IMPACTOS DO PROGRAMA DE AÇÃO ECONÔMICA DO GOVERNO (1964-1967) NA INDÚSTRIA DE TRANSFORMAÇÃO

Between 1964 and 1967, during the first military government, the Government Economic Action Program (Paeg) was implemented, whose main objectives werecombating high inflation rates and the balance of payments crisis. Despite these priorities, there was also, by the part of the economic authorities, the concern with economicgrowth. The growth target of 6% per year was not achieved, Brazil grew by 4,2% on average in the period. Such average, however, like all average, hides the diversity of performance across various sectors. Among the sectors most affected by the restrictive policiesadopted in this interregnum stands out the manufacturing industry, whose performancewas the least exciting and the most erratic. The objective of this article is to examine theeffects of Paeg’s fiscal, monetary and credit policy on the general performance of the Brazilian economy, and more specifically on the manufacturing industry and its main sectors.Entre 1964 e 1967, durante o primeiro governo militar, implementou-se oPrograma de Ação Econômica do Governo (Paeg), cujos objetivos principais compreendiam o combate às elevadas taxas de inflação e à crise do balanço de pagamentos. A despeito dessas prioridades precípuas, havia também, por parte das autoridadeseconômicas, a preocupação com o crescimento econômico. A meta de crescimentode 6% ao ano não foi atingida, o Brasil cresceu 4,2% em média no período. Tal média,no entanto, como toda média, oculta a diversidade de desempenhos entre os diversossetores. Entre os setores mais atingidos pelas políticas restritivas adotadas nesse interregno, destaca-se a indústria de transformação, cujo desempenho foi o menos empolgante e o mais errático. O objetivo do presente artigo é examinar os efeitos da políticafiscal, monetária e creditícia do Paeg sobre o desempenho geral da economia brasileirae, mais especificamente sobre a indústria de transformação e seus principais setores

A cor e a concretude da desigualdade no Brasil: a violência e o encarceramento dos jovens de cor ou raça preta ou parda / The color and concreteness of inequality in Brazil: violence and the incarceration of young people of black or brown color or race

Este artigo analisa se o perfil da população encarcerada no Brasil corresponde à distribuição da população brasileira em termos de cor, gênero e idade, com vista a verificar se há sobrerrepresentação de algum segmento populacional. Para isso, são apresentados, em primeiro lugar, as informações relativas à população total, por gênero, cor e idade, seguida de uma análise do mercado de trabalho, compreendendo a ocupação e o rendimento, também por gênero e cor. Em segundo lugar, são apontadas as características da população encarcerada, por gênero, idade, escolaridade, entre outros aspectos. Entre as conclusões a que o estudo chegou, destaca-se a sobrerrepresentação dos jovens homens negros ou pardos junto à população carcerária. 

Boletín NUESTRA AMÉRICA XXI - Desafíos y alternativas, num.40, Febrero 2020

Una excelente iniciativa del Grupo de Trabajo Crisis y economía mundial, coordinado por María Josefina Morales y Gabriela Roffinelli

Amblyomma sculptum Salivary PGE2 Modulates the Dendritic Cell-Rickettsia rickettsii Interactions in vitro and in vivo

Amblyomma sculptum is an important vector of Rickettsia rickettsii, causative agent of Rocky Mountain spotted fever and the most lethal tick-borne pathogen affecting humans. To feed on the vertebrate host's blood, A. sculptum secretes a salivary mixture, which may interact with skin resident dendritic cells (DCs) and modulate their function. The present work was aimed at depicting the A. sculptum saliva-host DC network and the biochemical nature of the immunomodulatory component(s) involved in this interface. A. sculptum saliva inhibits the production of inflammatory cytokines by murine DCs stimulated with LPS. The fractionation of the low molecular weight salivary content by reversed-phase chromatography revealed active fractions eluting from 49 to 55% of the acetonitrile gradient. Previous studies suggested that this pattern of elution matches with that observed for prostaglandin E2 (PGE2) and the molecular identity of this lipid mediator was unambiguously confirmed by a new high-resolution mass spectrometry methodology. A productive infection of murine DCs by R. rickettsii was demonstrated for the first time leading to proinflammatory cytokine production that was inhibited by both A. sculptum saliva and PGE2, a result also achieved with human DCs. The adoptive transfer of murine DCs incubated with R. rickettsii followed by treatment with A. sculptum saliva or PGE2 did not change the cytokine profile associated to cellular recall responses while IgG2a-specific antibodies were decreased in the serum of these mice. Together, these findings emphasize the role of PGE2 as a universal immunomodulator of tick saliva. In addition, it contributes to new approaches to explore R. rickettsii-DC interactions both in vitro and in vivo

IMPACTOS DO PROGRAMA DE AÇÃO ECONÔMICA DO GOVERNO (1964-1967) NA INDÚSTRIA DE TRANSFORMAÇÃO

Between 1964 and 1967, during the first military government, the Government Economic Action Program (Paeg) was implemented, whose main objectives werecombating high inflation rates and the balance of payments crisis. Despite these priorities, there was also, by the part of the economic authorities, the concern with economicgrowth. The growth target of 6% per year was not achieved, Brazil grew by 4,2% on average in the period. Such average, however, like all average, hides the diversity of performance across various sectors. Among the sectors most affected by the restrictive policiesadopted in this interregnum stands out the manufacturing industry, whose performancewas the least exciting and the most erratic. The objective of this article is to examine theeffects of Paeg’s fiscal, monetary and credit policy on the general performance of the Brazilian economy, and more specifically on the manufacturing industry and its main sectors.Entre 1964 e 1967, durante o primeiro governo militar, implementou-se oPrograma de Ação Econômica do Governo (Paeg), cujos objetivos principais compreendiam o combate às elevadas taxas de inflação e à crise do balanço de pagamentos. A despeito dessas prioridades precípuas, havia também, por parte das autoridadeseconômicas, a preocupação com o crescimento econômico. A meta de crescimentode 6% ao ano não foi atingida, o Brasil cresceu 4,2% em média no período. Tal média,no entanto, como toda média, oculta a diversidade de desempenhos entre os diversossetores. Entre os setores mais atingidos pelas políticas restritivas adotadas nesse interregno, destaca-se a indústria de transformação, cujo desempenho foi o menos empolgante e o mais errático. O objetivo do presente artigo é examinar os efeitos da políticafiscal, monetária e creditícia do Paeg sobre o desempenho geral da economia brasileirae, mais especificamente sobre a indústria de transformação e seus principais setores

The citrus flavonoid naringenin impairs the in vitro infection of human cells by Zika virus

Submitted by Manoel Barata ([email protected]) on 2019-12-03T19:15:53Z No. of bitstreams: 1 s41598-019-52626-3ok.pdf: 5313799 bytes, checksum: d20c9fb2c504897a712c12579e70ca58 (MD5)Approved for entry into archive by Manoel Barata ([email protected]) on 2019-12-18T20:05:03Z (GMT) No. of bitstreams: 1 s41598-019-52626-3ok.pdf: 5313799 bytes, checksum: d20c9fb2c504897a712c12579e70ca58 (MD5)Made available in DSpace on 2019-12-18T20:05:03Z (GMT). No. of bitstreams: 1 s41598-019-52626-3ok.pdf: 5313799 bytes, checksum: d20c9fb2c504897a712c12579e70ca58 (MD5) Previous issue date: 2019Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Física e Química. Laboratório de Física Biológica. Ribeirão Preto, São Paulo, Brasil.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas. Laboratório de Glicoimunologia. Ribeirão Preto, São Paulo, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Londrina, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Células Tronco. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.The Zika virus (ZIKV) is an arthropod-borne virus that belongs to the Flaviviridae family. The ZIKV infection is usually asymptomatic or is associated with mild clinical manifestations; however, increased numbers of cases of microcephaly and birth defects have been recently reported. To date, neither a vaccine nor an antiviral treatment has become available to control ZIKV replication. Among the natural compounds recognized for their medical properties, flavonoids, which can be found in fruits and vegetables, have been found to possess biological activity against a variety of viruses. Here, we demonstrate that the citrus flavanone naringenin (NAR) prevented ZIKV infection in human A549 cells in a concentration-dependent and ZIKV-lineage independent manner. NAR antiviral activity was also observed when primary human monocyte-derived dendritic cells were infected by ZIKV. NAR displayed its antiviral activity when the cells were treated after infection, suggesting that NAR acts on the viral replication or assembly of viral particles. Moreover, a molecular docking analysis suggests a potential interaction between NAR and the protease domain of the NS2B-NS3 protein of ZIKV which could explain the anti-ZIKV activity of NAR. Finally, the results support the potential of NAR as a suitable candidate molecule for developing anti-ZIKV treatments

Prevalence of the TP53 p.R337H mutation in breast cancer patients in Brazil

Germline TP53 mutations predispose individuals to multiple cancers and are associated with Li-Fraumeni/Li-Fraumeni-Like Syndromes (LFS/LFL). The founder mutation TP53 p.R337H is detected in 0.3% of the general population in southern Brazil. This mutation is associated with an increased risk of childhood adrenal cortical carcinoma (ACC) but is also common in Brazilian LFS/LFL families. Breast Cancer (BC) is one of the most common cancers diagnosed in TP53 mutation carriers. We have assessed the prevalence of p.R337H in two groups: (1) 59 BC affected women with a familial history (FH) suggestive of hereditary cancer syndrome but no LFS/LFL features; (2) 815 BC affected women unselected for cancer FH, diagnosed with BC at or before age 45 or at age 55 or older. Among group 1 and group 2 patients, 2/59 (3.4%, CI95%: 0.4%–11.7%) and 70/ 815 (8.6%, CI95%: 6.8%–10.7%), respectively, were p.R337H carriers in the germline. The prevalence of p.R337H was higher in women diagnosed with BC at or before age 45 (12.1%, CI95%: 9.1%–15.8%) than at age 55 or older (5.1%, CI95%: 3.2%– 7.7%), p,0.001). The Brazilian founder p.R337H haplotype was detected in all carriers analysed. These results suggest that inheritance of p.R337H may significantly contribute to the high incidence of BC in Brazil, in addition to its recently demonstrated impact on the risk of childhood ACC

Prevalence of the TP53 p.R337H mutation in breast cancer patients in Brazil

Germline TP53 mutations predispose individuals to multiple cancers and are associated with Li-Fraumeni/Li-Fraumeni-Like Syndromes (LFS/LFL). The founder mutation TP53 p.R337H is detected in 0.3% of the general population in southern Brazil. This mutation is associated with an increased risk of childhood adrenal cortical carcinoma (ACC) but is also common in Brazilian LFS/LFL families. Breast Cancer (BC) is one of the most common cancers diagnosed in TP53 mutation carriers. We have assessed the prevalence of p.R337H in two groups: (1) 59 BC affected women with a familial history (FH) suggestive of hereditary cancer syndrome but no LFS/LFL features; (2) 815 BC affected women unselected for cancer FH, diagnosed with BC at or before age 45 or at age 55 or older. Among group 1 and group 2 patients, 2/59 (3.4%, CI95%: 0.4%–11.7%) and 70/ 815 (8.6%, CI95%: 6.8%–10.7%), respectively, were p.R337H carriers in the germline. The prevalence of p.R337H was higher in women diagnosed with BC at or before age 45 (12.1%, CI95%: 9.1%–15.8%) than at age 55 or older (5.1%, CI95%: 3.2%– 7.7%), p,0.001). The Brazilian founder p.R337H haplotype was detected in all carriers analysed. These results suggest that inheritance of p.R337H may significantly contribute to the high incidence of BC in Brazil, in addition to its recently demonstrated impact on the risk of childhood ACC