Synthesis and control of generalised dynamically substructured systems

The experimental technique for testing engineering systems via the method of dynamic substructuring is receiving significant global interest, for example in the fields of large-scale structural, aerospace, and automotive system testing. Dynamically substructured systems (DSSs) enable full-size, critical components of a complete system to be physically tested in real-time, within a laboratory environment, while the remainder of the system is modelled numerically. The intention is that the combined physical-numerical DSS behaves as if it were the complete (or emulated) system.In an ideal mechanical DSS, for example, perfect synchronization of displacements and forces at the interfaces between the numerical and physical components (or substructures) is required. Hence, a key design feature of successful DSS systems is the high fidelity of the control action. Equally, a DSS controller must be able to cope with non-linear, time-varying, and uncertain parameters within the physical substructure dynamics.The main purpose of this paper is to present a generalized DSS framework, together with associated linear and adaptive control strategies, that are specifically tailored to achieve high synchronization performance. The initial studies of this problem, as described in an earlier paper by Stoten and Hyde, are therefore continued by generalizing both the DSS dynamics and the control strategies to include (a) a number of newly defined modes of operation and (b) multivariable dynamics. In addition, comparative implementation and simulation studies are included, based upon the DSS testing of a mechanical system (a planar quasi-motorcycle rig), which was specifically designed to highlight the main features of this research. The comparative studies show that excellent DSS control can be achieved, especially with the addition of an adaptive component to the controller, despite significant changes to the physical substructure dynamics

Hepatic stellate cells and parasite-induced liver fibrosis

ABSTRACT: Fibrogenesis is a common feature of many diseases where there is severe insult to the liver. The hepatic stellate cell trans-differentiation into a myofibroblast has been identified as an important event in liver fibrogenesis and has been well investigated over the last few years in a number of liver diseases. The trans-differentiation process can be monitored in vitro by evaluation of biomarkers that are characteristic of normal quiescent hepatic stellate cells or activated myofibroblasts. Two major parasitic diseases associated with liver injury and fibrosis are schistosomiasis and echinococcosis. Recent studies have highlighted a role for activated hepatic stellate cells in both murine and human schistosomiasis as well as demonstrating that schistosome antigens are able to regulate this trans-differentiation process. Study of the hepatic stellate cell and its interaction with parasite-derived antigens may be pivotal in our understanding of the pathology associated with schistosomiasis and other parasitic diseases, including echinococcosis, as well as revealing new information on the trans-differentiation process in this cell type

Adaptive Neural Network Feedforward Control for Dynamically Substructured Systems

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Immunotherapeutic potential of DISC-HSV and OX40L in cancer

Several vectors, viral and bacterial, have been developed over the past few years for means of generating an effective anti-tumor immune response. We have developed and studied a “model for immunotherapy” using a viral vector DISC-HSV, which efficiently transduces various tumor cell lines and offers a useful vehicle for the further development of cell based vaccines. The immunotherapeutic potential of DISC-HSV encoding GMCSF was demonstrated in a number of murine carcinoma models, leading to complete regression of well established tumors in up to 70% of the mice. Moreover, the therapeutic potential of DISC-HSV-GMCSF was significantly enhanced when used in combination therapy with either OX40L or dendritic cells (DC), even in poorly immunogenic tumor model. The ability of this vector to accept large gene inserts, its good safety profile, its ability to undergo only a single round of infection, the inherent viral immunostimulatory properties and its ability to infect various tumor cell lines efficiently, make DISC-HSV an ideal candidate vector for immunotherapy. The DISC- CT-26 tumor model has been used to investigate these mechanisms associated with immunotherapy – induced tumor rejection. Although CTL induction, was positively correlated with regression, MHC class I down regulation and accumulation of immature Gr1+ myeloid cells were shown to be the main immuno-suppressor mechanisms operating against regression and associated with progressive tumor growth

Design of liquid crystal based coplanar waveguide tunable phase shifter with no floating electrodes for 60-90 GHz applications

A continuously tunable millimeter wave (mm-wave) phase shifter for 60-90 GHz applications was proposed using a coplanar waveguide (CPW) structure without the use of a floating electrode (FE). In contrast to conventional CPW-FE structures, the proposed FE-free CPW device can be modulated by the nematic liquid crystal (LC) materials confined in two symmetric feeding channels. The nearly true-TEM nature of this CPW design enables wideband and low-loss operations, particularly in high frequencies up to 90 GHz. In order to optimize between high tunability and low loss, the aspect ratio of the CPW structure was optimized to maximize the defined Figure-of-Merit (FoM). By taking into account different loss mechanisms in the designed structure and the effect of LC orientations, the driving-voltage dependent impedance matching was examined to minimize the return and insertion losses. As an example, the design of a phase shifter aimed to operate at 79 GHz with low bias voltages (0-10 V) is presented, showing a wide phase shift range of 0-408° and a low insertion loss from -6.15dB to -4.56dB. The corresponding FoM is 66.3°/dB, which make it possible to outperform over other LC-based phase shifters as reported within the targeted frequency range of 60-90 GHz

Atomic Layer Deposition of ZnO on Multi-walled Carbon Nanotubes and Its Use for Synthesis of CNT-ZnO Heterostructures.

In this article, direct coating of ZnO on PECVD-grown multi-walled carbon nanotubes (MWCNTs) is achieved using atomic layer deposition (ALD). Transmission electron microscopy investigation shows that the deposited ZnO shell is continuous and uniform, in contrast to the previously reported particle morphology. The ZnO layer has a good crystalline quality as indicated by Raman and photoluminescence (PL) measurements. We also show that such ZnO layer can be used as seed layer for subsequent hydrothermal growth of ZnO nanorods, resulting in branched CNT-inorganic hybrid nanostructures. Potentially, this method can also apply to the fabrication of ZnO-based hybrid nanostructures on other carbon nanomaterials.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Provenance and tectonic setting of the Neoproterozoic Yanbian Group, western Yangtze Block (SW China)

Tectonic evolution of the Yangtze Block of South China during Neoproterozoic time has been a major focus of debate and is important in the reconstruction of the Rodinian supercontinent. The Yanbian Group in the western margin of the Yangtze Block is a well-preserved Neoproterozoic volcanic-sedimentary sequence and provides a rare opportunity to examine the provenance and tectonic setting. It consists of a lower part composed of ∼1500 m thick basaltic lavas and an upper part of ∼3500 m thick flysch deposits. The flysch sequence contains typical deep marine turbidites consisting mainly of fine-grained volcaniclastic sandstones and mudstones, indicating a submarine fan depositional system. Detrital zircon dating yields ages ranging from ca. 865 Ma to 1000 Ma with two peaks at ca. 900 Ma and 920 Ma, respectively. The Yanbian Group is intruded by the ∼860 Ma Guandaoshan dioritic pluton, constraining its depositional age at ca. 870 Ma. The sandstones contain abundant feldspar and lithic fragments with minor amounts of quartz and have an average composition of Q 16F 35L 49, suggesting a proximal source and an undissected to transitional arc setting. The lithic fragments in the sandstones point to andesitic and felsic volcanic rock sources. The sandstones and mudstones have intermediate SiO 2/Al 2O 3 (typically 3-6), high Fe 2O 3 + MgO contents (5-12 wt%), and moderate to high K 2O/Na 2O ratios (generally 0.1-1 and 1-10 for sandstones and mudstones, respectively). In comparison with average upper continental crust, they show strong negative Nb-Ta anomalies, slight depletion of Zr-Hf, La and Th, but moderate enrichment of V, Cr, Ni, and Sc. These rocks show LREE enrichment (La/Yb N = 5.3-7.4) with flat HREE, and pronounced negative Eu anomalies (Eu/Eu * = 0.6-0.74) in chondrite-normalized REE patterns, similar to post-Archean shales. Geochemical data for these rocks suggest an arc setting and intermediate-felsic volcanic source, consistent with a back-arc basin scenario for the basaltic lavas in the lower Yanbian Group. Together with regional geological evidence, the turbidites of the Yanbian Group strongly support a model in which the western margin of the Yangtze Block was a major magmatic arc, active probably from ∼920 Ma to 740 Ma, a period of more than 180 million years. © 2008 Elsevier B.V. All rights reserved.postprin

Design of Broadband Non-Foster Circuits Based on Resonant Tunneling Diodes

A non-Foster circuit (NFC) based on the resonant tunneling diode (RTD) is proposed for application to broadband impedance matching of electrically small antennas (ESAs). NFCs have traditionally been implemented with transistor pairs to achieve negative impedance, but these have limitations with respect to performance and operational bandwidth at high frequencies. At certain biasing voltages, double barrier RTDs behave as negative differential resistance (NDR) devices, which may be transformed to exhibit negative impedance. In contrast to the transistor-based NFC, these structures serve to gyrate or invert the load impedance, such that an inductive load will lead to a negative capacitance, and vice versa. This device is termed a negative impedance inverter (NII). We demonstrate negative impedance behavior for prototypes with measurements of negative resistance at up to 3 GHz, and device gain of around 5 dB from DC to 4 GHz. Design for stability of the RTD is performed using the Nyquist stability criterion. Stabilized negative capacitance NFCs show optimum performance from DC to the GHz range depending upon the load value. These NFCs are used to impedance match an antenna at low frequencies. An antenna with only one resonance at 3.5 GHz has been transformed with two different matching circuits: to an antenna encompassing the 1 to 2 GHz range; as well as the VHF/UHF bands from 300 MHz to 1 GHz. Additionally, RTDs have been demonstrated for operation at up to THz frequencies, so this topology can be extended to higher frequencies subject to fabrication constraints

Enhanced Surface Area Carbon Cathodes for the Hydrogen–Bromine Redox Flow Battery

This is the final version. Available on open access from MDPI via the DOI in this recordData Availability Statement: Data supporting the results can be found within the MELODY project community on the Zenodo repository: https://zenodo.org/communities/melody (accessed on 30 November 2022).The hydrogen–bromine redox flow battery is a promising energy storage technology with the potential for capital costs as low as 220 $ kWh−1 and high operational power densities in excess of 1.4 W cm−2. In this work, enhanced surface area bromine electrodes incorporating carbon black (CB) and graphene nanoplatelets (GnPs) on carbon paper and carbon cloth substrates were investigated, and the effect of electrolyte concentration on performance of the electrodes was studied. Carbon-black modified electrodes are found to possess the largest electrochemically active surface areas, i.e., up to 11 times that of unmodified materials, while GnP electrodes are shown to have superior kinetic activity towards the bromine electrode reaction. In terms of performance, lower electrolyte concentrations are found to favour the improved kinetic parameters associated with graphene nanoplatelet electrodes, while highly concentrated electrolytes favour the larger electrochemically active surface area of carbon black electrodes. The optimal performance was achieved on a carbon-black-modified carbon cloth electrode in a 6 M HBr/2 M Br2 electrolyte concentration, with polarisation current densities approaching 1.6 A cm−2 at overpotentials of ±400 mV, and mean overpotentials of 364 mV during oxidation and 343 mV during reduction, resulting from bromine oxidation/reduction cycling tests at ±1.5 A cm−2.European Union Horizon 2020Engineering and Physical Sciences Research Council (EPSRC