Manual técnico. Establecimiento de niveles de competencia

La determinación de estándares para la interpretación de los niveles de logro de los Exámenes para la Calidad y el Logro Educativos (Excale) constituye un proceso complejo en la construcción de las pruebas, el cual implica elementos de validación. La estrategia y los procedimientos utilizados para este propósito deben basarse en métodos sustentados en la experiencia que las diversas agencias e instituciones de evaluación, nacionales e internacionales han desarrollado y, a partir de ella, crear las interpretaciones de pruebas con sustento en estándares cuidadosamente diseñados, mediante soluciones ajustadas específicamente a los requerimientos de diseño, construcción y aplicación de los Excale

Modelo para la determinación de niveles de logro y puntos de corte de los EXCALE

La determinación de los Niveles de Logro (NL) o de estándares de ejecución de los Exámenes de la Calidad y el Logro Educativos (Excale), del Instituto nacional para la Evaluación de la Educación (INEE), constituye un proceso complejo propio de la construcción de pruebas de gran escala y que implica elementos de validación. Las estrategias y procedimientos que se utilizan para lograr un adecuado sistema de interpretación de resultados de las pruebas nacionales se basan, por lo general, en métodos que han sido probados por diversas agencias evaluadoras e instituciones académicas de prestigio internacional

Acerca de la Validez de los Exámenes de la Calidad y el Logro Educativos (Excale).

Este documento trata de la validación de una nueva generación de pruebas de aprovechamiento desarrollados por el Instituto Nacional para la Evaluación de la Educación conocidos como Exámenes de la Calidad y el Logro Educativos (Excale). En el documento se discuten consideraciones conceptuales acerca de su validez, se propone un marco conceptual basado en premisas, y un marco de referencia para el diseño de estudios de validez. El marco de referencia se basa en la idea de que casi toda la información que se colecta durante el desarrollo de una prueba es útil para su validación. Este marco considera tres aspectos fundamentales: 1) las etapas de desarrollo de una prueba a gran escala (diseño y elaboración, administración, calificación, análisis e interpretación y usos), 2) la evaluación de argumentos confirmatorios (en favor) y no-confirmatorios (en contra) y 3) la evidencia lógica y empírica (uso de metodología cuantitativa y cualitativa). De acuerdo con este marco de referencia, el documento finaliza con una propuesta de líneas de investigación para la validación de los Excale

Partial enterectomy decreases somatostatin-binding sites in residual intestine of rabbits

Three weeks after partial enterectomy in the rabbit there was an increased somatostatin concentration and a decreased number of somatostatin-binding sites (without changes in the corresponding affinity values) in the cytosol of the residual intestinal tissue, except in the terminal ileum and the colon.\ud Five weeks after surgery both the somatostatin concentration and the number of somatostatin-binding sites returned towards control values.\ud These results suggest that an increase in bowel somatostatin content could lead to down-regulation of somatostatin-binding sites in the intestinal mucosa

Percepción de los egresados de la carrera de medicina (Facultad de Ciencias Médicas, UNLP) sobre la adquisición de competencias profesionales básicas comprendidas en la RES. Nº 1314

El presente trabajo se enmarca dentro del Programa de Seguimiento de Graduados de la Facultad de Ciencias Médicas (2016-2019). El Programa indaga, entre otros aspectos, la percepción de los egresados acerca de la formación recibida durante la carrera con relación al grado de adquisición de las competencias médicas básicas (40 actividades-tareas) que define le Resolución 1314/07 del Ministerio de Educación, Ciencia y Tecnología de la Nación.Facultad de Ciencias Médica

Proteoma de la saliva de Ornithodoros moubata: comparativa entre machos y hembras

Comunicaciones a congreso

Assessment of Subclinical Psychotic Symptoms in Patients with Rheumatoid Arthritis and Spondyloarthritis

Inflammatory and autoimmune processes have been associated with the onset of depressive and psychotic symptoms. Rheumatoid arthritis (RA) and spondyloarthritis (SpA) are rheumatic diseases with an inflammatory etiology. A high prevalence of depressive and anxiety-related comorbidity has been reported for both diseases, with no evidence of a greater prevalence of psychosis. The objective of the present study was to evaluate for the first time subclinical psychotic symptoms in patients with RA and SpA. This is a cross-sectional, single-center study including RA and SpA patients, as well as healthy controls. Abnormal psychotic experiences (positive, negative, and depressive symptoms) were evaluated using the Community Assessment of Psychic Experiences (CAPE-42). Functional capacity was evaluated using the Short-Form Health Survey SF-12. We compared the CAPE and SF-12 scores between the three groups. We recruited 385 individuals: 218 with RA, 100 with SpA, and 67 healthy controls. According to the CAPE scale, the frequency of subclinical psychotic symptoms was greater in patients than in healthy controls (RA, 1.90 vs. 1.63, p < 0.001; SpA, 1.88 vs. 1.63, p = 0.001). Distress was also greater in patients than in controls owing to the presence of symptoms. No differences were observed between the three groups for the mental dimension scores in the SF-12 Health Survey (43.75 in RA, 45.54 in SpA, and 43.19 in healthy controls). Our findings point to a greater prevalence of subclinical psychotic symptoms in patients with RA and patients with SpA than in the general population. The results suggest an association between inflammation and depression/subclinical psychotic symptoms

Ferrocene derivatives of liquid chiral molecules allow assignment of absolute configuration by X-ray crystallography

The present study investigates a synthetically simple ferrocene derivatization of natural products and active pharmaceutical ingredients. Seven new crystal structures are analyzed together with 16 structures of ferrocene derivatives reported previously. In all cases, the unambiguous determination of the absolute structure was established from anomalous dispersion using the methods of Flack and Parsons. A comparison with other derivatization approaches shows the advantage of the described ferrocene derivatization for establishing the absolute configuration of novel compounds

Operando NAP-XPS studies of a ceria-supported Pd catalyst for CO oxidation

Supported Pd/CeO2 catalytic systems have been widely investigated in the low-temperature oxidation of CO (LTO CO) due to the unique oxygen storage capacity and redox properties of the ceria support, which highly influence the structural, chemical and electronic state of Pd species. Herein, operando near-ambient pressure XPS (NAP-XPS) technique has allowed the study of a conventional Pd/CeO2 catalyst surface during the CO oxidation reaction under experimental conditions closer to the actual catalytic reaction, unfeasible with other surface science techniques that demand UHV conditions. SEM, HRTEM and XRD analyses of the powder catalyst, prepared by conventional incipient wetness impregnation, reveal uniformly CeO2-loaded Pd NPs of less than 2 nm size, which generated an increase in oxygen vacancies with concomitant ceria reduction, as indicated by H2-TPR and Raman measurements. Adsorbed peroxide (O22-) species on the catalyst surface could also be detected by Raman spectra. Operando NAP-XPS results obtained at the ALBA Synchrotron Light Source revealed two kinds of Pd species under reaction conditions, namely PdOx and PdII ions in a PdxCe1-xO2-d solution, the latter one appearing to be crucial for the CO oxidation. By means of a non-destructive depth profile analysis using variable synchrotron excitation energies, the location and the role of these palladium species in the CO oxidation reaction could be clarified: PdOx was found to prevail on the upper surface layers of the metallic Pd supported NPs under CO, while under reaction mixture it was rapidly depleted from the surface, leaving a greater amount in the subsurface layers (7% vs. 12%, respectively). On the contrary, the PdxCe1-xO2-d phase, which was created at the Pd–CeO2 interface in contact with the gas environment, appeared to be predominant on the surface of the catalyst. Its presence was crucial for CO oxidation evolution, acting as a route through which active oxygen species could be transferred from ceria to Pd species for CO oxidation.Peer ReviewedPostprint (published version

Homochiral Metal-Organic Frameworks for Enantioselective Separations in Liquid Chromatography

Selective separation of enantiomers is a substantial challenge for the pharmaceutical industry. Chromatography on chiral stationary phases is the standard method, but at a very high cost for industrial-scale purification owing to the high cost of the chiral stationary phases. Typically, these materials are poorly robust, expensive to manufacture and often too specific for a single desired substrate, lacking desirable versatility across different chiral analytes. Here we disclose a porous, robust homochiral metal-organic framework (MOF), TAMOF-1, built from copper(II) and an affordable linker prepared from natural L-histidine. TAMOF-1 has shown to be able to separate a variety of model racemic mixtures, including drugs, in a wide range of solvents of different polarity, outperforming several commercial chiral columns for HPLC separations. Although not exploited in the present article, it is worthy to mention that the preparation of this new material is scalable to the multikilogram scale, opening unprecedented possibilities for low-energy chiral separation at the industrial scale