Measuring the Relational Aspects of Civic Engagement and Action

Civic leaders who are highly and effectively engaged often have strong relationships with key stakeholders across institutions and communities. The prevalence and nature of these relationships is not known among those with more typical levels of civic engagement. Via survey data of a random sample of residents of two neighboring French towns, we find that people perceive their neighbors to be, on average, more engaged than they perceive to be themselves, and that few individuals can provide specific action steps for how they would tackle social issues in their community. These results suggest that teaching civic action skills, including how to identify key decision makers as possible allies, is important for civic educators

COMPREHENDING HISTORICAL NARRATIVES: EXPLORING THE RELATIONSHIP BETWEEN CAUSAL LANGUAGE AND STUDENTS' MENTAL REPRESENTATIONS OF HISTORY

For over a century, history teachers throughout the United States have selected textbooks as the primary instructional material for their classrooms, while textbook authors and publishers have continuously produced a unified nation-state narrative that presents United States history as a series of objective historical facts for student memorization. Some researchers have suggested that teachers abandon the textbook in favor of primary sources. Yet, due in part to institutional, societal, and political pressures, classroom teachers continue to use these traditional texts. This study, a qualitative investigation of the causal and coherences structures in a sample textbook, a teacher's instructional explanation, and students' related summaries, seeks to determine the influence of a textbook passage and teacher's instructional explanation on students' mental representations of history: What causal and coherence structures are present in a sample US History textbook? To what extent do the causal and coherence structures of the textbook passage influence a teacher's mental representation of a historical event? To what extent do the causal and coherence structures of the textbook passage and the instructional explanation influence students' mental representations of a historical event? Using Kintsch's Construction-Integration Model and Halliday's Systemic Functional Linguistics, data from participants in a diverse setting east of Pittsburgh was analyzed, comparing the network chains and transitivity structures of the passage, the instructional explanation, and participants' summaries. Among this study's findings, students include information common to both the textbook passage and the teacher's instructional explanation in their summaries. Furthermore, the causal constructions identified in students' summaries are similar to those found in either the textbook or the instructional explanation, not often both. These findings have implications for teaching with textbooks, disciplinary literacy instruction, and the implementation of critical, historical thinking in K-12 history classrooms

Polymicrobial oral biofilm models: simplifying the complex

Over the past century, numerous studies have used oral biofilm models to investigate growth kinetics, biofilm formation, structure and composition, antimicrobial susceptibility and host–pathogen interactions. In vivo animal models provide useful models of some oral diseases; however, these are expensive and carry vast ethical implications. Oral biofilms grown or maintained in vitro offer a useful platform for certain studies and have the advantages of being inexpensive to establish and easy to reproduce and manipulate. In addition, a wide range of variables can be monitored and adjusted to mimic the dynamic environmental changes at different sites in the oral cavity, such as pH, temperature, salivary and gingival crevicular fluid flow rates, or microbial composition. This review provides a detailed insight for early-career oral science researchers into how the biofilm models used in oral research have progressed and improved over the years, their advantages and disadvantages, and how such systems have contributed to our current understanding of oral disease pathogenesis and aetiology

Simvastatin inhibits TLR8 signaling in primary human monocytes and spontaneous TNF production from rheumatoid synovial membrane cultures

Simvastatin has been shown to have anti-inflammatory effects that are independent of its serum cholesterol lowering action, but the mechanisms by which these anti-inflammatory effects are mediated have not been elucidated. To explore the mechanism involved, the effect of simvastatin on Toll-like receptor (TLR) signalling in primary human monocytes was investigated. A short pre-treatment with simvastatin dose-dependently inhibited the production of tumor necrosis factor-α (TNF) in response to TLR8 (but not TLRs 2, 4, or 5) activation. Statins are known inhibitors of the cholesterol biosynthetic pathway, but intriguingly TLR8 inhibition could not be reversed by addition of mevalonate or geranylgeranyl pyrophosphate; downstream products of cholesterol biosynthesis. TLR8 signalling was examined in HEK 293 cells stably expressing TLR8, where simvastatin inhibited IKKα/β phosphorylation and subsequent NF-κB activation without affecting the pathway to AP-1. Since simvastatin has been reported to have anti-inflammatory effects in RA patients and TLR8 signalling contributes to TNF production in human RA synovial tissue in culture, simvastatin was tested in these cultures. Simvastatin significantly inhibited the spontaneous release of TNF in this model which was not reversed by mevalonate. Together, these results demonstrate a hitherto unrecognized mechanism of simvastatin inhibition of TLR8 signalling that may in part explain its beneficial anti-inflammatory effects

An overview of the NIRSPEC upgrade for the Keck II telescope

NIRSPEC is a 1-5 micron echelle spectrograph in use on the Keck II Telescope since 1999. The spectrograph is capable of both moderate (R~2,000) and high (R~25,000) resolution observations and has been a workhorse instrument across many astronomical fields, from planetary science to extragalactic observations. In the latter half of 2018, we will upgrade NIRSPEC to improve the sensitivity and stability of the instrument and increase its lifetime. The major components of the upgrade include replacing the spectrometer and slit-viewing camera detectors with Teledyne H2RG arrays and replacing all transputer-based electronics. We present detailed design, testing, and analysis of the upgraded instrument, including the finalized optomechanical design of the new 1-5 micron slit-viewing camera, final alignment and assembly of the science array, electronics systems, and updated software design.Comment: Proceedings of the 2018 SPIE Astronomical Telescopes & Instrumentatio

The Peculiar Debris Disk of HD 111520 as Resolved by the Gemini Planet Imager

Using the Gemini Planet Imager (GPI), we have resolved the circumstellar debris disk around HD 111520 at a projected range of ~30-100 AU in both total and polarized $H$-band intensity. The disk is seen edge-on at a position angle of ~165$^{\circ}$ along the spine of emission. A slight inclination or asymmetric warping are covariant and alters the interpretation of the observed disk emission. We employ 3 point spread function (PSF) subtraction methods to reduce the stellar glare and instrumental artifacts to confirm that there is a roughly 2:1 brightness asymmetry between the NW and SE extension. This specific feature makes HD 111520 the most extreme examples of asymmetric debris disks observed in scattered light among similar highly inclined systems, such as HD 15115 and HD 106906. We further identify a tentative localized brightness enhancement and scale height enhancement associated with the disk at ~40 AU away from the star on the SE extension. We also find that the fractional polarization rises from 10 to 40% from 0.5" to 0.8" from the star. The combination of large brightness asymmetry and symmetric polarization fraction leads us to believe that an azimuthal dust density variation is causing the observed asymmetry.Comment: 9 pages, 8 Figures, 1 table, Accepted to Ap

Predictors of orbital convergence in primates: A test of the snake detection hypothesis of primate evolution

Traditional explanations for the evolution of high orbital convergence and stereoscopic vision in primates have focused on how stereopsis might have aided early primates in foraging or locomoting in an arboreal environment. It has recently been suggested that predation risk by constricting snakes was the selective force that favored the evolution of orbital convergence in early primates, and that later exposure to venomous snakes favored further degrees of convergence in anthropoid primates. Our study tests this snake detection hypothesis (SDH) by examining whether orbital convergence among extant primates is indeed associated with the shared evolutionary history with snakes or the risk that snakes pose for a given species. We predicted that orbital convergence would be higher in species that: 1) have a longer history of sympatry with venomous snakes, 2) are likely to encounter snakes more frequently, 3) are less able to detect or deter snakes due to group size effects, and 4) are more likely to be preyed upon by snakes. Results based on phylogenetically independent contrasts do not support the SDH. Orbital convergence shows no relationship to the shared history with venomous snakes, likelihood of encountering snakes, or group size. Moreover, those species less likely to be targeted as prey by snakes show significantly higher values of orbital convergence. Although an improved ability to detect camouflaged snakes, along with other cryptic stimuli, is likely a consequence of increased orbital convergence, this was unlikely to have been the primary selective force favoring the evolution of stereoscopic vision in primates

Dynamical Mass Measurement of the Young Spectroscopic Binary V343 Normae AaAb Resolved With the Gemini Planet Imager

We present new spatially resolved astrometry and photometry from the Gemini Planet Imager of the inner binary of the young multiple star system V343 Normae, which is a member of the beta Pictoris moving group. V343 Normae comprises a K0 and mid-M star in a ~4.5 year orbit (AaAb) and a wide 10" M5 companion (B). By combining these data with archival astrometry and radial velocities we fit the orbit and measure individual masses for both components of M_Aa = 1.10 +/- 0.10 M_sun and M_Ab = 0.290 +/- 0.018 M_sun. Comparing to theoretical isochrones, we find good agreement for the measured masses and JHK band magnitudes of the two components consistent with the age of the beta Pic moving group. We derive a model-dependent age for the beta Pic moving group of 26 +/- 3 Myr by combining our results for V343 Normae with literature measurements for GJ 3305, which is another group member with resolved binary components and dynamical masses.Comment: 12 pages, 7 figures. Accepted to A