8 research outputs found
The antiepileptic effect of Centella asiatica on the activities of Na+/K+, Mg2+ and Ca2+-ATPases in rat brain during pentylenetetrazol–induced epilepsy
Background: To study the anticonvulsant effect of different extracts
of Centella asiatica (CA) in male albino rats with reference to Na +
/K + , Mg 2+ and Ca 2+ -ATPase activities. Materials and Methods: Male
Wistar rats (150±25 g b.w.) were divided into seven groups of six
each i.e. (a) control rats treated with saline, (b) pentylenetetrazol
(PTZ)-induced epileptic group (60 mg/kg, i.p.), (c) epileptic group
pretreated with n-hexane extract (n-HE), (d) epileptic group pretreated
with chloroform extract (CE), (e) epileptic group pretreated with ethyl
acetate extract (EAE), (f) epileptic group pretreated with n-butanol
extract (n-BE), and (g) epileptic group pretreated with aqueous extract
(AE). Results: The activities of three ATPases were decreased in
different regions of brain during PTZ-induced epilepsy and were
increased in epileptic rats pretreated with different extracts of CA
except AE. Conclusion: The extracts of C. asiatica, except AE, possess
anticonvulsant and neuroprotective activity and thus can be used for
effective management in treatment of epileptic seizures