Stereochemical aspects and the synthetic scope of the SHi at the sulfur atom. Preparation of enantiopure 3-substituted 2,3-dihydro-1,2- benzoisothiazole 1-oxides and 1,1-dioxides

Intramolecular homolytic substitution (SHi) on the sulfur atom at acyclic N-(o-bromobenzyl)sulfinamides takes place with a complete inversion of the configuration and provides an excellent tool to connect N-tert-butanesulfinylimines with enantiopure 3-substituted benzo-fused sulfinamides (1,2-benzoisothiazoline 1-oxides) and the related pharmacologically relevant sulfonamidesThe Spanish Government (grant CTQ2012-35957) and Comunidad de Madrid (CCG08-UAM/PPQ-4151; S2009/PPQ1634

Sphere rolling on the surface of a cone

We analyse the motion of a sphere that rolls without slipping on a conical surface having its axis in the direction of the constant gravitational field of the Earth. This nonholonomic system admits a solution in terms of quadratures. We exhibit that the only circular of the system orbit is stable and furthermore show that all its solutions can be found using an analogy with central force problems. We also discuss the case of motion with no gravitational field, that is, of motion on a freely falling cone.Comment: 12 pages, 2 figures, to be published in Eur J Phy

Geology of the Falcón Basin (NW Venezuela)

This paper presents a geological map and cross-section of the Falcón Basin based both on published and unpublished work and on new data collected in the northern and southern basin margins. The geological map covers an area of 4600 km2 at 1:100,000 scale. The cross- section is oriented NNW-SSE, traversing perpendicular to the main structures. In general, the structure of the study area results from the inversion of a graben (Oligocene-early Miocene back-arc basin), that started in the middle Miocene due to the convergence between the Caribbean and South American plates. The map, the cross-section and the observations made in the field have been used to generate a tectonostratigraphic reconstruction of the Falcón Basin. The Oligocene-early Miocene sedimentary succession mapped and described is relevant to the hydrocarbon exploration in the Caribbean and in the Gulf of Venezuela, where new hydrocarbon resources have recently been discovered (i.e. Perla gas field)

Morphology and characterisation of the relict facies on the internal continental shelf in the Gulf of Cadiz, between Ayamonte and Huelva (southern Iberian Peninsula)

The objectives of the present paper are the determination of the morphologic characteristics of the superficial Quaternary relict facies on the internal continental shelf in the Gulf of Cadiz, between Ayamonte and Huelva (southern Spain), their characterisation, and their evolution in the final phases of the last eustatic hemicycle. The study area extends from the mouth of the Guadiana River to the mouth of the Tinto-Odiel River, and from the 6 m isobath to the 56 m isobath. High-resolution seismic profiles (3.5 kHz and Geopulse, 175 J), sonographic profiles (SSS, 100 kHz), and bathymetric profiles (Echotrac sounder) were used in this study. Sediment samples were obtained using Van Veen and Shipek drags. Bathymetric, physiographic, lithologic and morphologic analyses were performed to determine the superficial sediment distribution, relict facies distribution, and thickness of the unconsolidated sediment cover. Analysis of the data obtained indicated that the relict facies beaches and coastal barriers associated with coastal spits located in the ancient outlets of the rivers. Relict facies were grouped into well-differentiated depths, indicating that their position on the continental shelf is influenced by the still-stands and the periods of rapid sea-level changes. The nature of the outcropping relict facies shows that their final configuration can be related to the shelf construction processes, as well as to the most important Holocene transgressive phases.Los objetivos de este trabajo son la determinación de las características morfológicas, la caracterización de las facies relictas cuaternarias superficiales y el estudio de su evolución con relación a las fases finales del último hemiciclo eustático en la plataforma continental interna del golfo de Cádiz, entre Ayamonte y Huelva. El área de estudio abarca desde la desembocadura del río Guadiana hasta la del río Tinto-Odiel y desde los 6 m hasta 56 m de profundidad. Se utilizó gran cantidad de material geofísico, en el que se encuentran perfiles sísmicos de alta resolución (3.5 kHz y Geopulse, 175 J), perfiles sonográficos y perfiles batimétricos, además de muestras de sedimentos obtenidas con dragas Van Veen y Shipek. Con esta información se han realizado análisis batimétricos, fisiográficos, litológicos y morfológicos, además de determinar la distribución de los sedimentos superficiales y de las facies relictas y de cuantificar la potencia de la cobertera sedimentaria. Con todos los datos obtenidos se ha determinado que las facies relictas son interpretadas como playas y cordones litorales asociados a flechas litorales situadas en las antiguas desembocaduras de los ríos. Las formas descritas están agrupadas en zonaciones batimétricas bien diferenciadas, lo que indica que su posición en la plataforma continental está influida por las paradas y etapas de movimiento rápido del nivel del mar. Las características de las facies relictas aflorantes indican que su configuración final puede estar relacionada con los procesos de edificación de la plataforma a partir de las mayores fases transgresivas holocenas.Instituto Español de Oceanografí

Relativistically extended Blanchard recurrence relation for hydrogenic matrix elements

General recurrence relations for arbitrary non-diagonal, radial hydrogenic matrix elements are derived in Dirac relativistic quantum mechanics. Our approach is based on a generalization of the second hypervirial method previously employed in the non-relativistic Schr\"odinger case. A relativistic version of the Pasternack-Sternheimer relation is thence obtained in the diagonal (i.e. total angular momentum and parity the same) case, from such relation an expression for the relativistic virial theorem is deduced. To contribute to the utility of the relations, explicit expressions for the radial matrix elements of functions of the form $r^\lambda$ and $\beta r^\lambda$ ---where $\beta$ is a Dirac matrix--- are presented.Comment: 21 pages, to be published in J. Phys. B: At. Mol. Opt. Phys. in Apri

Estimation of shub height for fuel-type mapping combining airborne LiDAR and simultaneous color infrared ortho imaging

P. 341-348A fuel-type map of a predominantly shub-land area in central Portugal was generated for a fire research experimental site, by combining airborne light detection and ranging (LiDAR), and simultaneous color infrared ortho imaging. Since the vegetation canopy and the ground are too close together to be easily discerned by LiDAR pulses, standard of processing LiDAR data did not provide an accurate estimate of shrub heightS

Drug Repurposing for Cancers With Limited Survival: Protocol for a Retrospective Cohort Study

Only 5% of the molecules tested in oncology phase 1 trials reach the market after an average of 7.5 years of waiting and at a cost of tens of millions of dollars. To reduce the cost and shorten the time of discovery of new treatments, drug repurposing (research with molecules already approved for another indication) and the use of secondary data (not collected for the purpose of research) have been proposed. Due to advances in informatics in clinical care, secondary data can, in some cases, be of equal quality to primary data generated through prospective studies.Objective: The objective of this study is to identify drugs currently marketed for other indications that may have an effect on the prognosis of patients with cancer.Methods: We plan to monitor a cohort of patients with high-lethality cancers treated in the public health system of Catalonia between 2006 and 2012, retrospectively, for survival for 5 years after diagnosis or until death. A control cohort, comprising people without cancer, will also be retrospectively monitored for 5 years. The following study variables will be extracted from different population databases: type of cancer (patients with cancer cohort), date and cause of death, pharmacological treatment, sex, age, and place of residence. During the first stage of statistical analysis of the patients with cancer cohort, the drugs consumed by the long-term survivors (alive at 5 years) will be compared with those consumed by nonsurvivors. In the second stage, the survival associated with the consumption of each relevant drug will be analyzed. For the analyses, groups will be matched for potentially confounding variables, and multivariate analyses will be performed to adjust for residual confounding variables if necessary. The control cohort will be used to verify whether the associations found are exclusive to patients with cancer or whether they also occur in patients without cancer.Results: We anticipate discovering multiple significant associations between commonly used drugs and the survival outcomes of patients with cancer. We expect to publish the initial results in the first half of 2024.Conclusions: This retrospective study may identify several commonly used drugs as candidates for repurposing in the treatment of various cancers. All analyses are considered exploratory; therefore, the results will have to be confirmed in subsequent clinical trials. However, the results of this study may accelerate drug discovery in oncology

Discontinuous transitions in double exchange materials

It is shown that the double exchange Hamiltonian, with weak antiferromagnetic interactions, has a rich variety of first order transitions between phases with different electronic densities and/or magnetizations. For band fillings in the range $0.3 \le x \le 0.5$, and at finite temperatures, a discontinuous transition between phases with similar electronic densities but different magnetizations takes place. This sharp transition, which is not suppressed by electrostatic effects, and survives in the presence of an applied field, is consistent with the phenomenology of the doped manganites near the transition temperature.Comment: three more variational ansatzs considere

A relict oasis of living deep-sea mussels Bathymodiolus and microbial-mediated seep carbonates at newly-discovered active cold seeps in the Gulf of Cádiz, NE Atlantic Ocean

Extensive beds of the deep-sea mussel Bathymodiolus mauritanicus (currently also known as Gigantidas mauritanicus) linked to active cold seeps related to fissure-like activity on Al Gacel mud volcano, Gulf of Cádiz, were filmed and sampled for the first time during the oceanographic expedition SUBVENT-2 aboard R/V Sarmiento de Gamboa. Al Gacel mud volcano is one of up to 80 fluid venting submarine structures (mud volcanoes and mud volcano/diapir complexes) identified in the Gulf of Cádiz as result of explosive venting of hydrocarbon-enriched fluids sourced from deep seated reservoirs. This mud volcano is a cone-shaped edifice, 107 m high, 944 m in diameter constituted by mud breccias and, partially covered by pavements of seep carbonates. Extensive beds of this deep-sea mussel were detected at the northern flank at 810–815 m water depth associated with bacterial mats around intermittent buoyant vertical bubble methane plumes. High methane concentrations were measured in the water column above living mussel beds. Other chemosymbiotic species (Siboglinum sp., Solemya elarraichensis, Isorropodon sp., Thyasira vulcolutre and Lucinoma asapheus) were also found in different parts of Al Gacel mud volcano. Al Gacel mud volcano may currently represent one of the most active mud volcanoes in the Gulf of Cádiz, delivering significant amounts of thermogenic hydrocarbon fluids which contribute to foster the extensive chemosynthesis-based communities detected. This finding is of paramount importance for linking extremophile bivalve populations along the North Atlantic, including cold seeps of the Gulf of México, hydrothermal vents of the Mid-Atlantic Ridge and now, detailed documented at the Gulf of Cádiz.Versión del edito

Impact of Early Intrapatient Variability of Tacrolimus Concentrations on the Risk of Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation Using High-Dose Post-Transplant Cyclophosphamide

Tacrolimus (Tac) is a pivotal immunosuppressant agent used to prevent graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (alloHSCT). Tac is characterized by a narrow therapeutic window and a high inter-patient and intra-patient pharmacokinetic variability (IPV). Although high IPV of Tac concentrations has been associated with adverse post-transplant outcomes following solid organ transplantation, the effects of Tac IPV on alloHSCT recipients have not been determined. Tac IPV was therefore retrospectively evaluated in 128 alloHSCT recipients receiving high-dose post-transplant cyclophosphamide (PTCy) and the effects of Tac IPV on the occurrence of acute GVHD (aGVHD) were analyzed. Tac IPV was calculated from pre-dose concentrations (C0) measured during the first month after Tac initiation. The cumulative rates of grades II-IV and grades III-IV aGVHD at day +100 were 22.7% and 7%, respectively. Higher Tac IPV was associated with a greater risk of developing GVHD, with patients having IPV > 50th percentile having significantly higher rates of grades II-IV (34.9% vs. 10.8%; hazard ratio [HR] 3.858, p < 0.001) and grades III-IV (12.7% vs. 1.5%; HR 9.69, p = 0.033) aGVHD than patients having IPV ? 50th percentile. Similarly, patients with IPV > 75th percentile had higher rates of grades II-IV (41.9% vs. 16.5%; HR 3.30, p < 0.001) and grades III-IV (16.1% vs. 4.1%; HR 4.99, p = 0.012) aGVHD than patients with IPV ? 75th percentile. Multivariate analyses showed that high Tac IPV (>50th percentile) was an independent risk factor for grades II-IV (HR 2.99, p = 0.018) and grades III-IV (HR 9.12, p = 0.047) aGVHD. Determination of Tac IPV soon after alloHSCT could be useful in identifying patients at greater risk of aGVHD