184 research outputs found
Magneto-plasmonic heterodimers: Evaluation of different synthesis approaches
Nanomedicine has gained huge attention in recent years with new approaches in medical diagnosis and therapy. Particular consideration has been devoted to the nanoparticles (NPs) in theranostic field with specific interest for magnetic and gold NPs (MNPs and GNPs) due to their peculiar properties under exposition to electromagnetic fields. In this paper, we aim to develop magneto-plasmonic heterodimer by combining MNPs and GNPs through a facile and reproducible synthesis and to investigate the influence of different synthesis parameters on their response to magnetic and optical stimuli. In particular, various syntheses were performed by changing the functionalization step and using or not a reducing agent to obtain stable NP suspensions with tailored properties. The obtained heterodimers were characterized through physical, chemical, optical, and magnetic analysis, in order to evaluate their size, shape, plasmonic properties, and superparamagnetic behavior. The results revealed that the shape and dimensions of the nanocomposites can be tuned by MNPs surface functionalization, as well as by the use of a reducing agent, giving rise to nanoplatform suitable for biomedical application, exploiting the gold absorbing peak in the specific gold absorbing range of GNPs, while maintaining the superparamagnetic behavior typical of the MNPs. The obtained nanocomposites can be proposed as potential candidates for cancer theranostics
The Fate of Intranasally Instilled Silver Nanoarchitectures
The intranasal administration of drugs allows an effective and noninvasive therapeutic action on the respiratory tract. In an era of rapidly increasing antimicrobial resistance, new approaches to the treatment of communicable diseases, especially lung infections, are urgently needed. Metal nanoparticles are recognized as a potential last-line defense, but limited data on the biosafety and nano/biointeractions preclude their use. Here, we quantitatively and qualitatively assess the fate and the potential risks associated with the exposure to a silver nanomaterial model (i.e., silver ultrasmall-in-nano architectures, AgNAs) after a single dose instillation. Our results highlight that the biodistribution profile and the nano/biointeractions are critically influenced by both the design of the nanomaterial and the chemical nature of the metal. Overall, our data suggest that the instillation of rationally engineered nanomaterials might be exploited to develop future treatments for (non)communicable diseases of the respiratory tract
Quantized Nambu-Poisson Manifolds in a 3-Lie Algebra Reduced Model
We consider dimensional reduction of the Bagger-Lambert-Gustavsson theory to
a zero-dimensional 3-Lie algebra model and construct various stable solutions
corresponding to quantized Nambu-Poisson manifolds. A recently proposed Higgs
mechanism reduces this model to the IKKT matrix model. We find that in the
strong coupling limit, our solutions correspond to ordinary noncommutative
spaces arising as stable solutions in the IKKT model with D-brane backgrounds.
In particular, this happens for S^3, R^3 and five-dimensional Neveu-Schwarz
Hpp-waves. We expand our model around these backgrounds and find effective
noncommutative field theories with complicated interactions involving
higher-derivative terms. We also describe the relation of our reduced model to
a cubic supermatrix model based on an osp(1|32) supersymmetry algebra.Comment: 22 page
Membrane Sigma-Models and Quantization of Non-Geometric Flux Backgrounds
We develop quantization techniques for describing the nonassociative geometry
probed by closed strings in flat non-geometric R-flux backgrounds M. Starting
from a suitable Courant sigma-model on an open membrane with target space M,
regarded as a topological sector of closed string dynamics in R-space, we
derive a twisted Poisson sigma-model on the boundary of the membrane whose
target space is the cotangent bundle T^*M and whose quasi-Poisson structure
coincides with those previously proposed. We argue that from the membrane
perspective the path integral over multivalued closed string fields in Q-space
is equivalent to integrating over open strings in R-space. The corresponding
boundary correlation functions reproduce Kontsevich's deformation quantization
formula for the twisted Poisson manifolds. For constant R-flux, we derive
closed formulas for the corresponding nonassociative star product and its
associator, and compare them with previous proposals for a 3-product of fields
on R-space. We develop various versions of the Seiberg-Witten map which relate
our nonassociative star products to associative ones and add fluctuations to
the R-flux background. We show that the Kontsevich formula coincides with the
star product obtained by quantizing the dual of a Lie 2-algebra via convolution
in an integrating Lie 2-group associated to the T-dual doubled geometry, and
hence clarify the relation to the twisted convolution products for topological
nonassociative torus bundles. We further demonstrate how our approach leads to
a consistent quantization of Nambu-Poisson 3-brackets.Comment: 52 pages; v2: references adde
Influence of Analysis Technique on Measurement of Diffusion Tensor Imaging Parameters
We compared results from various methods of analysis of diffusion tensor imaging (DTI) data from a single data set consisting of 10 healthy adolescents
Cell Membrane-Coated Magnetic Nanocubes with a Homotypic Targeting Ability Increase Intracellular Temperature due to ROS Scavenging and Act as a Versatile Theranostic System for Glioblastoma Multiforme
In this study, hybrid nanocubes composed of magnetite (Fe3O4) and manganese dioxide (MnO2), coated with U-251 MG cell-derived membranes (CM-NCubes) are synthesized. The CM-NCubes demonstrate a concentration-dependent oxygen generation (up to 15%), and, for the first time in the literature, an intracellular increase of temperature (6 \ub0C) due to the exothermic scavenging reaction of hydrogen peroxide (H2O2) is showed. Internalization studies demonstrate that the CM-NCubes are internalized much faster and at a higher extent by the homotypic U-251 MG cell line compared to other cerebral cell lines. The ability of the CM-NCubes to cross an in vitro model of the blood-brain barrier is also assessed. The CM-NCubes show the ability to respond to a static magnet and to accumulate in cells even under flowing conditions. Moreover, it is demonstrated that 500 \ub5g mL 121 of sorafenib-loaded or unloaded CM-NCubes are able to induce cell death by apoptosis in U-251 MG spheroids that are used as a tumor model, after their exposure to an alternating magnetic field (AMF). Finally, it is shown that the combination of sorafenib and AMF induces a higher enzymatic activity of caspase 3 and caspase 9, probably due to an increment in reactive oxygen species by means of hyperthermia
Mindfulness-based interventions for young offenders: a scoping review
Youth offending is a problem worldwide. Young people in the criminal justice system have frequently experienced adverse childhood circumstances, mental health problems, difficulties regulating emotions and poor quality of life. Mindfulness-based interventions can help people manage problems resulting from these experiences, but their usefulness for youth offending populations is not clear. This review evaluated existing evidence for mindfulness-based interventions among such populations. To be included, each study used an intervention with at least one of the three core components of mindfulness-based stress reduction (breath awareness, body awareness, mindful movement) that was delivered to young people in prison or community rehabilitation programs. No restrictions were placed on methods used. Thirteen studies were included: three randomized controlled trials, one controlled trial, three pre-post study designs, three mixed-methods approaches and three qualitative studies. Pooled numbers (n = 842) comprised 99% males aged between 14 and 23. Interventions varied so it was not possible to identify an optimal approach in terms of content, dose or intensity. Studies found some improvement in various measures of mental health, self-regulation, problematic behaviour, substance use, quality of life and criminal propensity. In those studies measuring mindfulness, changes did not reach statistical significance. Qualitative studies reported participants feeling less stressed, better able to concentrate, manage emotions and behaviour, improved social skills and that the interventions were acceptable. Generally low study quality limits the generalizability of these findings. Greater clarity on intervention components and robust mixed-methods evaluation would improve clarity of reporting and better guide future youth offending prevention programs
Plant-Inspired Polyaleuritate–Nanocellulose Composite Photonic Films
Plant epidermis is a complex composite material composed by the cuticle and the epidermal cells. In order to prevent dehydration the cuticle is a water barrier composed of an outer layer (proper cuticle) connected to the cell wall of the epidermal cells via a complex matrix often referred to as cutinised cell wall, that acts as compatibilizer for the water repellent cutin and the hydrophilic polysaccharides in the cell walls. Here, biomimetic plant epidermis-inspired films with selective reflection properties were prepared by formation of an aliphatic polyester coating on chiral nematic cellulose nanocrystal (CNC) films. Aleuritic acid, a polyhydroxylated fatty acid, was sprayed on CNC films and polymerized by hot-pressing. The micromorphology of the resultant samples was characterized by scanning electron microscopy (SEM). Polarised optical microscopy confirmed the CNCs helicoidal organization in the films, responsible for the reflection of circularly polarised light, before and after the hot-pressing. The chemical analysis by attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) confirmed the polymerization of aleuritic acid into polyaleuritate with differences between filter paper and woodpulp substrates that were ascribed to water elimination during polycondensation. The characterization of the mechanical (Young’s modulus and hardness from nanoindentation tests) and hydrodynamic (water uptake and water vapor transmission rate) properties indicated that this process enhances the robustness and waterproof behaviour of CNC films. These properties were comparable to those of commercial and biodegradable materials commonly used in packaging such as polyesters and cellulose derivatives, thus making these natural composite ideal for optically responsive packaging applications.J.A.H.-G. acknowledges the funding by the Spanish “Ministerio de Ciencia, Innovación y Universidades”, project numbers RTI2018-096896-J-I00 and RYC2018-025079-I
Light and tree size influence belowground development in yellow birch and sugar maple
The effects of light and tree size on the root architecture and mycorrhiza of yellow birch (Betula alleghaniensis Britton) and sugar maple (Acer saccharum Marsh) growing in the understory of deciduous forests in southern Qu
G<sub>2</sub>-structures and quantization of non-geometric M-theory backgrounds
We describe the quantization of a four-dimensional locally non-geometric
M-theory background dual to a twisted three-torus by deriving a phase space
star product for deformation quantization of quasi-Poisson brackets related to
the nonassociative algebra of octonions. The construction is based on a choice
of -structure which defines a nonassociative deformation of the addition
law on the seven-dimensional vector space of Fourier momenta. We demonstrate
explicitly that this star product reduces to that of the three-dimensional
parabolic constant -flux model in the contraction of M-theory to string
theory, and use it to derive quantum phase space uncertainty relations as well
as triproducts for the nonassociative geometry of the four-dimensional
configuration space. By extending the -structure to a -structure,
we propose a 3-algebra structure on the full eight-dimensional M2-brane phase
space which reduces to the quasi-Poisson algebra after imposing a particular
gauge constraint, and whose deformation quantisation simultaneously encompasses
both the phase space star products and the configuration space triproducts. We
demonstrate how these structures naturally fit in with previous occurences of
3-algebras in M-theory.Comment: 41 pages; v2: Final version published in JHE
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