Aquagenic urticaria in twins

We describe the case of 18 year old twin brothers who presented to our unit with a 3 year history of aquagenic urticaria. This rare form of urticaria usually presents within an hour of contact with water. The aetiology is unknown. Most cases are sporadic but there are a small number of familial cases in the medical literature. A specific genetic mutation has not yet been found. To our knowledge, this is the first report of aquagenic urticaria in monozygotic twins, further supporting a genetic component to this disease

Logarithmic intertwining operators and vertex operators

This is the first in a series of papers where we study logarithmic intertwining operators for various vertex subalgebras of Heisenberg vertex operator algebras. In this paper we examine logarithmic intertwining operators associated with rank one Heisenberg vertex operator algebra $M(1)_a$, of central charge $1-12a^2$. We classify these operators in terms of {\em depth} and provide explicit constructions in all cases. Furthermore, for $a=0$ we focus on the vertex operator subalgebra L(1,0) of $M(1)_0$ and obtain logarithmic intertwining operators among indecomposable Virasoro algebra modules. In particular, we construct explicitly a family of {\em hidden} logarithmic intertwining operators, i.e., those that operate among two ordinary and one genuine logarithmic L(1,0)-module.Comment: 32 pages. To appear in CM

A survey of the treatment and management of patients with severe chronic spontaneous urticaria.

Chronic spontaneous urticaria (CSU) is characterized by the recurrent appearance of weals, angio‐oedema or both, occurring at least twice weekly for longer than 6 weeks.1 It is often managed with antihistamines, but occasionally requires other systemic agents in recalcitrant cases. A cross‐sectional survey was conducted by means of an internet‐based survey tool (Typeform; https://www.typeform.com). Participating consultants with a specialist interest in urticaria were identified through the specialist registers of the British Society of Allergy and Clinical Immunology (BSACI), the Improving Quality in Allergy Services (IQAS) Group and the British Association of Dermatologists (BAD), and invited to take part. The survey content was based on current CSU treatment guidelines from EAACI/GA2LEN/EDF/WAO1 and the British Society for Allergy and Clinical Immunology (BSACI).2 The EAACI/GA2LEN/EDF/WAO guidelines are a joint initiative of the Dermatology Section of the European Academy of Allergy and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA2LEN) (a European Union‐funded network of excellence), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO). To standardize responses, all participants were presented with a case of recalcitrant CSU (failed on maximum dose of nonsedating antihistamines and montelukast), requiring alternative systemic treatment. Questions covered usage of systemic treatments, routine disease severity assessments, adherence to treatment guidelines and perceived barriers to prescribing. Responses (Table 1) were received from 19 UK consultants (26 surveys sent; completion rate 73%), 15 of whom had > 10 years’ experience in the treatment of CSU. The majority were allergy (58%) and dermatology consultants (37%). Of the 19 consultants, 56% provide a dedicated urticaria service, 37% treat both adult and paediatric patients, and the majority (79%) use systemic medications other than antihistamines and montelukast. Omalizumab and ciclosporin were the most commonly used first‐line agents (47% and 27% respectively) (Fig. 1). The majority (84%) of consultants use validated measures to assess disease severity, including the weekly Urticaria Activity Score (UAS‐7, 63%), the Physician Global Assessment (63%), the Patient Global Assessment (44%) and the Dermatology Quality of Life Index (DLQI) (38%). Guidelines are used by 89% to direct their management of CSU, with 50% using the EAACI/GA2LEN/EDF/WAO guideline,1 compared with 31% primarily using the BSACI guideline.2 The main perceived barriers to prescribing systemic medications were potential adverse effects (AEs) (32% strongly agreed), potential long‐term toxicity (26% strongly agreed), cost of treatment (42% strongly agreed), and views expressed by the patient and their family (37% agreed)

Applying Brain Research to Classroom Strategies

Research in the field of neuroscience has exploded in the past decade. The word brain appears in the title of nearly 40,000 books and CDs indicating intense interest in this area of study. What can music educators learn from recent investigations—often termed brain research—to guide music teaching and learning? The following ideas are intended to have broad applications and may inspire you to investigate this fascinating area of literature more thoroughly. While some findings are new, other studies affirm what music educators have previously found to be effective

Applying Brain Research to Classroom Strategies

Research in the field of neuroscience has exploded in the past decade. The word brain appears in the title of nearly 40,000 books and CDs indicating intense interest in this area of study. What can music educators learn from recent investigations—often termed brain research—to guide music teaching and learning? The following ideas are intended to have broad applications and may inspire you to investigate this fascinating area of literature more thoroughly. While some findings are new, other studies affirm what music educators have previously found to be effective

The influence of the strength of bone on the deformation of acetabular shells : a laboratory experiment in cadavers

Date of Acceptance: 24/08/2014 ©2015 The British Editorial Society of Bone & Joint Surgery. The authors would like to thank N. Taylor (3D Measurement Company) for his work with regard to data acquisition and processing of experimental data. We would also like to thank Dr A. Blain of Newcastle University for performing the statistical analysis The research was supported by the NIHR Newcastle Biomedical Research Centre. The authors P. Dold, M. Flohr and R. Preuss are employed by Ceramtec GmbH. Martin Bone received a salary from the joint fund. The author or one or more of the authors have received or will receive benefits for personal or professional use from a commercial party related directly or indirectly to the subject of this article. This article was primary edited by G. Scott and first proof edited by J. Scott.Peer reviewedPostprin

The Haldane-Rezayi Quantum Hall State and Conformal Field Theory

We propose field theories for the bulk and edge of a quantum Hall state in the universality class of the Haldane-Rezayi wavefunction. The bulk theory is associated with the $c=-2$ conformal field theory. The topological properties of the state, such as the quasiparticle braiding statistics and ground state degeneracy on a torus, may be deduced from this conformal field theory. The 10-fold degeneracy on a torus is explained by the existence of a logarithmic operator in the $c=-2$ theory; this operator corresponds to a novel bulk excitation in the quantum Hall state. We argue that the edge theory is the $c=1$ chiral Dirac fermion, which is related in a simple way to the $c=-2$ theory of the bulk. This theory is reformulated as a truncated version of a doublet of Dirac fermions in which the $SU(2)$ symmetry -- which corresponds to the spin-rotational symmetry of the quantum Hall system -- is manifest and non-local. We make predictions for the current-voltage characteristics for transport through point contacts.Comment: 37 pages, LaTeX. Some references added, minor changes at the end of section

Generalized twisted modules associated to general automorphisms of a vertex operator algebra

We introduce a notion of strongly C^{\times}-graded, or equivalently, C/Z-graded generalized g-twisted V-module associated to an automorphism g, not necessarily of finite order, of a vertex operator algebra. We also introduce a notion of strongly C-graded generalized g-twisted V-module if V admits an additional C-grading compatible with g. Let V=\coprod_{n\in \Z}V_{(n)} be a vertex operator algebra such that V_{(0)}=\C\one and V_{(n)}=0 for n<0 and let u be an element of V of weight 1 such that L(1)u=0. Then the exponential of 2\pi \sqrt{-1} Res_{x} Y(u, x) is an automorphism g_{u} of V. In this case, a strongly C-graded generalized g_{u}-twisted V-module is constructed from a strongly C-graded generalized V-module with a compatible action of g_{u} by modifying the vertex operator map for the generalized V-module using the exponential of the negative-power part of the vertex operator Y(u, x). In particular, we give examples of such generalized twisted modules associated to the exponentials of some screening operators on certain vertex operator algebras related to the triplet W-algebras. An important feature is that we have to work with generalized (twisted) V-modules which are doubly graded by the group C/Z or C and by generalized eigenspaces (not just eigenspaces) for L(0), and the twisted vertex operators in general involve the logarithm of the formal variable.Comment: Final version to appear in Comm. Math. Phys. 38 pages. References on triplet W-algebras added, misprints corrected, and expositions revise

How to write a Critically Appraised Topic: evidence to underpin routine clinical practice

Critically appraised topics (CATs) are essential tools for busy clinicians who wish to ensure that their daily clinical practice is underpinned by evidence-based medicine. CATs are short summaries of the most up-to-date, high-quality available evidence that is found using thorough structured methods. They can be used to answer specific, patient-orientated questions that arise recurrently in real-life practice. This article provides readers with a detailed guide to performing their own CATs. It is split into four main sections reflecting the four main steps involved in performing a CAT: formulation of a focused question, a search for the most relevant and highest-quality evidence, critical appraisal of the evidence and application of the results back to the patient scenario. As well as helping to improve patient care on an individual basis by answering specific clinical questions that arise, CATs can help spread and share knowledge with colleagues on an international level through publication in the evidence-based dermatology section of the British Journal of Dermatolog