) to assess their use in clinical decision making and 3) to suggest alternative tools for a better assessment of notification protocols. Materials and methods: The biochemical critical risk result notifications reported during 12 months by routine and STAT laboratories in a tertiary care hospital were reviewed. Total number of reports, time for the notification and main magnitudes with critical risk results were calculated. The use of notifications in clinical decision making was assessed by reviewing medical records. Satisfaction with the notification protocol was assessed through an online questionnaire to requesting physicians and nurses. Results: Critical result was yielded by 0.1% of total laboratory tests. Median time for notification was 3.2 min (STAT) and 16.9 min (routine). The magnitudes with a greater number of critical results were glucose and potassium for routine analyses, and troponin, sodium for STAT. Most notifications were not reflected in the medical records. Overall mean satisfaction with the protocol was 4.2/5. Conclusion: The results obtained indicate that the current protocol is appropriate. Nevertheless, there are some limitations that hamper the evaluation of the impact on clinical decision making. Alternatives were proposed for a proper and precise evaluation

Hyperactive delirium during emergency department stay: analysis of risk factors and association with short-term outcomes

To investigate factors related to the development of hyperactive delirium in patients during emergency department (ED) stay and the association with short-term outcomes. A secondary analysis of the EDEN (Emergency Department and Elderly Needs) multipurpose multicenter cohort was performed. Patients older than 65 years arriving to the ED in a calm state and who developed confusion and/or psychomotor agitation requiring intravenous/intramuscular treatment during their stay in ED were assigned to delirium group. Patients with psychiatric and epileptic disorders and intracranial hemorrhage were excluded. Thirty-four variables were compared in both groups and outcomes were adjusted for age, sex, Charlson Comorbidity Index, Barthel Index and polypharmacy. Hyperactive delirium that needed treatment were developed in 301 out of 18,730 patients (1.6%). Delirium was directly associated with previous episodes of delirium (OR: 2.44, 95% CI 1.24-4.82), transfer to the ED observation unit (1.62, 1.23-2.15), chronic treatment with opiates (1.51, 1.09-2.09) and length of ED stay longer than 12 h (1.41, 1.02-1.97) and was indirectly associated with chronic kidney disease (0.60, 0.37-0.97). The 30-day all-cause mortality was 4.0% in delirium group and 2.9% in non-delirium group (OR: 1.52, 95% CI 0.83-2.78), need for hospitalization 25.6% and 25% (1.09, 0.83-1.43), in-hospital mortality 16.4% and 7.3% (2.32, 1.24-4.35), prolonged hospitalization 54.5% and 48.6% (1.27, 0.80-2.00), respectively, and 90-day post-discharge combined adverse event 36.4% and 35.8%, respectively (1.06, 0.82-2.00). Patients with previous episodes of delirium, treatment with opioids and longer stay in ED more frequently develop delirium during ED stay and preventive measures should be taken to minimize the incidence. Delirium is associated with in-hospital mortality during the index event