468 research outputs found
The Raman Spectra of Boron Trifluoride, Trichloride, and Tribromide. The Effect of the Boron Isotopes
The intratracheal administration of endotoxin: X. Dexamethasone downregulates neutrophil emigration and cytokine expression in vivo
Intratracheal instillation of endotoxin (LPS) causes acute pulmonary inflammation characterized by the accumulation of plasma proteins and leukocytes within the pulmonary airways. The synthetic glucocorticoid dexamethasone 1) inhibits the LPS-initiated vascular leak of plasma proteins into the airspace, 2) inhibits the LPS-initiated emigration of neutrophils and lymphocytes into the airspace in a dose-dependent fashion, and 3) inhibits LPS-initiated mRNA and/or bronchoalveolar lavage protein expression of cytokines (TNF, IL-1 and IL-6) and chemokines (MIP-l α , MIP-2 and MCP-1). In conclusion, dexamethasone inhibits both the vascular and cellular aspects of acute inflammation by downregulation of a broad spectrum of inflammatory cytokines and chemokines.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44515/1/10753_2005_Article_BF01487403.pd
Benutzerorientierte Software-Entwicklung:Konzepte, Methoden und Vorgehen zur Benutzerbeteiligung
On the Antenna Beam Shape Reconstruction Using Planet Transit
The calibration of the in-flight antenna beam shape and possible
beamdegradation is one of the most crucial tasks for the upcoming Planck
mission. We examine several effects which could significantly influence the
in-flight main beam calibration using planet transit: the problems of the
variability of the Jupiter's flux, the antenna temperature and passing of the
planets through the main beam. We estimate these effects on the antenna beam
shape calibration and calculate the limits on the main beam and far sidelobe
measurements, using observations of Jupiter and Saturn. We also discuss
possible effects of degradation of the mirror surfaces and specify
corresponding parameters which can help us to determine these effects.Comment: 10 pages, 8 figure
Broadband Meter-Wavelength Observations of Ionospheric Scintillation
Intensity scintillations of cosmic radio sources are used to study
astrophysical plasmas like the ionosphere, the solar wind, and the interstellar
medium. Normally these observations are relatively narrow band. With Low
Frequency Array (LOFAR) technology at the Kilpisj\"arvi Atmospheric Imaging
Receiver Array (KAIRA) station in northern Finland we have observed
scintillations over a 3 octave bandwidth. ``Parabolic arcs'', which were
discovered in interstellar scintillations of pulsars, can provide precise
estimates of the distance and velocity of the scattering plasma. Here we report
the first observations of such arcs in the ionosphere and the first broad-band
observations of arcs anywhere, raising hopes that study of the phenomenon may
similarly improve the analysis of ionospheric scintillations. These
observations were made of the strong natural radio source Cygnus-A and covered
the entire 30-250\,MHz band of KAIRA. Well-defined parabolic arcs were seen
early in the observations, before transit, and disappeared after transit
although scintillations continued to be obvious during the entire observation.
We show that this can be attributed to the structure of Cygnus-A. Initial
results from modeling these scintillation arcs are consistent with simultaneous
ionospheric soundings taken with other instruments, and indicate that
scattering is most likely to be associated more with the topside ionosphere
than the F-region peak altitude. Further modeling and possible extension to
interferometric observations, using international LOFAR stations, are
discussed.Comment: 11 pages, 17 figure
Radio source calibration for the VSA and other CMB instruments at around 30 GHz
Accurate calibration of data is essential for the current generation of CMB
experiments. Using data from the Very Small Array (VSA), we describe procedures
which will lead to an accuracy of 1 percent or better for experiments such as
the VSA and CBI. Particular attention is paid to the stability of the receiver
systems, the quality of the site and frequent observations of reference
sources. At 30 GHz the careful correction for atmospheric emission and
absorption is shown to be essential for achieving 1 percent precision. The
sources for which a 1 percent relative flux density calibration was achieved
included Cas A, Cyg A, Tau A and NGC7027 and the planets Venus, Jupiter and
Saturn. A flux density, or brightness temperature in the case of the planets,
was derived at 33 GHz relative to Jupiter which was adopted as the fundamental
calibrator. A spectral index at ~30 GHz is given for each. Cas A,Tau A, NGC7027
and Venus were examined for variability. Cas A was found to be decreasing at
percent per year over the period March 2001 to August 2004.
In the same period Tau A was decreasing at percent per year. A
survey of the published data showed that the planetary nebula NGC7027 decreased
at percent per year over the period 1967 to 2003. Venus showed
an insignificant ( percent) variation with Venusian illumination.
The integrated polarization of Tau A at 33 GHz was found to be
percent at pa .}Comment: 13 pages, 15 figures, submitted to MNRA
Intratracheal administration of endotoxin and cytokines: VIII. LPS induces E-selectin expression; anti-E-selectin and soluble E-selectin inhibit acute inflammation
E-selectin is an inducible endothelial adhesion molecule that binds neutrophils. E-selectin mRNA is not constitutively detectable in the lungs of rats. Intratracheal injection of LPS induces pulmonary E-selectin mRNA expression at 2â4 h. Intratracheal injection of LPS followed at 2 and 4 h by intravenous injection of mouse F(abâČ) 2 or F(abâČ)) anti-E-selectin monoclonal antibody inhibits the emigration of neutrophils into the bronchoalveolar space at 6 h by 50â70%. TNF and IL-6 bioactivity are not decreased in bronchoalveolar lavage fluid after treatment with anti-E-selectin antibody as compared to controls, suggesting that the anti-E-selectin does not affect the magnitude of the LPS-initiated cytokine cascade. Intratracheal injection of LPS followed at 2 and 4 h by intravenous injection of soluble E-selectin inhibits neutrophilic emigration at 6 h by 64%, suggesting that endogenous soluble E-selectin shed from activated endothelium may play a role in the endogenous down-regulation of acute inflammation. E-selectin-mediated adhesion of neutrophils to endothelium appears crucial to the full development of the acute inflammation response.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44513/1/10753_2005_Article_BF01534436.pd
Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung
Phagocytes not only coordinate acute inflammation and host defense at mucosal sites, but also contribute to tissue damage. Respiratory infection causes a globally significant disease burden and frequently progresses to acute respiratory distress syndrome, a devastating inflammatory condition characterized by neutrophil recruitment and accumulation of protein-rich edema fluid causing impaired lung function. We hypothesized that targeting the intracellular protein myeloid cell leukemia 1 (Mcl-1) by a cyclin-dependent kinase inhibitor (AT7519) or a flavone (wogonin) would accelerate neutrophil apoptosis and resolution of established inflammation, but without detriment to bacterial clearance. Mcl-1 loss induced human neutrophil apoptosis, but did not induce macrophage apoptosis nor impair phagocytosis of apoptotic neutrophils. Neutrophil-dominant inflammation was modelled in mice by either endotoxin or bacteria (Escherichia coli). Downregulating inflammatory cell Mcl-1 had anti-inflammatory, pro-resolution effects, shortening the resolution interval (R(i)) from 19 to 7âh and improved organ dysfunction with enhanced alveolarâcapillary barrier integrity. Conversely, attenuating drug-induced Mcl-1 downregulation inhibited neutrophil apoptosis and delayed resolution of endotoxin-mediated lung inflammation. Importantly, manipulating lung inflammatory cell Mcl-1 also accelerated resolution of bacterial infection (R(i); 50 to 16âh) concurrent with enhanced bacterial clearance. Therefore, manipulating inflammatory cell Mcl-1 accelerates inflammation resolution without detriment to host defense against bacteria, and represents a target for treating infection-associated inflammation
Morphology and kinematics of Lynds 1642
The high latitude translucent molecular cloud L1642 has been mapped in the
J=1-0 and J=2-1 transitions of 12CO, 13CO and C18O using the SEST radio
telescope. We have analysed the morphology and velocity structure of the cloud
using the Positive Matrix Factorization (PMF) method. The results show that
L1642 is composed of a main structure at radial velocity 0.2 km/s while the
higher velocity components at ~0.5 and 1.0 km/s form an incomplete ring around
it, suggesting an expanding shell structure. Fainter emission extends to the
north with a still higher velocity of up to 1.6 km/s. Such a velocity structure
suggests an elongated morphology in the line of sight direction. The physical
properties of the cloud have been investigated assuming LTE conditions, but
non-LTE radiative transfer models are also constructed for the 13CO
observations. We confirm that L1642 follows an r^-1 density distribution in its
outer parts while the distribution is considerably flatter in the core. The
cloud is close to virial equilibrium. In an Appendix the PMF results are
compared with the view obtained through the analysis of channel maps and by the
use of Principal Component Analysis (PCA). Both PMF and PCA present the
observations as a linear combination of basic spectral shapes that are
extracted from the data. Comparison of the methods shows that the PMF method in
particular is able to produce a presentation of the complex velocity that is
both compact and easily interpreted.Comment: Accepted to A&
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