On nonstandard chemotactic dynamics with logistic growth induced by a modified complex Ginzburg–Landau equation

The author is partially supported by MINECO-Feder (Spain), research grant number RTI2018- 098850-B-I00, as well as by Junta de Andalucía (Spain), Project PY18-RT-2422, and A-FQM-311- UGR18.In this paper, we derive a variant of the classical Keller-Segel model of chemotaxis incorporating a growth term of logistic type for the cell population n(t,x), say nu n(1-n) with nu>0, and a nonstandard chemical production-degradation mechanism involving first- and second-order derivatives of the logarithm of the cell density, say f lambda ab(n,nx,nxx)=lambda n+anxxn+bnx2n2 with lambda,a,b is an element of R, via the (n,S)-hydrodynamical system associated with a modified Ginzburg-Landau equation governing the evolution of the complex wavefunction psi=neiS. In a chemotactic context, S(t,x) will play the role of the concentration of chemical substance. Then, after carrying out a detailed analysis of the modulational stability of uniform-in-space plane waves, dark soliton-shaped traveling wave densities of the former system are constructed from solitary wave solutions of the latter.Junta de Andalucia European Commission PY18-RT-2422 and AFQM-311-UGR18MINECO-Feder (Spain

The Impact of Tumor Eco-Evolution in Renal Cell Carcinoma Sampling

Malignant tumors behave dynamically as cell communities governed by ecological principles. Massive sequencing tools are unveiling the true dimension of the heterogeneity of these communities along their evolution in most human neoplasms, clear cell renal cell carcinomas (CCRCC) included. Although initially thought to be purely stochastic processes, very recent genomic analyses have shown that temporal tumor evolution in CCRCC may follow some deterministic pathways that give rise to different clones and sub-clones randomly spatially distributed across the tumor. This fact makes each case unique, unrepeatable and unpredictable. Precise and complete molecular information is crucial for patients with cancer since it may help in establishing a personalized therapy. Intratumor heterogeneity (ITH) detection relies on the correctness of tumor sampling and this is part of the pathologist's daily work. International protocols for tumor sampling are insufficient today. They were conceived decades ago, when ITH was not an issue, and have remained unchanged until now. Noteworthy, an alternative and more efficient sampling method for detecting ITH has been developed recently. This new method, called multisite tumor sampling (MSTS), is specifically addressed to large tumors that are impossible to be totally sampled, and represent an opportunity to improve ITH detection without extra costs.This work has been partially funded by the grant SAF2016-79847-R from Ministerio de Economía y Competitividad (MINECO), Spain (J.I.L.)

De las TIG a las TAG en la formación docente

Aportación a la mesa redonda: “LA FORMACIÓN EN TIG EN LOS NUEVOS PLANES DE GRADOS Y MÁSTERES”, desarrollada en el marco del XVII Congreso Nacional de TIG.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Stretch and shrink flanging of AA2024-T3 sheet by single point incremental forming

Flanging is a forming process widely used to increase the sti ness of sheet parts in industrial applications such as the production of aircraft and automobile components. Flanges are usually formed by rubber forming or using a punch and a die, as these processes are fast and economical for producing a large number of parts. However, there is increasing interest in the manufacturing of anges using nonconventional processes, such as single point incremental forming (SPIF), that allow cost savings due to their exibility and low tooling. This thesis studies the manufacturing of open stretch and shrink anges of AA2024-T3 sheets by SPIF for a wide range of process parameters, including the ange principal radius, spindle speed and tool diameter. In this context, an experimental campaign was performed for each type of ange, classifying the principal modes of failure in the sheet and assessing its formability within the forming limit diagram (FLD). For stretch anging, FE modelling in combination with a theoretical framework based on Barlat's 89 anisotropic yield criterion was used to evaluate the formability in the stress triaxiality space. The fracture forming limit (FFL) obtained for proportional loading and the evolution of the anges were compared in the average stress triaxiality versus equivalent strain space, showing that this space might be the most appropriate for making failure predictions in SPIF. A geometry analysis of shrink anges obtained by SPIF was carried out to evaluate their formability in terms of their tendency to develop wrinkling. The elastic recovery in successful and failed is also studied. Finally, a new approach based on the analysis of compression stresses was proposed to predict the onset of failure in this type of ange. In this regard, it was shown that there exists a stress limit at which the anges analysed fail by wrinkling.El rebordeado de ancos es un proceso de conformado de chapa ampliamente usado en industrias como la aeron autica o la automobilistica para la fabricaci on de componentes estructurales de chapa delgada. Este tipo de proceso se suele realizar sobre metal, normalmente aplicando presion a trav es de una almohadilla de goma o directamente usando una matriz y un punz on met alicos. Estos dos m etodos tienen la ventaja de ser r apidos y rentables en la fabricaci on de grandes lotes. Sin embargo, son cada vez m as los trabajos que estudian el uso de procesos no convencionales, como el conformado incremental monopunto o SPIF (por sus siglas en ingl es), en aplicaciones tales como el rebordeado de agujeros, aprovechando as la exibilidad y el ahorro de utillaje que proporciona esta t ecnica. En este contexto, esta tesis presenta un estudio sobre el conformado incremental monopunto aplicado al rebordeado de ancos abiertos de AA2024-T3 para geometr as c oncavas y convexas. Este trabajo se centra en la evaluaci on de la conformabilidad en el diagrama l mite de conformado (FLD), teniendo en cuenta di erentes par ametros tales como el radio principal del anco, la velocidad de giro de la herramienta o el tama~no de la misma. As mismo, se han obtenido las ventanas de proceso para las dos geometr as propuestas, analizando las caracter sticas de los diferentes modos de fallo. Adem as, se ha usado un modelo num erico junto con un marco te orico basados en el criterio de plasticidad de Barlat 89 para analizar la conformabilidad de los ancos c oncavos en el espacio de la triaxialidad, mostrando que este enfoque puede ser m as adecuado para la predicci on del fallo que el basado en el analysis de deformaciones en el FLD. Por otro lado, se ha realizado un an alisis geom etrico de los ancos convexos, evaluando los efectos de la recuperaci on el astica en ancos exitosos y fallidos. Finalmente, se ha propuesto para este tipo de ancos un nuevo enfoque basado en la predicci on del fallo mediante el an alisis de las tensiones de compresi on. En este sentido, los resultados muestran que existe un l mite de compresi on en t erminos de tensiones a partir del cual este tipo de ancos falla por arrugamiento

A repertoire of repulsive Keller–Segel models with logarithmic sensitivity: Derivation, traveling waves, and quasi-stationary dynamics

In this paper, we show how the chemotactic model {partial derivative(t)rho = d(1) Delta(x)rho - del(x) . (rho del(x)c) partial derivative(t)c = d(2) Delta(x)c + F(rho, c, del(x)rho, del(x)c, Delta x rho) introduced in Alejo and Lopez (2021), which accounts for a chemical production-degradation operator of Hamilton-Jacobi type involving first- and second-order derivatives of the logarithm of the cell concentration, namely, F = mu + tau c - sigma rho + A Delta(x)rho/rho + B vertical bar del(x)rho vertical bar(2)/rho(2) + C vertical bar del(x)c vertical bar(2), with mu, tau, sigma, A, B, C is an element of R, can be formally reduced to a repulsive Keller-Segel model with logarithmic sensitivity { partial derivative(t)rho = D-1 Delta(x)rho + chi del(x) . (rho del(x) log(c)), chi, lambda, beta > 0, partial derivative(t)c = D-2 Delta(x)c + lambda rho c - beta c whenever the chemotactic parameters are appropriately chosen and the cell concentration keeps strictly positive. In this way, some explicit solutions (namely, traveling waves and stationary cell density profiles) of the former system can be transferred to a number of variants of the the latter by means of an adequate change of variables.Spanish Government RTI2018-098850-B-I00 Junta de AndaluciaEuropean Commission PY18-RT-2422 B-FQM-580-UGRUniversidad de Granada/CBU

Jurásico Medio

Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEpu

Conferencia: Secciones condensadas y máximos transgresivos. Una relación equívoca

El método analítico de la estratigrafía secuencial permite aclarar la organización espacio-temporal de los depósitos en las cuencas sedimentarias. Sin embargo, la distribución relativa de las inconformidades y de las secciones condensadas no puede seguir siendo utilizada como criterio diagnóstico de una localización paleogeográfica particular, o de cambios eustáticos hacia condiciones más oceánicas o de mayor profundidad, en relación con etapas de máxima transgresión regional. [ABSTRACT] Sequence stratigraphy allows to elucida te the time-space organization of the deposits in the sedimentary basins. However, the relative distribution of the unconformities as well as of the condensed sections can neither be used as a diagnostic criteria for a particular paleogeographic setting, nor as an indicator of eustatic changes towards deeper conditions related to maximum regional transgressions. Condensation processes can occur during maximum transgressive stages in the distal portion of the basins, but condensation processes are also present along maximum regression stages in the shallowest portions of the platforms. Condensed sections are not only related to the maximum flooding surfaces but also to the systems tracts generated under low sea level conditions. The stratigraphic, sedimentary and taphonomic condensation concepts are useful to analyze the sediments distribution patterns in the sedimentary basins, and also to estima te the lateral and vertical variations in rates (VTS) and sedimentation velocities (VVS). Against the most usual in terpretation about the development of the shallowing-upward sequences or parasequences, the maximum rate, velocity, and amount of accommodation values, as well as the highest relative depth, correspond to the lowest le veIs of these sequences, and are decreasing towards the topo Durante las etapas de máxima transgresión pueden ocurrir procesos de condensación en las partes distales de las cuencas, pero también hay procesos de condensación durante las etapas de máxima regresión en las partes más someras de las plataformas. Las secciones condensadas no sólo están asociadas a las superficies de máxima transgresión sino también a los cortejos generados en condiciones de bajo nivel del mar. Los conceptos de condensación estratigráfica, condensación sedimentaria y condensación tafonómica son útiles para analizar las pautas de distribución de los sedimentos en las cuencas, así como para estimar las variaciones laterales y verticales de las tasas (VTS) y de las velocidades de sedimentación (VVS). En contra de la interpretación más usual del desarrollo de las secuencias de somerización o de las parasecuencias, los máximos valores de tasa, velocidad, profundidad relativa y grado de acomodación de los sedimentos de estas secuencias corresponden a los niveles basales, y los valores de estas variables disminuyen hacia el techo. La distinción entre los procesos de condensación de estas tres categorías permite predecir que los grados de condensación sedimentaria y de condensación estratigráfica serán mayores hacia las partes distales de las plataformas; mientras que los procesos de condensación estratigráfica sin condensación sedimentaria presentarán su máxima intensidad y frecuencia en las áreas más someras de las plataformas. Las secciones condensadas pueden servir para evidenciar ciclos eustáticos y para establecer correlaciones temporales. Sin embargo, si se siguen correlacionando indiscriminadamente las secciones condensadas de las zonas medias y distales de las cuencas, generadas durante máximos transgresivos, con las secciones condensadas de las zonas proximales, debidas a máximos regresivos, las correlaciones temporales establecidas serán tan diacrónicas como las facies más progradantes o retrogradan tes desarrolladas en las plataformas. The distinction between processes of each one of the three categories of condensation allows to make the prediction that sedimentary and stratigraphic condensation degrees will be higher towards the distal portions of the platforms, whilst the stratigraphic condensation processes without sedimentary condensation will show the maximum intensity and frequency in the shallowest portions of the platforms. Condensed sections can serve to evidence eustatic cycles and the establishment of temporal correlations. However, if the condensed sections from the middle and distal portions of the basins, generated during maximum transgressions, are correlated with the condensed sections of the proximal zones, due to regressive maximums, the temporal correlations can be as diachronous as the most retrogradational or progradational facies developed in the shelves

El Jurásico en la región de Chelva-Domeño (Valencia)

Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEpu