The sanctuary of Apollo in Pompeii: new geophysical and archaeological investigations

The paper discusses recent and integrated investigations in the Sanctuary of Apollo in Pompeii, which contribute to the overall understanding of the diachronic evolution of this sacred place, from the archaic period to the eruption of AD 79. High-resolution geophysical surveys have been interpreted in comparison with a new reading of the publication of Maiuri’s excavations and the most recent excavations. The latest research offers significant additional information, not only on the constructive episodes of the architectural complex and the urban landscape in which it is inserted, but also on aspects related to the cult of Apollo and the associated rituality

Picenum and the Ager Gallicus at the dawn of the Roman conquest : landscape archaeology and material culture

Picenum and the Ager Gallicus at the Dawn of the Roman Conquest. Landscape Archaeology and Material Culture is a coherent collection of papers presented at an International Workshop held in Ravenna (Italy) on 13-14 May 2019. The event, organized by the Universities of Bologna and Ghent and Arcadria, focused on the transition between Italic culture and Romanized society in the central Adriatic area – the regions ager Gallicus and Picenum under Roman dominance – from the fourth to the second centuries BCE. By bringing together the experience of international research on this topic, the volume highlights a period that marks a profound transformation in the whole of central Italy by analysing the relationships between the central settlements and their territories and, more in general, by measuring the impact of early Romanization on the territorial structure, social organization and cultural substrata of populations living here. The volume also discusses methodological aspects for best practices in fieldwork, landscape investigation and study of material culture, identifying research lines and perspectives for future deepening of knowledge on this crucial period of central Adriatic archaeology

Conclusions : towards a research agenda for Picenum and the ager Gallicus between the fourth and second centuries BC

none3siPicenum and the Ager Gallicus at the Dawn of the Roman Conquest: Landscape Archaeology and Material Culture is a coherent collection of papers presented at an International Workshop held in Ravenna (Italy) on 13-14 May 2019. The event, organized by the Universities of Bologna and Ghent and Arcadria, focussed on the transition between Italic culture and Romanised society in the central Adriatic area – the regions ager Gallicus and Picenum under Roman dominance – from the fourth to the second centuries BCE. By bringing together the experience of international research on this topic, the volume highlights a period that marks a profound transformation in the whole of central Italy by analysing the relationships between the central settlements and their territories and, more generally, by measuring the impact of early Romanization on the territorial structure, social organization and cultural substrata of populations living here. The volume also discusses methodological aspects regarding best practices in fieldwork, landscape investigation and study of material culture, identifying research lines and perspectives for the future deepening of knowledge in this crucial period of central Adriatic archaeologymixedEnrico Giorgi; Federica Boschi; Frank VermeulenEnrico Giorgi; Federica Boschi; Frank Vermeule

Geo-archaeology of the Roman palaeosurface of Sena Gallica (Senigallia, Italy)

ABSTRACTSena Gallica (Senigallia), in the northern Marche region, was the first Roman colony on the Adriatic coast founded at the beginning of the third century BC. This research adopted an integrated approach to different information sources that combines old and new data, archaeological excavations, topographic and geophysical surveys, and geological and geomorphological analyses. The data are managed within a GIS and supported by 3D modelling. One of the results of this work is a map which represents the geomorphological setting of the Roman colony, close to the mouth of the Misa river. The settlement exploited the top-surface of the uppermost Pleistocene–early Holocene coastal fan of the Misa river, now only preserved at the apex sector truncated seaward by wave erosion. The top-surface of the fan apex, in turn, was partly re-incised by stream erosion producing a series of slight topographic mounds, which were selected for the earliest human settlement (V-IV c. BC). Some of the mounds resulted in a pr..

Age-related changes in the matrisome of the mouse skeletal muscle

Aging is characterized by a progressive decline of skeletal muscle (SM) mass and strength which may lead to sarcopenia in older persons. To date, a limited number of studies have been performed in the old SM looking at the whole, complex network of the extracellular matrix (i.e., matrisome) and its aging-associated changes. In this study, skeletal muscle proteins were isolated from whole gastrocnemius muscles of adult (12 mo.) and old (24 mo.) mice using three sequential extractions, each one analyzed by liquid chromatography with tandem mass spectrometry. Muscle sections were investigated using fluorescence- and transmission electron microscopy. This study provided the first characterization of the matrisome in the old SM demonstrating several statistically significantly increased matrisome proteins in the old vs. adult SM. Several proteomic findings were confirmed and expanded by morphological data. The current findings shed new light on the mutually cooperative interplay between cells and the extracellular environment in the aging SM. These data open the door for a better understanding of the mechanisms modulating myocellular behavior in aging (e.g., by altering mechano-sensing stimuli as well as signaling pathways) and their contribution to age-dependent muscle dysfunction

Aged gastrocnemius muscle of mice positively responds to a late onset adapted physical training

Introduction: A regular physical training is known to contribute to preserve muscle mass and strength, maintaining structure and function of neural and vascular compartments and preventing muscle insulin resistance and inflammation. However, physical activity is progressively reduced during aging causing mobility limitations and poor quality of life. Although physical exercise for rehabilitation purposes (e.g., after fractures or cardiovascular events) or simply aiming to counteract the development of sarcopenia is frequently advised by physicians, nevertheless few data are available on the targets and the global effects on the muscle organ of adapted exercise especially if started at old age.Methods: To contribute answering this question for medical translational purposes, the proteomic profile of the gastrocnemius muscle was analyzed in 24-month-old mice undergoing adapted physical training on a treadmill for 12 weeks or kept under a sedentary lifestyle condition. Proteomic data were implemented by morphological and morphometrical ultrastructural evaluations.Results and Discussion: Data demonstrate that muscles can respond to adapted physical training started at old age, positively modulating their morphology and the proteomic profile fostering protective and saving mechanisms either involving the extracellular compartment as well as muscle cell components and pathways (i.e., mitochondrial processes, cytoplasmic translation pathways, chaperone-dependent protein refolding, regulation of skeletal muscle contraction). Therefore, this study provides important insights on the targets of adapted physical training, which can be regarded as suitable benchmarks for future in vivo studies further exploring the effects of this type of physical activity by functional/metabolic approaches

Development and Evaluation of the Magnetic Properties of a New Manganese (II) Complex: A Potential MRI Contrast Agent

Magnetic resonance imaging (MRI) is a non-invasive powerful modern clinical technique that is extensively used for the high-resolution imaging of soft tissues. To obtain high-definition pictures of tissues or of the whole organism this technique is enhanced by the use of contrast agents. Gadolinium-based contrast agents have an excellent safety profile. However, over the last two decades, some specific concerns have surfaced. Mn(II) has different favorable physicochemical characteristics and a good toxicity profile, which makes it a good alternative to the Gd(III)-based MRI contrast agents currently used in clinics. Mn(II)-disubstituted symmetrical complexes containing dithiocarbamates ligands were prepared under a nitrogen atmosphere. The magnetic measurements on Mn complexes were carried out with MRI phantom measurements at 1.5 T with a clinical magnetic resonance. Relaxivity values, contrast, and stability were evaluated by appropriate sequences. Studies conducted to evaluate the properties of paramagnetic imaging in water using a clinical magnetic resonance showed that the contrast, produced by the complex [Mn(II)(L’)2] × 2H2O (L’ = 1.4-dioxa-8-azaspiro[4.5]decane-8-carbodithioate), is comparable to that produced by gadolinium complexes currently used in medicine as a paramagnetic contrast agent

Backdating systematic shell ornament making in Europe to 45,000 years ago.

Personal ornaments are commonly linked to the emergence of symbolic behavior. Although their presence in Africa dates back to the Middle Stone Age, evidence of ornament manufacturing in Eurasia are sporadically observed in Middle Palaeolithic contexts, and until now, large-scale diffusion has been well documented only since the Upper Palaeolithic. Nevertheless, little is known during the period between ca. 50,000 and 40,000 years ago (ka), when modern humans colonized Eurasia replacing existing hominin populations such as the Neandertals, and a variety of “transitional” and/or early Upper Palaeolithic cultures emerged. Here, we present shell ornaments from the Uluzzian site of Grotta del Cavallo in Italy, southern Europe. Our results show evidence of a local production of shell beads for ornamental purposes as well as a trend toward higher homogeneity in tusk bead shape and size over time. The temporal interval of the layers of interest (45–40 ka) makes Cavallo the earliest known shell ornament making context in Europe