384 research outputs found
On the motion of a classical charged particle
We show that the Lorentz-Dirac equation is not an unavoidable consequence of
energy-momentum conservation for a point charge. What follows solely from
conservation laws is a less restrictive equation already obtained by Honig and
Szamosi. The latter is not properly an equation of motion because, as it
contains an extra scalar variable, it does not determine the future evolution
of the charge. We show that a supplementary constitutive relation can be added
so that the motion is determined and free from the troubles that are customary
in Lorentz-Dirac equation, i. e. preacceleration and runaways
Hydrogen Epoch of Reionization Array (HERA)
The Hydrogen Epoch of Reionization Array (HERA) is a staged experiment to
measure 21 cm emission from the primordial intergalactic medium (IGM)
throughout cosmic reionization (), and to explore earlier epochs of our
Cosmic Dawn (). During these epochs, early stars and black holes
heated and ionized the IGM, introducing fluctuations in 21 cm emission. HERA is
designed to characterize the evolution of the 21 cm power spectrum to constrain
the timing and morphology of reionization, the properties of the first
galaxies, the evolution of large-scale structure, and the early sources of
heating. The full HERA instrument will be a 350-element interferometer in South
Africa consisting of 14-m parabolic dishes observing from 50 to 250 MHz.
Currently, 19 dishes have been deployed on site and the next 18 are under
construction. HERA has been designated as an SKA Precursor instrument.
In this paper, we summarize HERA's scientific context and provide forecasts
for its key science results. After reviewing the current state of the art in
foreground mitigation, we use the delay-spectrum technique to motivate
high-level performance requirements for the HERA instrument. Next, we present
the HERA instrument design, along with the subsystem specifications that ensure
that HERA meets its performance requirements. Finally, we summarize the
schedule and status of the project. We conclude by suggesting that, given the
realities of foreground contamination, current-generation 21 cm instruments are
approaching their sensitivity limits. HERA is designed to bring both the
sensitivity and the precision to deliver its primary science on the basis of
proven foreground filtering techniques, while developing new subtraction
techniques to unlock new capabilities. The result will be a major step toward
realizing the widely recognized scientific potential of 21 cm cosmology.Comment: 26 pages, 24 figures, 2 table
What is evidence required for and who generates that evidence in the Finnish Educational System?
Peer reviewe
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Chagas disease, leishmaniasis and sleeping sickness affect 20 million people worldwide and lead to more than 50,000 deaths annually. The diseases are caused by infection with the kinetoplastid parasites Trypanosoma cruzi, Leishmania spp. and Trypanosoma brucei spp., respectively. These parasites have similar biology and genomic sequence, suggesting that all three diseases could be cured with drugs that modulate the activity of a conserved parasite target. However, no such molecular targets or broad spectrum drugs have been identified to date. Here we describe a selective inhibitor of the kinetoplastid proteasome (GNF6702) with unprecedented in vivo efficacy, which cleared parasites from mice in all three models of infection. GNF6702 inhibits the kinetoplastid proteasome through a non-competitive mechanism, does not inhibit the mammalian proteasome or growth of mammalian cells, and is well-tolerated in mice. Our data provide genetic and chemical validation of the parasite proteasome as a promising therapeutic target for treatment of kinetoplastid infections, and underscore the possibility of developing a single class of drugs for these neglected diseases
The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage
The priming effect of extracellular UTP on human neutrophils: Role of calcium released from thapsigargin-sensitive intracellular stores
P2Y2 receptors, which are equally responsive to ATP and UTP, can trigger intracellular signaling events, such as intracellular calcium mobilization and mitogen-activated protein (MAP) kinase phosphorylation in polymorphonuclear leukocytes (PMN). Moreover, extracellular nucleotides have been shown to prime chemoattractant-induced superoxide production. The aim of our study was to investigate the mechanism responsible for the priming effect of extracellular nucleotides on reactive oxygen species (ROS) production induced in human neutrophils by two different chemoattractants: formyl-methionyl-leucyl-phenylalanine (fMLP) and interleukin-8 (IL-8). Nucleotide-induced priming of ROS production was concentration- and time-dependent. When UTP was added to neutrophil suspensions prior to chemoattractant, the increase of the response reached the maximum at 1 min of pre-incubation with the nucleotide. UTP potentiated the phosphorylation of p44/42 and p38 MAP kinases induced by chemoattractants, however the P2 receptor-mediated potentiation of ROS production was still detectable in the presence of a SB203580 or U0126, supporting the view that MAP kinases do not play a major role in regulating the nucleotide-induced effect. In the presence of thapsigargin, an inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca2+-ATPases in mammalian cells, the effect of fMLP was not affected, but UTP-induced priming was abolished, suggesting that the release of calcium from thapsigargin-sensitive intracellular stores is essential for nucleotide-induced priming in human neutrophils
Recommended from our members
Foreground modelling via Gaussian process regression: An application to HERA data
The key challenge in the observation of the redshifted 21-cm signal from
cosmic reionization is its separation from the much brighter foreground
emission. Such separation relies on the different spectral properties of the
two components, although, in real life, the foreground intrinsic spectrum is
often corrupted by the instrumental response, inducing systematic effects that
can further jeopardize the measurement of the 21-cm signal. In this paper, we
use Gaussian Process Regression to model both foreground emission and
instrumental systematics in hours of data from the Hydrogen Epoch of
Reionization Array. We find that a simple co-variance model with three
components matches the data well, giving a residual power spectrum with white
noise properties. These consist of an "intrinsic" and instrumentally corrupted
component with a coherence-scale of 20 MHz and 2.4 MHz respectively (dominating
the line of sight power spectrum over scales h
cMpc) and a baseline dependent periodic signal with a period of
MHz (dominating over h cMpc) which should
be distinguishable from the 21-cm EoR signal whose typical coherence-scales is
MHz
Recommended from our members
Foreground modelling via Gaussian process regression: An application to HERA data
The key challenge in the observation of the redshifted 21-cm signal from
cosmic reionization is its separation from the much brighter foreground
emission. Such separation relies on the different spectral properties of the
two components, although, in real life, the foreground intrinsic spectrum is
often corrupted by the instrumental response, inducing systematic effects that
can further jeopardize the measurement of the 21-cm signal. In this paper, we
use Gaussian Process Regression to model both foreground emission and
instrumental systematics in hours of data from the Hydrogen Epoch of
Reionization Array. We find that a simple co-variance model with three
components matches the data well, giving a residual power spectrum with white
noise properties. These consist of an "intrinsic" and instrumentally corrupted
component with a coherence-scale of 20 MHz and 2.4 MHz respectively (dominating
the line of sight power spectrum over scales h
cMpc) and a baseline dependent periodic signal with a period of
MHz (dominating over h cMpc) which should
be distinguishable from the 21-cm EoR signal whose typical coherence-scales is
MHz
- …