Systemic Lupus Erythematosus: relationship between different treatments and clinical evolution

O Lúpus Eritematoso Sistêmico (LES) é uma doença inflamatória crônica de origem autoimune que apresenta manifestações clínicas variáveis, sendo progressiva e potencialmente fatal, se não tratado. Os tratamentos padrões incluem antimaláricos, corticosteroides (CS) e imunossupressores. No entanto, apesar do melhor entendimento do processo da doença, ainda há uma necessidade significativa e não atendida de novo tratamento devido ao alto risco continuado de mortalidade e progressão de danos aos órgãos. Assim, o objetivo do presente estudo foi fazer um levantamento bibliográfico acerca dos diferentes tratamentos publicados para o manejo do LES relacionando com a melhora clínica do paciente. Para tanto, utilizou-se as bases de dados Lilacs, SciELO, PubMed e Google Acadêmico e os Descritores em Ciências da Saúde (DeCS) utilizados foram: “lúpus eritematoso sistêmico”, “terapêutica” e “qualidade de vida”. Os artigos selecionados foram publicados em língua inglesa e portuguesa, entre os anos de 2014 e 2020. As referências encontradas permitiram constatar que os antimaláricos e a infusão de plasma fresco congelado são os recursos terapêuticos com maior eficácia. Além disso, a suplementação com vitamina D apresentou mostrou ter função benéfica sob o quadro clínico de pacientes lúpicos. Outro tratamento efetivo para as lesões dermáticas foi a utilização de laser de corante pulsado. Desse modo, são necessários mais estudos acerca da demonstração da eficácia dos diferentes tratamentos para o LES, a fim de elucidar a eficácia e a segurança das diversas terapias utilizadas.Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease of autoimmune origin that presents variable clinical manifestations, being progressive and potentially fatal, if not treated. Standard treatments include antimalarials, corticosteroids (CS) and immunosuppressants. However, despite a better understanding of the disease process, there is still a significant and unmet need for new treatment due to the continued high risk of mortality and progression of organ damage. Thus, the objective of the present study was making a bibliographical survey about the different treatments published for the management of SLE related to the patient’s clinical improvement. For that, the Lilacs, SciELO, PubMed and Google Scholar databases were used, and the Health Sciences Descriptors (DeCS) used were: “systemic lupus erythematosus”, “therapeutics” and “quality of life”. The selected articles were published in English and Portuguese, between the years 2014 and 2020. The references found showed that antimalarials and the infusion of fresh frozen plasma are the most effective therapeutic resources. In addition, vitamin D supplementation showed to have a beneficial function under the clinical picture of lupus patients. Another effective treatment for skin lesions was the use of pulsed dye laser. Thus, further studies are needed on demonstrating the effectiveness of different treatments for SLE in order to elucidate the efficacy and safety of the different therapies used

A valorização dos conjuntos urbanos através do turismo: o caso da Cidade de Goiás

O presente trabalho trata da importância da valorização de conjuntos históricos através do turismo, tendo como estudo a Cidade de Goiás. Tombada como Patrimônio mundial em dezembro de 2001, pela UNESCO, Goiás é um bom exemplo de cidade mineradora dos séculos XVIII e XIX que permaneceu conservada, incluindo seu meio ambiente natural e o centro histórico. A análise abrange aspectos históricos, culturais, ambientais e econômicos, além das paisagens arquitetônicas que demonstram o favorecimento das possibilidades turísticas

CARACTERIZAÇÕES ANATÔMICA E FÍSICO-MECÂNICA DA MADEIRA DE Liquidambar sp.

Este trabalho teve como objetivo a caracterização anatômica e físico-mecânica da madeira de Liquidambar sp. Para tanto, foram utilizadas três árvores com oito anos de idade, provenientes de um arboreto localizado do município de Guaçuí, Espírito Santo. As características anatômicas analisadas foram as dimensões das fibras (comprimento, diâmetro total e do lume e espessura da parede), dos elementos de vasos (diâmetro tangencial e frequência) e dos raios (altura, largura e frequência). Para a caracterização físico-mecânica foram avaliadas a massa específica (básica, aparente a 12% de umidade e anidra), as contrações totais lineares e volumétrica, a resistência à flexão estática, à compressão paralela às fibras, ao cisalhamento e dureza Janka. Constatou-se frequência vascular numerosa com vasos de pequeno diâmetro tangencial, raios heterocelulares ocorrendo em baixa frequência, e fibras libriformes longas de paredes delgadas a espessas. A massa específica básica da madeira proveniente de discos retirados a 1,30 m do nível do solo foi de 0,48 g cm-3, sendo considerada média, a estabilidade dimensional foi considerada baixa, e houve grande influência da umidade nos valores de resistência da madeira. AbstractAnatomical and physical-mechanical characterization of Liquidambar sp. wood. This research aimed to improve anatomical, physical and mechanical characterization of Liquidambar sp.wood. Three trees were obtained, at eight years of age, from an arboretum located in Guaçuí, Espírito Santo State, Brazil. The analyzed variables were dimensions of the fibers (length, total diameter and diameter of the lumen and wall thickness), the vessel elements (tangential diameter and frequency), and ray (height, width and frequency). The specific gravity (basic, at 12% moisture content and dry), and total volumetric and linear shrinkages, resistance to bending, compression parallel to the fibers, shear and Janka hardness. For anatomical description it was found numerous vessels often with small tangential diameter, heterocellular rays occurring at low frequency, and long libriform fibers with thick to thin walls. The specific gravity of wood from disks taken at 1.30 m from ground level was 0.48 g cm-3, wich we considered average, the dimensional stability was low, and there was great influence of moisture in the resistance values in wood.Keywords: Anatomy; specific gravity; dimensional stability; mechanical strength.This research aimed to improve anatomical, physical and mechanical characterization of Liquidambar sp.wood. Three trees were obtained, at eight years of age, from an arboretum located in Guaçuí, Espírito Santo State, Brazil. The analyzed variables were dimensions of the fibers (length, total diameter and diameter of the lumen and wall thickness), the vessel elements (tangential diameter and frequency), and ray (height, width and frequency). The specific gravity (basic, at 12% moisture content and dry), and total volumetric and linear shrinkages, resistance to bending, compression parallel to the fibers, shear and Janka hardness. For anatomical description it was found numerous vessels often with small tangential diameter, heterocellular rays occurring at low frequency, and long libriform fibers with thick to thin walls. The specific gravity of wood from disks taken at 1.30 m from ground level was 0.48 g cm-3, wich we considered average, the dimensional stability was low, and there was great influence of moisture in the resistance values in wood

Photodynamic Therapy With Bengal Rose and Derivatives Against Leishmania amazonensis

Introduction: The treatment of cutaneous leishmaniasis (CL) is based primarily on the use of pentavalent antimonials, which may lead to many side effects limiting their use. Photodynamic therapy (PDT) is an alternative for the treatment of CL, and some xanthene dyes have the potential for use in PDT.Methods: The xanthenes rose bengal B (RB) and its derivatives rose bengal methyl ester (RBMET), and butyl ester (RBBUT) were analyzed for leishmanicidal activity against promastigotes and intracellular amastigotes of Leishmania amazonensis. Cytotoxicity was assessed in J774.A1 macrophages.Results: RB derivates RBMET (IC50 9.83 μM), and RBBUT (IC50 45.08 μM) showed leishmanicidal activity, however, were toxic to J774.A1 macrophages, resulting in low selectivity index.Conclusion: The RBMET and RBBUT showed to be effective against the L. amazonensis and the low selectivity index presented may not be a limitation for their use in PDT to CL treatment

Effect of thermal treatment variables on the thermogravimetric properties of eucalypt wood

Thermal treatments have the effect of reducing the hygroscopicity and improving the resistance to microbiological attack of wood by the degradation of its chemical constituents. During the treatments, the mass of the wood is reduced, a factor that can affect the quality of the materials according to their use. The objective was to verify the effect of the thermal treatment variables on the thermogravimetric properties and the chemical composition of Eucalyptus grandis. The treatments were carried out in a vacuum oven with three atmosphere conditions - vacuum; N2; vacuum+N2 at temperatures of 140, 180 and 220 °C for 6 hours. It was observed that the mass loss during treatments differed only according to the temperatures used. The extractive content, total lignin and holocellulose presented significant changes only at 220°C in all three atmospheres. In the thermogravimetric analysis, the greatest value of residual mass was found in the treatment that used nitrogen and 220 °C, thus demonstrating that this treatment was more invasive, leading to the conclusion that the vacuum application can help to reduce the degradation of the constituents of the eucalypti wood. wood, which can lead to the production of thermally treated wood without great losses in the mechanical properties

Quality Of Life Of Patients With Breast And Gynecological Cancer Faced With Anticancer Chemotherapy

Quality of life of patients with breast and gynecological cancer faced with anticancer chemotherapy  Backgroud: the evaluation of quality of life in cancer patients is of interest to researchers due to its impact on health policies. The aim of this study was to assess the quality of life of patients with breast and gynecological cancer, undergoing chemotherapy.  Methods and Findings: this was a quantitative, descriptive and longitudinal study, conducted in the Clinical Hospital of the Triangulo Mineiro Federal University. To assess the quality of life, the Portuguese brief version of the World Health Organization Quality of Life (WHOQOL-BREF) instrument was applied. The paired Student’s t-test was used for the analysis of the means of/ the scores of the domains. The study included 14 women. The lowest means were observed in the physical domain, 51.78±15.89 and 50.25±15.37, respectively before and after treatment. There was also a compromise of the psychological and environment domains, however, the data analyzed did not show statistical significance. The main limitation of this study is the sample size.  Conclusion: quality of life presents itself as an important factor for the measurement of results in clinical studies. Keywords: Quality of Life; Breast Neoplasms; Genital Neoplasms, Females; Chemotherapy

Perfil epidemiológico da meningite bacteriana nas diferentes regiões brasileiras

RESUMO: A meningite é uma doença infectocontagiosa que corresponde ao processo inflamatório das meninges, o que se dá por meio da penetração de microrganismos no espaço subaracnóideo, onde encontra-se o líquido cefalorraquidiano (LCR). Pode ser causada por vírus, bactérias, protozoários e fungos. O quadro clínico caracteriza-se por febre, cefaleia, náusea, vômito, rigidez de nuca, prostração e confusão mental, sinais de irritação meníngea, acompanhadas de alterações do líquor. Além disso, é uma doença de notificação compulsória. O objetivo do presente estudo foi descrever o perfil epidemiológico da meningite bacteriana nas diferentes regiões brasileiras. Trata-se de uma mini revisão de literatura, em que a coleta de dados foi feita a partir de fontes secundárias de 11 artigos selecionados em levantamento bibliográfico prévio. A busca foi realizada nas bases de dados Scientific Library Online (SCIELO) e no Google Acadêmico. Além da consulta em dados do Guia de Vigilância em Saúde, do Ministério da Saúde, de 2019. Utilizou-se os Descritores em Ciências da Saúde (DeCS): “meningite” e “perfil epidemiológico”, sendo selecionados artigos publicados entre os anos de 2015 e 2019. Demonstrou-se que ocorrem variações em relação ao perfil epidemiológico associado à meningite nas diferentes regiões brasileiras. Pode-se concluir, por meio da análise dos artigos e do objetivo traçado, que o perfil epidemiológico da meningite nas regiões brasileiras possui as seguintes características, de acordo com a maioria dos artigos: cor variável de acordo com cada região, idade de zero a nove anos e predominância no sexo masculino. Associado a isso, fica evidente que dados como etnia, sexo, situação financeira, moradia e trabalho são as principais variáveis que determinam a capacidade de infecção da meningite no Brasil. &nbsp