A Review of Atrial Fibrillation Detection Methods as a Service

Atrial Fibrillation (AF) is a common heart arrhythmia that often goes undetected, and even if it is detected, managing the condition may be challenging. In this paper, we review how the RR interval and Electrocardiogram (ECG) signals, incorporated into a monitoring system, can be useful to track AF events. Were such an automated system to be implemented, it could be used to help manage AF and thereby reduce patient morbidity and mortality. The main impetus behind the idea of developing a service is that a greater data volume analyzed can lead to better patient outcomes. Based on the literature review, which we present herein, we introduce the methods that can be used to detect AF efficiently and automatically via the RR interval and ECG signals. A cardiovascular disease monitoring service that incorporates one or multiple of these detection methods could extend event observation to all times, and could therefore become useful to establish any AF occurrence. The development of an automated and efficient method that monitors AF in real time would likely become a key component for meeting public health goals regarding the reduction of fatalities caused by the disease. Yet, at present, significant technological and regulatory obstacles remain, which prevent the development of any proposed system. Establishment of the scientific foundation for monitoring is important to provide effective service to patients and healthcare professionals

A Smart Service Platform for Cost Efficient Cardiac Health Monitoring

Aim: In this study we have investigated the problem of cost effective wireless heart health monitoring from a service design perspective. Subject and Methods: There is a great medical and economic need to support the diagnosis of a wide range of debilitating and indeed fatal non-communicable diseases, like Cardiovascular Disease (CVD), Atrial Fibrillation (AF), diabetes, and sleep disorders. To address this need, we put forward the idea that the combination of Heart Rate (HR) measurements, Internet of Things (IoT), and advanced Artificial Intelligence (AI), forms a Heart Health Monitoring Service Platform (HHMSP). This service platform can be used for multi-disease monitoring, where a distinct service meets the needs of patients having a specific disease. The service functionality is realized by combining common and distinct modules. This forms the technological basis which facilitates a hybrid diagnosis process where machines and practitioners work cooperatively to improve outcomes for patients. Results: Human checks and balances on independent machine decisions maintain safety and reliability of the diagnosis. Cost efficiency comes from efficient signal processing and replacing manual analysis with AI based machine classification. To show the practicality of the proposed service platform, we have implemented an AF monitoring service. Conclusion: Having common modules allows us to harvest the economies of scale. That is an advantage, because the fixed cost for the infrastructure is shared among a large group of customers. Distinct modules define which AI models are used and how the communication with practitioners, caregivers and patients is handled. That makes the proposed HHMSP agile enough to address safety, reliability and functionality needs from healthcare providers

Formal and model driven design of the bright light therapy system Luxamet

Seasonal depression seriously diminishes the quality of life for many patients. To improve their condition, we propose LUXAMET, a bright light therapy system. This system has the potential to relieve patients from some of the symptoms caused by seasonal depression. The system was designed with a formal and model driven design methodology. This methodology enabled us to minimize systemic hazards, like blinding patients with an unhealthy dose of light. This was achieved by controlling race conditions and memory leaks, during design time. We prove that the system specification is deadlock as well as livelock free and there are no invariant violations. These proofs, together with the similarity between specification model and implementation code, make us confident that the implemented system is a reliable tool which can help patients during seasonal depression

Cost-Effective and Non-Invasive Automated Benign & Malignant Thyroid Lesion Classification in 3D Contrast-Enhanced Ultrasound Using Combination of Wavelets and Textures: A Class of ThyroScan™ Algorithms

Ultrasound has great potential to aid in the differential diagnosis of malignant and benign thyroid lesions, but interpretative pitfalls exist and the accuracy is still poor. To overcome these difficulties, we developed and analyzed a range of knowledge representation techniques, which are a class of ThyroScan™ algorithms from Global Biomedical Technologies Inc., California, USA, for automatic classification of benign and malignant thyroid lesions. The analysis is based on data obtained from twenty nodules (ten benign and ten malignant) taken from 3D contrast-enhanced ultrasound images. Fine needle aspiration biopsy and histology confirmed malignancy. Discrete Wavelet Transform (DWT) and texture algorithms are used to extract relevant features from the thyroid images. The resulting feature vectors are fed to three different classifiers: K-Nearest Neighbor (K-NN), Probabilistic Neural Network (PNN), and Decision Tree (DeTr). The performance of these classifiers is compared using Receiver Operating Characteristic (ROC) curves. Our results show that combination of DWT and texture features coupled with K-NN resulted in good performance measures with the area of under the ROC curve of 0.987, a classification accuracy of 98.9%, a sensitivity of 98%, and a specificity of 99.8%. Finally, we have proposed a novel integrated index called Thyroid Malignancy Index (TMI), which is made up of texture features, to diagnose benign or malignant nodules using just one index. We hope that this TMI will help clinicians in a more objective detection of benign and malignant thyroid lesions

Linear and nonlinear analysis of normal and CAD-affected heart rate signals

Coronary Artery Disease (CAD) is one of the dangerous cardiac disease, often may lead to sudden cardiac death. It is difficult to diagnose CAD by manual inspection of electrocardiogram (ECG) signals. To automate this detection task, in this study, we extracted the Heart Rate (HR) from the ECG signals and used them as base signal for further analysis. We then analyzed the HR signals of both normal and CAD subjects using (i) time domain, (ii) frequency domain and (iii) nonlinear techniques. The following are the nonlinear methods that were used in this work: Poincare plots, Recurrence Quantification Analysis (RQA) parameters, Shannon entropy, Approximate Entropy (ApEn), Sample Entropy (SampEn), Higher Order Spectra (HOS) methods, Detrended Fluctuation Analysis (DFA), Empirical Mode Decomposition (EMD), Cumulants, and Correlation Dimension. As a result of the analysis, we present unique recurrence, Poincare and HOS plots for normal and CAD subjects. We have also observed significant variations in the range of these features with respect to normal and CAD classes, and have presented the same in this paper. We found that the RQA parameters were higher for CAD subjects indicating more rhythm. Since the activity of CAD subjects is less, similar signal patterns repeat more frequently compared to the normal subjects. The entropy based parameters, ApEn and SampEn, are lower for CAD subjects indicating lower entropy (less activity due to impairment) for CAD. Almost all HOS parameters showed higher values for the CAD group, indicating the presence of higher frequency content in the CAD signals. Thus, our study provides a deep insight into how such nonlinear features could be exploited to effectively and reliably detect the presence of CAD

An approach to build an event set of European wind storms based on ECMWF EPS

The properties of European wind storms under present climate conditions are estimated on the basis of surface wind forecasts from the European Center of Medium-Range Weather Forecast (ECMWF) Ensemble Prediction System (EPS). While the EPS is designed to provide forecast information of the range of possible weather developments starting from the observed state of weather, we use its archive in a climatological context. It provides a large number of modifications of observed storm events, and includes storms that did not occur in reality. Thus it is possible to create a large sample of storm events, which entirely originate from a physically consistent model, whose ensemble spread represents feasible alternative storm realizations of the covered period. This paper shows that the huge amount of identifiable events in the EPS is applicable to reduce uncertainties in a wide range of fields of research focusing on winter storms. Wind storms are identified and tracked in this study over their lifetime using an algorithm, based on the local exceedance of the 98th percentile of instantaneous 10 m wind speed, calculating a storm severity measure. After removing inhomogeneities in the dataset arising from major modifications of the operational system, the distributions of storm severity, storm size and storm duration are computed. The overall principal properties of the homogenized EPS storm data set are in good agreement with storms from the ERA-Interim dataset, making it suitable for climatological investigations of these extreme events. A demonstrated benefit in the climatological context by the EPS is presented. It gives a clear evidence of a linear increase of maximum storm intensity and wind field size with storm duration. This relation is not recognizable from a sparse ERA-Interim sample for long lasting events, as the number of events in the reanalysis is not sufficient to represent these characteristics

Разработка модели контейнера для сбора компактных люминесцентных ламп

Предложена конструкция контейнера для сбора у населения компактных люминесцентных ламп. Разработан и создан демонстрационный макет контейнера. Проверена его работоспособность.A container design is proposed for collecting compact fluorescent lamps from the city residents. A demonstration mock-up of the container was developed and created. It is checked up its working capacity

Automated detection of atrial fibrillation using long short-term memory network with RR interval signals

Atrial Fibrillation (AF), either permanent or intermittent (paroxysnal AF), increases the risk of cardioembolic stroke. Accurate diagnosis of AF is obligatory for initiation of effective treatment to prevent stroke. Long term cardiac monitoring improves the likelihood of diagnosing paroxysmal AF. We used a deep learning system to detect AF beats in Heart Rate (HR) signals. The data was partitioned with a sliding window of 100 beats. The resulting signal blocks were directly fed into a deep Recurrent Neural Network (RNN) with Long Short-Term Memory (LSTM). The system was validated and tested with data from the MIT-BIH Atrial Fibrillation Database. It achieved 98.51% accuracy with 10-fold cross-validation (20 subjects) and 99.77% with blindfold validation (3 subjects). The proposed system structure is straight forward, because there is no need for information reduction through feature extraction. All the complexity resides in the deep learning system, which gets the entire information from a signal block. This setup leads to the robust performance for unknown data, as measured with the blind fold validation. The proposed Computer-Aided Diagnosis (CAD) system can be used for long-term monitoring of the human heart. To the best of our knowledge, the proposed system is the first to incorporate deep learning for AF beat detection

Improving the safety of atrial fibrillation monitoring systems through human verification

In this paper we propose a hybrid decision-making process for medical diagnosis. The hypothesis tested is that a deep learning system can provide real-time monitoring of Atrial Fibrillation (AF), a prevalent heart arrhythmia, and a human cardiologist will then verify the results and reach a diagnosis. The verification step adds the necessary checks and balances to increase the safety of the computer-based diagnostic process. In order to test hybrid-decision making, we created a prototype AF monitoring service. The service is based on Heart Rate (HR) sensors for signal acquisition as well as Internet of Things (IoT) technology for data communication and storage. These technologies enable transfer of HR data from patient to central cloud server. A deep learning system is used to analyze the data, which is then presented to a cardiologist when a dangerous condition is detected. This human specialist then works to verify the deep learning results based on the HR data and additional knowledge obtained through patient records or by personal interaction with the patient. A prerequisite for safety in any computer expert system is the clarity of purpose for the decision-making process. Health-care providers are considered customers who register patients with the AF monitoring service. The service delivers real-time diagnostic support by providing timely alarm messages and HR analysis. The safety critical decision then lies with the human practitioner