286 research outputs found
Perspectives of using sodium alginate with different molecular weight in the complex cancer therapy
The article presents the results of screening research of influence of sodium alginate with different molecular weight on the development of transplantable tumor in mice and the effectiveness of cytostatic treatment. It was determined that sodium alginates with both high (М = 403 kDa) and low (M = 1-10 kDa and M = 1 kDa) molecular weight suppress growth of Ehrlich ascites carcinoma; using sodium alginate (M = 20-30 kDa) in the scheme of chemotherapy increases effectiveness of treatment. Alginates with low molecular weight arrest development of dissemination of Lewis lung carcinoma and sodium alginates (M = 403 kDa and M = 20-30 kDa) in combination with cyclophosphan increase its antimetastatic effect
The priming of potato plants induced by brassinosteroids reduces oxidative stress and increases salt tolerance
This is the first study to show that brief pretreatment of potato plants with two brassinosteroids differing in structure causes in plants the ability to react to delayed salt stress by accumulation of compounds with antioxidant activity and by increased salt tolerance
Another look at the BL Lacertae flux and spectral variability
The GLAST-AGILE Support Program (GASP) of the Whole Earth Blazar Telescope
(WEBT) monitored BL Lacertae in 2008-2009 at radio, near-IR, and optical
frequencies. During this period, high-energy observations were performed by
XMM-Newton, Swift, and Fermi. We analyse these data with particular attention
to the calibration of Swift UV data, and apply a helical jet model to interpret
the source broad-band variability. The GASP-WEBT observations show an optical
flare in 2008 February-March, and oscillations of several tenths of mag on a
few-day time scale afterwards. The radio flux is only mildly variable. The UV
data from both XMM-Newton and Swift seem to confirm a UV excess that is likely
caused by thermal emission from the accretion disc. The X-ray data from
XMM-Newton indicate a strongly concave spectrum, as well as moderate flux
variability on an hour time scale. The Swift X-ray data reveal fast (interday)
flux changes, not correlated with those observed at lower energies. We compare
the spectral energy distribution (SED) corresponding to the 2008 low-brightness
state, which was characterised by a synchrotron dominance, to the 1997 outburst
state, where the inverse-Compton emission was prevailing. A fit with an
inhomogeneous helical jet model suggests that two synchrotron components are at
work with their self inverse-Compton emission. Most likely, they represent the
radiation from two distinct emitting regions in the jet. We show that the
difference between the source SEDs in 2008 and 1997 can be explained in terms
of pure geometrical variations. The outburst state occurred when the
jet-emitting regions were better aligned with the line of sight, producing an
increase of the Doppler beaming factor. Our analysis demonstrates that the jet
geometry can play an extremely important role in the BL Lacertae flux and
spectral variability.Comment: 12 pages, 10 figures, accepted for publication in A&
The unprecedented optical outburst of the quasar 3C 454.3. The WEBT campaign of 2004-2005
The radio quasar 3C 454.3 underwent an exceptional optical outburst lasting
more than 1 year and culminating in spring 2005. The maximum brightness
detected was R = 12.0, which represents the most luminous quasar state thus far
observed (M_B ~ -31.4). In order to follow the emission behaviour of the source
in detail, a large multiwavelength campaign was organized by the Whole Earth
Blazar Telescope (WEBT). Continuous optical, near-IR and radio monitoring was
performed in several bands. ToO pointings by the Chandra and INTEGRAL
satellites provided additional information at high energies in May 2005. The
historical radio and optical light curves show different behaviours. Until
about 2001.0 only moderate variability was present in the optical regime, while
prominent and long-lasting radio outbursts were visible at the various radio
frequencies, with higher-frequency variations preceding the lower-frequency
ones. After that date, the optical activity increased and the radio flux is
less variable. This suggests that the optical and radio emissions come from two
separate and misaligned jet regions, with the inner optical one acquiring a
smaller viewing angle during the 2004-2005 outburst. Moreover, the colour-index
behaviour (generally redder-when-brighter) during the outburst suggests the
presence of a luminous accretion disc. A huge mm outburst followed the optical
one, peaking in June-July 2005. The high-frequency (37-43 GHz) radio flux
started to increase in early 2005 and reached a maximum at the end of our
observing period (end of September 2005). VLBA observations at 43 GHz during
the summer confirm theComment: 7 pages, 4 figures, to be published in A&
WEBT and XMM-Newton observations of 3C 454.3 during the post-outburst phase. Detection of the little and big blue bumps
The blazar 3C 454.3 underwent an unprecedented optical outburst in spring
2005. This was first followed by a mm and then by a cm radio outburst, which
peaked in February 2006. We report on follow-up observations by the WEBT to
study the multiwavelength emission in the post-outburst phase. XMM-Newton
observations on July and December 2006 added information on the X-ray and UV
fluxes. The source was in a faint state. The radio flux at the higher
frequencies showed a fast decreasing trend, which represents the tail of the
big radio outburst. It was followed by a quiescent state, common at all radio
frequencies. In contrast, moderate activity characterized the NIR and optical
light curves, with a progressive increase of the variability amplitude with
increasing wavelength. We ascribe this redder-when-brighter behaviour to the
presence of a "little blue bump" due to line emission from the broad line
region, which is clearly visible in the source SED during faint states.
Moreover, the data from the XMM-Newton OM reveal a rise of the SED in the UV,
suggesting the existence of a "big blue bump" due to thermal emission from the
accretion disc. The X-ray spectra are well fitted with a power-law model with
photoelectric absorption, possibly larger than the Galactic one. However, the
comparison with previous X-ray observations would imply that the amount of
absorbing matter is variable. Alternatively, the intrinsic X-ray spectrum
presents a curvature, which may depend on the X-ray brightness. In this case,
two scenarios are possible.Comment: 9 pages, 7 figures, accepted for publication in A&
The brightest gamma-ray flaring blazar in the sky: AGILE and multi-wavelength observations of 3C 454.3 during November 2010
Since 2005, the blazar 3C 454.3 has shown remarkable flaring activity at all
frequencies, and during the last four years it has exhibited more than one
gamma-ray flare per year, becoming the most active gamma-ray blazar in the sky.
We present for the first time the multi-wavelength AGILE, SWIFT, INTEGRAL, and
GASP-WEBT data collected in order to explain the extraordinary gamma-ray flare
of 3C 454.3 which occurred in November 2010. On 2010 November 20 (MJD 55520),
3C 454.3 reached a peak flux (E>100 MeV) of F_gamma(p) = (6.8+-1.0)E-5 ph/cm2/s
on a time scale of about 12 hours, more than a factor of 6 higher than the flux
of the brightest steady gamma-ray source, the Vela pulsar, and more than a
factor of 3 brighter than its previous super-flare on 2009 December 2-3. The
multi-wavelength data make a thorough study of the present event possible: the
comparison with the previous outbursts indicates a close similarity to the one
that occurred in 2009. By comparing the broadband emission before, during, and
after the gamma-ray flare, we find that the radio, optical and X-ray emission
varies within a factor 2-3, whereas the gamma-ray flux by a factor of 10. This
remarkable behavior is modeled by an external Compton component driven by a
substantial local enhancement of soft seed photons.Comment: Accepted for publication in ApJ Letters. 18 Pages, 4 Figures, 1 Tabl
Long-term multi-wavelength variability and correlation study of Markarian 421 from 2007 to 2009
We study the multi-band variability and correlations of the TeV blazar Mrk
421 on year time scales, which can bring additional insight on the processes
responsible for its broadband emission. We observed Mrk 421 in the very high
energy (VHE) gamma-ray range with the Cherenkov telescope MAGIC-I from March
2007 to June 2009 for a total of 96 hours of effective time after quality cuts.
The VHE flux variability is quantified with several methods, including the
Bayesian Block algorithm, which is applied to data from Cherenkov telescopes
for the first time. The 2.3 year long MAGIC light curve is complemented with
data from the Swift/BAT and RXTE/ASM satellites and the KVA, GASP-WEBT, OVRO,
and Mets\"ahovi telescopes from February 2007 to July 2009, allowing for an
excellent characterisation of the multi-band variability and correlations over
year time scales. Mrk 421 was found in different gamma-ray emission states
during the 2.3 year long observation period. Flares and different levels of
variability in the gamma-ray light curve could be identified with the Bayesian
Block algorithm. The same behaviour of a quiet and active emission was found in
the X-ray light curves measured by Swift/BAT and the RXTE/ASM, with a direct
correlation in time. The behaviour of the optical light curve of GASP-WEBT and
the radio light curves by OVRO and Mets\"ahovi are different as they show no
coincident features with the higher energetic light curves and a less variable
emission. The fractional variability is overall increasing with energy. The
comparable variability in the X-ray and VHE bands and their direct correlation
during both high- and low-activity periods spanning many months show that the
electron populations radiating the X-ray and gamma-ray photons are either the
same, as expected in the Synchrotron-Self-Compton mechanism, or at least
strongly correlated, as expected in electromagnetic cascades.Comment: Corresponding authors: Ann-Kristin Overkemping
([email protected]), Marina Manganaro
([email protected]), Diego Tescaro ([email protected]), To be published
in Astronomy&Astrophysics (A&A), 12 pages, 9 figure
The structure and emission model of the relativistic jet in the quasar 3C 279 inferred from radio to high-energy gamma-ray observations in 2008-2010
We present time-resolved broad-band observations of the quasar 3C 279
obtained from multi-wavelength campaigns conducted during the first two years
of the Fermi Gamma-ray Space Telescope mission. While investigating the
previously reported gamma-ray/optical flare accompanied by a change in optical
polarization, we found that the optical emission appears delayed with respect
to the gamma-ray emission by about 10 days. X-ray observations reveal a pair of
`isolated' flares separated by ~90 days, with only weak gamma-ray/optical
counterparts. The spectral structure measured by Spitzer reveals a synchrotron
component peaking in the mid-infrared band with a sharp break at the
far-infrared band during the gamma-ray flare, while the peak appears in the
mm/sub-mm band in the low state. Selected spectral energy distributions are
fitted with leptonic models including Comptonization of external radiation
produced in a dusty torus or the broad-line region. Adopting the interpretation
of the polarization swing involving propagation of the emitting region along a
curved trajectory, we can explain the evolution of the broad-band spectra
during the gamma-ray flaring event by a shift of its location from ~ 1 pc to ~
4 pc from the central black hole. On the other hand, if the gamma-ray flare is
generated instead at sub-pc distance from the central black hole, the
far-infrared break can be explained by synchrotron self-absorption. We also
model the low spectral state, dominated by the mm/sub-mm peaking synchrotron
component, and suggest that the corresponding inverse-Compton component
explains the steady X-ray emission.Comment: 23 pages, 18 figures 5 tables, Accepted for publication in The
Astrophysical Journa
Suppression of AP1 Transcription Factor Function in Keratinocyte Suppresses Differentiation
Our previous study shows that inhibiting activator protein one (AP1) transcription factor function in murine epidermis, using dominant-negative c-jun (TAM67), increases cell proliferation and delays differentiation. To understand the mechanism of action, we compare TAM67 impact in mouse epidermis and in cultured normal human keratinocytes. We show that TAM67 localizes in the nucleus where it forms TAM67 homodimers that competitively interact with AP1 transcription factor DNA binding sites to reduce endogenous jun and fos factor binding. Involucrin is a marker of keratinocyte differentiation that is expressed in the suprabasal epidermis and this expression requires AP1 factor interaction at the AP1-5 site in the promoter. TAM67 interacts competitively at this site to reduce involucrin expression. TAM67 also reduces endogenous c-jun, junB and junD mRNA and protein level. Studies with c-jun promoter suggest that this is due to reduced transcription of the c-jun gene. We propose that TAM67 suppresses keratinocyte differentiation by interfering with endogenous AP1 factor binding to regulator elements in differentiation-associated target genes, and by reducing endogenous c-jun factor expression
- …