Unraveling the Genetic Basis of Asthma and Allergic Diseases

Asthma and allergic diseases are believed to be complex genetic diseases which may result from the interaction of multiple genetic factors and environmental stimuli. In past decades, great efforts have been exerted in unraveling their genetic basis. The strategies in discovering genes and genetic variants, confirming their importance in pathogenesis of asthma and allergic diseases, as well as their strengths and limitations are summarized comprehensively and concisely. The current consensus about the genetic basis of asthma and allergic diseases is briefly described as well

The Qur'an and Identity in Contemporary Chinese Fiction

How is it possible to comprehend and assess the impact of the Qur’an on the literary expressions of Chinese Muslims (Hui) when the first full ‘translations’ of the Qur’an in Chinese made by non-Muslims from Japanese and English appeared only in 1927 and 1931, and by a Muslim from Arabic in 1932? But perhaps the fact that such a translation appeared so late in the history of the Muslim community in China, who have had a continuous presence since the ninth-century, is the best starting point. For it would be possible to address the relationship between the sacred text (as well as language) and identity among minority groups in a different way. This paper looks at the ways in which the Qur’an is imagined then embodied in literary texts authored by two prize-winning Chinese Muslim authors: Huo Da (b. 1945) and Zhang Chengzhi (b. 1948). While Huo Da, who does not have access to the Arabic language, alludes to the Chinese Qur’an in her novel, The Muslim’s Funeral (1982), transforming the its teachings into ritual performances of alterity through injecting Arabic and Persian words for religious rituals into her narrative of a Muslim family’s fortunes at the turn of the twentieth century, Zhang Chengzhi, who learned Arabic as an adult and travelled widely in the Muslim world, involves himself in reconstructing the history of the spread and persecution of the Jahriyya Sufi sect (an off-shoot of the Naqshabandiyya) in China between the seventeenth and nineteenth centuries in his only historical novel, A History of the Soul (1991), and in education reform in Muslim communities, inventing an identity for Chinese Muslims based on direct knowledge of the sacred text and tradition and informed by the history of Islam not in China alone but in the global Islamic world, especially Arabic Islamic history

The international WAO/EAACI guideline for the management of hereditary angioedema – the 2017 revision and update

Abstract Hereditary Angioedema (HAE) is a rare and disabling disease. Early diagnosis and appropriate therapy are essential. This update and revision of the global guideline for HAE provides up-to-date consensus recommendations for the management of HAE. In the development of this update and revision of the guideline, an international expert panel reviewed the existing evidence and developed 20 recommendations that were discussed, finalized and consented during the guideline consensus conference in June 2016 in Vienna. The final version of this update and revision of the guideline incorporates the contributions of a board of expert reviewers and the endorsing societies. The goal of this guideline update and revision is to provide clinicians and their patients with guidance that will assist them in making rational decisions in the management of HAE with deficient C1-inhibitor (type 1) and HAE with dysfunctional C1-inhibitor (type 2). The key clinical questions covered by these recommendations are: 1) How should HAE-1/2 be defined and classified?, 2) How should HAE-1/2 be diagnosed?, 3) Should HAE-1/2 patients receive prophylactic and/or on-demand treatment and what treatment options should be used?, 4) Should HAE-1/2 management be different for special HAE-1/2 patient groups such as pregnant/lactating women or children?, and 5) Should HAE-1/2 management incorporate self-administration of therapies and patient support measures? This article is co-published with permission in Allergy and the World Allergy Organization Journal